NCI-H2196 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: carcinoma; small cell lung cancer (lung primary) (Cell Line Ontology, CLO_0008063)
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Genes

158 genes mutated in the NCI-H2196 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
AASDH aminoadipate-semialdehyde dehydrogenase
ACVR1B activin A receptor, type IB
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ADCY5 adenylate cyclase 5
ADIPOR2 adiponectin receptor 2
ADRBK2 adrenergic, beta, receptor kinase 2
ALG10 ALG10, alpha-1,2-glucosyltransferase
ALKBH7 alkB, alkylation repair homolog 7 (E. coli)
ANKHD1 ankyrin repeat and KH domain containing 1
ANKHD1-EIF4EBP3 ANKHD1-EIF4EBP3 readthrough
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
ARHGAP17 Rho GTPase activating protein 17
ARHGAP32 Rho GTPase activating protein 32
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ARMCX4 armadillo repeat containing, X-linked 4
ASXL1 additional sex combs like transcriptional regulator 1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BBX bobby sox homolog (Drosophila)
BOD1L1 biorientation of chromosomes in cell division 1-like 1
C12ORF50 chromosome 12 open reading frame 50
C9ORF72 chromosome 9 open reading frame 72
CAMTA1 calmodulin binding transcription activator 1
CBX4 chromobox homolog 4
CCDC154 coiled-coil domain containing 154
CCDC67 coiled-coil domain containing 67
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CDAN1 codanin 1
CDC25A cell division cycle 25A
CDCA8 cell division cycle associated 8
CDK12 cyclin-dependent kinase 12
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CEMP1 cementum protein 1
CFAP44 cilia and flagella associated protein 44
CKAP4 cytoskeleton-associated protein 4
CLCN5 chloride channel, voltage-sensitive 5
CLDN11 claudin 11
CNTNAP5 contactin associated protein-like 5
COL22A1 collagen, type XXII, alpha 1
COL6A1 collagen, type VI, alpha 1
COMP cartilage oligomeric matrix protein
CSRP2BP CSRP2 binding protein
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CUL5 cullin 5
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAGLA diacylglycerol lipase, alpha
DAPK1 death-associated protein kinase 1
DCAF8 DDB1 and CUL4 associated factor 8
DGKG diacylglycerol kinase, gamma 90kDa
DLG4 discs, large homolog 4 (Drosophila)
DOCK9 dedicator of cytokinesis 9
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EIF3C eukaryotic translation initiation factor 3, subunit C
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FAM129B family with sequence similarity 129, member B
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGF12 fibroblast growth factor 12
FIGN fidgetin
GGCT gamma-glutamylcyclotransferase
GLTP glycolipid transfer protein
GSDMD gasdermin D
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1
HELZ2 helicase with zinc finger 2, transcriptional coactivator
HIST1H1C histone cluster 1, H1c
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HRCT1 histidine rich carboxyl terminus 1
HTATSF1 HIV-1 Tat specific factor 1
HTT huntingtin
IRF8 interferon regulatory factor 8
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
KIAA0232 KIAA0232
KIDINS220 kinase D-interacting substrate, 220kDa
KLHDC8B kelch domain containing 8B
KMT2D lysine (K)-specific methyltransferase 2D
L3MBTL3 l(3)mbt-like 3 (Drosophila)
LTBP4 latent transforming growth factor beta binding protein 4
MACF1 microtubule-actin crosslinking factor 1
MARC1 mitochondrial amidoxime reducing component 1
MCM6 minichromosome maintenance complex component 6
MCOLN2 mucolipin 2
MDN1 MDN1, midasin homolog (yeast)
MEGF8 multiple EGF-like-domains 8
MMD monocyte to macrophage differentiation-associated
MPDZ multiple PDZ domain protein
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MTMR7 myotubularin related protein 7
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
NWD1 NACHT and WD repeat domain containing 1
OCM2 oncomodulin 2
OLFM1 olfactomedin 1
OSCP1 organic solute carrier partner 1
PCDHB13 protocadherin beta 13
PCDHGB7 protocadherin gamma subfamily B, 7
PCED1B PC-esterase domain containing 1B
PCNXL3 pecanex-like 3 (Drosophila)
PDCD2L programmed cell death 2-like
PDE1A phosphodiesterase 1A, calmodulin-dependent
PDE8B phosphodiesterase 8B
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PLCB4 phospholipase C, beta 4
PLIN4 perilipin 4
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POU2F2 POU class 2 homeobox 2
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PRDM10 PR domain containing 10
PROSER3 proline and serine rich 3
PRPF4B pre-mRNA processing factor 4B
PTCH1 patched 1
PYHIN1 pyrin and HIN domain family, member 1
R3HCC1 R3H domain and coiled-coil containing 1
REEP1 receptor accessory protein 1
RHBDD1 rhomboid domain containing 1
RNF213 ring finger protein 213
RPL30 ribosomal protein L30
RPRD2 regulation of nuclear pre-mRNA domain containing 2
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RSRC1 arginine/serine-rich coiled-coil 1
SDK1 sidekick cell adhesion molecule 1
SEC22C SEC22 vesicle trafficking protein homolog C (S. cerevisiae)
SEC23A Sec23 homolog A (S. cerevisiae)
SEC24B SEC24 family member B
SEC63 SEC63 homolog (S. cerevisiae)
SEZ6L seizure related 6 homolog (mouse)-like
SF3B3 splicing factor 3b, subunit 3, 130kDa
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase
SIK1 salt-inducible kinase 1
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLC22A23 solute carrier family 22, member 23
SLC38A6 solute carrier family 38, member 6
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17
SNX16 sorting nexin 16
SPHKAP SPHK1 interactor, AKAP domain containing
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
SUOX sulfite oxidase
TACC1 transforming, acidic coiled-coil containing protein 1
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast)
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast)
TLE3 transducin-like enhancer of split 3
TMEM173 transmembrane protein 173
TMEM19 transmembrane protein 19
TNRC18 trinucleotide repeat containing 18
TP53 tumor protein p53
TRIM54 tripartite motif containing 54
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSHZ1 teashirt zinc finger homeobox 1
TXNRD1 thioredoxin reductase 1
UBAP2L ubiquitin associated protein 2-like
UBE3A ubiquitin protein ligase E3A
USP28 ubiquitin specific peptidase 28
USP43 ubiquitin specific peptidase 43
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
WDR59 WD repeat domain 59
WWP1 WW domain containing E3 ubiquitin protein ligase 1
XPO4 exportin 4
ZNF280A zinc finger protein 280A
ZNF782 zinc finger protein 782