NCI-H508 Gene Set

Dataset COSMIC Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: colorectal adenocarcinoma (Cell Line Ontology, CLO_0008091)
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448 genes mutated in the NCI-H508 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

Symbol Name
A2M alpha-2-macroglobulin
AADAT aminoadipate aminotransferase
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
ABI3BP ABI family, member 3 (NESH) binding protein
ACOT11 acyl-CoA thioesterase 11
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADAM19 ADAM metallopeptidase domain 19
ADAM21 ADAM metallopeptidase domain 21
AFAP1L1 actin filament associated protein 1-like 1
AHNAK AHNAK nucleoprotein
ALPK3 alpha-kinase 3
AMHR2 anti-Mullerian hormone receptor, type II
ANKRD13A ankyrin repeat domain 13A
ANKRD30A ankyrin repeat domain 30A
ANKRD55 ankyrin repeat domain 55
APOB apolipoprotein B
ARHGAP20 Rho GTPase activating protein 20
ASXL3 additional sex combs like transcriptional regulator 3
ATAT1 alpha tubulin acetyltransferase 1
ATG9A autophagy related 9A
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP7B ATPase, Cu++ transporting, beta polypeptide
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
ATXN2 ataxin 2
BAIAP2L1 BAI1-associated protein 2-like 1
BANK1 B-cell scaffold protein with ankyrin repeats 1
BBS9 Bardet-Biedl syndrome 9
BCL9 B-cell CLL/lymphoma 9
BIN1 bridging integrator 1
BPIFA1 BPI fold containing family A, member 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
CA1 carbonic anhydrase I
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CAMKV CaM kinase-like vesicle-associated
CAPN13 calpain 13
CAPN5 calpain 5
CAPZA3 capping protein (actin filament) muscle Z-line, alpha 3
CBX4 chromobox homolog 4
CCDC175 coiled-coil domain containing 175
CCDC60 coiled-coil domain containing 60
CCDC62 coiled-coil domain containing 62
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD177 CD177 molecule
CDC14A cell division cycle 14A
CDCP1 CUB domain containing protein 1
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH4 cadherin 4, type 1, R-cadherin (retinal)
CDK17 cyclin-dependent kinase 17
CDK18 cyclin-dependent kinase 18
CDKN2A cyclin-dependent kinase inhibitor 2A
CDX4 caudal type homeobox 4
CELA2A chymotrypsin-like elastase family, member 2A
CENPE centromere protein E, 312kDa
CEP192 centrosomal protein 192kDa
CEP350 centrosomal protein 350kDa
CFAP43 cilia and flagella associated protein 43
CHD4 chromodomain helicase DNA binding protein 4
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CILP2 cartilage intermediate layer protein 2
CLYBL citrate lyase beta like
CMYA5 cardiomyopathy associated 5
CNOT10 CCR4-NOT transcription complex, subunit 10
CNTRL centriolin
COL18A1 collagen, type XVIII, alpha 1
COL22A1 collagen, type XXII, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL6A3 collagen, type VI, alpha 3
COL9A3 collagen, type IX, alpha 3
CORO1B coronin, actin binding protein, 1B
CPB2 carboxypeptidase B2 (plasma)
CPNE4 copine IV
CPZ carboxypeptidase Z
CREBBP CREB binding protein
CRHBP corticotropin releasing hormone binding protein
CRHR1 corticotropin releasing hormone receptor 1
CRIP3 cysteine-rich protein 3
CRYAA crystallin, alpha A
CSNK1G2 casein kinase 1, gamma 2
CUEDC2 CUE domain containing 2
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
D2HGDH D-2-hydroxyglutarate dehydrogenase
DCAF15 DDB1 and CUL4 associated factor 15
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae)
DDX12P DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29
DIRC2 disrupted in renal carcinoma 2
DNAH10 dynein, axonemal, heavy chain 10
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
DNMBP dynamin binding protein
DOCK5 dedicator of cytokinesis 5
DRG2 developmentally regulated GTP binding protein 2
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EEF2K eukaryotic elongation factor 2 kinase
EGFLAM EGF-like, fibronectin type III and laminin G domains
EGR3 early growth response 3
EGR4 early growth response 4
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
ELL3 elongation factor RNA polymerase II-like 3
ENOX1 ecto-NOX disulfide-thiol exchanger 1
EPB41L4A erythrocyte membrane protein band 4.1 like 4A
EPHA8 EPH receptor A8
EPPK1 epiplakin 1
EPX eosinophil peroxidase
ERBB4 erb-b2 receptor tyrosine kinase 4
ERC2 ELKS/RAB6-interacting/CAST family member 2
ESD esterase D
EVC2 Ellis van Creveld syndrome 2
FAM104B family with sequence similarity 104, member B
FAM170B family with sequence similarity 170, member B
FAM179A family with sequence similarity 179, member A
FAM47C family with sequence similarity 47, member C
FAM50B family with sequence similarity 50, member B
FAM71B family with sequence similarity 71, member B
FAM91A1 family with sequence similarity 91, member A1
FASN fatty acid synthase
FBN1 fibrillin 1
FGA fibrinogen alpha chain
FGD4 FYVE, RhoGEF and PH domain containing 4
FLG filaggrin
FLNB filamin B, beta
FMN2 formin 2
FOXJ3 forkhead box J3
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GBP6 guanylate binding protein family, member 6
GDF5 growth differentiation factor 5
GDF5OS growth differentiation factor 5 opposite strand
GJB4 gap junction protein, beta 4, 30.3kDa
GLRA2 glycine receptor, alpha 2
GM2A GM2 ganglioside activator
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GOLGB1 golgin B1
GPR137C G protein-coupled receptor 137C
GPR141 G protein-coupled receptor 141
GRAMD3 GRAM domain containing 3
GRXCR1 glutaredoxin, cysteine rich 1
GSDMB gasdermin B
GTF3A general transcription factor IIIA
GTPBP1 GTP binding protein 1
GUCY2D guanylate cyclase 2D, membrane (retina-specific)
HACD3 3-hydroxyacyl-CoA dehydratase 3
HBG2 hemoglobin, gamma G
HDAC8 histone deacetylase 8
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BH histone cluster 1, H2bh
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HJURP Holliday junction recognition protein
HK2 hexokinase 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA4L heat shock 70kDa protein 4-like
HSPG2 heparan sulfate proteoglycan 2
HYAL3 hyaluronoglucosaminidase 3
HYDIN HYDIN, axonemal central pair apparatus protein
IFITM10 interferon induced transmembrane protein 10
IFT43 intraflagellar transport 43
IGSF10 immunoglobulin superfamily, member 10
IKZF2 IKAROS family zinc finger 2 (Helios)
IL10 interleukin 10
IL4R interleukin 4 receptor
IL7R interleukin 7 receptor
IMPG1 interphotoreceptor matrix proteoglycan 1
IQGAP3 IQ motif containing GTPase activating protein 3
IQSEC3 IQ motif and Sec7 domain 3
IRS1 insulin receptor substrate 1
ITGB4 integrin, beta 4
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KANK4 KN motif and ankyrin repeat domains 4
KBTBD6 kelch repeat and BTB (POZ) domain containing 6
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KDM3B lysine (K)-specific demethylase 3B
KIAA1671 KIAA1671
KIF16B kinesin family member 16B
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLC3 kinesin light chain 3
KLF11 Kruppel-like factor 11
KLHL23 kelch-like family member 23
KLHL25 kelch-like family member 25
KMT2C lysine (K)-specific methyltransferase 2C
KRT31 keratin 31, type I
KRTAP21-1 keratin associated protein 21-1
KRTAP4-12 keratin associated protein 4-12
L3MBTL4 l(3)mbt-like 4 (Drosophila)
LARP6 La ribonucleoprotein domain family, member 6
LCE1E late cornified envelope 1E
LCMT2 leucine carboxyl methyltransferase 2
LDLR low density lipoprotein receptor
LIMK2 LIM domain kinase 2
LMNB2 lamin B2
LPIN1 lipin 1
LRRC37A3 leucine rich repeat containing 37, member A3
LRRC8A leucine rich repeat containing 8 family, member A
LRRTM4 leucine rich repeat transmembrane neuronal 4
LRTM2 leucine-rich repeats and transmembrane domains 2
LXN latexin
MAK male germ cell-associated kinase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K19 mitogen-activated protein kinase kinase kinase 19
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAPK7 mitogen-activated protein kinase 7
MARCH10 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
MB myoglobin
MBP myelin basic protein
MCM2 minichromosome maintenance complex component 2
MDH1B malate dehydrogenase 1B, NAD (soluble)
MET MET proto-oncogene, receptor tyrosine kinase
METTL21B methyltransferase like 21B
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MFSD9 major facilitator superfamily domain containing 9
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MPHOSPH9 M-phase phosphoprotein 9
MPND MPN domain containing
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MS4A8 membrane-spanning 4-domains, subfamily A, member 8
MSC musculin
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MUC16 mucin 16, cell surface associated
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYO16 myosin XVI
MYO18A myosin XVIIIA
MYO1B myosin IB
MYO3A myosin IIIA
MYO7A myosin VIIA
MYOM2 myomesin 2
NAGK N-acetylglucosamine kinase
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NCOA5 nuclear receptor coactivator 5
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NEB nebulin
NEBL nebulette
NECAB3 N-terminal EF-hand calcium binding protein 3
NELL2 NEL-like 2 (chicken)
NEURL1B neuralized E3 ubiquitin protein ligase 1B
NLRP4 NLR family, pyrin domain containing 4
NLRP7 NLR family, pyrin domain containing 7
NMS neuromedin S
NOL4 nucleolar protein 4
NOS2 nitric oxide synthase 2, inducible
NOTCH3 notch 3
NRCAM neuronal cell adhesion molecule
NRXN1 neurexin 1
NRXN3 neurexin 3
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NUMA1 nuclear mitotic apparatus protein 1
OAZ3 ornithine decarboxylase antizyme 3
OLIG2 oligodendrocyte lineage transcription factor 2
OR10A2 olfactory receptor, family 10, subfamily A, member 2
OR1N1 olfactory receptor, family 1, subfamily N, member 1
OR2M2 olfactory receptor, family 2, subfamily M, member 2
OR4Q3 olfactory receptor, family 4, subfamily Q, member 3
OR5AR1 olfactory receptor, family 5, subfamily AR, member 1 (gene/pseudogene)
OR5K2 olfactory receptor, family 5, subfamily K, member 2
OR5T1 olfactory receptor, family 5, subfamily T, member 1
OR6C75 olfactory receptor, family 6, subfamily C, member 75
OR7D4 olfactory receptor, family 7, subfamily D, member 4
OTUD4P1 OTUD4 pseudogene 1
OVCH1 ovochymase 1
PALB2 partner and localizer of BRCA2
PAPPA2 pappalysin 2
PARK2 parkin RBR E3 ubiquitin protein ligase
PARL presenilin associated, rhomboid-like
PCDH10 protocadherin 10
PCDHA1 protocadherin alpha 1
PCDHB10 protocadherin beta 10
PCDHB13 protocadherin beta 13
PCDHG@ protocadherin gamma cluster
PCDHGA12 protocadherin gamma subfamily A, 12
PCDHGA2 protocadherin gamma subfamily A, 2
PCDHGA3 protocadherin gamma subfamily A, 3
PCSK1 proprotein convertase subtilisin/kexin type 1
PDAP1 PDGFA associated protein 1
PDE11A phosphodiesterase 11A
PDE4DIP phosphodiesterase 4D interacting protein
PEG3 paternally expressed 3
PGBD1 piggyBac transposable element derived 1
PIGX phosphatidylinositol glycan anchor biosynthesis, class X
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIWIL2 piwi-like RNA-mediated gene silencing 2
PKD1L1 polycystic kidney disease 1 like 1
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1
PLD3 phospholipase D family, member 3
PLEKHH1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
POLQ polymerase (DNA directed), theta
POTEC POTE ankyrin domain family, member C
PPAPDC1A phosphatidic acid phosphatase type 2 domain containing 1A
PPHLN1 periphilin 1
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PRDM16 PR domain containing 16
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRSS1 protease, serine, 1 (trypsin 1)
PRUNE2 prune homolog 2 (Drosophila)
PSD2 pleckstrin and Sec7 domain containing 2
PSG9 pregnancy specific beta-1-glycoprotein 9
PTPRF protein tyrosine phosphatase, receptor type, F
PTPRM protein tyrosine phosphatase, receptor type, M
PXDNL peroxidasin-like
PYGM phosphorylase, glycogen, muscle
PYHIN1 pyrin and HIN domain family, member 1
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB23 RAB23, member RAS oncogene family
RASA2 RAS p21 protein activator 2
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
RBM42 RNA binding motif protein 42
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like
RC3H1 ring finger and CCCH-type domains 1
RELN reelin
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RHBDD1 rhomboid domain containing 1
RIF1 replication timing regulatory factor 1
RIMS4 regulating synaptic membrane exocytosis 4
RNF13 ring finger protein 13
RNF157 ring finger protein 157
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF17 ring finger protein 17
RNF216 ring finger protein 216
RNF222 ring finger protein 222
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPLP1 ribosomal protein, large, P1
RPS14 ribosomal protein S14
RRBP1 ribosome binding protein 1
RYR3 ryanodine receptor 3
SAMD3 sterile alpha motif domain containing 3
SCAMP3 secretory carrier membrane protein 3
SCLY selenocysteine lyase
SCN4A sodium channel, voltage gated, type IV alpha subunit
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SENP1 SUMO1/sentrin specific peptidase 1
SENP7 SUMO1/sentrin specific peptidase 7
SEPT7 septin 7
SET SET nuclear proto-oncogene
SGCE sarcoglycan, epsilon
SGK223 homolog of rat pragma of Rnd2
SH3BP2 SH3-domain binding protein 2
SH3RF1 SH3 domain containing ring finger 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIGLEC6 sialic acid binding Ig-like lectin 6
SLAIN2 SLAIN motif family, member 2
SLC16A6 solute carrier family 16, member 6
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC41A3 solute carrier family 41, member 3
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
SLIT2 slit homolog 2 (Drosophila)
SNTG1 syntrophin, gamma 1
SNX13 sorting nexin 13
SOGA1 suppressor of glucose, autophagy associated 1
SPATA13 spermatogenesis associated 13
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPOP speckle-type POZ protein
SPSB4 splA/ryanodine receptor domain and SOCS box containing 4
SPTA1 spectrin, alpha, erythrocytic 1
SRBD1 S1 RNA binding domain 1
SSC5D scavenger receptor cysteine rich family, 5 domains
STK10 serine/threonine kinase 10
STRA6 stimulated by retinoic acid 6
STRN striatin, calmodulin binding protein
STX17 syntaxin 17
STXBP5L syntaxin binding protein 5-like
SVIL supervillin
SYCP1 synaptonemal complex protein 1
SYNC syncoilin, intermediate filament protein
SYNE1 spectrin repeat containing, nuclear envelope 1
SYTL2 synaptotagmin-like 2
TADA3 transcriptional adaptor 3
TAT tyrosine aminotransferase
TBCD tubulin folding cofactor D
TBX4 T-box 4
TCERG1 transcription elongation regulator 1
TCP1 t-complex 1
TESPA1 thymocyte expressed, positive selection associated 1
TGM4 transglutaminase 4
TGS1 trimethylguanosine synthase 1
THOC5 THO complex 5
TMCC2 transmembrane and coiled-coil domain family 2
TMEM181 transmembrane protein 181
TMEM200C transmembrane protein 200C
TMPRSS4 transmembrane protease, serine 4
TNK2 tyrosine kinase, non-receptor, 2
TNS3 tensin 3
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast)
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53 tumor protein p53
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TRIM10 tripartite motif containing 10
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TRPV5 transient receptor potential cation channel, subfamily V, member 5
TSSC1 tumor suppressing subtransferable candidate 1
TSSK1B testis-specific serine kinase 1B
TTC3 tetratricopeptide repeat domain 3
TTC30B tetratricopeptide repeat domain 30B
TTLL5 tubulin tyrosine ligase-like family member 5
UBE2O ubiquitin-conjugating enzyme E2O
UBLCP1 ubiquitin-like domain containing CTD phosphatase 1
USP30 ubiquitin specific peptidase 30
VANGL2 VANGL planar cell polarity protein 2
VCAN versican
WBSCR17 Williams-Beuren syndrome chromosome region 17
WDR41 WD repeat domain 41
WDR90 WD repeat domain 90
WNK2 WNK lysine deficient protein kinase 2
XIRP2 xin actin binding repeat containing 2
XKR6 XK, Kell blood group complex subunit-related family, member 6
XPO4 exportin 4
XYLT2 xylosyltransferase II
ZACN zinc activated ligand-gated ion channel
ZBTB16 zinc finger and BTB domain containing 16
ZBTB43 zinc finger and BTB domain containing 43
ZC3H7A zinc finger CCCH-type containing 7A
ZC3HC1 zinc finger, C3HC-type containing 1
ZCCHC5 zinc finger, CCHC domain containing 5
ZDHHC6 zinc finger, DHHC-type containing 6
ZIM2 zinc finger, imprinted 2
ZNF17 zinc finger protein 17
ZNF215 zinc finger protein 215
ZNF253 zinc finger protein 253
ZNF274 zinc finger protein 274
ZNF346 zinc finger protein 346
ZNF385A zinc finger protein 385A
ZNF451 zinc finger protein 451
ZNF470 zinc finger protein 470
ZNF492 zinc finger protein 492
ZNF525 zinc finger protein 525
ZNF585A zinc finger protein 585A
ZNF607 zinc finger protein 607
ZNF683 zinc finger protein 683
ZNF804B zinc finger protein 804B
ZNF91 zinc finger protein 91
ZNFX1 zinc finger, NFX1-type containing 1
ZSCAN2 zinc finger and SCAN domain containing 2
ZSCAN5CP zinc finger and SCAN domain containing 5C, pseudogene
ZW10 zw10 kinetochore protein
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1