NCI-H2196 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description disease: carcinoma; small cell lung cancer (lung primary) (Cell Line Ontology, CLO_0008063)
Similar Terms
Downloads & Tools

Genes

307 genes with high or low expression in NCI-H2196 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
LGI2 leucine-rich repeat LGI family, member 2 3.46271
TSN translin 3.05354
PCP4 Purkinje cell protein 4 2.94532
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 2.84018
SPIDR scaffolding protein involved in DNA repair 2.75103
HLTF helicase-like transcription factor 2.71502
MC5R melanocortin 5 receptor 2.67872
TPH1 tryptophan hydroxylase 1 2.6663
TBCCD1 TBCC domain containing 1 2.55912
LRRC3 leucine rich repeat containing 3 2.4647
PDK4 pyruvate dehydrogenase kinase, isozyme 4 2.44059
NRIP3 nuclear receptor interacting protein 3 2.418
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 2.41641
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 2.36893
DZIP3 DAZ interacting zinc finger protein 3 2.36367
CCP110 centriolar coiled coil protein 110kDa 2.35788
OPA1 optic atrophy 1 (autosomal dominant) 2.35586
SEPW1 selenoprotein W, 1 2.35319
ACYP1 acylphosphatase 1, erythrocyte (common) type 2.35289
CA10 carbonic anhydrase X 2.32788
CCDC40 coiled-coil domain containing 40 2.32182
RAX retina and anterior neural fold homeobox 2.29213
SPIN2A spindlin family, member 2A 2.26667
NR0B2 nuclear receptor subfamily 0, group B, member 2 2.2404
EPOR erythropoietin receptor 2.22311
AMACR alpha-methylacyl-CoA racemase 2.19091
OPRK1 opioid receptor, kappa 1 2.17698
CHGB chromogranin B 2.16185
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 2.15682
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 2.14813
MED21 mediator complex subunit 21 2.14751
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.14386
DMC1 DNA meiotic recombinase 1 2.13859
CDC7 cell division cycle 7 2.13265
MRFAP1L1 Morf4 family associated protein 1-like 1 2.09623
ECT2 epithelial cell transforming 2 2.08474
LIFR leukemia inhibitory factor receptor alpha 2.08097
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 2.07985
RMST rhabdomyosarcoma 2 associated transcript (non-protein coding) 2.07872
SERGEF secretion regulating guanine nucleotide exchange factor 2.07187
PRRG3 proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) 2.06163
MAN1C1 mannosidase, alpha, class 1C, member 1 2.0496
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 2.04385
SMC4 structural maintenance of chromosomes 4 2.03989
ZMAT4 zinc finger, matrin-type 4 2.02587
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 1.98396
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 1.97842
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 1.97746
ROM1 retinal outer segment membrane protein 1 1.97007
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 1.96665
GDE1 glycerophosphodiester phosphodiesterase 1 1.96429
LDHC lactate dehydrogenase C 1.96064
PSIP1 PC4 and SFRS1 interacting protein 1 1.95298
SCN2A sodium channel, voltage gated, type II alpha subunit 1.9443
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 1.93587
CA4 carbonic anhydrase IV 1.93545
RECQL RecQ helicase-like 1.92376
SCN1B sodium channel, voltage gated, type I beta subunit 1.91681
KCNK10 potassium channel, two pore domain subfamily K, member 10 1.90293
SCG2 secretogranin II 1.89053
CRTAC1 cartilage acidic protein 1 1.8755
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 1.87069
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 1.86923
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 1.8619
CDH22 cadherin 22, type 2 1.85282
MYF6 myogenic factor 6 (herculin) 1.84614
RPA2 replication protein A2, 32kDa 1.84539
TTTY15 testis-specific transcript, Y-linked 15 (non-protein coding) 1.83873
CASD1 CAS1 domain containing 1 1.83624
PCSK1 proprotein convertase subtilisin/kexin type 1 1.82475
PCNP PEST proteolytic signal containing nuclear protein 1.82036
LOC650293 seven transmembrane helix receptor 1.79912
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 1.78884
EXOC4 exocyst complex component 4 1.78737
SPARCL1 SPARC-like 1 (hevin) 1.78658
NOL4 nucleolar protein 4 1.76575
ZBTB20 zinc finger and BTB domain containing 20 1.76548
RELN reelin 1.76317
FHL5 four and a half LIM domains 5 1.7631
STMN3 stathmin-like 3 1.7597
RFC4 replication factor C (activator 1) 4, 37kDa 1.75851
RANBP2 RAN binding protein 2 1.75795
C2CD5 C2 calcium-dependent domain containing 5 1.75683
PHTF2 putative homeodomain transcription factor 2 1.75655
MSH2 mutS homolog 2 1.75099
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 1.75084
STAU2 staufen double-stranded RNA binding protein 2 1.74904
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 1.74572
ALG6 ALG6, alpha-1,3-glucosyltransferase 1.74494
GCA grancalcin, EF-hand calcium binding protein 1.74269
ADCY2 adenylate cyclase 2 (brain) 1.73506
RIBC2 RIB43A domain with coiled-coils 2 1.72277
SIX2 SIX homeobox 2 1.72275
NUDC nudC nuclear distribution protein 1.7211
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 1.71943
TIMELESS timeless circadian clock 1.71551
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 1.71332
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1.71299
KIAA1324 KIAA1324 1.69851
RGS17 regulator of G-protein signaling 17 1.69414
CCDC121 coiled-coil domain containing 121 1.69226
EDN2 endothelin 2 1.6913
ELAVL3 ELAV like neuron-specific RNA binding protein 3 1.69129
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 1.68192
FGF14 fibroblast growth factor 14 1.6812
TTLL7 tubulin tyrosine ligase-like family member 7 1.67963
MAGEF1 melanoma antigen family F1 1.67903
SYT17 synaptotagmin XVII 1.67761
GRM8 glutamate receptor, metabotropic 8 1.67457
LRRC8B leucine rich repeat containing 8 family, member B 1.67211
CTNNA3 catenin (cadherin-associated protein), alpha 3 1.67093
KCNMB2 potassium channel subfamily M regulatory beta subunit 2 1.66998
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 1.66946
TSPAN12 tetraspanin 12 1.66682
NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 1.65826
BPIFA1 BPI fold containing family A, member 1 1.64241
ZBTB16 zinc finger and BTB domain containing 16 1.63792
SLC35A5 solute carrier family 35, member A5 1.6375
SYTL2 synaptotagmin-like 2 1.63649
PGBD5 piggyBac transposable element derived 5 1.63603
HIST1H3C histone cluster 1, H3c 1.6259
HMGB3 high mobility group box 3 1.62445
CCL16 chemokine (C-C motif) ligand 16 1.61602
CTSV cathepsin V 1.61535
SUSD6 sushi domain containing 6 1.61495
ZNF322P1 zinc finger protein 322 pseudogene 1 1.60923
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 1.6085
ASTN2 astrotactin 2 1.60727
COG2 component of oligomeric golgi complex 2 1.60665
NFYB nuclear transcription factor Y, beta 1.60346
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa 1.5988
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.59832
EPHA7 EPH receptor A7 1.59733
SCN3A sodium channel, voltage gated, type III alpha subunit 1.59707
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 1.58055
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase 1.57823
PBK PDZ binding kinase 1.57728
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 1.5772
RFC1 replication factor C (activator 1) 1, 145kDa 1.57415
C1QTNF3 C1q and tumor necrosis factor related protein 3 1.57111
SLC35G2 solute carrier family 35, member G2 1.56903
CPB1 carboxypeptidase B1 (tissue) 1.56126
HAUS7 HAUS augmin-like complex, subunit 7 1.5557
IL19 interleukin 19 1.55373
OTUD3 OTU deubiquitinase 3 1.55369
PLN phospholamban 1.55105
RANBP6 RAN binding protein 6 1.55085
CEP192 centrosomal protein 192kDa 1.54982
ENAH enabled homolog (Drosophila) 1.54979
ZNF484 zinc finger protein 484 1.54645
GDAP1 ganglioside induced differentiation associated protein 1 1.54638
PCYOX1L prenylcysteine oxidase 1 like 1.54335
LTB4R2 leukotriene B4 receptor 2 1.53914
LOC284244 uncharacterized LOC284244 1.5375
CALCA calcitonin-related polypeptide alpha 1.53531
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 1.53475
FAM153A family with sequence similarity 153, member A 1.53388
APOO apolipoprotein O 1.52962
PRKD1 protein kinase D1 1.52412
SYNJ1 synaptojanin 1 1.52084
GPR31 G protein-coupled receptor 31 1.5092
GNA14 guanine nucleotide binding protein (G protein), alpha 14 1.50691
EXTL3 exostosin-like glycosyltransferase 3 1.5015
ASCL1 achaete-scute family bHLH transcription factor 1 1.50052
MAP6D1 MAP6 domain containing 1 1.49383
FAM168A family with sequence similarity 168, member A 1.49376
ACVR1 activin A receptor, type I 1.49298
CCDC14 coiled-coil domain containing 14 1.49221
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 1.48923
MTX2 metaxin 2 1.48322
DONSON downstream neighbor of SON 1.48197
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma 1.48118
MEX3D mex-3 RNA binding family member D 1.47657
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 1.47394
KLF11 Kruppel-like factor 11 1.4736
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 1.47328
CDHR1 cadherin-related family member 1 1.46908
ERMP1 endoplasmic reticulum metallopeptidase 1 1.46521
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 1.46025
TCEAL2 transcription elongation factor A (SII)-like 2 1.45616
DHRS7 dehydrogenase/reductase (SDR family) member 7 1.45549
COQ3 coenzyme Q3 methyltransferase 1.45518
TFCP2L1 transcription factor CP2-like 1 1.45186
MKL2 MKL/myocardin-like 2 1.44865
TUBA8 tubulin, alpha 8 1.44738
OTC ornithine carbamoyltransferase 1.44652
ACO2 aconitase 2, mitochondrial 1.44451
MYRIP myosin VIIA and Rab interacting protein 1.43977
DEXI Dexi homolog (mouse) 1.43696
ZDHHC13 zinc finger, DHHC-type containing 13 1.43619
NDC80 NDC80 kinetochore complex component 1.43423
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 1.41895
MAK male germ cell-associated kinase 1.41862
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 1.41669

low expression

Symbol Name Standardized Value
KCMF1 potassium channel modulatory factor 1 -3.08908
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 -2.96716
MTRF1 mitochondrial translational release factor 1 -2.95442
RANBP10 RAN binding protein 10 -2.93086
RPLP1 ribosomal protein, large, P1 -2.91432
TPT1 tumor protein, translationally-controlled 1 -2.88371
RPS17 ribosomal protein S17 -2.75545
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein -2.73817
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase -2.73083
RPL37 ribosomal protein L37 -2.68007
RPL15 ribosomal protein L15 -2.64006
BAHD1 bromo adjacent homology domain containing 1 -2.62325
RPL39 ribosomal protein L39 -2.60521
TGIF2 TGFB-induced factor homeobox 2 -2.50177
RPL19 ribosomal protein L19 -2.35084
RPL27 ribosomal protein L27 -2.34792
RPL13 ribosomal protein L13 -2.29954
STK24 serine/threonine kinase 24 -2.27596
HBE1 hemoglobin, epsilon 1 -2.24507
PGAP3 post-GPI attachment to proteins 3 -2.19964
RPS27A ribosomal protein S27a -2.19261
NLE1 notchless homolog 1 (Drosophila) -2.16945
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 -2.15971
RPL28 ribosomal protein L28 -2.15673
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -2.15492
MKRN2 makorin ring finger protein 2 -2.12928
OXR1 oxidation resistance 1 -2.12347
GPATCH4 G patch domain containing 4 -2.11054
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 -2.10858
PABPC3 poly(A) binding protein, cytoplasmic 3 -2.09562
RPS23 ribosomal protein S23 -2.07349
RPS8 ribosomal protein S8 -2.06877
TRA T cell receptor alpha locus -2.0687
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -2.03428
RPL23 ribosomal protein L23 -2.02567
GLTSCR2 glioma tumor suppressor candidate region gene 2 -1.99202
PWWP2A PWWP domain containing 2A -1.99041
RPL13A ribosomal protein L13a -1.97035
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta -1.96233
WBP11 WW domain binding protein 11 -1.93627
ACACA acetyl-CoA carboxylase alpha -1.92217
RPL32 ribosomal protein L32 -1.91756
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 -1.91129
RPL14 ribosomal protein L14 -1.90472
PADI1 peptidyl arginine deiminase, type I -1.88843
HDAC5 histone deacetylase 5 -1.88146
EIF3L eukaryotic translation initiation factor 3, subunit L -1.87388
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) -1.87367
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -1.86238
RPL3 ribosomal protein L3 -1.84946
RPS14 ribosomal protein S14 -1.84593
PABPC1 poly(A) binding protein, cytoplasmic 1 -1.83594
AUP1 ancient ubiquitous protein 1 -1.82509
MINA MYC induced nuclear antigen -1.80437
UNC45A unc-45 homolog A (C. elegans) -1.80422
AHCTF1 AT hook containing transcription factor 1 -1.80172
SUCLG1 succinate-CoA ligase, alpha subunit -1.79356
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 -1.79109
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 -1.79038
BRPF1 bromodomain and PHD finger containing, 1 -1.77506
RPL4 ribosomal protein L4 -1.76174
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -1.7584
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 -1.74644
FBXL6 F-box and leucine-rich repeat protein 6 -1.74099
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -1.73454
GDI2 GDP dissociation inhibitor 2 -1.72591
MON1B MON1 secretory trafficking family member B -1.72564
IL7 interleukin 7 -1.69781
CDK10 cyclin-dependent kinase 10 -1.69128
RPS16 ribosomal protein S16 -1.67959
LYPLA2 lysophospholipase II -1.65729
RPUSD2 RNA pseudouridylate synthase domain containing 2 -1.64897
VGLL4 vestigial-like family member 4 -1.64856
HEATR1 HEAT repeat containing 1 -1.64442
STARD3 StAR-related lipid transfer (START) domain containing 3 -1.63673
RPL10 ribosomal protein L10 -1.63108
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -1.61904
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) -1.61576
TRPC3 transient receptor potential cation channel, subfamily C, member 3 -1.61486
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A -1.60828
RPL29 ribosomal protein L29 -1.60099
KARS lysyl-tRNA synthetase -1.59815
EIF3D eukaryotic translation initiation factor 3, subunit D -1.59321
GTPBP1 GTP binding protein 1 -1.58128
MSX2 msh homeobox 2 -1.58094
TNPO1 transportin 1 -1.57737
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -1.57515
RPL31 ribosomal protein L31 -1.56993
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant -1.56934
COL4A1 collagen, type IV, alpha 1 -1.55822
RPL10A ribosomal protein L10a -1.5455
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -1.52297
EIF1 eukaryotic translation initiation factor 1 -1.51584
NADSYN1 NAD synthetase 1 -1.51476
SEC31A SEC31 homolog A (S. cerevisiae) -1.48427
NDEL1 nudE neurodevelopment protein 1-like 1 -1.48301
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 -1.47351
ERF Ets2 repressor factor -1.47225
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -1.457
IL12RB1 interleukin 12 receptor, beta 1 -1.45603
SNHG3 small nucleolar RNA host gene 3 -1.45539
PLAGL1 pleiomorphic adenoma gene-like 1 -1.45508
TMEM92 transmembrane protein 92 -1.45298
F2R coagulation factor II (thrombin) receptor -1.44508
MICALL1 MICAL-like 1 -1.44442
SCAND2P SCAN domain containing 2 pseudogene -1.43859
TMEM57 transmembrane protein 57 -1.43801
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding) -1.43657
RPS24 ribosomal protein S24 -1.43485
USP3 ubiquitin specific peptidase 3 -1.43484
INPP5A inositol polyphosphate-5-phosphatase, 40kDa -1.42585
DET1 de-etiolated homolog 1 (Arabidopsis) -1.42092
TBC1D2B TBC1 domain family, member 2B -1.41956