NCI-H2198 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: carcinoma; small cell lung cancer (lung primary) (Cell Line Ontology, CLO_0008064)
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Genes

143 genes mutated in the NCI-H2198 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
A1BG alpha-1-B glycoprotein
ACVR1B activin A receptor, type IB
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ADCY5 adenylate cyclase 5
ADIPOR2 adiponectin receptor 2
ADRBK2 adrenergic, beta, receptor kinase 2
ALG10 ALG10, alpha-1,2-glucosyltransferase
ALKBH7 alkB, alkylation repair homolog 7 (E. coli)
ANKHD1 ankyrin repeat and KH domain containing 1
ANKHD1-EIF4EBP3 ANKHD1-EIF4EBP3 readthrough
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
ARHGAP17 Rho GTPase activating protein 17
ARHGAP32 Rho GTPase activating protein 32
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ARL17A ADP-ribosylation factor-like 17A
ARMCX4 armadillo repeat containing, X-linked 4
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BOD1L1 biorientation of chromosomes in cell division 1-like 1
C9ORF72 chromosome 9 open reading frame 72
CAMTA1 calmodulin binding transcription activator 1
CDC25A cell division cycle 25A
CDCA8 cell division cycle associated 8
CDK12 cyclin-dependent kinase 12
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CHPT1 choline phosphotransferase 1
CLDN11 claudin 11
CNTNAP5 contactin associated protein-like 5
COL12A1 collagen, type XII, alpha 1
COL6A1 collagen, type VI, alpha 1
CSRP2BP CSRP2 binding protein
CUL5 cullin 5
CYFIP2 cytoplasmic FMR1 interacting protein 2
DLG4 discs, large homolog 4 (Drosophila)
ECE2 endothelin converting enzyme 2
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EIF3C eukaryotic translation initiation factor 3, subunit C
ERBB4 erb-b2 receptor tyrosine kinase 4
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FAM120A family with sequence similarity 120A
FAM129B family with sequence similarity 129, member B
FAM131B family with sequence similarity 131, member B
FAM83H family with sequence similarity 83, member H
FANCG Fanconi anemia, complementation group G
FBP1 fructose-1,6-bisphosphatase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FIGN fidgetin
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
GDF10 growth differentiation factor 10
GGCT gamma-glutamylcyclotransferase
GLTP glycolipid transfer protein
GSDMD gasdermin D
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1
HELZ2 helicase with zinc finger 2, transcriptional coactivator
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HRCT1 histidine rich carboxyl terminus 1
HTT huntingtin
IRF8 interferon regulatory factor 8
KCMF1 potassium channel modulatory factor 1
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
KIDINS220 kinase D-interacting substrate, 220kDa
KLHDC8B kelch domain containing 8B
KLRC1 killer cell lectin-like receptor subfamily C, member 1
KMT2D lysine (K)-specific methyltransferase 2D
L3MBTL3 l(3)mbt-like 3 (Drosophila)
LMBRD1 LMBR1 domain containing 1
LTBP4 latent transforming growth factor beta binding protein 4
MACF1 microtubule-actin crosslinking factor 1
MDN1 MDN1, midasin homolog (yeast)
MEGF8 multiple EGF-like-domains 8
MMD monocyte to macrophage differentiation-associated
MPDZ multiple PDZ domain protein
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MTMR7 myotubularin related protein 7
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic
MYO7A myosin VIIA
NADK NAD kinase
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
NME5 NME/NM23 family member 5
NWD1 NACHT and WD repeat domain containing 1
OSCP1 organic solute carrier partner 1
PCDHB13 protocadherin beta 13
PCDHGB7 protocadherin gamma subfamily B, 7
PCNXL3 pecanex-like 3 (Drosophila)
PDE1A phosphodiesterase 1A, calmodulin-dependent
PDE8B phosphodiesterase 8B
PEX10 peroxisomal biogenesis factor 10
PLA2G4F phospholipase A2, group IVF
PLCB4 phospholipase C, beta 4
PLIN4 perilipin 4
PNPLA7 patatin-like phospholipase domain containing 7
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PRDM10 PR domain containing 10
PROSER3 proline and serine rich 3
PRPF4B pre-mRNA processing factor 4B
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PTCH1 patched 1
R3HCC1 R3H domain and coiled-coil containing 1
RAET1G retinoic acid early transcript 1G
REEP1 receptor accessory protein 1
RHBDD1 rhomboid domain containing 1
RNF19B ring finger protein 19B
RNF213 ring finger protein 213
RPL30 ribosomal protein L30
RPRD2 regulation of nuclear pre-mRNA domain containing 2
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RSRC1 arginine/serine-rich coiled-coil 1
SCUBE1 signal peptide, CUB domain, EGF-like 1
SEC23A Sec23 homolog A (S. cerevisiae)
SEC63 SEC63 homolog (S. cerevisiae)
SEZ6L seizure related 6 homolog (mouse)-like
SF3B3 splicing factor 3b, subunit 3, 130kDa
SH2D3A SH2 domain containing 3A
SH3RF2 SH3 domain containing ring finger 2
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLC22A23 solute carrier family 22, member 23
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SNX16 sorting nexin 16
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
SUOX sulfite oxidase
TACC1 transforming, acidic coiled-coil containing protein 1
TMEM173 transmembrane protein 173
TMEM19 transmembrane protein 19
TNR tenascin R
TP53 tumor protein p53
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSHZ1 teashirt zinc finger homeobox 1
TTC21A tetratricopeptide repeat domain 21A
TXNRD1 thioredoxin reductase 1
UBE3A ubiquitin protein ligase E3A
USP28 ubiquitin specific peptidase 28
USP43 ubiquitin specific peptidase 43
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
WNT4 wingless-type MMTV integration site family, member 4
WWP1 WW domain containing E3 ubiquitin protein ligase 1
XPO4 exportin 4
ZNF462 zinc finger protein 462
ZNF605 zinc finger protein 605
ZNF853 zinc finger protein 853