NCI-H2172 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: non-small cell lung cancer (Cell Line Ontology, CLO_0008061)
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Genes

449 genes mutated in the NCI-H2172 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
AAR2 AAR2 splicing factor homolog (S. cerevisiae)
AARS2 alanyl-tRNA synthetase 2, mitochondrial
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1
ACVR2B activin A receptor, type IIB
ADCK4 aarF domain containing kinase 4
ADGRB2 adhesion G protein-coupled receptor B2
ADGRE1 adhesion G protein-coupled receptor E1
ADGRL3 adhesion G protein-coupled receptor L3
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
AGFG2 ArfGAP with FG repeats 2
AHNAK AHNAK nucleoprotein
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
AMBRA1 autophagy/beclin-1 regulator 1
ANKRD32 ankyrin repeat domain 32
ANKS6 ankyrin repeat and sterile alpha motif domain containing 6
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ASB13 ankyrin repeat and SOCS box containing 13
ASCC1 activating signal cointegrator 1 complex subunit 1
ASIC3 acid sensing (proton gated) ion channel 3
ATAD2B ATPase family, AAA domain containing 2B
ATG2B autophagy related 2B
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
ATXN1L ataxin 1-like
AVL9 AVL9 homolog (S. cerevisiase)
BAHD1 bromo adjacent homology domain containing 1
BCHE butyrylcholinesterase
BCL9L B-cell CLL/lymphoma 9-like
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
BHMT betaine--homocysteine S-methyltransferase
BIRC6 baculoviral IAP repeat containing 6
BMPER BMP binding endothelial regulator
BRCA1 breast cancer 1, early onset
BRPF1 bromodomain and PHD finger containing, 1
BTBD2 BTB (POZ) domain containing 2
BTF3L4 basic transcription factor 3-like 4
C11ORF30 chromosome 11 open reading frame 30
C14ORF80 chromosome 14 open reading frame 80
C3 complement component 3
C4ORF3 chromosome 4 open reading frame 3
C5ORF42 chromosome 5 open reading frame 42
CADM2 cell adhesion molecule 2
CANX calnexin
CARD6 caspase recruitment domain family, member 6
CCDC102A coiled-coil domain containing 102A
CCDC132 coiled-coil domain containing 132
CCDC59 coiled-coil domain containing 59
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CDH10 cadherin 10, type 2 (T2-cadherin)
CDH23 cadherin-related 23
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDK9 cyclin-dependent kinase 9
CEP104 centrosomal protein 104kDa
CEP250 centrosomal protein 250kDa
CERCAM cerebral endothelial cell adhesion molecule
CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5
CHD8 chromodomain helicase DNA binding protein 8
CHURC1 churchill domain containing 1
CHURC1-FNTB CHURC1-FNTB readthrough
CKAP2L cytoskeleton associated protein 2-like
CLCN2 chloride channel, voltage-sensitive 2
CLCN3 chloride channel, voltage-sensitive 3
CNOT10 CCR4-NOT transcription complex, subunit 10
CNST consortin, connexin sorting protein
COL11A1 collagen, type XI, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
COL5A1 collagen, type V, alpha 1
COX4I1 cytochrome c oxidase subunit IV isoform 1
CPED1 cadherin-like and PC-esterase domain containing 1
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CREB3L1 cAMP responsive element binding protein 3-like 1
CRISP3 cysteine-rich secretory protein 3
CXXC1 CXXC finger protein 1
CYB5R2 cytochrome b5 reductase 2
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
DCAF5 DDB1 and CUL4 associated factor 5
DCUN1D5 DCN1, defective in cullin neddylation 1, domain containing 5
DEPDC5 DEP domain containing 5
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DIO2 deiodinase, iodothyronine, type II
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DIRC2 disrupted in renal carcinoma 2
DKKL1 dickkopf-like 1
DLG5 discs, large homolog 5 (Drosophila)
DMRTA2 DMRT-like family A2
DNA2 DNA replication helicase/nuclease 2
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21
DOCK4 dedicator of cytokinesis 4
DOCK9 dedicator of cytokinesis 9
DST dystonin
DUSP4 dual specificity phosphatase 4
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
ECEL1 endothelin converting enzyme-like 1
EFTUD1 elongation factor Tu GTP binding domain containing 1
EID2B EP300 interacting inhibitor of differentiation 2B
EIF3H eukaryotic translation initiation factor 3, subunit H
ELMSAN1 ELM2 and Myb/SANT-like domain containing 1
ELP2 elongator acetyltransferase complex subunit 2
EPS15 epidermal growth factor receptor pathway substrate 15
ERLIN2 ER lipid raft associated 2
EXTL3 exostosin-like glycosyltransferase 3
EYA3 EYA transcriptional coactivator and phosphatase 3
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM114A1 family with sequence similarity 114, member A1
FAM189B family with sequence similarity 189, member B
FAM214A family with sequence similarity 214, member A
FAT1 FAT atypical cadherin 1
FAT4 FAT atypical cadherin 4
FBLN2 fibulin 2
FBXL17 F-box and leucine-rich repeat protein 17
FBXO36 F-box protein 36
FBXO46 F-box protein 46
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FLRT2 fibronectin leucine rich transmembrane protein 2
FRYL FRY-like
FUCA1 fucosidase, alpha-L- 1, tissue
FXR2 fragile X mental retardation, autosomal homolog 2
FYB FYN binding protein
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GAK cyclin G associated kinase
GAPVD1 GTPase activating protein and VPS9 domains 1
GLIS3 GLIS family zinc finger 3
GLTSCR2 glioma tumor suppressor candidate region gene 2
GMPS guanine monphosphate synthase
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GON4L gon-4-like (C. elegans)
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GRK5 G protein-coupled receptor kinase 5
GSN gelsolin
GYG2 glycogenin 2
HAUS3 HAUS augmin-like complex, subunit 3
HDAC10 histone deacetylase 10
HEATR5A HEAT repeat containing 5A
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HIPK2 homeodomain interacting protein kinase 2
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HLX H2.0-like homeobox
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
HOMER3 homer scaffolding protein 3
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12
HSDL1 hydroxysteroid dehydrogenase like 1
HTRA3 HtrA serine peptidase 3
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase
ICE1 interactor of little elongation complex ELL subunit 1
IL17RA interleukin 17 receptor A
IMPACT impact RWD domain protein
INO80E INO80 complex subunit E
INTS3 integrator complex subunit 3
IPMK inositol polyphosphate multikinase
IRX3 iroquois homeobox 3
IRX5 iroquois homeobox 5
ITGB5 integrin, beta 5
JADE3 jade family PHD finger 3
JUND jun D proto-oncogene
KATNAL2 katanin p60 subunit A-like 2
KEAP1 kelch-like ECH-associated protein 1
KIAA1407 KIAA1407
KIAA1429 KIAA1429
KIAA2018 KIAA2018
KIF11 kinesin family member 11
KIF18A kinesin family member 18A
KIF23 kinesin family member 23
KIF7 kinesin family member 7
KLHL17 kelch-like family member 17
KLHL4 kelch-like family member 4
KMT2C lysine (K)-specific methyltransferase 2C
L3HYPDH L-3-hydroxyproline dehydratase (trans-)
LAMC3 laminin, gamma 3
LIMCH1 LIM and calponin homology domains 1
LMO4 LIM domain only 4
LMOD3 leiomodin 3 (fetal)
LMTK2 lemur tyrosine kinase 2
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRIF1 ligand dependent nuclear receptor interacting factor 1
LRP12 low density lipoprotein receptor-related protein 12
LRP1B low density lipoprotein receptor-related protein 1B
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LTBP1 latent transforming growth factor beta binding protein 1
LTN1 listerin E3 ubiquitin protein ligase 1
MAEA macrophage erythroblast attacher
MALL mal, T-cell differentiation protein-like
MAN2C1 mannosidase, alpha, class 2C, member 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MAST4 microtubule associated serine/threonine kinase family member 4
MDH1 malate dehydrogenase 1, NAD (soluble)
MIA3 melanoma inhibitory activity family, member 3
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MKI67 marker of proliferation Ki-67
MLPH melanophilin
MMS22L MMS22-like, DNA repair protein
MN1 meningioma (disrupted in balanced translocation) 1
MORC3 MORC family CW-type zinc finger 3
MORN1 MORN repeat containing 1
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MROH1 maestro heat-like repeat family member 1
MRPL46 mitochondrial ribosomal protein L46
MTPAP mitochondrial poly(A) polymerase
MTSS1L metastasis suppressor 1-like
MUC16 mucin 16, cell surface associated
MUT methylmalonyl CoA mutase
MYH10 myosin, heavy chain 10, non-muscle
MYLK myosin light chain kinase
MYOCD myocardin
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NADSYN1 NAD synthetase 1
NAT9 N-acetyltransferase 9 (GCN5-related, putative)
NBAS neuroblastoma amplified sequence
NBEA neurobeachin
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPH2 non-SMC condensin II complex, subunit H2
NCK1 NCK adaptor protein 1
NCOR2 nuclear receptor corepressor 2
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NEFM neurofilament, medium polypeptide
NF2 neurofibromin 2 (merlin)
NINL ninein-like
NKX6-1 NK6 homeobox 1
NPC1 Niemann-Pick disease, type C1
NPEPL1 aminopeptidase-like 1
NPHP3 nephronophthisis 3 (adolescent)
NPR1 natriuretic peptide receptor 1
NPR3 natriuretic peptide receptor 3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NSUN6 NOP2/Sun domain family, member 6
NT5C2 5'-nucleotidase, cytosolic II
NT5E 5'-nucleotidase, ecto (CD73)
NTN4 netrin 4
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
NUP37 nucleoporin 37kDa
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
ODC1 ornithine decarboxylase 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P4HB prolyl 4-hydroxylase, beta polypeptide
PAN3 PAN3 poly(A) specific ribonuclease subunit
PANK1 pantothenate kinase 1
PCF11 PCF11 cleavage and polyadenylation factor subunit
PCGF5 polycomb group ring finger 5
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCLO piccolo presynaptic cytomatrix protein
PDCD6IP programmed cell death 6 interacting protein
PDE3A phosphodiesterase 3A, cGMP-inhibited
PDE4D phosphodiesterase 4D, cAMP-specific
PDHX pyruvate dehydrogenase complex, component X
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PEG10 paternally expressed 10
PGAP3 post-GPI attachment to proteins 3
PHKB phosphorylase kinase, beta
PHLDB3 pleckstrin homology-like domain, family B, member 3
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PKN3 protein kinase N3
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLIN3 perilipin 3
PLIN4 perilipin 4
PML promyelocytic leukemia
PNKP polynucleotide kinase 3'-phosphatase
PNPLA6 patatin-like phospholipase domain containing 6
POLE polymerase (DNA directed), epsilon, catalytic subunit
POSTN periostin, osteoblast specific factor
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPM1N protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
PPOX protoporphyrinogen oxidase
PRC1 protein regulator of cytokinesis 1
PRDM2 PR domain containing 2, with ZNF domain
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PRKD1 protein kinase D1
PRR14L proline rich 14-like
PRRT1 proline-rich transmembrane protein 1
PRX periaxin
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSME4 proteasome (prosome, macropain) activator subunit 4
PTOV1 prostate tumor overexpressed 1
PTPRK protein tyrosine phosphatase, receptor type, K
PURB purine-rich element binding protein B
PVRL3 poliovirus receptor-related 3
QPCTL glutaminyl-peptide cyclotransferase-like
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic)
RAD17 RAD17 homolog (S. pombe)
RAG1 recombination activating gene 1
RAI1 retinoic acid induced 1
RANBP17 RAN binding protein 17
RANGAP1 Ran GTPase activating protein 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RB1 retinoblastoma 1
RBM6 RNA binding motif protein 6
REST RE1-silencing transcription factor
RHOA ras homolog family member A
RIF1 replication timing regulatory factor 1
RIN2 Ras and Rab interactor 2
RMI1 RecQ mediated genome instability 1
RNF26 ring finger protein 26
RNF43 ring finger protein 43
RP1L1 retinitis pigmentosa 1-like 1
RSRC1 arginine/serine-rich coiled-coil 1
RTEL1 regulator of telomere elongation helicase 1
RTTN rotatin
SACS sacsin molecular chaperone
SAMHD1 SAM domain and HD domain 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SART1 squamous cell carcinoma antigen recognized by T cells
SCAF11 SR-related CTD-associated factor 11
SCNM1 sodium channel modifier 1
SECISBP2 SECIS binding protein 2
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SETD7 SET domain containing (lysine methyltransferase) 7
SF3A1 splicing factor 3a, subunit 1, 120kDa
SH3BP1 SH3-domain binding protein 1
SIK1 salt-inducible kinase 1
SIN3B SIN3 transcription regulator family member B
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC35B3 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
SMC4 structural maintenance of chromosomes 4
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SMYD5 SMYD family member 5
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPIRE1 spire-type actin nucleation factor 1
SPP1 secreted phosphoprotein 1
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SRFBP1 serum response factor binding protein 1
SSH1 slingshot protein phosphatase 1
SSH3 slingshot protein phosphatase 3
ST7 suppression of tumorigenicity 7
STK4 serine/threonine kinase 4
SUN1 Sad1 and UNC84 domain containing 1
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
SURF2 surfeit 2
SYCP2 synaptonemal complex protein 2
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
SYNE1 spectrin repeat containing, nuclear envelope 1
SYNM synemin, intermediate filament protein
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D5 TBC1 domain family, member 5
TCF20 transcription factor 20 (AR1)
TDRD3 tudor domain containing 3
TEK TEK tyrosine kinase, endothelial
TET2 tet methylcytosine dioxygenase 2
TGFBR1 transforming growth factor, beta receptor 1
THADA thyroid adenoma associated
THSD4 thrombospondin, type I, domain containing 4
TIGD5 tigger transposable element derived 5
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast)
TLDC1 TBC/LysM-associated domain containing 1
TLR4 toll-like receptor 4
TMBIM4 transmembrane BAX inhibitor motif containing 4
TMEM135 transmembrane protein 135
TMEM151A transmembrane protein 151A
TMEM19 transmembrane protein 19
TMEM2 transmembrane protein 2
TMEM38B transmembrane protein 38B
TMEM5 transmembrane protein 5
TMEM63B transmembrane protein 63B
TMTC1 transmembrane and tetratricopeptide repeat containing 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TNRC18 trinucleotide repeat containing 18
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TP63 tumor protein p63
TRAF5 TNF receptor-associated factor 5
TRIM25 tripartite motif containing 25
TRIM47 tripartite motif containing 47
TRIO trio Rho guanine nucleotide exchange factor
TSKU tsukushi, small leucine rich proteoglycan
TTC14 tetratricopeptide repeat domain 14
TTC38 tetratricopeptide repeat domain 38
TTC39C tetratricopeptide repeat domain 39C
TTLL12 tubulin tyrosine ligase-like family member 12
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UBE3A ubiquitin protein ligase E3A
UBN1 ubinuclein 1
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative)
UCK2 uridine-cytidine kinase 2
USO1 USO1 vesicle transport factor
USP40 ubiquitin specific peptidase 40
USP51 ubiquitin specific peptidase 51
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VIT vitrin
VLDLR very low density lipoprotein receptor
WDR11 WD repeat domain 11
WDR27 WD repeat domain 27
WDR75 WD repeat domain 75
WIPF1 WAS/WASL interacting protein family, member 1
XPO7 exportin 7
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YLPM1 YLP motif containing 1
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
ZBTB2 zinc finger and BTB domain containing 2
ZBTB39 zinc finger and BTB domain containing 39
ZBTB40 zinc finger and BTB domain containing 40
ZBTB7A zinc finger and BTB domain containing 7A
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC8 zinc finger, CCHC domain containing 8
ZDBF2 zinc finger, DBF-type containing 2
ZFC3H1 zinc finger, C3H1-type containing
ZFHX3 zinc finger homeobox 3
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF134 zinc finger protein 134
ZNF146 zinc finger protein 146
ZNF239 zinc finger protein 239
ZNF260 zinc finger protein 260
ZNF282 zinc finger protein 282
ZNF333 zinc finger protein 333
ZNF337 zinc finger protein 337
ZNF341 zinc finger protein 341
ZNF394 zinc finger protein 394
ZNF397 zinc finger protein 397
ZNF516 zinc finger protein 516
ZNF544 zinc finger protein 544
ZNF574 zinc finger protein 574
ZNF582 zinc finger protein 582
ZNF593 zinc finger protein 593
ZNF619 zinc finger protein 619
ZNF638 zinc finger protein 638
ZNF654 zinc finger protein 654
ZNF667 zinc finger protein 667
ZNF687 zinc finger protein 687
ZNF691 zinc finger protein 691
ZNF782 zinc finger protein 782
ZNF814 zinc finger protein 814
ZRANB3 zinc finger, RAN-binding domain containing 3
ZSCAN30 zinc finger and SCAN domain containing 30