NCI-H2228 Gene Set

Dataset COSMIC Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: adenocarcinoma; non-small cell lung cancer (Cell Line Ontology, CLO_0008067)
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348 genes mutated in the NCI-H2228 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ADAM20 ADAM metallopeptidase domain 20
ADCY8 adenylate cyclase 8 (brain)
ADGRF3 adhesion G protein-coupled receptor F3
ADGRV1 adhesion G protein-coupled receptor V1
AGBL4 ATP/GTP binding protein-like 4
AHCTF1 AT hook containing transcription factor 1
AHNAK AHNAK nucleoprotein
ALK anaplastic lymphoma receptor tyrosine kinase
AMBN ameloblastin (enamel matrix protein)
AMPD1 adenosine monophosphate deaminase 1
ANKRD13C ankyrin repeat domain 13C
ANO6 anoctamin 6
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
API5 apoptosis inhibitor 5
APIP APAF1 interacting protein
APOA2 apolipoprotein A-II
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARF1 ADP-ribosylation factor 1
ARHGAP30 Rho GTPase activating protein 30
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARID4A AT rich interactive domain 4A (RBP1-like)
ARRB2 arrestin, beta 2
ATR ATR serine/threonine kinase
BAHCC1 BAH domain and coiled-coil containing 1
BCAS3 breast carcinoma amplified sequence 3
BCL6 B-cell CLL/lymphoma 6
BIRC6 baculoviral IAP repeat containing 6
BYSL bystin-like
C3 complement component 3
C6 complement component 6
C9 complement component 9
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CARD17 caspase recruitment domain family, member 17
CARF calcium responsive transcription factor
CCDC88B coiled-coil domain containing 88B
CCS copper chaperone for superoxide dismutase
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDH12 cadherin 12, type 2 (N-cadherin 2)
CDH24 cadherin 24, type 2
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDHR2 cadherin-related family member 2
CDK1 cyclin-dependent kinase 1
CDK10 cyclin-dependent kinase 10
CEP170B centrosomal protein 170B
CHL1 cell adhesion molecule L1-like
CLEC14A C-type lectin domain family 14, member A
CLEC4M C-type lectin domain family 4, member M
CLIP1 CAP-GLY domain containing linker protein 1
CLSPN claspin
CLSTN1 calsyntenin 1
CNIH4 cornichon family AMPA receptor auxiliary protein 4
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CPEB2 cytoplasmic polyadenylation element binding protein 2
CPED1 cadherin-like and PC-esterase domain containing 1
CPNE4 copine IV
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSMD2 CUB and Sushi multiple domains 2
CSMD3 CUB and Sushi multiple domains 3
CSPG4 chondroitin sulfate proteoglycan 4
CSPP1 centrosome and spindle pole associated protein 1
CST1 cystatin SN
CT47B1 cancer/testis antigen family 47, member B1
CTPS1 CTP synthase 1
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DCAF13 DDB1 and CUL4 associated factor 13
DCDC2 doublecortin domain containing 2
DHRS12 dehydrogenase/reductase (SDR family) member 12
DICER1 dicer 1, ribonuclease type III
DLG1 discs, large homolog 1 (Drosophila)
DLL1 delta-like 1 (Drosophila)
DNAH9 dynein, axonemal, heavy chain 9
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNM2 dynamin 2
DOCK10 dedicator of cytokinesis 10
DPF3 D4, zinc and double PHD fingers, family 3
DPYSL3 dihydropyrimidinase-like 3
EFHC1 EF-hand domain (C-terminal) containing 1
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8
FAM185A family with sequence similarity 185, member A
FAM90A20P putative protein FAM90A20
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial
FASN fatty acid synthase
FAT3 FAT atypical cadherin 3
FBN2 fibrillin 2
FBP2 fructose-1,6-bisphosphatase 2
FCAR Fc fragment of IgA receptor
FCGBP Fc fragment of IgG binding protein
FGFBP2 fibroblast growth factor binding protein 2
FLG filaggrin
FMN2 formin 2
FNDC9 fibronectin type III domain containing 9
FREM2 FRAS1 related extracellular matrix protein 2
FRMPD2 FERM and PDZ domain containing 2
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GARNL3 GTPase activating Rap/RanGAP domain-like 3
GIMAP2 GTPase, IMAP family member 2
GLG1 golgi glycoprotein 1
GLT6D1 glycosyltransferase 6 domain containing 1
GMEB1 glucocorticoid modulatory element binding protein 1
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GNMT glycine N-methyltransferase
GOLGA4 golgin A4
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GRM2 glutamate receptor, metabotropic 2
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
HACD4 3-hydroxyacyl-CoA dehydratase 4
HAGHL hydroxyacylglutathione hydrolase-like
HAPLN1 hyaluronan and proteoglycan link protein 1
HCFC1 host cell factor C1
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1
HEATR4 HEAT repeat containing 4
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HIPK3 homeodomain interacting protein kinase 3
HLA-A major histocompatibility complex, class I, A
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HMCN1 hemicentin 1
HOXA1 homeobox A1
HOXA11 homeobox A11
HOXB3 homeobox B3
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IL9 interleukin 9
IMPAD1 inositol monophosphatase domain containing 1
INHBA inhibin, beta A
INMT indolethylamine N-methyltransferase
ITGA6 integrin, alpha 6
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4
KCNU1 potassium channel, subfamily U, member 1
KDM2B lysine (K)-specific demethylase 2B
KDM4A lysine (K)-specific demethylase 4A
KIF11 kinesin family member 11
KIF26A kinesin family member 26A
KLF6 Kruppel-like factor 6
KLHDC3 kelch domain containing 3
KLHL4 kelch-like family member 4
KLK13 kallikrein-related peptidase 13
KMT2C lysine (K)-specific methyltransferase 2C
KPNA5 karyopherin alpha 5 (importin alpha 6)
KRT33A keratin 33A, type I
KRT38 keratin 38, type I
KRT75 keratin 75, type II
L2HGDH L-2-hydroxyglutarate dehydrogenase
LAMC1 laminin, gamma 1 (formerly LAMB2)
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LINS lines homolog (Drosophila)
LIPF lipase, gastric
LMO7 LIM domain 7
LOX lysyl oxidase
LRP4 low density lipoprotein receptor-related protein 4
LRRC32 leucine rich repeat containing 32
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAF1 MAF1 homolog (S. cerevisiae)
MAML3 mastermind-like 3 (Drosophila)
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MATN2 matrilin 2
MBOAT1 membrane bound O-acyltransferase domain containing 1
MBTPS1 membrane-bound transcription factor peptidase, site 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCM10 minichromosome maintenance complex component 10
MCMBP minichromosome maintenance complex binding protein
MGAM maltase-glucoamylase
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MPP1 membrane protein, palmitoylated 1, 55kDa
MTCP1 mature T-cell proliferation 1
MTG1 mitochondrial ribosome-associated GTPase 1
MTRF1 mitochondrial translational release factor 1
MUC12 mucin 12, cell surface associated
MYBPC1 myosin binding protein C, slow type
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
MYH7B myosin, heavy chain 7B, cardiac muscle, beta
MYO18A myosin XVIIIA
NAP1L5 nucleosome assembly protein 1-like 5
NBPF14 neuroblastoma breakpoint family, member 14
NBR1 neighbor of BRCA1 gene 1
NCAPG non-SMC condensin I complex, subunit G
NEB nebulin
NEFM neurofilament, medium polypeptide
NFE2L2 nuclear factor, erythroid 2-like 2
NID2 nidogen 2 (osteonidogen)
NPEPPS aminopeptidase puromycin sensitive
NSF N-ethylmaleimide-sensitive factor
NTNG1 netrin G1
NUMB numb homolog (Drosophila)
NUP35 nucleoporin 35kDa
OCA2 oculocutaneous albinism II
OLA1 Obg-like ATPase 1
OPA1 optic atrophy 1 (autosomal dominant)
OR10J5 olfactory receptor, family 10, subfamily J, member 5
OR2A5 olfactory receptor, family 2, subfamily A, member 5
OR2J3 olfactory receptor, family 2, subfamily J, member 3
OR4A47 olfactory receptor, family 4, subfamily A, member 47
OR4X2 olfactory receptor, family 4, subfamily X, member 2 (gene/pseudogene)
OR5H1 olfactory receptor, family 5, subfamily H, member 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7
PCDH7 protocadherin 7
PCDHB11 protocadherin beta 11
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCNXL3 pecanex-like 3 (Drosophila)
PCSK7 proprotein convertase subtilisin/kexin type 7
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDE8B phosphodiesterase 8B
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDRG1 p53 and DNA-damage regulated 1
PDZRN4 PDZ domain containing ring finger 4
PFAS phosphoribosylformylglycinamidine synthase
PGBD2 piggyBac transposable element derived 2
PGM1 phosphoglucomutase 1
PHOX2B paired-like homeobox 2b
PI4K2B phosphatidylinositol 4-kinase type 2 beta
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLEKHA5 pleckstrin homology domain containing, family A member 5
POM121 POM121 transmembrane nucleoporin
POTEF POTE ankyrin domain family, member F
PPM1J protein phosphatase, Mg2+/Mn2+ dependent, 1J
PPP1R8 protein phosphatase 1, regulatory subunit 8
PRDM14 PR domain containing 14
PRR14L proline rich 14-like
PRUNE2 prune homolog 2 (Drosophila)
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PTPRT protein tyrosine phosphatase, receptor type, T
PXDNL peroxidasin-like
RAB3IP RAB3A interacting protein
RABGAP1L RAB GTPase activating protein 1-like
RAD21 RAD21 homolog (S. pombe)
RB1 retinoblastoma 1
RBM33 RNA binding motif protein 33
RC3H1 ring finger and CCCH-type domains 1
RET ret proto-oncogene
RFX4 regulatory factor X, 4 (influences HLA class II expression)
RIC3 RIC3 acetylcholine receptor chaperone
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RYR3 ryanodine receptor 3
SAMHD1 SAM domain and HD domain 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCN11A sodium channel, voltage gated, type XI alpha subunit
SCYL1 SCY1-like 1 (S. cerevisiae)
SEC16B SEC16 homolog B (S. cerevisiae)
SECISBP2L SECIS binding protein 2-like
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC35F1 solute carrier family 35, member F1
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SORCS3 sortilin-related VPS10 domain containing receptor 3
SOX15 SRY (sex determining region Y)-box 15
SP100 SP100 nuclear antigen
SPATA6 spermatogenesis associated 6
SPEF2 sperm flagellar 2
SPIN4 spindlin family, member 4
SPSB2 splA/ryanodine receptor domain and SOCS box containing 2
SRBD1 S1 RNA binding domain 1
SRRM2 serine/arginine repetitive matrix 2
STK11IP serine/threonine kinase 11 interacting protein
STK33 serine/threonine kinase 33
STK39 serine threonine kinase 39
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
SYNE1 spectrin repeat containing, nuclear envelope 1
SYT7 synaptotagmin VII
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TARS threonyl-tRNA synthetase
TAS2R7 taste receptor, type 2, member 7
TBCEL tubulin folding cofactor E-like
TBRG1 transforming growth factor beta regulator 1
TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
TCOF1 Treacher Collins-Franceschetti syndrome 1
TCP10L2 t-complex 10-like 2
TENM2 teneurin transmembrane protein 2
TFB1M transcription factor B1, mitochondrial
TGFBR3 transforming growth factor, beta receptor III
THNSL2 threonine synthase-like 2 (S. cerevisiae)
THSD7B thrombospondin, type I, domain containing 7B
TLR6 toll-like receptor 6
TMEM80 transmembrane protein 80
TMPO thymopoietin
TMPRSS15 transmembrane protease, serine 15
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TRIM64C tripartite motif containing 64C
TRIO trio Rho guanine nucleotide exchange factor
TRIP10 thyroid hormone receptor interactor 10
TRIP12 thyroid hormone receptor interactor 12
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TSPYL6 TSPY-like 6
TTC21A tetratricopeptide repeat domain 21A
TTC28 tetratricopeptide repeat domain 28
TTC8 tetratricopeptide repeat domain 8
TTL tubulin tyrosine ligase
TTLL13P tubulin tyrosine ligase-like family member 13, pseudogene
TTLL6 tubulin tyrosine ligase-like family member 6
TTN titin
TTYH3 tweety family member 3
UBE2O ubiquitin-conjugating enzyme E2O
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
UGT2B11 UDP glucuronosyltransferase 2 family, polypeptide B11
UNC13C unc-13 homolog C (C. elegans)
USH2A Usher syndrome 2A (autosomal recessive, mild)
USP16 ubiquitin specific peptidase 16
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae)
VRTN vertebrae development associated
WBSCR17 Williams-Beuren syndrome chromosome region 17
WDR3 WD repeat domain 3
WDR36 WD repeat domain 36
WDR70 WD repeat domain 70
WDR74 WD repeat domain 74
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
XYLT1 xylosyltransferase I
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
ZBTB47 zinc finger and BTB domain containing 47
ZBTB7C zinc finger and BTB domain containing 7C
ZCCHC2 zinc finger, CCHC domain containing 2
ZFAND4 zinc finger, AN1-type domain 4
ZFHX3 zinc finger homeobox 3
ZIM3 zinc finger, imprinted 3
ZMYM6 zinc finger, MYM-type 6
ZNF138 zinc finger protein 138
ZNF33A zinc finger protein 33A
ZNF341 zinc finger protein 341
ZNF395 zinc finger protein 395
ZNF423 zinc finger protein 423
ZNF462 zinc finger protein 462
ZNF862 zinc finger protein 862
ZRANB3 zinc finger, RAN-binding domain containing 3
ZSCAN32 zinc finger and SCAN domain containing 32
ZXDA zinc finger, X-linked, duplicated A