NCI-H2171 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: carcinoma; small cell lung cancer (lung primary) (Cell Line Ontology, CLO_0008060)
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Genes

137 genes mutated in the NCI-H2171 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABHD12 abhydrolase domain containing 12
ACSF2 acyl-CoA synthetase family member 2
ADAM22 ADAM metallopeptidase domain 22
ADCY1 adenylate cyclase 1 (brain)
AGRN agrin
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ANKIB1 ankyrin repeat and IBR domain containing 1
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ARFGEF3 ARFGEF family member 3
ATG2B autophagy related 2B
BRWD3 bromodomain and WD repeat domain containing 3
C10ORF88 chromosome 10 open reading frame 88
C7ORF60 chromosome 7 open reading frame 60
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4
CAMTA1 calmodulin binding transcription activator 1
CARM1 coactivator-associated arginine methyltransferase 1
CCDC102A coiled-coil domain containing 102A
CD8B CD8b molecule
CDC5L cell division cycle 5-like
CECR2 cat eye syndrome chromosome region, candidate 2
CECR6 cat eye syndrome chromosome region, candidate 6
CENPQ centromere protein Q
CFAP61 cilia and flagella associated protein 61
CHD5 chromodomain helicase DNA binding protein 5
CLSPN claspin
CNST consortin, connexin sorting protein
COL9A2 collagen, type IX, alpha 2
COMP cartilage oligomeric matrix protein
CTCF CCCTC-binding factor (zinc finger protein)
D2HGDH D-2-hydroxyglutarate dehydrogenase
DACT1 dishevelled-binding antagonist of beta-catenin 1
DCX doublecortin
DDIAS DNA damage-induced apoptosis suppressor
DIDO1 death inducer-obliterator 1
DNAH17 dynein, axonemal, heavy chain 17
DNHD1 dynein heavy chain domain 1
DOCK3 dedicator of cytokinesis 3
DOCK4 dedicator of cytokinesis 4
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EFCAB3 EF-hand calcium binding domain 3
EME2 essential meiotic structure-specific endonuclease subunit 2
EXD3 exonuclease 3'-5' domain containing 3
FAM222A family with sequence similarity 222, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBL fibrillarin
FIBP fibroblast growth factor (acidic) intracellular binding protein
FLYWCH2 FLYWCH family member 2
FRAS1 Fraser extracellular matrix complex subunit 1
GALK2 galactokinase 2
GANAB glucosidase, alpha; neutral AB
GON4L gon-4-like (C. elegans)
GPC5 glypican 5
GSPT2 G1 to S phase transition 2
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
HELZ2 helicase with zinc finger 2, transcriptional coactivator
IFT20 intraflagellar transport 20
ITCH itchy E3 ubiquitin protein ligase
ITGA7 integrin, alpha 7
KDELC2 KDEL (Lys-Asp-Glu-Leu) containing 2
KDM2A lysine (K)-specific demethylase 2A
KIF1A kinesin family member 1A
KMT2D lysine (K)-specific methyltransferase 2D
LRPPRC leucine-rich pentatricopeptide repeat containing
LRRK2 leucine-rich repeat kinase 2
LYST lysosomal trafficking regulator
MAN1B1 mannosidase, alpha, class 1B, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MBD5 methyl-CpG binding domain protein 5
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MICU1 mitochondrial calcium uptake 1
MOSPD2 motile sperm domain containing 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC20 mucin 20, cell surface associated
MXRA8 matrix-remodelling associated 8
MYEOV2 myeloma overexpressed 2
MYO5A myosin VA (heavy chain 12, myoxin)
N4BP2L2 NEDD4 binding protein 2-like 2
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
NCAPG2 non-SMC condensin II complex, subunit G2
NELFA negative elongation factor complex member A
OLFM4 olfactomedin 4
PAK1IP1 PAK1 interacting protein 1
PAPD7 PAP associated domain containing 7
PARD6G par-6 family cell polarity regulator gamma
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PCID2 PCI domain containing 2
PCNT pericentrin
PCNX pecanex homolog (Drosophila)
PDZD7 PDZ domain containing 7
PDZD8 PDZ domain containing 8
PEG10 paternally expressed 10
PHF13 PHD finger protein 13
PHRF1 PHD and ring finger domains 1
PLA2G4F phospholipase A2, group IVF
PLCD3 phospholipase C, delta 3
PLXNA2 plexin A2
PLXNB2 plexin B2
PMFBP1 polyamine modulated factor 1 binding protein 1
POLR2M polymerase (RNA) II (DNA directed) polypeptide M
PPAPDC3 phosphatidic acid phosphatase type 2 domain containing 3
PRNP prion protein
PTPRD protein tyrosine phosphatase, receptor type, D
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic)
RB1 retinoblastoma 1
RING1 ring finger protein 1
RNF115 ring finger protein 115
RPTOR regulatory associated protein of MTOR, complex 1
RREB1 ras responsive element binding protein 1
SECISBP2 SECIS binding protein 2
SERINC2 serine incorporator 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SEZ6L seizure related 6 homolog (mouse)-like
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SNX14 sorting nexin 14
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
STARD9 StAR-related lipid transfer (START) domain containing 9
TECPR1 tectonin beta-propeller repeat containing 1
TMEM2 transmembrane protein 2
TP53 tumor protein p53
TRAF1 TNF receptor-associated factor 1
TTLL9 tubulin tyrosine ligase-like family member 9
UBQLN2 ubiquilin 2
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
UGT3A2 UDP glycosyltransferase 3 family, polypeptide A2
USP42 ubiquitin specific peptidase 42
VWA1 von Willebrand factor A domain containing 1
WBP2 WW domain binding protein 2
ZDBF2 zinc finger, DBF-type containing 2
ZDHHC11 zinc finger, DHHC-type containing 11
ZFR zinc finger RNA binding protein
ZNF227 zinc finger protein 227
ZNF521 zinc finger protein 521
ZNF778 zinc finger protein 778
ZPR1 ZPR1 zinc finger