NCI-H2227 Gene Set

Dataset COSMIC Cell Line Gene CNV Profiles
Category genomics
Type cell line
Description disease: carcinoma; small cell lung cancer (Cell Line Ontology, CLO_0008066)
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Genes

199 genes with high or low copy number in NCI-H2227 relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.

high copy number

Symbol Name Standardized Value
ZNF28 zinc finger protein 28 2.93899
SYNE4 spectrin repeat containing, nuclear envelope family member 4 2.49065
APLP1 amyloid beta (A4) precursor-like protein 1 2.49065
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 2.49065
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.49065
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta 2.49065
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 2.49065
KMT2B lysine (K)-specific methyltransferase 2B 2.49065
PRODH2 proline dehydrogenase (oxidase) 2 2.49065
CLIP3 CAP-GLY domain containing linker protein 3 2.49065
UPK1A-AS1 UPK1A antisense RNA 1 2.49065
THAP8 THAP domain containing 8 2.49065
KIRREL2 kin of IRRE like 2 (Drosophila) 2.49065
SDHAF1 succinate dehydrogenase complex assembly factor 1 2.49065
KRTDAP keratinocyte differentiation-associated protein 2.49065
ETV2 ets variant 2 2.49065
ARHGAP33 Rho GTPase activating protein 33 2.49065
UPK1A uroplakin 1A 2.49065
HCST hematopoietic cell signal transducer 2.49065
U2AF1L4 U2 small nuclear RNA auxiliary factor 1-like 4 2.49065
TYROBP TYRO protein tyrosine kinase binding protein 2.49065
IGFLR1 IGF-like family receptor 1 2.49065
HAUS5 HAUS augmin-like complex, subunit 5 2.49065
ZBTB32 zinc finger and BTB domain containing 32 2.49065
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 2.49065
WDR62 WD repeat domain 62 2.49065
PSENEN presenilin enhancer gamma secretase subunit 2.49065
LIN37 lin-37 DREAM MuvB core complex component 2.49065
ALKBH6 alkB, alkylation repair homolog 6 (E. coli) 2.49065
RBM42 RNA binding motif protein 42 2.49065
LOC100506469 2.44392
FFAR2 free fatty acid receptor 2 2.44392
LOC100128682 2.44392
HAMP hepcidin antimicrobial peptide 2.44392
TMEM147 transmembrane protein 147 2.44392
LSR lipolysis stimulated lipoprotein receptor 2.44392
ZNF571-AS1 ZNF571 antisense RNA 1 2.44392
FAM187B family with sequence similarity 187, member B 2.44392
LGI4 leucine-rich repeat LGI family, member 4 2.44392
USF2 upstream transcription factor 2, c-fos interacting 2.44392
FXYD1 FXYD domain containing ion transport regulator 1 2.44392
FXYD3 FXYD domain containing ion transport regulator 3 2.44392
FXYD5 FXYD domain containing ion transport regulator 5 2.44392
FXYD7 FXYD domain containing ion transport regulator 7 2.44392
CD22 CD22 molecule 2.44392
HPN-AS1 HPN antisense RNA 1 2.44392
ZNF569 zinc finger protein 569 2.44392
ZNF793 zinc finger protein 793 2.44392
MIR5196 microRNA 5196 2.44392
DMKN dermokine 2.44392
SBSN suprabasin 2.44392
ZNF570 zinc finger protein 570 2.44392
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 2.44392
ZNF571 zinc finger protein 571 2.44392
FFAR1 free fatty acid receptor 1 2.44392
HPN hepsin 2.44392
MAG myelin associated glycoprotein 2.44392
GRAMD1A GRAM domain containing 1A 2.44392
ZNF527 zinc finger protein 527 2.44392
ZNF540 zinc finger protein 540 2.44392
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 2.44392
SCN1B sodium channel, voltage gated, type I beta subunit 2.44392
KIAA0355 KIAA0355 2.41451
FAM98C family with sequence similarity 98, member C 2.41451
SPINT2 serine peptidase inhibitor, Kunitz type, 2 2.41451
GPATCH1 G patch domain containing 1 2.41451
GPI glucose-6-phosphate isomerase 2.41451
ZNF792 zinc finger protein 792 2.41451
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 2.41451
C19ORF33 chromosome 19 open reading frame 33 2.41451
RHPN2 rhophilin, Rho GTPase binding protein 2 2.41451
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 2.41451
ZFP30 ZFP30 zinc finger protein 2.41451
LRP3 low density lipoprotein receptor-related protein 3 2.41451
DPF1 D4, zinc and double PHD fingers family 1 2.41451
KCNK6 potassium channel, two pore domain subfamily K, member 6 2.41451
CATSPERG catsper channel auxiliary subunit gamma 2.41451
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 2.41451
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 2.41451
WDR88 WD repeat domain 88 2.41451
RASGRP4 RAS guanyl releasing protein 4 2.41451
C19ORF40 chromosome 19 open reading frame 40 2.41451
GGN gametogenetin 2.41451
SPRED3 sprouty-related, EVH1 domain containing 3 2.41451
PDCD2L programmed cell death 2-like 2.41451
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A 2.41451
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 2.39327
IFNL2 interferon, lambda 2 2.39327
CAPN12 calpain 12 2.39327
LOC400685 uncharacterized LOC400685 2.39327
PAPL iron/zinc purple acid phosphatase-like protein 2.39327
LINC00904 long intergenic non-protein coding RNA 904 2.39327
ZNF181 zinc finger protein 181 2.39327
RYR1 ryanodine receptor 1 (skeletal) 2.39327
CEP89 centrosomal protein 89kDa 2.39327
SCGB2B2 secretoglobin, family 2B, member 2 2.39327
WTIP Wilms tumor 1 interacting protein 2.39327
IFNL3 interferon, lambda 3 2.39327
SCGB1B2P secretoglobin, family 1B, member 2, pseudogene 2.39327
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 2.39327
ZNF30 zinc finger protein 30 2.39327
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 2.39327
KCTD15 potassium channel tetramerization domain containing 15 2.39327
EIF3K eukaryotic translation initiation factor 3, subunit K 2.39327
ZNF599 zinc finger protein 599 2.39327
IFNL4 interferon, lambda 4 (gene/pseudogene) 2.39327
SCGB2B3P secretoglobin, family 2B, member 3, pseudogene 2.39327
UBA2 ubiquitin-like modifier activating enzyme 2 2.39327
LGALS7 lectin, galactoside-binding, soluble, 7 2.39327
SYCN syncollin 2.39327
ZNF302 zinc finger protein 302 2.39327
ACTN4 actinin, alpha 4 2.39327
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) 2.39327
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 2.36889
PDCD5 programmed cell death 5 2.36889
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.36889
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.36889
LOC100505835 2.36889
RINL Ras and Rab interactor-like 2.36889
TDRD12 tudor domain containing 12 2.36889
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 2.36889
ECH1 enoyl CoA hydratase 1, peroxisomal 2.36889
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 2.36889
ZNF781 zinc finger protein 781 2.36889
LOC400684 uncharacterized LOC400684 2.36889
RGS9BP regulator of G protein signaling 9 binding protein 2.36889
PEPD peptidase D 2.36889
MRPS12 mitochondrial ribosomal protein S12 2.36889
FBXO17 F-box protein 17 2.36889
SIRT2 sirtuin 2 2.36889
LINC00906 long intergenic non-protein coding RNA 906 2.36889
CEBPA-AS1 CEBPA antisense RNA 1 (head to head) 2.36889
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) 2.36889
FBXO27 F-box protein 27 2.36889
DPY19L3 dpy-19-like 3 (C. elegans) 2.36889
ZNF507 zinc finger protein 507 2.36889
SARS2 seryl-tRNA synthetase 2, mitochondrial 2.36889
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 2.35236
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 2.3178
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 2.3178
IFNL1 interferon, lambda 1 2.3178
THEG5 testis highly expressed protein 5 2.30944
GMFG glia maturation factor, gamma 2.30944
SAMD4B sterile alpha motif domain containing 4B 2.283
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.283
EID2 EP300 interacting inhibitor of differentiation 2 2.283
SELV selenoprotein V 2.283
LGALS13 lectin, galactoside-binding, soluble, 13 2.283
MIR4530 microRNA 4530 2.283
ZFP36 ZFP36 ring finger protein 2.283
EID2B EP300 interacting inhibitor of differentiation 2B 2.283
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 2.283
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 2.283
DLL3 delta-like 3 (Drosophila) 2.283
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) 2.283
TSHZ3 teashirt zinc finger homeobox 3 2.283
RPS16 ribosomal protein S16 2.283
MED29 mediator complex subunit 29 2.283
LOC100129935 lectin, galactoside-binding, soluble, 14 pseudogene 2.26395
LGALS14 lectin, galactoside-binding, soluble, 14 2.26395
LGALS16 lectin, galactoside-binding, soluble, 16 2.26395
LGALS17A Charcot-Leyden crystal protein pseudogene 2.26395
CLC Charcot-Leyden crystal galectin 2.26395
ZNF536 zinc finger protein 536 2.26395
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) 2.25904
LOC284395 uncharacterized LOC284395 2.24139
VSTM2B V-set and transmembrane domain containing 2B 2.24139
URI1 URI1, prefoldin-like chaperone 2.2355
PSG4 pregnancy specific beta-1-glycoprotein 4 2.15605
LOC100289650 uncharacterized LOC100289650 2.12564
PSG6 pregnancy specific beta-1-glycoprotein 6 2.12528
FFAR3 free fatty acid receptor 3 2.12053
PSG11 pregnancy specific beta-1-glycoprotein 11 2.11483
PSG5 pregnancy specific beta-1-glycoprotein 5 2.11467
PSG1 pregnancy specific beta-1-glycoprotein 1 2.11467
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) 2.11467
PSG3 pregnancy specific beta-1-glycoprotein 3 2.11467
PSG10P pregnancy specific beta-1-glycoprotein 10, pseudogene 2.11467
PSG2 pregnancy specific beta-1-glycoprotein 2 2.10992
HKR1 HKR1, GLI-Kruppel zinc finger family member 2.09073
NSFP1 N-ethylmaleimide-sensitive factor pseudogene 1 2.08453
LRRC37A leucine rich repeat containing 37A 2.08334
LGALS4 lectin, galactoside-binding, soluble, 4 2.08334
NSF N-ethylmaleimide-sensitive factor 2.08334
LGALS7B lectin, galactoside-binding, soluble, 7B 2.08334
LRRC37A2 leucine rich repeat containing 37, member A2 2.08334
ARL17A ADP-ribosylation factor-like 17A 2.08068
WDR87 WD repeat domain 87 2.08021
ZNF573 zinc finger protein 573 2.08021
SIPA1L3 signal-induced proliferation-associated 1 like 3 2.08021
LOC100631378 uncharacterized 100631378 2.08021
LOC644554 uncharacterized LOC644554 2.08021
ZNF607 zinc finger protein 607 2.08021
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 2.06341

low copy number

Symbol Name Standardized Value
ADAM12 ADAM metallopeptidase domain 12 -3.2703
FANK1 fibronectin type III and ankyrin repeat domains 1 -3.2703
FANK1-AS1 FANK1 antisense RNA 1 -3.2703
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32 -3.2703
LOC284344 uncharacterized LOC284344 -2.74526