NCI-H596 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description Human lung adenosquamous carcinoma cell line; derived in 1983 from a tumor mass in the chest wall of a patient with adenosquamous carcinoma of the lung. (BRENDA Tissue and Enzyme Source Ontology, BTO_0002209)
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Genes

243 genes with high or low expression in NCI-H596 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
SEMG1 semenogelin I 3.60177
SNX13 sorting nexin 13 3.04743
H2AFV H2A histone family, member V 2.93657
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 2.56525
BTN3A3 butyrophilin, subfamily 3, member A3 2.52505
WDR76 WD repeat domain 76 2.38106
INPP1 inositol polyphosphate-1-phosphatase 2.36521
SDHAP1 succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 1 2.33647
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.32374
DPY19L1 dpy-19-like 1 (C. elegans) 2.28322
ANP32C acidic (leucine-rich) nuclear phosphoprotein 32 family, member C 2.22108
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 2.17603
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E 2.14373
ANKMY2 ankyrin repeat and MYND domain containing 2 2.08916
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 2.08211
HIBADH 3-hydroxyisobutyrate dehydrogenase 2.06199
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 2.0595
POU4F3 POU class 4 homeobox 3 2.03609
RPA3 replication protein A3, 14kDa 2.00132
IDO1 indoleamine 2,3-dioxygenase 1 1.99535
MUT methylmalonyl CoA mutase 1.96386
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 1.9619
RNF114 ring finger protein 114 1.89303
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 1.87751
POSTN periostin, osteoblast specific factor 1.87692
HSPB3 heat shock 27kDa protein 3 1.86858
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 1.85919
NCK1 NCK adaptor protein 1 1.81115
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 1.80024
CP ceruloplasmin (ferroxidase) 1.77217
PDCD6 programmed cell death 6 1.73608
BLVRA biliverdin reductase A 1.73403
MRPS22 mitochondrial ribosomal protein S22 1.7182
CD1D CD1d molecule 1.70574
CD14 CD14 molecule 1.7042
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 1.68621
APOL1 apolipoprotein L, 1 1.67898
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 1.6685
MEPE matrix extracellular phosphoglycoprotein 1.66413
LRRC16A leucine rich repeat containing 16A 1.66167
XDH xanthine dehydrogenase 1.65318
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 1.64339
PRDM9 PR domain containing 9 1.61335
ARSF arylsulfatase F 1.60942
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 1.60693
RUNDC3B RUN domain containing 3B 1.60432
MR1 major histocompatibility complex, class I-related 1.59717
TLR3 toll-like receptor 3 1.58955
DAP death-associated protein 1.5884
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 1.5829
HUS1 HUS1 checkpoint homolog (S. pombe) 1.57893
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 1.57578
AQP3 aquaporin 3 (Gill blood group) 1.57487
GFOD1 glucose-fructose oxidoreductase domain containing 1 1.56499
BRIX1 BRX1, biogenesis of ribosomes 1.55834
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.55015
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 1.54873
SLC35A5 solute carrier family 35, member A5 1.54778
NIPBL Nipped-B homolog (Drosophila) 1.54701
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 1.54195
BLCAP bladder cancer associated protein 1.53428
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 1.53263
STARD5 StAR-related lipid transfer (START) domain containing 5 1.51641
CRYGB crystallin, gamma B 1.51579
CSNK2B casein kinase 2, beta polypeptide 1.50767
CROT carnitine O-octanoyltransferase 1.49632
ZNF80 zinc finger protein 80 1.49393
LAP3 leucine aminopeptidase 3 1.49263
SH3GLB1 SH3-domain GRB2-like endophilin B1 1.48824
ADAM10 ADAM metallopeptidase domain 10 1.4834
LNPEP leucyl/cystinyl aminopeptidase 1.47911
HIGD1B HIG1 hypoxia inducible domain family, member 1B 1.47824
SEPT7 septin 7 1.47803
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 1.47736
FGF12 fibroblast growth factor 12 1.47559
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.47514
PPY pancreatic polypeptide 1.47226
TAS2R9 taste receptor, type 2, member 9 1.47031
BMPER BMP binding endothelial regulator 1.46755
GPER1 G protein-coupled estrogen receptor 1 1.46681
RAB8B RAB8B, member RAS oncogene family 1.46626
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 1.46508
PCDHB6 protocadherin beta 6 1.46186
CFB complement factor B 1.45369
TMEM14A transmembrane protein 14A 1.45326
FKBP14 FK506 binding protein 14, 22 kDa 1.4512
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.44977
PI3 peptidase inhibitor 3, skin-derived 1.444
MXRA5 matrix-remodelling associated 5 1.43182
ZNF552 zinc finger protein 552 1.42607
TMEM106B transmembrane protein 106B 1.42245
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 1.42018

low expression

Symbol Name Standardized Value
GSK3A glycogen synthase kinase 3 alpha -3.53725
PRDM4 PR domain containing 4 -3.53722
PLK3 polo-like kinase 3 -3.53722
BRAP BRCA1 associated protein -3.05016
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 -2.96666
KRAS Kirsten rat sarcoma viral oncogene homolog -2.86915
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit -2.73466
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit -2.70815
SBNO1 strawberry notch homolog 1 (Drosophila) -2.61793
BMI1 BMI1 proto-oncogene, polycomb ring finger -2.50281
IFT88 intraflagellar transport 88 -2.47337
CASC3 cancer susceptibility candidate 3 -2.45476
CEP164 centrosomal protein 164kDa -2.36064
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) -2.35914
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -2.3516
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 -2.33622
ZNF197 zinc finger protein 197 -2.33423
TBC1D5 TBC1 domain family, member 5 -2.33112
ANKRD28 ankyrin repeat domain 28 -2.32275
R3HCC1 R3H domain and coiled-coil containing 1 -2.28409
MTA1 metastasis associated 1 -2.26908
ZBTB39 zinc finger and BTB domain containing 39 -2.22397
CHMP7 charged multivesicular body protein 7 -2.18379
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) -2.15832
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 -2.1
TRIM33 tripartite motif containing 33 -2.09991
CSNK2A2 casein kinase 2, alpha prime polypeptide -2.0801
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 -2.0668
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) -2.06007
MARS methionyl-tRNA synthetase -2.05371
FZD3 frizzled class receptor 3 -2.02445
CEP290 centrosomal protein 290kDa -2.01877
MBTD1 mbt domain containing 1 -2.0131
CBFB core-binding factor, beta subunit -2.00441
POLI polymerase (DNA directed) iota -1.99939
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 -1.98161
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -1.97973
HOXC8 homeobox C8 -1.97766
STAT5B signal transducer and activator of transcription 5B -1.97187
CAMSAP1 calmodulin regulated spectrin-associated protein 1 -1.95355
KAT7 K(lysine) acetyltransferase 7 -1.94099
CCDC59 coiled-coil domain containing 59 -1.93514
CARM1 coactivator-associated arginine methyltransferase 1 -1.92383
GPSM3 G-protein signaling modulator 3 -1.9226
ZNF623 zinc finger protein 623 -1.92185
DENR density-regulated protein -1.92033
KIR3DX1 killer cell immunoglobulin-like receptor, three domains, X1 -1.91336
BMP5 bone morphogenetic protein 5 -1.88761
LEFTY1 left-right determination factor 1 -1.85738
PDPN podoplanin -1.8546
PIGN phosphatidylinositol glycan anchor biosynthesis, class N -1.8532
PATZ1 POZ (BTB) and AT hook containing zinc finger 1 -1.84212
SNX11 sorting nexin 11 -1.8414
SMYD5 SMYD family member 5 -1.81394
TRRAP transformation/transcription domain-associated protein -1.81067
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) -1.80669
RNMT RNA (guanine-7-) methyltransferase -1.79127
RSAD1 radical S-adenosyl methionine domain containing 1 -1.76038
MED1 mediator complex subunit 1 -1.74759
ZSWIM8 zinc finger, SWIM-type containing 8 -1.74697
PTPRA protein tyrosine phosphatase, receptor type, A -1.74342
ZNF223 zinc finger protein 223 -1.74214
MKL1 megakaryoblastic leukemia (translocation) 1 -1.74003
SPDEF SAM pointed domain containing ETS transcription factor -1.73081
TBPL1 TBP-like 1 -1.72105
RPL23 ribosomal protein L23 -1.7194
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) -1.71581
MED13L mediator complex subunit 13-like -1.71377
ACLY ATP citrate lyase -1.71355
HIP1R huntingtin interacting protein 1 related -1.71016
DCAF4 DDB1 and CUL4 associated factor 4 -1.70819
PES1 pescadillo ribosomal biogenesis factor 1 -1.70463
NEK3 NIMA-related kinase 3 -1.70408
RNF122 ring finger protein 122 -1.70003
BCL2A1 BCL2-related protein A1 -1.69291
PLCD1 phospholipase C, delta 1 -1.69096
TEX10 testis expressed 10 -1.68755
STMN3 stathmin-like 3 -1.6837
EPC1 enhancer of polycomb homolog 1 (Drosophila) -1.67381
FGF6 fibroblast growth factor 6 -1.66872
R3HDM2 R3H domain containing 2 -1.66858
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) -1.66371
ADAP2 ArfGAP with dual PH domains 2 -1.65913
ZMYM5 zinc finger, MYM-type 5 -1.65397
WIPF1 WAS/WASL interacting protein family, member 1 -1.64584
PCBP2 poly(rC) binding protein 2 -1.6453
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast) -1.6419
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled -1.6415
RPS12 ribosomal protein S12 -1.64009
OLAH oleoyl-ACP hydrolase -1.63496
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -1.63385
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -1.6331
SP4 Sp4 transcription factor -1.62201
SLC25A30 solute carrier family 25, member 30 -1.61591
LPIN1 lipin 1 -1.61384
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) -1.61355
ARID3A AT rich interactive domain 3A (BRIGHT-like) -1.60696
NARS asparaginyl-tRNA synthetase -1.60336
PUS7 pseudouridylate synthase 7 (putative) -1.59927
RPL10L ribosomal protein L10-like -1.59922
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) -1.59557
EP400 E1A binding protein p400 -1.59472
OR7E37P olfactory receptor, family 7, subfamily E, member 37 pseudogene -1.59358
HNF1B HNF1 homeobox B -1.59268
ZNF248 zinc finger protein 248 -1.58921
CECR7 cat eye syndrome chromosome region, candidate 7 (non-protein coding) -1.5852
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -1.58085
TBC1D17 TBC1 domain family, member 17 -1.56835
CPS1 carbamoyl-phosphate synthase 1, mitochondrial -1.56724
ORC5 origin recognition complex, subunit 5 -1.5666
PLEK pleckstrin -1.55973
NLE1 notchless homolog 1 (Drosophila) -1.55918
RHOT1 ras homolog family member T1 -1.55821
WDR62 WD repeat domain 62 -1.55718
CRNKL1 crooked neck pre-mRNA splicing factor 1 -1.55711
MVK mevalonate kinase -1.54748
CLDN15 claudin 15 -1.5455
SYMPK symplekin -1.54332
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 -1.53271
ORAI2 ORAI calcium release-activated calcium modulator 2 -1.52472
TMEM5 transmembrane protein 5 -1.52201
RPL27 ribosomal protein L27 -1.51854
WDR43 WD repeat domain 43 -1.51091
WDR19 WD repeat domain 19 -1.4996
RPL17 ribosomal protein L17 -1.49813
ANKZF1 ankyrin repeat and zinc finger domain containing 1 -1.4909
RPL32 ribosomal protein L32 -1.489
BRD1 bromodomain containing 1 -1.48739
AKAP9 A kinase (PRKA) anchor protein 9 -1.48112
SFI1 Sfi1 homolog, spindle assembly associated (yeast) -1.47931
PAPOLG poly(A) polymerase gamma -1.47576
LONRF1 LON peptidase N-terminal domain and ring finger 1 -1.47279
HOXC5 homeobox C5 -1.47015
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa -1.45464
PTPN11 protein tyrosine phosphatase, non-receptor type 11 -1.45422
BHMT betaine--homocysteine S-methyltransferase -1.45387
MVB12B multivesicular body subunit 12B -1.45354
ULK1 unc-51 like autophagy activating kinase 1 -1.44831
DLG4 discs, large homolog 4 (Drosophila) -1.44292
SGPL1 sphingosine-1-phosphate lyase 1 -1.44252
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -1.4421
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 -1.43599
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -1.43308
CADPS Ca++-dependent secretion activator -1.43256
RPL14 ribosomal protein L14 -1.4297
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 -1.42661
PEX1 peroxisomal biogenesis factor 1 -1.42651
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -1.41847
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 -1.41785
MAL mal, T-cell differentiation protein -1.41753
COL2A1 collagen, type II, alpha 1 -1.41715