NCI-H510A Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: carcinoma; small cell lung cancer (unknown primary) (Cell Line Ontology, CLO_0008092)
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Genes

403 genes mutated in the NCI-H510A cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABHD4 abhydrolase domain containing 4
ABRACL ABRA C-terminal like
ACACA acetyl-CoA carboxylase alpha
ADAM23 ADAM metallopeptidase domain 23
ADGRB3 adhesion G protein-coupled receptor B3
ADGRL2 adhesion G protein-coupled receptor L2
ADGRV1 adhesion G protein-coupled receptor V1
ADRA2C adrenoceptor alpha 2C
AEN apoptosis enhancing nuclease
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1
AGRN agrin
AIM1 absent in melanoma 1
ALG2 ALG2, alpha-1,3/1,6-mannosyltransferase
AMER1 APC membrane recruitment protein 1
AMOT angiomotin
AMPD3 adenosine monophosphate deaminase 3
ANKHD1 ankyrin repeat and KH domain containing 1
ANKHD1-EIF4EBP3 ANKHD1-EIF4EBP3 readthrough
ANKMY1 ankyrin repeat and MYND domain containing 1
ANKRD12 ankyrin repeat domain 12
ANKRD13B ankyrin repeat domain 13B
ANKRD17 ankyrin repeat domain 17
ANLN anillin, actin binding protein
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
APC adenomatous polyposis coli
APLF aprataxin and PNKP like factor
APP amyloid beta (A4) precursor protein
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ARHGAP21 Rho GTPase activating protein 21
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARID1B AT rich interactive domain 1B (SWI1-like)
ARMC6 armadillo repeat containing 6
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough
ARRDC1 arrestin domain containing 1
ASTN1 astrotactin 1
ASTN2 astrotactin 2
ASXL3 additional sex combs like transcriptional regulator 3
ATAD5 ATPase family, AAA domain containing 5
ATF6B activating transcription factor 6 beta
ATP11B ATPase, class VI, type 11B
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
AUNIP aurora kinase A and ninein interacting protein
B3GALT6 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6
BARD1 BRCA1 associated RING domain 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BBS9 Bardet-Biedl syndrome 9
BBX bobby sox homolog (Drosophila)
BCORL1 BCL6 corepressor-like 1
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1
BOD1L1 biorientation of chromosomes in cell division 1-like 1
C11ORF68 chromosome 11 open reading frame 68
C21ORF33 chromosome 21 open reading frame 33
C2ORF42 chromosome 2 open reading frame 42
C9ORF9 chromosome 9 open reading frame 9
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CALB2 calbindin 2
CAV2 caveolin 2
CBR1 carbonyl reductase 1
CCDC136 coiled-coil domain containing 136
CCDC138 coiled-coil domain containing 138
CCDC39 coiled-coil domain containing 39
CCDC57 coiled-coil domain containing 57
CCDC94 coiled-coil domain containing 94
CCNY cyclin Y
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CDCA7 cell division cycle associated 7
CDH23 cadherin-related 23
CDH7 cadherin 7, type 2
CENPB centromere protein B, 80kDa
CENPF centromere protein F, 350/400kDa
CEP152 centrosomal protein 152kDa
CEP164 centrosomal protein 164kDa
CEP44 centrosomal protein 44kDa
CGGBP1 CGG triplet repeat binding protein 1
CHPF chondroitin polymerizing factor
CHRM3 cholinergic receptor, muscarinic 3
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CLCN3 chloride channel, voltage-sensitive 3
CLINT1 clathrin interactor 1
CLSTN2 calsyntenin 2
CMIP c-Maf inducing protein
CNFN cornifelin
CNTN1 contactin 1
CNTNAP5 contactin associated protein-like 5
COG6 component of oligomeric golgi complex 6
COL12A1 collagen, type XII, alpha 1
COL22A1 collagen, type XXII, alpha 1
COL4A1 collagen, type IV, alpha 1
COPB1 coatomer protein complex, subunit beta 1
CORO2B coronin, actin binding protein, 2B
COX14 COX14 cytochrome c oxidase assembly factor
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTNNA2 catenin (cadherin-associated protein), alpha 2
CYB5RL cytochrome b5 reductase-like
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
DACT2 dishevelled-binding antagonist of beta-catenin 2
DCLRE1A DNA cross-link repair 1A
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
DENND4B DENN/MADD domain containing 4B
DISP1 dispatched homolog 1 (Drosophila)
DLG4 discs, large homolog 4 (Drosophila)
DMWD dystrophia myotonica, WD repeat containing
DMXL1 Dmx-like 1
DNAH14 dynein, axonemal, heavy chain 14
DOT1L DOT1-like histone H3K79 methyltransferase
DPY19L3 dpy-19-like 3 (C. elegans)
DROSHA drosha, ribonuclease type III
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHX3 epoxide hydrolase 3
EVC2 Ellis van Creveld syndrome 2
EXOC2 exocyst complex component 2
EXPH5 exophilin 5
FAM160A1 family with sequence similarity 160, member A1
FAM173B family with sequence similarity 173, member B
FAM210A family with sequence similarity 210, member A
FANCI Fanconi anemia, complementation group I
FARSB phenylalanyl-tRNA synthetase, beta subunit
FAT1 FAT atypical cadherin 1
FAT3 FAT atypical cadherin 3
FBXL7 F-box and leucine-rich repeat protein 7
FBXO18 F-box protein, helicase, 18
FBXO34 F-box protein 34
FGF12 fibroblast growth factor 12
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1
FMN2 formin 2
FOXA2 forkhead box A2
FOXN2 forkhead box N2
FOXP2 forkhead box P2
FRAS1 Fraser extracellular matrix complex subunit 1
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GBX2 gastrulation brain homeobox 2
GIN1 gypsy retrotransposon integrase 1
GLB1L galactosidase, beta 1-like
GLCE glucuronic acid epimerase
GLRX3 glutaredoxin 3
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPM6A glycoprotein M6A
GPR39 G protein-coupled receptor 39
GPR75 G protein-coupled receptor 75
GPRASP2 G protein-coupled receptor associated sorting protein 2
GRIK3 glutamate receptor, ionotropic, kainate 3
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
GRM8 glutamate receptor, metabotropic 8
GSDMB gasdermin B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HABP2 hyaluronan binding protein 2
HABP4 hyaluronan binding protein 4
HAUS7 HAUS augmin-like complex, subunit 7
HBE1 hemoglobin, epsilon 1
HELQ helicase, POLQ-like
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
HYI hydroxypyruvate isomerase (putative)
IDH3B isocitrate dehydrogenase 3 (NAD+) beta
IFT57 intraflagellar transport 57
IGFBP6 insulin-like growth factor binding protein 6
ING3 inhibitor of growth family, member 3
INO80C INO80 complex subunit C
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IPO11 importin 11
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KANK1 KN motif and ankyrin repeat domains 1
KAT6A K(lysine) acetyltransferase 6A
KBTBD3 kelch repeat and BTB (POZ) domain containing 3
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6
KCNK10 potassium channel, two pore domain subfamily K, member 10
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KCTD8 potassium channel tetramerization domain containing 8
KDM6B lysine (K)-specific demethylase 6B
KIAA1024 KIAA1024
KIAA1109 KIAA1109
KIAA1324 KIAA1324
KIAA1324L KIAA1324-like
KIF13B kinesin family member 13B
KIF19 kinesin family member 19
KIRREL3 kin of IRRE like 3 (Drosophila)
KLHL11 kelch-like family member 11
KLHL22 kelch-like family member 22
KLHL28 kelch-like family member 28
KLHL32 kelch-like family member 32
KLK14 kallikrein-related peptidase 14
KMT2D lysine (K)-specific methyltransferase 2D
LACTB lactamase, beta
LAMA1 laminin, alpha 1
LAS1L LAS1-like (S. cerevisiae)
LINGO2 leucine rich repeat and Ig domain containing 2
LMTK2 lemur tyrosine kinase 2
LPPR1 lipid phosphate phosphatase-related protein type 1
LRFN5 leucine rich repeat and fibronectin type III domain containing 5
LTK leukocyte receptor tyrosine kinase
LTN1 listerin E3 ubiquitin protein ligase 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP2 microtubule-associated protein 2
MAP9 microtubule-associated protein 9
MAPK15 mitogen-activated protein kinase 15
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MATR3 matrin 3
MCTP1 multiple C2 domains, transmembrane 1
MDM1 Mdm1 nuclear protein homolog (mouse)
MED25 mediator complex subunit 25
METTL13 methyltransferase like 13
MEX3B mex-3 RNA binding family member B
MGAT4C MGAT4 family, member C
MKL1 megakaryoblastic leukemia (translocation) 1
MLH1 mutL homolog 1
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MON2 MON2 homolog (S. cerevisiae)
MRPL15 mitochondrial ribosomal protein L15
MRPL21 mitochondrial ribosomal protein L21
MSH6 mutS homolog 6
MTMR6 myotubularin related protein 6
MYO18A myosin XVIIIA
NARF nuclear prelamin A recognition factor
NBEA neurobeachin
NCOR2 nuclear receptor corepressor 2
NEMF nuclear export mediator factor
NF1 neurofibromin 1
NKD2 naked cuticle homolog 2 (Drosophila)
NOL11 nucleolar protein 11
NOVA1 neuro-oncological ventral antigen 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRXN1 neurexin 1
NSRP1 nuclear speckle splicing regulatory protein 1
NTNG1 netrin G1
NUP133 nucleoporin 133kDa
NUP98 nucleoporin 98kDa
OLFM3 olfactomedin 3
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PANX1 pannexin 1
PARD3B par-3 family cell polarity regulator beta
PCDH10 protocadherin 10
PCDH7 protocadherin 7
PCLO piccolo presynaptic cytomatrix protein
PCNXL2 pecanex-like 2 (Drosophila)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PGLS 6-phosphogluconolactonase
PHF3 PHD finger protein 3
PIDD1 p53-induced death domain protein 1
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PLCL2 phospholipase C-like 2
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
PLS3 plastin 3
PLXND1 plexin D1
PML promyelocytic leukemia
PPP1R15B protein phosphatase 1, regulatory subunit 15B
PQLC2L PQ loop repeat containing 2-like
PRDM11 PR domain containing 11
PRKD3 protein kinase D3
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PROS1 protein S (alpha)
PRPH peripherin
PRR22 proline rich 22
PRRT3 proline-rich transmembrane protein 3
PTPRS protein tyrosine phosphatase, receptor type, S
QKI QKI, KH domain containing, RNA binding
QSOX2 quiescin Q6 sulfhydryl oxidase 2
RAB3IP RAB3A interacting protein
RAB8A RAB8A, member RAS oncogene family
RALYL RALY RNA binding protein-like
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RB1CC1 RB1-inducible coiled-coil 1
RBM25 RNA binding motif protein 25
RCC2 regulator of chromosome condensation 2
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RELN reelin
RERE arginine-glutamic acid dipeptide (RE) repeats
RGAG4 retrotransposon gag domain containing 4
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF10 ring finger protein 10
RNF213 ring finger protein 213
RNF219 ring finger protein 219
RTBDN retbindin
RTN2 reticulon 2
SALL3 spalt-like transcription factor 3
SATB2 SATB homeobox 2
SCAF1 SR-related CTD-associated factor 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCUBE1 signal peptide, CUB domain, EGF-like 1
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SENP1 SUMO1/sentrin specific peptidase 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SETBP1 SET binding protein 1
SETDB1 SET domain, bifurcated 1
SETX senataxin
SEZ6 seizure related 6 homolog (mouse)
SFRP1 secreted frizzled-related protein 1
SGOL2 shugoshin-like 2 (S. pombe)
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIPA1L2 signal-induced proliferation-associated 1 like 2
SKIDA1 SKI/DACH domain containing 1
SLC39A11 solute carrier family 39, member 11
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SLITRK6 SLIT and NTRK-like family, member 6
SMAD4 SMAD family member 4
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SOGA1 suppressor of glucose, autophagy associated 1
SOX9 SRY (sex determining region Y)-box 9
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SRCAP Snf2-related CREBBP activator protein
SRPK1 SRSF protein kinase 1
STAG1 stromal antigen 1
STK11IP serine/threonine kinase 11 interacting protein
STOX1 storkhead box 1
STX4 syntaxin 4
SUB1 SUB1 homolog (S. cerevisiae)
SYN3 synapsin III
TACC2 transforming, acidic coiled-coil containing protein 2
TBCD tubulin folding cofactor D
TBX10 T-box 10
TC2N tandem C2 domains, nuclear
TCF3 transcription factor 3
TCTN3 tectonic family member 3
TDRD5 tudor domain containing 5
TELO2 telomere maintenance 2
TENM4 teneurin transmembrane protein 4
TET1 tet methylcytosine dioxygenase 1
TEX2 testis expressed 2
THAP2 THAP domain containing, apoptosis associated protein 2
TLN2 talin 2
TLR5 toll-like receptor 5
TM9SF1 transmembrane 9 superfamily member 1
TMEM132D transmembrane protein 132D
TMEM182 transmembrane protein 182
TMTC2 transmembrane and tetratricopeptide repeat containing 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TNRC18 trinucleotide repeat containing 18
TOP3A topoisomerase (DNA) III alpha
TP53 tumor protein p53
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRAFD1 TRAF-type zinc finger domain containing 1
TRIM25 tripartite motif containing 25
TRIM58 tripartite motif containing 58
TRIO trio Rho guanine nucleotide exchange factor
TRRAP transformation/transcription domain-associated protein
TSPAN33 tetraspanin 33
UBA6 ubiquitin-like modifier activating enzyme 6
UBE2J2 ubiquitin-conjugating enzyme E2, J2
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UNC79 unc-79 homolog (C. elegans)
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
USP53 ubiquitin specific peptidase 53
USP9X ubiquitin specific peptidase 9, X-linked
VEGFC vascular endothelial growth factor C
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WDR24 WD repeat domain 24
WDR4 WD repeat domain 4
WDR75 WD repeat domain 75
WFS1 Wolfram syndrome 1 (wolframin)
WWOX WW domain containing oxidoreductase
XDH xanthine dehydrogenase
XPO1 exportin 1
XRN1 5'-3' exoribonuclease 1
YLPM1 YLP motif containing 1
YTHDC2 YTH domain containing 2
ZBTB10 zinc finger and BTB domain containing 10
ZBTB7A zinc finger and BTB domain containing 7A
ZC2HC1C zinc finger, C2HC-type containing 1C
ZCCHC8 zinc finger, CCHC domain containing 8
ZDBF2 zinc finger, DBF-type containing 2
ZDHHC11 zinc finger, DHHC-type containing 11
ZDHHC17 zinc finger, DHHC-type containing 17
ZFAT zinc finger and AT hook domain containing
ZFHX4 zinc finger homeobox 4
ZFP42 ZFP42 zinc finger protein
ZIC1 Zic family member 1
ZNF142 zinc finger protein 142
ZNF2 zinc finger protein 2
ZNF25 zinc finger protein 25
ZNF337 zinc finger protein 337
ZNF419 zinc finger protein 419
ZNF490 zinc finger protein 490
ZNF514 zinc finger protein 514
ZNF615 zinc finger protein 615
ZNF621 zinc finger protein 621
ZNF746 zinc finger protein 746
ZNF770 zinc finger protein 770
ZNF777 zinc finger protein 777
ZSCAN26 zinc finger and SCAN domain containing 26
ZYG11B zyg-11 family member B, cell cycle regulator