NCI-H460 Gene Set

Dataset COSMIC Cell Line Gene Mutation Profiles
Category genomics
Type cell line
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442 genes mutated in the NCI-H460 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

Symbol Name
AACS acetoacetyl-CoA synthetase
AASDH aminoadipate-semialdehyde dehydrogenase
ACAT2 acetyl-CoA acetyltransferase 2
ACR acrosin
ACSM2B acyl-CoA synthetase medium-chain family member 2B
ACTN2 actinin, alpha 2
ADAM29 ADAM metallopeptidase domain 29
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14
ADCY5 adenylate cyclase 5
ADGRG4 adhesion G protein-coupled receptor G4
AFF2 AF4/FMR2 family, member 2
AHNAK2 AHNAK nucleoprotein 2
AKAP9 A kinase (PRKA) anchor protein 9
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ALMS1 Alstrom syndrome protein 1
ALOXE3 arachidonate lipoxygenase 3
ANGEL1 angel homolog 1 (Drosophila)
ANKMY2 ankyrin repeat and MYND domain containing 2
ANKRD39 ankyrin repeat domain 39
ANKRD60 ankyrin repeat domain 60
AP4B1 adaptor-related protein complex 4, beta 1 subunit
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARID1A AT rich interactive domain 1A (SWI-like)
ARID1B AT rich interactive domain 1B (SWI1-like)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ARMC4 armadillo repeat containing 4
ASB4 ankyrin repeat and SOCS box containing 4
ASPN asporin
ASTL astacin-like metallo-endopeptidase (M12 family)
ASTN2 astrotactin 2
ATAD3B ATPase family, AAA domain containing 3B
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAHCC1 BAH domain and coiled-coil containing 1
BBS7 Bardet-Biedl syndrome 7
BCL6 B-cell CLL/lymphoma 6
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like
BNC1 basonuclin 1
BOC BOC cell adhesion associated, oncogene regulated
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BRPF1 bromodomain and PHD finger containing, 1
BTNL9 butyrophilin-like 9
BUD13 BUD13 homolog (S. cerevisiae)
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
C4BPB complement component 4 binding protein, beta
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4
CADPS Ca++-dependent secretion activator
CAPN10 calpain 10
CASQ2 calsequestrin 2 (cardiac muscle)
CCDC112 coiled-coil domain containing 112
CCDC144A coiled-coil domain containing 144A
CCDC144CP coiled-coil domain containing 144C, pseudogene
CCDC180 coiled-coil domain containing 180
CCNT2 cyclin T2
CCR7 chemokine (C-C motif) receptor 7
CD164 CD164 molecule, sialomucin
CDR2 cerebellar degeneration-related protein 2, 62kDa
CDYL2 chromodomain protein, Y-like 2
CLK1 CDC-like kinase 1
CNPY1 canopy FGF signaling regulator 1
CNTRL centriolin
COL14A1 collagen, type XIV, alpha 1
COL25A1 collagen, type XXV, alpha 1
COQ10A coenzyme Q10 homolog A (S. cerevisiae)
CPXCR1 CPX chromosome region, candidate 1
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTCFL CCCTC-binding factor (zinc finger protein)-like
CTSA cathepsin A
CUL3 cullin 3
CYB5R4 cytochrome b5 reductase 4
CYTH4 cytohesin 4
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCAF4L2 DDB1 and CUL4 associated factor 4-like 2
DGKB diacylglycerol kinase, beta 90kDa
DHCR7 7-dehydrocholesterol reductase
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DNAH10 dynein, axonemal, heavy chain 10
DNAH2 dynein, axonemal, heavy chain 2
DNAH8 dynein, axonemal, heavy chain 8
DNAH9 dynein, axonemal, heavy chain 9
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
DOCK5 dedicator of cytokinesis 5
DPP10 dipeptidyl-peptidase 10 (non-functional)
DPPA2 developmental pluripotency associated 2
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EBP emopamil binding protein (sterol isomerase)
EBPL emopamil binding protein-like
EIF3A eukaryotic translation initiation factor 3, subunit A
EIF4B eukaryotic translation initiation factor 4B
ENTHD2 ENTH domain containing 2
EPHA7 EPH receptor A7
ERAP2 endoplasmic reticulum aminopeptidase 2
ERICH6B glutamate-rich 6B
ETNPPL ethanolamine-phosphate phospho-lyase
EXOC2 exocyst complex component 2
EXOC3 exocyst complex component 3
F5 coagulation factor V (proaccelerin, labile factor)
FAIM2 Fas apoptotic inhibitory molecule 2
FAM166A family with sequence similarity 166, member A
FAM170A family with sequence similarity 170, member A
FAM177B family with sequence similarity 177, member B
FAM71C family with sequence similarity 71, member C
FAM86C1 family with sequence similarity 86, member C1
FANCD2 Fanconi anemia, complementation group D2
FAT2 FAT atypical cadherin 2
FAT3 FAT atypical cadherin 3
FBXO44 F-box protein 44
FGF9 fibroblast growth factor 9
FLG filaggrin
FLYWCH1 FLYWCH-type zinc finger 1
FMN2 formin 2
FNDC7 fibronectin type III domain containing 7
FRMPD3 FERM and PDZ domain containing 3
FSIP2 fibrous sheath interacting protein 2
FSTL4 follistatin-like 4
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6
GAS2L3 growth arrest-specific 2 like 3
GAS7 growth arrest-specific 7
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GHSR growth hormone secretagogue receptor
GLB1L galactosidase, beta 1-like
GLS2 glutaminase 2 (liver, mitochondrial)
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GOLGA4 golgin A4
GOLGA5 golgin A5
GOLGB1 golgin B1
GPATCH8 G patch domain containing 8
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
GPR32 G protein-coupled receptor 32
GRAMD3 GRAM domain containing 3
GRIK1 glutamate receptor, ionotropic, kainate 1
GRIP2 glutamate receptor interacting protein 2
GSAP gamma-secretase activating protein
H2AFY H2A histone family, member Y
HDAC9 histone deacetylase 9
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HEG1 heart development protein with EGF-like domains 1
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HHATL hedgehog acyltransferase-like
HOXC5 homeobox C5
HPS4 Hermansky-Pudlak syndrome 4
HRC histidine rich calcium binding protein
HSPA1L heat shock 70kDa protein 1-like
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
HYDIN HYDIN, axonemal central pair apparatus protein
ICOS inducible T-cell co-stimulator
IGSF21 immunoglobin superfamily, member 21
IL1RL1 interleukin 1 receptor-like 1
IL4 interleukin 4
IPO7 importin 7
ITGAD integrin, alpha D
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB6 integrin, beta 6
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
ITPKB inositol-trisphosphate 3-kinase B
ITPKC inositol-trisphosphate 3-kinase C
JAG1 jagged 1
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDM7A lysine (K)-specific demethylase 7A
KDR kinase insert domain receptor
KEAP1 kelch-like ECH-associated protein 1
KIAA0825 KIAA0825
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF2B kinesin family member 2B
KIF6 kinesin family member 6
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KPNA7 karyopherin alpha 7 (importin alpha 8)
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT26 keratin 26, type I
L3MBTL4 l(3)mbt-like 4 (Drosophila)
LAMA3 laminin, alpha 3
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
LAT2 linker for activation of T cells family, member 2
LDHA lactate dehydrogenase A
LGI2 leucine-rich repeat LGI family, member 2
LIFR leukemia inhibitory factor receptor alpha
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
LIPH lipase, member H
LIPJ lipase, family member J
LIPK lipase, family member K
LMF2 lipase maturation factor 2
LNPEP leucyl/cystinyl aminopeptidase
LOXHD1 lipoxygenase homology domains 1
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRIT2 leucine-rich repeat, immunoglobulin-like and transmembrane domains 2
LRP2 low density lipoprotein receptor-related protein 2
LRRC32 leucine rich repeat containing 32
LYST lysosomal trafficking regulator
MAP2K1 mitogen-activated protein kinase kinase 1
MAP7D3 MAP7 domain containing 3
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MED25 mediator complex subunit 25
METTL5 methyltransferase like 5
MFSD2B major facilitator superfamily domain containing 2B
MGAT4C MGAT4 family, member C
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLEC malectin
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMS22L MMS22-like, DNA repair protein
MON2 MON2 homolog (S. cerevisiae)
MRGPRG MAS-related GPR, member G
MROH1 maestro heat-like repeat family member 1
MRPL3 mitochondrial ribosomal protein L3
MRPS7 mitochondrial ribosomal protein S7
MUC13 mucin 13, cell surface associated
MYH11 myosin, heavy chain 11, smooth muscle
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic
MYH7 myosin, heavy chain 7, cardiac muscle, beta
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal
MYO15A myosin XVA
MYOM2 myomesin 2
MYT1L myelin transcription factor 1-like
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit
NBN nibrin
NCKAP5 NCK-associated protein 5
NCOA6 nuclear receptor coactivator 6
NCOR1 nuclear receptor corepressor 1
NELFCD negative elongation factor complex member C/D
NES nestin
NEUROD6 neuronal differentiation 6
NHSL1 NHS-like 1
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
NIN ninein (GSK3B interacting protein)
NIPBL Nipped-B homolog (Drosophila)
NOL11 nucleolar protein 11
NOMO1 NODAL modulator 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NOSTRIN nitric oxide synthase trafficking
NOTCH3 notch 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRXN3 neurexin 3
NTN3 netrin 3
NUP210 nucleoporin 210kDa
NUTM2F NUT family member 2F
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OLFML2B olfactomedin-like 2B
OR10G7 olfactory receptor, family 10, subfamily G, member 7
OR10G9 olfactory receptor, family 10, subfamily G, member 9
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene)
OR2L1P olfactory receptor, family 2, subfamily L, member 1 pseudogene
OR2L2 olfactory receptor, family 2, subfamily L, member 2
OR2M3 olfactory receptor, family 2, subfamily M, member 3
OR4N4 olfactory receptor, family 4, subfamily N, member 4
OR51B2 olfactory receptor, family 51, subfamily B, member 2 (gene/pseudogene)
OR52E2 olfactory receptor, family 52, subfamily E, member 2
OR5AR1 olfactory receptor, family 5, subfamily AR, member 1 (gene/pseudogene)
OSTN osteocrin
OTOA otoancorin
OTUD7B OTU deubiquitinase 7B
OXSR1 oxidative stress responsive 1
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2
PARK2 parkin RBR E3 ubiquitin protein ligase
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PCDH10 protocadherin 10
PCDHA5 protocadherin alpha 5
PCDHA7 protocadherin alpha 7
PCDHB10 protocadherin beta 10
PCDHB5 protocadherin beta 5
PCDHGA1 protocadherin gamma subfamily A, 1
PCNT pericentrin
PDE4DIP phosphodiesterase 4D interacting protein
PDE8B phosphodiesterase 8B
PDLIM4 PDZ and LIM domain 4
PEAR1 platelet endothelial aggregation receptor 1
PGK2 phosphoglycerate kinase 2
PHACTR3 phosphatase and actin regulator 3
PHF8 PHD finger protein 8
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIGW phosphatidylinositol glycan anchor biosynthesis, class W
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G3 phospholipase A2, group III
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLEC plectin
PLEK2 pleckstrin 2
POFUT1 protein O-fucosyltransferase 1
POTEG POTE ankyrin domain family, member G
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1
PREP prolyl endopeptidase
PRKCG protein kinase C, gamma
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
PRLR prolactin receptor
PROS1 protein S (alpha)
PRRC2B proline-rich coiled-coil 2B
PRRC2C proline-rich coiled-coil 2C
PSKH2 protein serine kinase H2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRD protein tyrosine phosphatase, receptor type, D
PTPRN protein tyrosine phosphatase, receptor type, N
PTRF polymerase I and transcript release factor
PTTG1IP pituitary tumor-transforming 1 interacting protein
PTX4 pentraxin 4, long
PYCARD PYD and CARD domain containing
R3HDML R3H domain containing-like
RAD21 RAD21 homolog (S. pombe)
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic)
RAP1B RAP1B, member of RAS oncogene family
RASD2 RASD family, member 2
REN renin
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RHOC ras homolog family member C
RIC3 RIC3 acetylcholine receptor chaperone
RNF111 ring finger protein 111
RNF181 ring finger protein 181
RNF214 ring finger protein 214
RNF220 ring finger protein 220
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPL13 ribosomal protein L13
RPL41 ribosomal protein L41
RPL7L1 ribosomal protein L7-like 1
RPTOR regulatory associated protein of MTOR, complex 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RTTN rotatin
SALL1 spalt-like transcription factor 1
SCAF4 SR-related CTD-associated factor 4
SCN5A sodium channel, voltage gated, type V alpha subunit
SDCCAG8 serologically defined colon cancer antigen 8
SDK1 sidekick cell adhesion molecule 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10
SETD5 SET domain containing 5
SEZ6 seizure related 6 homolog (mouse)
SGMS2 sphingomyelin synthase 2
SH3PXD2B SH3 and PX domains 2B
SHANK2 SH3 and multiple ankyrin repeat domains 2
SHROOM3 shroom family member 3
SIL1 SIL1 nucleotide exchange factor
SLC17A4 solute carrier family 17, member 4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC22A14 solute carrier family 22, member 14
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2
SLC35D3 solute carrier family 35, member D3
SLC35G5 solute carrier family 35, member G5
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLIT1 slit homolog 1 (Drosophila)
SMC2 structural maintenance of chromosomes 2
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX30 SRY (sex determining region Y)-box 30
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SPATA17 spermatogenesis associated 17
SPINK9 serine peptidase inhibitor, Kazal type 9
SPRY4 sprouty homolog 4 (Drosophila)
SRRM2 serine/arginine repetitive matrix 2
SSTR3 somatostatin receptor 3
ST18 suppression of tumorigenicity 18, zinc finger
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
STAT2 signal transducer and activator of transcription 2, 113kDa
STK11 serine/threonine kinase 11
SUGP2 SURP and G patch domain containing 2
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SVIL supervillin
SYDE2 synapse defective 1, Rho GTPase, homolog 2 (C. elegans)
SYN2 synapsin II
TAAR1 trace amine associated receptor 1
TDRD5 tudor domain containing 5
TEP1 telomerase-associated protein 1
THRA thyroid hormone receptor, alpha
THSD7B thrombospondin, type I, domain containing 7B
TIAM1 T-cell lymphoma invasion and metastasis 1
TLL2 tolloid-like 2
TMED8 transmembrane emp24 protein transport domain containing 8
TMEM2 transmembrane protein 2
TMEM33 transmembrane protein 33
TMEM57 transmembrane protein 57
TMEM87B transmembrane protein 87B
TMX3 thioredoxin-related transmembrane protein 3
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPP1 tripeptidyl peptidase I
TRHDE thyrotropin-releasing hormone degrading enzyme
TRIM13 tripartite motif containing 13
TRIM22 tripartite motif containing 22
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSPY1 testis specific protein, Y-linked 1
TSSK2 testis-specific serine kinase 2
TTC26 tetratricopeptide repeat domain 26
TTC34 tetratricopeptide repeat domain 34
TTC7A tetratricopeptide repeat domain 7A
TTN titin
TYR tyrosinase
UNC45B unc-45 homolog B (C. elegans)
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
USP30 ubiquitin specific peptidase 30
USP42 ubiquitin specific peptidase 42
VIM vimentin
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
VWC2L von Willebrand factor C domain containing protein 2-like
WDR41 WD repeat domain 41
WDR72 WD repeat domain 72
WDR90 WD repeat domain 90
WISP2 WNT1 inducible signaling pathway protein 2
WNT5B wingless-type MMTV integration site family, member 5B
XIRP2 xin actin binding repeat containing 2
YIPF7 Yip1 domain family, member 7
ZBBX zinc finger, B-box domain containing
ZBTB26 zinc finger and BTB domain containing 26
ZCCHC14 zinc finger, CCHC domain containing 14
ZDHHC13 zinc finger, DHHC-type containing 13
ZFHX3 zinc finger homeobox 3
ZFP64 ZFP64 zinc finger protein
ZFYVE27 zinc finger, FYVE domain containing 27
ZIC1 Zic family member 1
ZNF160 zinc finger protein 160
ZNF208 zinc finger protein 208
ZNF217 zinc finger protein 217
ZNF257 zinc finger protein 257
ZNF273 zinc finger protein 273
ZNF341 zinc finger protein 341
ZNF382 zinc finger protein 382
ZNF438 zinc finger protein 438
ZNF467 zinc finger protein 467
ZNF470 zinc finger protein 470
ZNF517 zinc finger protein 517
ZNF560 zinc finger protein 560
ZNF638 zinc finger protein 638
ZNF652 zinc finger protein 652
ZNF655 zinc finger protein 655
ZNF774 zinc finger protein 774
ZPLD1 zona pellucida-like domain containing 1
ZRANB3 zinc finger, RAN-binding domain containing 3
ZSCAN21 zinc finger and SCAN domain containing 21