NCI-H2291 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description disease: adenocarcinoma; non-small cell lung cancer (lung primary) (Cell Line Ontology, CLO_0008070)
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Genes

335 genes with high or low expression in NCI-H2291 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
OR3A1 olfactory receptor, family 3, subfamily A, member 1 2.89871
OR3A2 olfactory receptor, family 3, subfamily A, member 2 2.77299
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 2.72281
RBMS2 RNA binding motif, single stranded interacting protein 2 2.44083
TRNAU1AP tRNA selenocysteine 1 associated protein 1 2.40313
GPX4 glutathione peroxidase 4 2.37694
NEFH neurofilament, heavy polypeptide 2.35987
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 2.34823
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 2.27934
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.25807
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.25306
UBE2L3 ubiquitin-conjugating enzyme E2L 3 2.22999
ITGB6 integrin, beta 6 2.16885
IL37 interleukin 37 2.16846
NPC2 Niemann-Pick disease, type C2 2.15109
FOXE1 forkhead box E1 2.12506
ADGRF5 adhesion G protein-coupled receptor F5 2.09974
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 2.06433
TMEM43 transmembrane protein 43 2.02891
SOAT1 sterol O-acyltransferase 1 2.00789
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 1.99572
CHMP2B charged multivesicular body protein 2B 1.9801
RPP14 ribonuclease P/MRP 14kDa subunit 1.96846
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 1.89156
EPHX3 epoxide hydrolase 3 1.87681
GMPPB GDP-mannose pyrophosphorylase B 1.85125
TUBB4B tubulin, beta 4B class IVb 1.84631
AK1 adenylate kinase 1 1.8347
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.81112
ZNF702P zinc finger protein 702, pseudogene 1.80955
TWISTNB TWIST neighbor 1.79416
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 1.78495
TXN thioredoxin 1.77895
ALPK3 alpha-kinase 3 1.77781
TUSC2 tumor suppressor candidate 2 1.77596
MYD88 myeloid differentiation primary response 88 1.75298
RHOA ras homolog family member A 1.7416
ADAM5 ADAM metallopeptidase domain 5 (pseudogene) 1.7206
MYL7 myosin, light chain 7, regulatory 1.70979
MGLL monoglyceride lipase 1.70235
ARPC5L actin related protein 2/3 complex, subunit 5-like 1.70156
HMOX2 heme oxygenase 2 1.69263
YOD1 YOD1 deubiquitinase 1.68835
PLAUR plasminogen activator, urokinase receptor 1.68424
NCAPG2 non-SMC condensin II complex, subunit G2 1.67494
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) 1.66649
PTBP3 polypyrimidine tract binding protein 3 1.65569
RASAL2 RAS protein activator like 2 1.65064
MYH9 myosin, heavy chain 9, non-muscle 1.65044
ZNF223 zinc finger protein 223 1.64918
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 1.64867
MBIP MAP3K12 binding inhibitory protein 1 1.6455
HN1 hematological and neurological expressed 1 1.62837
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 1.61993
PITRM1 pitrilysin metallopeptidase 1 1.61772
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 1.61601
KITLG KIT ligand 1.6119
RANBP1 RAN binding protein 1 1.60835
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 1.60535
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 1.58949
ABHD5 abhydrolase domain containing 5 1.58183
TRAPPC3 trafficking protein particle complex 3 1.56938
TPO thyroid peroxidase 1.56498
ALCAM activated leukocyte cell adhesion molecule 1.56225
DIAPH3 diaphanous-related formin 3 1.55014
RALB v-ral simian leukemia viral oncogene homolog B 1.54984
MAPKAP1 mitogen-activated protein kinase associated protein 1 1.54799
STAG3 stromal antigen 3 1.54602
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 1.54263
PRPF4 pre-mRNA processing factor 4 1.54099
CORO1C coronin, actin binding protein, 1C 1.53892
TMEM30A transmembrane protein 30A 1.53041
STS steroid sulfatase (microsomal), isozyme S 1.51655
SMC5 structural maintenance of chromosomes 5 1.4925
FBP1 fructose-1,6-bisphosphatase 1 1.4903
RPP30 ribonuclease P/MRP 30kDa subunit 1.48737
OAT ornithine aminotransferase 1.48441
RPE ribulose-5-phosphate-3-epimerase 1.48321
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 1.48212
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) 1.47662
CKS2 CDC28 protein kinase regulatory subunit 2 1.47489
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2 1.47119
KIR2DS3 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3 1.46992
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 1.4683
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 1.46187
COPS6 COP9 signalosome subunit 6 1.45987
IL27RA interleukin 27 receptor, alpha 1.45064
UBA3 ubiquitin-like modifier activating enzyme 3 1.44832
CALB2 calbindin 2 1.44435
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 1.44195
CDCA3 cell division cycle associated 3 1.43903
RPA3 replication protein A3, 14kDa 1.43391
PTER phosphotriesterase related 1.43243
VRK2 vaccinia related kinase 2 1.43065
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 1.42798
KRT7 keratin 7, type II 1.42783
NPTX2 neuronal pentraxin II 1.4265
GPR39 G protein-coupled receptor 39 1.4241
T T, brachyury homolog (mouse) 1.42327
REG1B regenerating islet-derived 1 beta 1.42106

low expression

Symbol Name Standardized Value
PTPRA protein tyrosine phosphatase, receptor type, A -3.49935
PPP6R3 protein phosphatase 6, regulatory subunit 3 -3.44013
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) -3.13981
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -3.11288
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 -3.11233
MRPS31 mitochondrial ribosomal protein S31 -3.07288
AAAS achalasia, adrenocortical insufficiency, alacrimia -3.0341
RBM10 RNA binding motif protein 10 -3.02878
DAXX death-domain associated protein -2.96079
BCL9 B-cell CLL/lymphoma 9 -2.95512
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 -2.95077
MTMR6 myotubularin related protein 6 -2.92483
WBP4 WW domain binding protein 4 -2.91242
RXRB retinoid X receptor, beta -2.88599
HDDC2 HD domain containing 2 -2.87485
N4BP2L2 NEDD4 binding protein 2-like 2 -2.85822
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) -2.75681
DCAF8 DDB1 and CUL4 associated factor 8 -2.72627
POLR1D polymerase (RNA) I polypeptide D, 16kDa -2.60967
FAN1 FANCD2/FANCI-associated nuclease 1 -2.60087
LARS leucyl-tRNA synthetase -2.55752
KIAA0141 KIAA0141 -2.47367
SNX5 sorting nexin 5 -2.3887
PAPOLG poly(A) polymerase gamma -2.38443
FAM168A family with sequence similarity 168, member A -2.29786
SNX11 sorting nexin 11 -2.29265
SETDB1 SET domain, bifurcated 1 -2.28857
CUL4A cullin 4A -2.28472
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -2.25719
ANKZF1 ankyrin repeat and zinc finger domain containing 1 -2.24267
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 -2.24045
MTRF1 mitochondrial translational release factor 1 -2.23346
S100PBP S100P binding protein -2.22865
UVRAG UV radiation resistance associated -2.22699
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) -2.22067
PARP16 poly (ADP-ribose) polymerase family, member 16 -2.19135
MAP2K5 mitogen-activated protein kinase kinase 5 -2.17478
SPATS2 spermatogenesis associated, serine-rich 2 -2.17464
RGL1 ral guanine nucleotide dissociation stimulator-like 1 -2.1701
PELP1 proline, glutamate and leucine rich protein 1 -2.16267
SGK2 serum/glucocorticoid regulated kinase 2 -2.1448
MCM3AP minichromosome maintenance complex component 3 associated protein -2.13894
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.12772
BBS1 Bardet-Biedl syndrome 1 -2.10089
ZMYM5 zinc finger, MYM-type 5 -2.09643
TIPRL TOR signaling pathway regulator -2.0959
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 -2.08695
CRADD CASP2 and RIPK1 domain containing adaptor with death domain -2.08077
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 -2.07175
PHF21A PHD finger protein 21A -2.06902
PSPC1 paraspeckle component 1 -2.06416
AFG3L2 AFG3-like AAA ATPase 2 -2.05958
INTS6 integrator complex subunit 6 -2.03941
MAP3K15 mitogen-activated protein kinase kinase kinase 15 -2.02139
NEB nebulin -2.01521
RBM26 RNA binding motif protein 26 -2.01056
REPS1 RALBP1 associated Eps domain containing 1 -2.00736
SIRT2 sirtuin 2 -2.00557
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) -1.99878
PHF10 PHD finger protein 10 -1.98974
PTDSS2 phosphatidylserine synthase 2 -1.98894
ZBTB22 zinc finger and BTB domain containing 22 -1.9849
CALHM2 calcium homeostasis modulator 2 -1.97009
TTC31 tetratricopeptide repeat domain 31 -1.96487
PCYOX1L prenylcysteine oxidase 1 like -1.95699
ZNF271P zinc finger protein 271, pseudogene -1.94941
ZBTB3 zinc finger and BTB domain containing 3 -1.93424
ERC1 ELKS/RAB6-interacting/CAST family member 1 -1.93164
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase -1.93135
ADARB1 adenosine deaminase, RNA-specific, B1 -1.92991
SIRT6 sirtuin 6 -1.92378
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -1.899
ZNF423 zinc finger protein 423 -1.89848
SIDT2 SID1 transmembrane family, member 2 -1.89472
TBC1D16 TBC1 domain family, member 16 -1.89105
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -1.88936
FRY furry homolog (Drosophila) -1.88689
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -1.87475
PPOX protoporphyrinogen oxidase -1.86781
PLA2G4B phospholipase A2, group IVB (cytosolic) -1.86419
PEX12 peroxisomal biogenesis factor 12 -1.86147
GRM6 glutamate receptor, metabotropic 6 -1.85973
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding) -1.85514
CRY2 cryptochrome circadian clock 2 -1.85083
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit -1.84301
RNASEH2B ribonuclease H2, subunit B -1.84096
TCF12 transcription factor 12 -1.83481
PEX11B peroxisomal biogenesis factor 11 beta -1.83426
ERLIN2 ER lipid raft associated 2 -1.82767
MPHOSPH8 M-phase phosphoprotein 8 -1.8242
ZMYM2 zinc finger, MYM-type 2 -1.82334
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -1.81547
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -1.80916
ZCCHC2 zinc finger, CCHC domain containing 2 -1.80843
NCOA1 nuclear receptor coactivator 1 -1.80674
CAMK2B calcium/calmodulin-dependent protein kinase II beta -1.80255
ATM ATM serine/threonine kinase -1.80172
CDK8 cyclin-dependent kinase 8 -1.79891
ANKMY1 ankyrin repeat and MYND domain containing 1 -1.79333
WDR7 WD repeat domain 7 -1.79243
PAN2 PAN2 poly(A) specific ribonuclease subunit -1.78302
IFT88 intraflagellar transport 88 -1.78276
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 -1.77377
STK19 serine/threonine kinase 19 -1.77254
NT5C 5', 3'-nucleotidase, cytosolic -1.76876
ARL17A ADP-ribosylation factor-like 17A -1.76729
CUTA cutA divalent cation tolerance homolog (E. coli) -1.76327
RBM8A RNA binding motif protein 8A -1.75579
FAM192A family with sequence similarity 192, member A -1.75537
TTC17 tetratricopeptide repeat domain 17 -1.75117
ZNF324 zinc finger protein 324 -1.7469
CELF1 CUGBP, Elav-like family member 1 -1.74588
GM2A GM2 ganglioside activator -1.73853
ZNF335 zinc finger protein 335 -1.7372
ZNF652 zinc finger protein 652 -1.73371
CSNK2A1 casein kinase 2, alpha 1 polypeptide -1.72852
ECM1 extracellular matrix protein 1 -1.72657
PTCD2 pentatricopeptide repeat domain 2 -1.72163
CPT1A carnitine palmitoyltransferase 1A (liver) -1.71881
CCS copper chaperone for superoxide dismutase -1.71747
USP6 ubiquitin specific peptidase 6 -1.71179
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -1.70998
RAB11FIP3 RAB11 family interacting protein 3 (class II) -1.70686
FCHSD2 FCH and double SH3 domains 2 -1.70564
ZNF329 zinc finger protein 329 -1.70154
SARNP SAP domain containing ribonucleoprotein -1.69907
PEMT phosphatidylethanolamine N-methyltransferase -1.69585
THAP3 THAP domain containing, apoptosis associated protein 3 -1.69492
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) -1.69297
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -1.68586
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 -1.68495
CHSY1 chondroitin sulfate synthase 1 -1.68403
SULT4A1 sulfotransferase family 4A, member 1 -1.68266
HIST1H1T histone cluster 1, H1t -1.67941
CDC16 cell division cycle 16 -1.67878
ATG13 autophagy related 13 -1.67506
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) -1.66997
PRUNE prune exopolyphosphatase -1.66662
DGKZ diacylglycerol kinase, zeta -1.66585
LMO2 LIM domain only 2 (rhombotin-like 1) -1.66032
MAST3 microtubule associated serine/threonine kinase 3 -1.66021
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -1.65894
FAM8A1 family with sequence similarity 8, member A1 -1.65406
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -1.65381
UBL3 ubiquitin-like 3 -1.65019
PAQR6 progestin and adipoQ receptor family member VI -1.64922
PDLIM3 PDZ and LIM domain 3 -1.64136
STC2 stanniocalcin 2 -1.63899
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -1.63866
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -1.63242
RBM4B RNA binding motif protein 4B -1.63181
ALMS1 Alstrom syndrome protein 1 -1.631
NARS asparaginyl-tRNA synthetase -1.6303
DYM dymeclin -1.62725
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila) -1.62085
SEC23B Sec23 homolog B (S. cerevisiae) -1.6204
COIL coilin -1.61916
GLI2 GLI family zinc finger 2 -1.6184
TMEM19 transmembrane protein 19 -1.61406
TCF7 transcription factor 7 (T-cell specific, HMG-box) -1.61219
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae) -1.60681
KALRN kalirin, RhoGEF kinase -1.60338
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic -1.59517
FKBP1A FK506 binding protein 1A, 12kDa -1.59233
ZFC3H1 zinc finger, C3H1-type containing -1.58867
AKAP11 A kinase (PRKA) anchor protein 11 -1.58208
MED12 mediator complex subunit 12 -1.58143
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -1.5705
ZNF133 zinc finger protein 133 -1.56725
ZNF236 zinc finger protein 236 -1.56558
HMBOX1 homeobox containing 1 -1.56393
POLR2G polymerase (RNA) II (DNA directed) polypeptide G -1.56174
DLX2 distal-less homeobox 2 -1.56027
TUBGCP3 tubulin, gamma complex associated protein 3 -1.55883
ARMC4 armadillo repeat containing 4 -1.55722
SCAF8 SR-related CTD-associated factor 8 -1.55701
HDAC7 histone deacetylase 7 -1.55579
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -1.54806
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 -1.54739
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -1.54464
ZNF428 zinc finger protein 428 -1.53854
PCSK6 proprotein convertase subtilisin/kexin type 6 -1.53783
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor -1.53684
MAPKBP1 mitogen-activated protein kinase binding protein 1 -1.52733
WSB1 WD repeat and SOCS box containing 1 -1.52693
ZMYM4 zinc finger, MYM-type 4 -1.52517
USP12 ubiquitin specific peptidase 12 -1.52488
ATF2 activating transcription factor 2 -1.52239
IFT74 intraflagellar transport 74 -1.51412
LONRF1 LON peptidase N-terminal domain and ring finger 1 -1.51238
DXO decapping exoribonuclease -1.5119
CFDP1 craniofacial development protein 1 -1.50969
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast) -1.50953
CTAG2 cancer/testis antigen 2 -1.50711
COX15 cytochrome c oxidase assembly homolog 15 (yeast) -1.50362
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -1.50201
HOXC4 homeobox C4 -1.50195
PDE7B phosphodiesterase 7B -1.49563
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa -1.49376
TBC1D17 TBC1 domain family, member 17 -1.49303
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) -1.49007
MYBBP1A MYB binding protein (P160) 1a -1.48651
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -1.48522
PER2 period circadian clock 2 -1.48389
RSAD1 radical S-adenosyl methionine domain containing 1 -1.48141
NUP43 nucleoporin 43kDa -1.48041
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 -1.47554
CLUL1 clusterin-like 1 (retinal) -1.47495
TDRD3 tudor domain containing 3 -1.47354
DVL2 dishevelled segment polarity protein 2 -1.47022
ZBTB5 zinc finger and BTB domain containing 5 -1.46961
KIF13A kinesin family member 13A -1.4693
SRSF6 serine/arginine-rich splicing factor 6 -1.4686
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 -1.46493
STAT5B signal transducer and activator of transcription 5B -1.46471
PMEL premelanosome protein -1.46291
BAG1 BCL2-associated athanogene -1.45844
TMPRSS15 transmembrane protease, serine 15 -1.45763
ZNF507 zinc finger protein 507 -1.45574
WDR59 WD repeat domain 59 -1.45352
FAR2 fatty acyl CoA reductase 2 -1.45286
SLC39A6 solute carrier family 39 (zinc transporter), member 6 -1.44842
DBT dihydrolipoamide branched chain transacylase E2 -1.44792
PGAP3 post-GPI attachment to proteins 3 -1.4474
TRAPPC6A trafficking protein particle complex 6A -1.44711
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -1.44663
HDAC3 histone deacetylase 3 -1.44484
HOXA7 homeobox A7 -1.44276
LZTS1 leucine zipper, putative tumor suppressor 1 -1.43926
MAPRE2 microtubule-associated protein, RP/EB family, member 2 -1.42571
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 -1.42407
PRKCB protein kinase C, beta -1.4212
MTA1 metastasis associated 1 -1.42109
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) -1.41638
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 -1.4159