NCI-H345 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description Small cell lung cancer cell line. (BRENDA Tissue and Enzyme Source Ontology, BTO_0003019)
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Genes

293 genes mutated in the NCI-H345 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
AATF apoptosis antagonizing transcription factor
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD12 abhydrolase domain containing 12
ABHD13 abhydrolase domain containing 13
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ABLIM1 actin binding LIM protein 1
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADAM17 ADAM metallopeptidase domain 17
ADCY5 adenylate cyclase 5
AKAP1 A kinase (PRKA) anchor protein 1
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
ANKHD1 ankyrin repeat and KH domain containing 1
ANKHD1-EIF4EBP3 ANKHD1-EIF4EBP3 readthrough
ANKRD12 ankyrin repeat domain 12
ANO1 anoctamin 1, calcium activated chloride channel
ANO10 anoctamin 10
ANO5 anoctamin 5
ANXA11 annexin A11
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
APAF1 apoptotic peptidase activating factor 1
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARFGEF3 ARFGEF family member 3
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ASTN1 astrotactin 1
ASXL2 additional sex combs like transcriptional regulator 2
ATG2B autophagy related 2B
ATP11A ATPase, class VI, type 11A
ATRN attractin
AUTS2 autism susceptibility candidate 2
AVIL advillin
B3GAT1 beta-1,3-glucuronyltransferase 1
BAHCC1 BAH domain and coiled-coil containing 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL9L B-cell CLL/lymphoma 9-like
BRD2 bromodomain containing 2
BRWD1 bromodomain and WD repeat domain containing 1
C14ORF93 chromosome 14 open reading frame 93
C19ORF44 chromosome 19 open reading frame 44
C2CD3 C2 calcium-dependent domain containing 3
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CADM2 cell adhesion molecule 2
CANX calnexin
CAPN15 calpain 15
CAPS2 calcyphosine 2
CCDC53 coiled-coil domain containing 53
CCDC89 coiled-coil domain containing 89
CD276 CD276 molecule
CDR2L cerebellar degeneration-related protein 2-like
CECR6 cat eye syndrome chromosome region, candidate 6
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CHN2 chimerin 2
CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
CKLF-CMTM1 CKLF-CMTM1 readthrough
CKMT1A creatine kinase, mitochondrial 1A
CKMT1B creatine kinase, mitochondrial 1B
CLP1 cleavage and polyadenylation factor I subunit 1
CLUH clustered mitochondria (cluA/CLU1) homolog
CMTM1 CKLF-like MARVEL transmembrane domain containing 1
CNTN1 contactin 1
CREBBP CREB binding protein
CRYBG3 beta-gamma crystallin domain containing 3
CSMD3 CUB and Sushi multiple domains 3
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
DACH1 dachshund family transcription factor 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DGKI diacylglycerol kinase, iota
DIAPH1 diaphanous-related formin 1
DNAH6 dynein, axonemal, heavy chain 6
DNAH7 dynein, axonemal, heavy chain 7
DOK3 docking protein 3
DPP10 dipeptidyl-peptidase 10 (non-functional)
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2)
DSEL dermatan sulfate epimerase-like
DTNB dystrobrevin, beta
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
DZIP1L DAZ interacting zinc finger protein 1-like
EFCAB3 EF-hand calcium binding domain 3
EFCAB7 EF-hand calcium binding domain 7
EFTUD2 elongation factor Tu GTP binding domain containing 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELAVL2 ELAV like neuron-specific RNA binding protein 2
EML5 echinoderm microtubule associated protein like 5
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans)
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPS8 epidermal growth factor receptor pathway substrate 8
EXOSC10 exosome component 10
EXTL2 exostosin-like glycosyltransferase 2
FAM185A family with sequence similarity 185, member A
FAM19A2 family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
FAM212B family with sequence similarity 212, member B
FANCF Fanconi anemia, complementation group F
FANCM Fanconi anemia, complementation group M
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FAT3 FAT atypical cadherin 3
FAXC failed axon connections homolog (Drosophila)
FBXL16 F-box and leucine-rich repeat protein 16
FBXL19 F-box and leucine-rich repeat protein 19
FBXO10 F-box protein 10
FIZ1 FLT3-interacting zinc finger 1
FLNC filamin C, gamma
FRAS1 Fraser extracellular matrix complex subunit 1
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13
GLO1 glyoxalase I
GPRASP1 G protein-coupled receptor associated sorting protein 1
HDGF hepatoma-derived growth factor
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
HEYL hes-related family bHLH transcription factor with YRPW motif-like
HHAT hedgehog acyltransferase
HOXB5 homeobox B5
HSD11B1L hydroxysteroid (11-beta) dehydrogenase 1-like
IKZF2 IKAROS family zinc finger 2 (Helios)
INA internexin neuronal intermediate filament protein, alpha
IVNS1ABP influenza virus NS1A binding protein
KAT6A K(lysine) acetyltransferase 6A
KAT6B K(lysine) acetyltransferase 6B
KAT8 K(lysine) acetyltransferase 8
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNK9 potassium channel, two pore domain subfamily K, member 9
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KIAA0100 KIAA0100
KIAA1211 KIAA1211
KIF13B kinesin family member 13B
KIF4B kinesin family member 4B
KIFC1 kinesin family member C1
KLF14 Kruppel-like factor 14
KMT2E lysine (K)-specific methyltransferase 2E
KSR2 kinase suppressor of ras 2
LARP1 La ribonucleoprotein domain family, member 1
LIMCH1 LIM and calponin homology domains 1
LMBRD2 LMBR1 domain containing 2
LMLN leishmanolysin-like (metallopeptidase M8 family)
LMNA lamin A/C
LRP6 low density lipoprotein receptor-related protein 6
LRPPRC leucine-rich pentatricopeptide repeat containing
LRRC61 leucine rich repeat containing 61
LYPD6 LY6/PLAUR domain containing 6
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MINK1 misshapen-like kinase 1
MON1B MON1 secretory trafficking family member B
MSH2 mutS homolog 2
MTMR4 myotubularin related protein 4
MVD mevalonate (diphospho) decarboxylase
MYT1L myelin transcription factor 1-like
N4BP2 NEDD4 binding protein 2
NADSYN1 NAD synthetase 1
NAF1 nuclear assembly factor 1 ribonucleoprotein
NAMPT nicotinamide phosphoribosyltransferase
NBAS neuroblastoma amplified sequence
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
NEK10 NIMA-related kinase 10
NF1 neurofibromin 1
NIPBL Nipped-B homolog (Drosophila)
NUDT17 nudix (nucleoside diphosphate linked moiety X)-type motif 17
OGFR opioid growth factor receptor
OSBP oxysterol binding protein
OTX1 orthodenticle homeobox 1
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PAPL iron/zinc purple acid phosphatase-like protein
PARD3B par-3 family cell polarity regulator beta
PCDHB16 protocadherin beta 16
PCDHGC3 protocadherin gamma subfamily C, 3
PCLO piccolo presynaptic cytomatrix protein
PDIA4 protein disulfide isomerase family A, member 4
PDZRN3 PDZ domain containing ring finger 3
PIAS1 protein inhibitor of activated STAT, 1
PLA2G4F phospholipase A2, group IVF
PLAA phospholipase A2-activating protein
PLCB4 phospholipase C, beta 4
PLEC plectin
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
PLXNA4 plexin A4
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR1A polymerase (RNA) I polypeptide A, 194kDa
POLR1B polymerase (RNA) I polypeptide B, 128kDa
POLR3B polymerase (RNA) III (DNA directed) polypeptide B
POU4F1 POU class 4 homeobox 1
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PREPL prolyl endopeptidase-like
PRODH proline dehydrogenase (oxidase) 1
PRRC1 proline-rich coiled-coil 1
PTH2R parathyroid hormone 2 receptor
PTPDC1 protein tyrosine phosphatase domain containing 1
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPRF protein tyrosine phosphatase, receptor type, F
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
QSER1 glutamine and serine rich 1
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB11FIP4 RAB11 family interacting protein 4 (class II)
RAB3A RAB3A, member RAS oncogene family
RAD54B RAD54 homolog B (S. cerevisiae)
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RARS arginyl-tRNA synthetase
RASA3 RAS p21 protein activator 3
RBM26 RNA binding motif protein 26
RBM47 RNA binding motif protein 47
RELN reelin
RHPN1 rhophilin, Rho GTPase binding protein 1
RNF152 ring finger protein 152
RNF19B ring finger protein 19B
RRP1B ribosomal RNA processing 1B
RSBN1L round spermatid basic protein 1-like
SALL3 spalt-like transcription factor 3
SAMD9 sterile alpha motif domain containing 9
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SESTD1 SEC14 and spectrin domains 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3BP4 SH3-domain binding protein 4
SHKBP1 SH3KBP1 binding protein 1
SIGMAR1 sigma non-opioid intracellular receptor 1
SIN3A SIN3 transcription regulator family member A
SKI SKI proto-oncogene
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A4 solute carrier family 7, member 4
SLIT3 slit homolog 3 (Drosophila)
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMG7 SMG7 nonsense mediated mRNA decay factor
SNRPA small nuclear ribonucleoprotein polypeptide A
SPATA6L spermatogenesis associated 6-like
SPPL3 signal peptide peptidase like 3
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRCAP Snf2-related CREBBP activator protein
SRRM2 serine/arginine repetitive matrix 2
STAB2 stabilin 2
STK32C serine/threonine kinase 32C
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
SYN1 synapsin I
SYNE2 spectrin repeat containing, nuclear envelope 2
TACC1 transforming, acidic coiled-coil containing protein 1
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D10A TBC1 domain family, member 10A
TBC1D10B TBC1 domain family, member 10B
TBC1D15 TBC1 domain family, member 15
TDP2 tyrosyl-DNA phosphodiesterase 2
TDRD3 tudor domain containing 3
TECTA tectorin alpha
TIAM1 T-cell lymphoma invasion and metastasis 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2
TMEM132D transmembrane protein 132D
TMEM56-RWDD3 TMEM56-RWDD3 readthrough
TMEM67 transmembrane protein 67
TMTC1 transmembrane and tetratricopeptide repeat containing 1
TOMM40L translocase of outer mitochondrial membrane 40 homolog (yeast)-like
TP53 tumor protein p53
TSC2 tuberous sclerosis 2
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
ULK4 unc-51 like kinase 4
UNC80 unc-80 homolog (C. elegans)
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae)
USP16 ubiquitin specific peptidase 16
VANGL2 VANGL planar cell polarity protein 2
VASP vasodilator-stimulated phosphoprotein
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WAPAL wings apart-like homolog (Drosophila)
WDR66 WD repeat domain 66
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB22 zinc finger and BTB domain containing 22
ZBTB25 zinc finger and BTB domain containing 25
ZBTB33 zinc finger and BTB domain containing 33
ZBTB48 zinc finger and BTB domain containing 48
ZC3H6 zinc finger CCCH-type containing 6
ZCCHC4 zinc finger, CCHC domain containing 4
ZDHHC11 zinc finger, DHHC-type containing 11
ZDHHC13 zinc finger, DHHC-type containing 13
ZEB1 zinc finger E-box binding homeobox 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZMYM4 zinc finger, MYM-type 4
ZNF202 zinc finger protein 202
ZNF213 zinc finger protein 213
ZNF292 zinc finger protein 292
ZNF318 zinc finger protein 318
ZNF462 zinc finger protein 462
ZNF624 zinc finger protein 624
ZYG11B zyg-11 family member B, cell cycle regulator