NCI-H3122 Gene Set

Dataset COSMIC Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description cell line derived from lung (Catalogue of Somatic Mutations In Cancer)
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Genes

379 genes mutated in the NCI-H3122 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACLY ATP citrate lyase
ACOX1 acyl-CoA oxidase 1, palmitoyl
ACPT acid phosphatase, testicular
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
AFF3 AF4/FMR2 family, member 3
AGK acylglycerol kinase
AHI1 Abelson helper integration site 1
AHNAK2 AHNAK nucleoprotein 2
AKIRIN1 akirin 1
ALB albumin
ANGPT4 angiopoietin 4
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD35 ankyrin repeat domain 35
ANKRD36 ankyrin repeat domain 36
ANO7 anoctamin 7
AP1B1 adaptor-related protein complex 1, beta 1 subunit
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
APOL6 apolipoprotein L, 6
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ARID1B AT rich interactive domain 1B (SWI1-like)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ARSE arylsulfatase E (chondrodysplasia punctata 1)
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ATF3 activating transcription factor 3
ATF7IP activating transcription factor 7 interacting protein
ATP13A2 ATPase type 13A2
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3
BAG3 BCL2-associated athanogene 3
BBS1 Bardet-Biedl syndrome 1
BCAS3 breast carcinoma amplified sequence 3
BICD1 bicaudal D homolog 1 (Drosophila)
BOC BOC cell adhesion associated, oncogene regulated
BRD8 bromodomain containing 8
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BSPH1 binder of sperm protein homolog 1
C7 complement component 7
CASP8AP2 caspase 8 associated protein 2
CCDC114 coiled-coil domain containing 114
CCDC116 coiled-coil domain containing 116
CCDC117 coiled-coil domain containing 117
CCDC129 coiled-coil domain containing 129
CCDC183 coiled-coil domain containing 183
CCDC33 coiled-coil domain containing 33
CCNE1 cyclin E1
CDC14B cell division cycle 14B
CDC73 cell division cycle 73
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH7 cadherin 7, type 2
CEACAM18 carcinoembryonic antigen-related cell adhesion molecule 18
CENPE centromere protein E, 312kDa
CES5A carboxylesterase 5A
CHIT1 chitinase 1 (chitotriosidase)
CHRND cholinergic receptor, nicotinic, delta (muscle)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLCC1 chloride channel CLIC-like 1
CLCN3 chloride channel, voltage-sensitive 3
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family)
CNPPD1 cyclin Pas1/PHO80 domain containing 1
COL10A1 collagen, type X, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL4A4 collagen, type IV, alpha 4
COPS4 COP9 signalosome subunit 4
CPED1 cadherin-like and PC-esterase domain containing 1
CPN2 carboxypeptidase N, polypeptide 2
CRB2 crumbs family member 2
CRLF1 cytokine receptor-like factor 1
CRTC1 CREB regulated transcription coactivator 1
CSRP2 cysteine and glycine-rich protein 2
CST8 cystatin 8 (cystatin-related epididymal specific)
CTNND2 catenin (cadherin-associated protein), delta 2
CTSC cathepsin C
CUL7 cullin 7
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
DGCR6L DiGeorge syndrome critical region gene 6-like
DIDO1 death inducer-obliterator 1
DIO1 deiodinase, iodothyronine, type I
DMBT1 deleted in malignant brain tumors 1
DNA2 DNA replication helicase/nuclease 2
DNAH11 dynein, axonemal, heavy chain 11
DNAH14 dynein, axonemal, heavy chain 14
DNPEP aspartyl aminopeptidase
DOCK1 dedicator of cytokinesis 1
DOCK4 dedicator of cytokinesis 4
DONSON downstream neighbor of SON
DSG2 desmoglein 2
DUSP27 dual specificity phosphatase 27 (putative)
DUSP5 dual specificity phosphatase 5
EIF2A eukaryotic translation initiation factor 2A, 65kDa
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ENDOD1 endonuclease domain containing 1
ERGIC2 ERGIC and golgi 2
ERLEC1 endoplasmic reticulum lectin 1
EXO1 exonuclease 1
EXOC3L1 exocyst complex component 3-like 1
EXOC4 exocyst complex component 4
FAM110B family with sequence similarity 110, member B
FAM129B family with sequence similarity 129, member B
FAM135B family with sequence similarity 135, member B
FAM47B family with sequence similarity 47, member B
FAM84A family with sequence similarity 84, member A
FANCA Fanconi anemia, complementation group A
FLNC filamin C, gamma
FMN1 formin 1
FNDC1 fibronectin type III domain containing 1
FOXC2 forkhead box C2
FOXH1 forkhead box H1
FSD2 fibronectin type III and SPRY domain containing 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene)
GALNT8 polypeptide N-acetylgalactosaminyltransferase 8
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
GAPVD1 GTPase activating protein and VPS9 domains 1
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GJA9 gap junction protein, alpha 9, 59kDa
GPR17 G protein-coupled receptor 17
GRAMD1A GRAM domain containing 1A
GRID2 glutamate receptor, ionotropic, delta 2
HDAC5 histone deacetylase 5
HDAC8 histone deacetylase 8
HECA headcase homolog (Drosophila)
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
HHIPL1 HHIP-like 1
HHLA1 HERV-H LTR-associating 1
HIPK2 homeodomain interacting protein kinase 2
HIST1H1T histone cluster 1, H1t
HIST2H3PS2 histone cluster 2, H3, pseudogene 2
HNRNPCL1 heterogeneous nuclear ribonucleoprotein C-like 1
HOXA2 homeobox A2
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
HUNK hormonally up-regulated Neu-associated kinase
HYDIN HYDIN, axonemal central pair apparatus protein
ICA1 islet cell autoantigen 1, 69kDa
ICE1 interactor of little elongation complex ELL subunit 1
IDS iduronate 2-sulfatase
IFI44 interferon-induced protein 44
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGF2R insulin-like growth factor 2 receptor
IGSF21 immunoglobin superfamily, member 21
IL12A interleukin 12A
INSIG2 insulin induced gene 2
INSRR insulin receptor-related receptor
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JPH4 junctophilin 4
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1
KDM4A lysine (K)-specific demethylase 4A
KIAA1107 KIAA1107
KIAA1671 KIAA1671
KIFC2 kinesin family member C2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIRREL2 kin of IRRE like 2 (Drosophila)
KMT2D lysine (K)-specific methyltransferase 2D
LAMA1 laminin, alpha 1
LAMA2 laminin, alpha 2
LBH limb bud and heart development
LDOC1L leucine zipper, down-regulated in cancer 1-like
LIM2 lens intrinsic membrane protein 2, 19kDa
LIMD1 LIM domains containing 1
LLGL2 lethal giant larvae homolog 2 (Drosophila)
LPA lipoprotein, Lp(a)
LRRCC1 leucine rich repeat and coiled-coil centrosomal protein 1
MADD MAP-kinase activating death domain
MAEL maelstrom spermatogenic transposon silencer
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MAS1L MAS1 proto-oncogene like, G protein-coupled receptor
MAST2 microtubule associated serine/threonine kinase 2
MBTPS1 membrane-bound transcription factor peptidase, site 1
MEGF6 multiple EGF-like-domains 6
MIA2 melanoma inhibitory activity 2
MINK1 misshapen-like kinase 1
MKL1 megakaryoblastic leukemia (translocation) 1
MKL2 MKL/myocardin-like 2
MNX1 motor neuron and pancreas homeobox 1
MPPED1 metallophosphoesterase domain containing 1
MT1E metallothionein 1E
MTMR10 myotubularin related protein 10
MTMR12 myotubularin related protein 12
MUC16 mucin 16, cell surface associated
MUC4 mucin 4, cell surface associated
MUS81 MUS81 structure-specific endonuclease subunit
MYH7 myosin, heavy chain 7, cardiac muscle, beta
MYH7B myosin, heavy chain 7B, cardiac muscle, beta
MYPN myopalladin
NAMPTP1 nicotinamide phosphoribosyltransferase pseudogene 1
NCDN neurochondrin
NEK5 NIMA-related kinase 5
NF1 neurofibromin 1
NFRKB nuclear factor related to kappaB binding protein
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2
NLRP12 NLR family, pyrin domain containing 12
NLRP5 NLR family, pyrin domain containing 5
NOG noggin
NOL12 nucleolar protein 12
NOS1 nitric oxide synthase 1 (neuronal)
NPHP4 nephronophthisis 4
NPNT nephronectin
NPR3 natriuretic peptide receptor 3
NTNG2 netrin G2
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OCM2 oncomodulin 2
OPN4 opsin 4
OR13A1 olfactory receptor, family 13, subfamily A, member 1
OR13C3 olfactory receptor, family 13, subfamily C, member 3
OR2G6 olfactory receptor, family 2, subfamily G, member 6
OR51H1 olfactory receptor, family 51, subfamily H, member 1
OR6B3 olfactory receptor, family 6, subfamily B, member 3
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAIP1 poly(A) binding protein interacting protein 1
PARG poly (ADP-ribose) glycohydrolase
PARP4 poly (ADP-ribose) polymerase family, member 4
PARP6 poly (ADP-ribose) polymerase family, member 6
PBX3 pre-B-cell leukemia homeobox 3
PCDH11X protocadherin 11 X-linked
PCDH18 protocadherin 18
PCDHA5 protocadherin alpha 5
PCDHB11 protocadherin beta 11
PCDHGA10 protocadherin gamma subfamily A, 10
PDCD1 programmed cell death 1
PEAK1 pseudopodium-enriched atypical kinase 1
PEG10 paternally expressed 10
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PIR pirin (iron-binding nuclear protein)
PLA2G4D phospholipase A2, group IVD (cytosolic)
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLBD2 phospholipase B domain containing 2
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHA7 pleckstrin homology domain containing, family A member 7
PLK4 polo-like kinase 4
PLXNA4 plexin A4
PNMA5 paraneoplastic Ma antigen family member 5
POLR1C polymerase (RNA) I polypeptide C, 30kDa
POLR2M polymerase (RNA) II (DNA directed) polypeptide M
POMT1 protein-O-mannosyltransferase 1
POU4F2 POU class 4 homeobox 2
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PROCR protein C receptor, endothelial
PTCH2 patched 2
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTX4 pentraxin 4, long
PZP pregnancy-zone protein
RAD54L2 RAD54-like 2 (S. cerevisiae)
RADIL Ras association and DIL domains
RALY RALY heterogeneous nuclear ribonucleoprotein
RANBP2 RAN binding protein 2
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASGRP4 RAS guanyl releasing protein 4
RB1 retinoblastoma 1
RBL1 retinoblastoma-like 1
RBM46 RNA binding motif protein 46
RBMX RNA binding motif protein, X-linked
RBP4 retinol binding protein 4, plasma
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RCOR2 REST corepressor 2
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RGS18 regulator of G-protein signaling 18
RNASE9 ribonuclease, RNase A family, 9 (non-active)
RNLS renalase, FAD-dependent amine oxidase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SACS sacsin molecular chaperone
SAMM50 SAMM50 sorting and assembly machinery component
SCN11A sodium channel, voltage gated, type XI alpha subunit
SELV selenoprotein V
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SF1 splicing factor 1
SFR1 SWI5-dependent recombination repair 1
SH3GL2 SH3-domain GRB2-like 2
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SIGLEC8 sialic acid binding Ig-like lectin 8
SIGLEC9 sialic acid binding Ig-like lectin 9
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5
SLC22A14 solute carrier family 22, member 14
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12
SLC39A10 solute carrier family 39 (zinc transporter), member 10
SLC45A1 solute carrier family 45, member 1
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17
SLCO1B7 solute carrier organic anion transporter family, member 1B7 (non-functional)
SLITRK2 SLIT and NTRK-like family, member 2
SMTN smoothelin
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
SNRPA small nuclear ribonucleoprotein polypeptide A
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNX24 sorting nexin 24
SPAG1 sperm associated antigen 1
SPAG8 sperm associated antigen 8
SPHKAP SPHK1 interactor, AKAP domain containing
SPRR1B small proline-rich protein 1B
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
SSPN sarcospan
ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
STARD9 StAR-related lipid transfer (START) domain containing 9
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SVIL supervillin
TACC2 transforming, acidic coiled-coil containing protein 2
TAS2R41 taste receptor, type 2, member 41
TBC1D2 TBC1 domain family, member 2
TBC1D4 TBC1 domain family, member 4
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCHHL1 trichohyalin-like 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THOC6 THO complex 6
THUMPD3 THUMP domain containing 3
TLN2 talin 2
TMEM132D transmembrane protein 132D
TMEM199 transmembrane protein 199
TMEM237 transmembrane protein 237
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TP53 tumor protein p53
TPTE transmembrane phosphatase with tensin homology
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
TRAP1 TNF receptor-associated protein 1
TRAPPC9 trafficking protein particle complex 9
TRPC7 transient receptor potential cation channel, subfamily C, member 7
TSHZ3 teashirt zinc finger homeobox 3
TSPYL4 TSPY-like 4
TTC28 tetratricopeptide repeat domain 28
TTLL11 tubulin tyrosine ligase-like family member 11
TYRP1 tyrosinase-related protein 1
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UBXN11 UBX domain protein 11
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
USH2A Usher syndrome 2A (autosomal recessive, mild)
VCAN versican
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
VWDE von Willebrand factor D and EGF domains
WDR26 WD repeat domain 26
WNK1 WNK lysine deficient protein kinase 1
WWOX WW domain containing oxidoreductase
XKR6 XK, Kell blood group complex subunit-related family, member 6
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
YY1AP1 YY1 associated protein 1
ZC3H10 zinc finger CCCH-type containing 10
ZDHHC13 zinc finger, DHHC-type containing 13
ZFAND2A zinc finger, AN1-type domain 2A
ZNF132 zinc finger protein 132
ZNF197 zinc finger protein 197
ZNF329 zinc finger protein 329
ZNF438 zinc finger protein 438
ZNF44 zinc finger protein 44
ZNF470 zinc finger protein 470
ZNF496 zinc finger protein 496
ZNF500 zinc finger protein 500
ZNF528 zinc finger protein 528
ZNF639 zinc finger protein 639
ZNF644 zinc finger protein 644
ZNF646 zinc finger protein 646
ZNF705A zinc finger protein 705A
ZNF799 zinc finger protein 799
ZNF804A zinc finger protein 804A
ZNF862 zinc finger protein 862
ZP1 zona pellucida glycoprotein 1 (sperm receptor)