NCI-H446 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: carcinoma; small cell lung cancer (lung primary) (Cell Line Ontology, CLO_0008088)
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Genes

258 genes mutated in the NCI-H446 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
AARS2 alanyl-tRNA synthetase 2, mitochondrial
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACVR2B activin A receptor, type IIB
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAT2 adenosine deaminase, tRNA-specific 2
ADGRL3 adhesion G protein-coupled receptor L3
AK2 adenylate kinase 2
AKAP13 A kinase (PRKA) anchor protein 13
AMOTL1 angiomotin like 1
ANKRD12 ankyrin repeat domain 12
ANKRD13D ankyrin repeat domain 13 family, member D
ANKRD26 ankyrin repeat domain 26
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARMCX4 armadillo repeat containing, X-linked 4
ATP13A2 ATPase type 13A2
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATRN attractin
ATRX alpha thalassemia/mental retardation syndrome X-linked
AXL AXL receptor tyrosine kinase
BANK1 B-cell scaffold protein with ankyrin repeats 1
BDKRB1 bradykinin receptor B1
BFSP1 beaded filament structural protein 1, filensin
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAMSAP3 calmodulin regulated spectrin-associated protein family, member 3
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CARS cysteinyl-tRNA synthetase
CCDC34 coiled-coil domain containing 34
CCPG1 cell cycle progression 1
CDH10 cadherin 10, type 2 (T2-cadherin)
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CECR2 cat eye syndrome chromosome region, candidate 2
CECR6 cat eye syndrome chromosome region, candidate 6
CENPN centromere protein N
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1
CSNK2A3 casein kinase 2, alpha 3 polypeptide
CTNNA2 catenin (cadherin-associated protein), alpha 2
DACT3 dishevelled-binding antagonist of beta-catenin 3
DAP death-associated protein
DENND5B DENN/MADD domain containing 5B
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16
DISP2 dispatched homolog 2 (Drosophila)
DLGAP3 discs, large (Drosophila) homolog-associated protein 3
DOCK7 dedicator of cytokinesis 7
DSCAML1 Down syndrome cell adhesion molecule like 1
DUSP16 dual specificity phosphatase 16
DYM dymeclin
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
EFTUD2 elongation factor Tu GTP binding domain containing 2
ENO2 enolase 2 (gamma, neuronal)
ERBB2IP erbb2 interacting protein
FAM57B family with sequence similarity 57, member B
FAM63B family with sequence similarity 63, member B
FBF1 Fas (TNFRSF6) binding factor 1
FBXO33 F-box protein 33
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FHOD3 formin homology 2 domain containing 3
FKBP10 FK506 binding protein 10, 65 kDa
FURIN furin (paired basic amino acid cleaving enzyme)
FXR1 fragile X mental retardation, autosomal homolog 1
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GCC1 GRIP and coiled-coil domain containing 1
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GJC1 gap junction protein, gamma 1, 45kDa
GON4L gon-4-like (C. elegans)
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRID2 glutamate receptor, ionotropic, delta 2
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HDX highly divergent homeobox
HELZ2 helicase with zinc finger 2, transcriptional coactivator
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIRIP3 HIRA interacting protein 3
HKR1 HKR1, GLI-Kruppel zinc finger family member
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
HSPG2 heparan sulfate proteoglycan 2
IFT122 intraflagellar transport 122
IFT20 intraflagellar transport 20
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IL17RA interleukin 17 receptor A
IPO13 importin 13
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITPK1 inositol-tetrakisphosphate 1-kinase
JADE1 jade family PHD finger 1
JAM2 junctional adhesion molecule 2
KANK2 KN motif and ankyrin repeat domains 2
KAT5 K(lysine) acetyltransferase 5
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KIAA0196 KIAA0196
KIF1B kinesin family member 1B
KIF21B kinesin family member 21B
KIF6 kinesin family member 6
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHDC3 kelch domain containing 3
KLHL20 kelch-like family member 20
KLHL9 kelch-like family member 9
KMT2C lysine (K)-specific methyltransferase 2C
KMT2D lysine (K)-specific methyltransferase 2D
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast)
KTN1 kinectin 1 (kinesin receptor)
LACE1 lactation elevated 1
LAMA5 laminin, alpha 5
LBR lamin B receptor
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIMK2 LIM domain kinase 2
LINGO2 leucine rich repeat and Ig domain containing 2
LRP1B low density lipoprotein receptor-related protein 1B
LRRC8C leucine rich repeat containing 8 family, member C
LTC4S leukotriene C4 synthase
MED17 mediator complex subunit 17
MEGF8 multiple EGF-like-domains 8
MEPCE methylphosphate capping enzyme
MN1 meningioma (disrupted in balanced translocation) 1
MON2 MON2 homolog (S. cerevisiae)
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MPPED1 metallophosphoesterase domain containing 1
MSL2 male-specific lethal 2 homolog (Drosophila)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MVD mevalonate (diphospho) decarboxylase
MYBPC1 myosin binding protein C, slow type
MYT1L myelin transcription factor 1-like
NALCN sodium leak channel, non selective
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma
NAT14 N-acetyltransferase 14 (GCN5-related, putative)
NAV3 neuron navigator 3
NBN nibrin
NCKAP1 NCK-associated protein 1
NCOR2 nuclear receptor corepressor 2
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa
NEURL4 neuralized E3 ubiquitin protein ligase 4
NF1 neurofibromin 1
NFYA nuclear transcription factor Y, alpha
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1
NLGN1 neuroligin 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRCAM neuronal cell adhesion molecule
NRG3 neuregulin 3
NRP1 neuropilin 1
NUP210 nucleoporin 210kDa
NXPE3 neurexophilin and PC-esterase domain family, member 3
OSBPL5 oxysterol binding protein-like 5
OTX1 orthodenticle homeobox 1
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6
PBRM1 polybromo 1
PCLO piccolo presynaptic cytomatrix protein
PDCD11 programmed cell death 11
PDE1A phosphodiesterase 1A, calmodulin-dependent
PDIA6 protein disulfide isomerase family A, member 6
PDZD7 PDZ domain containing 7
PHF23 PHD finger protein 23
PHIP pleckstrin homology domain interacting protein
PHRF1 PHD and ring finger domains 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNPLA2 patatin-like phospholipase domain containing 2
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF6 pre-mRNA processing factor 6
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PTCH1 patched 1
PTGFRN prostaglandin F2 receptor inhibitor
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPRO protein tyrosine phosphatase, receptor type, O
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB3IP RAB3A interacting protein
RANBP9 RAN binding protein 9
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIMS1 regulating synaptic membrane exocytosis 1
RPN2 ribophorin II
SCARB1 scavenger receptor class B, member 1
SCARF2 scavenger receptor class F, member 2
SEC16B SEC16 homolog B (S. cerevisiae)
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SESN3 sestrin 3
SETBP1 SET binding protein 1
SF3A2 splicing factor 3a, subunit 2, 66kDa
SFXN5 sideroflexin 5
SHANK3 SH3 and multiple ankyrin repeat domains 3
SIK3 SIK family kinase 3
SIPA1 signal-induced proliferation-associated 1
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13
SLC38A5 solute carrier family 38, member 5
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein
SLC5A10 solute carrier family 5 (sodium/sugar cotransporter), member 10
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SMR3A submaxillary gland androgen regulated protein 3A
SNAP91 synaptosomal-associated protein, 91kDa
SORBS1 sorbin and SH3 domain containing 1
SOX5 SRY (sex determining region Y)-box 5
SOX9 SRY (sex determining region Y)-box 9
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRF serum response factor (c-fos serum response element-binding transcription factor)
SS18 synovial sarcoma translocation, chromosome 18
STARD9 StAR-related lipid transfer (START) domain containing 9
STBD1 starch binding domain 1
SYT1 synaptotagmin I
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like
TCHH trichohyalin
TFEB transcription factor EB
TIAM1 T-cell lymphoma invasion and metastasis 1
TIGD2 tigger transposable element derived 2
TLN2 talin 2
TM9SF3 transmembrane 9 superfamily member 3
TMEM168 transmembrane protein 168
TOP3A topoisomerase (DNA) III alpha
TOPBP1 topoisomerase (DNA) II binding protein 1
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TP53 tumor protein p53
TRIM44 tripartite motif containing 44
TRIM56 tripartite motif containing 56
TRIO trio Rho guanine nucleotide exchange factor
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TTL tubulin tyrosine ligase
TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum)
TXNRD2 thioredoxin reductase 2
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UBTD2 ubiquitin domain containing 2
UNC13A unc-13 homolog A (C. elegans)
USP16 ubiquitin specific peptidase 16
USP6NL USP6 N-terminal like
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VGF VGF nerve growth factor inducible
WBP1L WW domain binding protein 1-like
WDR1 WD repeat domain 1
WDTC1 WD and tetratricopeptide repeats 1
ZBTB10 zinc finger and BTB domain containing 10
ZDBF2 zinc finger, DBF-type containing 2
ZFHX4 zinc finger homeobox 4
ZKSCAN8 zinc finger with KRAB and SCAN domains 8
ZNF197 zinc finger protein 197
ZNF217 zinc finger protein 217
ZNF264 zinc finger protein 264
ZNF507 zinc finger protein 507
ZNF529 zinc finger protein 529
ZNF555 zinc finger protein 555
ZNF649 zinc finger protein 649
ZNF804A zinc finger protein 804A
ZSCAN16 zinc finger and SCAN domain containing 16
ZXDB zinc finger, X-linked, duplicated B
ZYG11B zyg-11 family member B, cell cycle regulator