NCI-H358 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
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337 genes mutated in the NCI-H358 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
AARS2 alanyl-tRNA synthetase 2, mitochondrial
ABHD5 abhydrolase domain containing 5
ACAD9 acyl-CoA dehydrogenase family, member 9
ADAM19 ADAM metallopeptidase domain 19
ADAT3 adenosine deaminase, tRNA-specific 3
ADCY1 adenylate cyclase 1 (brain)
ADGRB1 adhesion G protein-coupled receptor B1
AFF1 AF4/FMR2 family, member 1
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AIF1L allograft inflammatory factor 1-like
AIP aryl hydrocarbon receptor interacting protein
ALCAM activated leukocyte cell adhesion molecule
ALDH16A1 aldehyde dehydrogenase 16 family, member A1
ALG8 ALG8, alpha-1,3-glucosyltransferase
ANKRD33B ankyrin repeat domain 33B
ANO1 anoctamin 1, calcium activated chloride channel
AP2A1 adaptor-related protein complex 2, alpha 1 subunit
AQR aquarius intron-binding spliceosomal factor
ASCC3 activating signal cointegrator 1 complex subunit 3
ATAD2 ATPase family, AAA domain containing 2
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3
ATXN7L3 ataxin 7-like 3
BCAN brevican
BCL6 B-cell CLL/lymphoma 6
BTD biotinidase
C8ORF44-SGK3 C8orf44-SGK3 readthrough
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CARD11 caspase recruitment domain family, member 11
CC2D1B coiled-coil and C2 domain containing 1B
CCDC91 coiled-coil domain containing 91
CCDC94 coiled-coil domain containing 94
CCS copper chaperone for superoxide dismutase
CDCA2 cell division cycle associated 2
CECR5 cat eye syndrome chromosome region, candidate 5
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CENPB centromere protein B, 80kDa
CENPC centromere protein C
CENPI centromere protein I
CEP126 centrosomal protein 126kDa
CEP250 centrosomal protein 250kDa
CEP350 centrosomal protein 350kDa
CEP85 centrosomal protein 85kDa
CGRRF1 cell growth regulator with ring finger domain 1
CHD3 chromodomain helicase DNA binding protein 3
CHD8 chromodomain helicase DNA binding protein 8
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CHIC2 cysteine-rich hydrophobic domain 2
CIR1 corepressor interacting with RBPJ, 1
CKAP2 cytoskeleton associated protein 2
CLSPN claspin
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3
CNPY2 canopy FGF signaling regulator 2
COL18A1 collagen, type XVIII, alpha 1
COL5A1 collagen, type V, alpha 1
COL7A1 collagen, type VII, alpha 1
COPG1 coatomer protein complex, subunit gamma 1
CORO7 coronin 7
CORO7-PAM16 CORO7-PAM16 readthrough
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CTH cystathionine gamma-lyase
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSF cathepsin F
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYTH1 cytohesin 1
DCAF10 DDB1 and CUL4 associated factor 10
DCAF15 DDB1 and CUL4 associated factor 15
DCP1A decapping mRNA 1A
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae)
DGKQ diacylglycerol kinase, theta 110kDa
DHTKD1 dehydrogenase E1 and transketolase domain containing 1
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DOCK4 dedicator of cytokinesis 4
DOHH deoxyhypusine hydroxylase/monooxygenase
DROSHA drosha, ribonuclease type III
DST dystonin
DTNB dystrobrevin, beta
DUSP2 dual specificity phosphatase 2
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2
EPRS glutamyl-prolyl-tRNA synthetase
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EXPH5 exophilin 5
FAM46A family with sequence similarity 46, member A
FAM83H family with sequence similarity 83, member H
FAM98C family with sequence similarity 98, member C
FANCC Fanconi anemia, complementation group C
FAT2 FAT atypical cadherin 2
FAT4 FAT atypical cadherin 4
FBLN1 fibulin 1
FBLN2 fibulin 2
FBRSL1 fibrosin-like 1
FGFR1 fibroblast growth factor receptor 1
FJX1 four jointed box 1 (Drosophila)
FLII flightless I homolog (Drosophila)
FOXA1 forkhead box A1
FTCD formimidoyltransferase cyclodeaminase
FZD4 frizzled class receptor 4
GAK cyclin G associated kinase
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GLS glutaminase
GPATCH8 G patch domain containing 8
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GSPT1 G1 to S phase transition 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTPBP3 GTP binding protein 3 (mitochondrial)
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
HBP1 HMG-box transcription factor 1
HDLBP high density lipoprotein binding protein
HEG1 heart development protein with EGF-like domains 1
HELB helicase (DNA) B
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase
INTS2 integrator complex subunit 2
JARID2 jumonji, AT rich interactive domain 2
JMJD4 jumonji domain containing 4
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KDM5A lysine (K)-specific demethylase 5A
KIAA0141 KIAA0141
KIAA1429 KIAA1429
KIF21A kinesin family member 21A
KIF4B kinesin family member 4B
KIFAP3 kinesin-associated protein 3
KLF11 Kruppel-like factor 11
KLHL23 kelch-like family member 23
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT75 keratin 75, type II
LIG1 ligase I, DNA, ATP-dependent
LIMK1 LIM domain kinase 1
LRP12 low density lipoprotein receptor-related protein 12
LRRC8E leucine rich repeat containing 8 family, member E
LTBP1 latent transforming growth factor beta binding protein 1
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3
MACROD1 MACRO domain containing 1
MALSU1 mitochondrial assembly of ribosomal large subunit 1
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK15 mitogen-activated protein kinase 15
MAX MYC associated factor X
MBOAT7 membrane bound O-acyltransferase domain containing 7
MED12 mediator complex subunit 12
MED7 mediator complex subunit 7
MEF2B myocyte enhancer factor 2B
MEGF6 multiple EGF-like-domains 6
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MIDN midnolin
MOV10 Mov10 RISC complex RNA helicase
MPLKIP M-phase specific PLK1 interacting protein
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MRPL32 mitochondrial ribosomal protein L32
MSH3 mutS homolog 3
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
MTMR11 myotubularin related protein 11
MUC16 mucin 16, cell surface associated
MUTYH mutY homolog
MYO18B myosin XVIIIB
MYO1B myosin IB
MYO5C myosin VC
N6AMT2 N-6 adenine-specific DNA methyltransferase 2 (putative)
NBAS neuroblastoma amplified sequence
NCOA3 nuclear receptor coactivator 3
NCOR2 nuclear receptor corepressor 2
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NELL2 NEL-like 2 (chicken)
NES nestin
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
NFU1 NFU1 iron-sulfur cluster scaffold
NOL12 nucleolar protein 12
NOV nephroblastoma overexpressed
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRCAM neuronal cell adhesion molecule
NRD1 nardilysin (N-arginine dibasic convertase)
NRK Nik related kinase
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OCLN occludin
OLFML2B olfactomedin-like 2B
OR4C6 olfactory receptor, family 4, subfamily C, member 6
OSBPL10 oxysterol binding protein-like 10
PCDH1 protocadherin 1
PCDHB13 protocadherin beta 13
PEX6 peroxisomal biogenesis factor 6
PFDN4 prefoldin subunit 4
PGPEP1 pyroglutamyl-peptidase I
PHF20 PHD finger protein 20
PHLDB3 pleckstrin homology-like domain, family B, member 3
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PITX1 paired-like homeodomain 1
PKP2 plakophilin 2
PLEC plectin
PLXNA3 plexin A3
PML promyelocytic leukemia
PNKP polynucleotide kinase 3'-phosphatase
POLQ polymerase (DNA directed), theta
POLR1B polymerase (RNA) I polypeptide B, 128kDa
POMT2 protein-O-mannosyltransferase 2
POT1 protection of telomeres 1
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRKD1 protein kinase D1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PROS1 protein S (alpha)
PRPF31 pre-mRNA processing factor 31
PTDSS1 phosphatidylserine synthase 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PXMP2 peroxisomal membrane protein 2, 22kDa
PYGL phosphorylase, glycogen, liver
QSOX2 quiescin Q6 sulfhydryl oxidase 2
RAD51D RAD51 paralog D
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARA retinoic acid receptor, alpha
RASGEF1C RasGEF domain family, member 1C
RBBP8 retinoblastoma binding protein 8
RCCD1 RCC1 domain containing 1
REXO1 REX1, RNA exonuclease 1 homolog (S. cerevisiae)
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RNF17 ring finger protein 17
RNF212 ring finger protein 212
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SACS sacsin molecular chaperone
SAE1 SUMO1 activating enzyme subunit 1
SAMD9 sterile alpha motif domain containing 9
SATB2 SATB homeobox 2
SCD5 stearoyl-CoA desaturase 5
SCIN scinderin
SCRN3 secernin 3
SELO selenoprotein O
SELPLG selectin P ligand
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SETD1A SET domain containing 1A
SF3B1 splicing factor 3b, subunit 1, 155kDa
SGK3 serum/glucocorticoid regulated kinase family, member 3
SGSM3 small G protein signaling modulator 3
SH2B2 SH2B adaptor protein 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLAMF7 SLAM family member 7
SLC12A9 solute carrier family 12, member 9
SLC16A14 solute carrier family 16, member 14
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC25A44 solute carrier family 25, member 44
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC35E1 solute carrier family 35, member E1
SLC44A3 solute carrier family 44, member 3
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLFN5 schlafen family member 5
SLMAP sarcolemma associated protein
SLX4 SLX4 structure-specific endonuclease subunit
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SP2 Sp2 transcription factor
SPATA5 spermatogenesis associated 5
SPATS2 spermatogenesis associated, serine-rich 2
SPICE1 spindle and centriole associated protein 1
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SRRD SRR1 domain containing
STIL SCL/TAL1 interrupting locus
STK11IP serine/threonine kinase 11 interacting protein
STK36 serine/threonine kinase 36
STXBP4 syntaxin binding protein 4
STYK1 serine/threonine/tyrosine kinase 1
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
SYMPK symplekin
SYNE2 spectrin repeat containing, nuclear envelope 2
TACC2 transforming, acidic coiled-coil containing protein 2
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
TBC1D31 TBC1 domain family, member 31
TBL3 transducin (beta)-like 3
TCF3 transcription factor 3
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TICAM1 toll-like receptor adaptor molecule 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TJAP1 tight junction associated protein 1 (peripheral)
TLN1 talin 1
TLR6 toll-like receptor 6
TMC8 transmembrane channel-like 8
TMEM121 transmembrane protein 121
TMEM245 transmembrane protein 245
TMTC2 transmembrane and tetratricopeptide repeat containing 2
TNC tenascin C
TNIK TRAF2 and NCK interacting kinase
TP63 tumor protein p63
TPP2 tripeptidyl peptidase II
TPST2 tyrosylprotein sulfotransferase 2
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TRIM13 tripartite motif containing 13
TRIM38 tripartite motif containing 38
TRIM39 tripartite motif containing 39
TRIM39-RPP21 TRIM39-RPP21 readthrough
TRIM65 tripartite motif containing 65
TROAP trophinin associated protein
TSC22D1 TSC22 domain family, member 1
TSSC1 tumor suppressing subtransferable candidate 1
TTLL4 tubulin tyrosine ligase-like family member 4
TXNDC11 thioredoxin domain containing 11
UBR5 ubiquitin protein ligase E3 component n-recognin 5
USB1 U6 snRNA biogenesis 1
USP19 ubiquitin specific peptidase 19
USP24 ubiquitin specific peptidase 24
USP28 ubiquitin specific peptidase 28
USP32 ubiquitin specific peptidase 32
USP54 ubiquitin specific peptidase 54
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)
VSNL1 visinin-like 1
WDR33 WD repeat domain 33
WNK1 WNK lysine deficient protein kinase 1
XPO6 exportin 6
ZBED4 zinc finger, BED-type containing 4
ZBTB49 zinc finger and BTB domain containing 49
ZDHHC24 zinc finger, DHHC-type containing 24
ZFHX3 zinc finger homeobox 3
ZFP91 ZFP91 zinc finger protein
ZNF268 zinc finger protein 268
ZNF518A zinc finger protein 518A
ZNF608 zinc finger protein 608
ZNF691 zinc finger protein 691
ZNF717 zinc finger protein 717
ZNF770 zinc finger protein 770
ZSCAN25 zinc finger and SCAN domain containing 25
ZSCAN5A zinc finger and SCAN domain containing 5A
ZSCAN5B zinc finger and SCAN domain containing 5B