NCI-H2405 Gene Set

Dataset COSMIC Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: adenocarcinoma; non-small cell lung cancer (lung primary) (Cell Line Ontology, CLO_0008075)
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Genes

242 genes mutated in the NCI-H2405 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

Symbol Name
AARS alanyl-tRNA synthetase
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10
ADAMTSL1 ADAMTS-like 1
ADAMTSL2 ADAMTS-like 2
ADCY6 adenylate cyclase 6
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AHI1 Abelson helper integration site 1
AJAP1 adherens junctions associated protein 1
AKAP13 A kinase (PRKA) anchor protein 13
AMY2A amylase, alpha 2A (pancreatic)
ANKRD36C ankyrin repeat domain 36C
AP3B2 adaptor-related protein complex 3, beta 2 subunit
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARHGAP31 Rho GTPase activating protein 31
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ATG9A autophagy related 9A
ATP10A ATPase, class V, type 10A
B3GAT3 beta-1,3-glucuronyltransferase 3
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
BLK BLK proto-oncogene, Src family tyrosine kinase
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRICD5 BRICHOS domain containing 5
C4A complement component 4A (Rodgers blood group)
C4B complement component 4B (Chido blood group)
CA11 carbonic anhydrase XI
CA5BP1 carbonic anhydrase VB pseudogene 1
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CASP8AP2 caspase 8 associated protein 2
CCDC157 coiled-coil domain containing 157
CCP110 centriolar coiled coil protein 110kDa
CD180 CD180 molecule
CDK15 cyclin-dependent kinase 15
CEP57 centrosomal protein 57kDa
CFAP46 cilia and flagella associated protein 46
CIC capicua transcriptional repressor
CKAP2 cytoskeleton associated protein 2
CLCN7 chloride channel, voltage-sensitive 7
CLSPN claspin
COBL cordon-bleu WH2 repeat protein
COL11A2 collagen, type XI, alpha 2
COL20A1 collagen, type XX, alpha 1
COL4A4 collagen, type IV, alpha 4
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CSMD3 CUB and Sushi multiple domains 3
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCAF6 DDB1 and CUL4 associated factor 6
DDAH1 dimethylarginine dimethylaminohydrolase 1
DGCR14 DiGeorge syndrome critical region gene 14
DHTKD1 dehydrogenase E1 and transketolase domain containing 1
DLC1 DLC1 Rho GTPase activating protein
DMRT3 doublesex and mab-3 related transcription factor 3
DNAH17 dynein, axonemal, heavy chain 17
DNAH3 dynein, axonemal, heavy chain 3
EBF3 early B-cell factor 3
ECEL1 endothelin converting enzyme-like 1
EDC3 enhancer of mRNA decapping 3
EFCAB5 EF-hand calcium binding domain 5
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
EMP2 epithelial membrane protein 2
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPHX2 epoxide hydrolase 2, cytoplasmic
EPOR erythropoietin receptor
ERCC5 excision repair cross-complementation group 5
EVPL envoplakin
FAM111B family with sequence similarity 111, member B
FAM134B family with sequence similarity 134, member B
FAM19A4 family with sequence similarity 19 (chemokine (C-C motif)-like), member A4
FAT4 FAT atypical cadherin 4
FBN1 fibrillin 1
FCRL1 Fc receptor-like 1
FCRL4 Fc receptor-like 4
FER fer (fps/fes related) tyrosine kinase
FERMT3 fermitin family member 3
FGF6 fibroblast growth factor 6
FLCN folliculin
FOPNL FGFR1OP N-terminal like
FOXD4 forkhead box D4
FOXP2 forkhead box P2
FXYD5 FXYD domain containing ion transport regulator 5
FYB FYN binding protein
FZD6 frizzled class receptor 6
GAGE2B G antigen 2B
GAK cyclin G associated kinase
GANAB glucosidase, alpha; neutral AB
GSDMC gasdermin C
GYS2 glycogen synthase 2 (liver)
HAPLN1 hyaluronan and proteoglycan link protein 1
HDC histidine decarboxylase
HEATR1 HEAT repeat containing 1
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IL17RE interleukin 17 receptor E
IMPG1 interphotoreceptor matrix proteoglycan 1
INSRR insulin receptor-related receptor
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
ITGA8 integrin, alpha 8
ITGA9 integrin, alpha 9
ITGAV integrin, alpha V
KDM6A lysine (K)-specific demethylase 6A
KIAA1671 KIAA1671
KRTAP16-1 keratin associated protein 16-1
LIFR leukemia inhibitory factor receptor alpha
LIN54 lin-54 DREAM MuvB core complex component
LRP5 low density lipoprotein receptor-related protein 5
MAB21L1 mab-21-like 1 (C. elegans)
MADD MAP-kinase activating death domain
MANSC4 MANSC domain containing 4
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MBD5 methyl-CpG binding domain protein 5
MCM7 minichromosome maintenance complex component 7
MCM8 minichromosome maintenance complex component 8
MCU mitochondrial calcium uniporter
MED14 mediator complex subunit 14
MINA MYC induced nuclear antigen
MKL1 megakaryoblastic leukemia (translocation) 1
MOG myelin oligodendrocyte glycoprotein
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MROH2B maestro heat-like repeat family member 2B
MTNR1A melatonin receptor 1A
MUC16 mucin 16, cell surface associated
MUC19 mucin 19, oligomeric
MUC2 mucin 2, oligomeric mucus/gel-forming
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYLK myosin light chain kinase
MYO18B myosin XVIIIB
MYOF myoferlin
NCOR1 nuclear receptor corepressor 1
NDRG4 NDRG family member 4
NID2 nidogen 2 (osteonidogen)
NOP56 NOP56 ribonucleoprotein
NOS2 nitric oxide synthase 2, inducible
NPTN neuroplastin
NR2C2 nuclear receptor subfamily 2, group C, member 2
NUBP1 nucleotide binding protein 1
NXPE1 neurexophilin and PC-esterase domain family, member 1
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
ODF2L outer dense fiber of sperm tails 2-like
OLFM3 olfactomedin 3
OPA1 optic atrophy 1 (autosomal dominant)
OR1J2 olfactory receptor, family 1, subfamily J, member 2
OR2M2 olfactory receptor, family 2, subfamily M, member 2
OR5K1 olfactory receptor, family 5, subfamily K, member 1
PABPN1 poly(A) binding protein, nuclear 1
PACRGL PARK2 co-regulated-like
PATL1 protein associated with topoisomerase II homolog 1 (yeast)
PCDHA10 protocadherin alpha 10
PCDHB3 protocadherin beta 3
PCNXL3 pecanex-like 3 (Drosophila)
PDGFC platelet derived growth factor C
PDS5B PDS5 cohesin associated factor B
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PHYH phytanoyl-CoA 2-hydroxylase
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKN1 protein kinase N1
PKNOX1 PBX/knotted 1 homeobox 1
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLCH2 phospholipase C, eta 2
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
PLEKHM3 pleckstrin homology domain containing, family M, member 3
POM121 POM121 transmembrane nucleoporin
PPCDC phosphopantothenoylcysteine decarboxylase
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRDM5 PR domain containing 5
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PTPN9 protein tyrosine phosphatase, non-receptor type 9
PXDNL peroxidasin-like
RANBP6 RAN binding protein 6
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RIN3 Ras and Rab interactor 3
RMDN1 regulator of microtubule dynamics 1
RNF141 ring finger protein 141
RNF169 ring finger protein 169
RPL7L1 ribosomal protein L7-like 1
SCN5A sodium channel, voltage gated, type V alpha subunit
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SETD1B SET domain containing 1B
SGK2 serum/glucocorticoid regulated kinase 2
SH3GLB1 SH3-domain GRB2-like endophilin B1
SHC4 SHC (Src homology 2 domain containing) family, member 4
SHROOM1 shroom family member 1
SIRPB2 signal-regulatory protein beta 2
SIRT5 sirtuin 5
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC25A53 solute carrier family 25, member 53
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A7 solute carrier family 38, member 7
SLC41A2 solute carrier family 41 (magnesium transporter), member 2
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SLITRK5 SLIT and NTRK-like family, member 5
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SP100 SP100 nuclear antigen
SPANXD SPANX family, member D
SPDEF SAM pointed domain containing ETS transcription factor
SPICE1 spindle and centriole associated protein 1
SRGN serglycin
SSTR1 somatostatin receptor 1
STARD9 StAR-related lipid transfer (START) domain containing 9
STEAP3 STEAP family member 3, metalloreductase
STYXL1 serine/threonine/tyrosine interacting-like 1
TBX10 T-box 10
TENM4 teneurin transmembrane protein 4
TET3 tet methylcytosine dioxygenase 3
TMEM132C transmembrane protein 132C
TMEM180 transmembrane protein 180
TMEM200C transmembrane protein 200C
TMEM225 transmembrane protein 225
TNKS1BP1 tankyrase 1 binding protein 1, 182kDa
TOP2B topoisomerase (DNA) II beta 180kDa
TP53 tumor protein p53
TRAPPC10 trafficking protein particle complex 10
TRIM26 tripartite motif containing 26
TRIM41 tripartite motif containing 41
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TTN titin
TUFM Tu translation elongation factor, mitochondrial
TXNDC11 thioredoxin domain containing 11
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2O ubiquitin-conjugating enzyme E2O
USH2A Usher syndrome 2A (autosomal recessive, mild)
USP24 ubiquitin specific peptidase 24
VTI1B vesicle transport through interaction with t-SNAREs 1B
VWA5B2 von Willebrand factor A domain containing 5B2
WDFY4 WDFY family member 4
WDHD1 WD repeat and HMG-box DNA binding protein 1
XRRA1 X-ray radiation resistance associated 1
ZC3H8 zinc finger CCCH-type containing 8
ZNF181 zinc finger protein 181
ZNF280D zinc finger protein 280D
ZNF451 zinc finger protein 451
ZNF600 zinc finger protein 600
ZNF740 zinc finger protein 740
ZNF827 zinc finger protein 827
ZSWIM4 zinc finger, SWIM-type containing 4