NCI-H2135 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: non-small cell lung cancer (Cell Line Ontology, CLO_0008057)
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Genes

216 genes mutated in the NCI-H2135 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADAMTSL5 ADAMTS-like 5
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
ALDH16A1 aldehyde dehydrogenase 16 family, member A1
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
AP4B1 adaptor-related protein complex 4, beta 1 subunit
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
AURKC aurora kinase C
BBS9 Bardet-Biedl syndrome 9
BCAM basal cell adhesion molecule (Lutheran blood group)
BIVM-ERCC5 BIVM-ERCC5 readthrough
BOD1L1 biorientation of chromosomes in cell division 1-like 1
BRWD3 bromodomain and WD repeat domain containing 3
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
C10ORF12 chromosome 10 open reading frame 12
C1ORF35 chromosome 1 open reading frame 35
C5ORF24 chromosome 5 open reading frame 24
C8ORF58 chromosome 8 open reading frame 58
CARD6 caspase recruitment domain family, member 6
CBX2 chromobox homolog 2
CCDC117 coiled-coil domain containing 117
CCNB2 cyclin B2
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CENPB centromere protein B, 80kDa
CEP290 centrosomal protein 290kDa
CGN cingulin
CHML choroideremia-like (Rab escort protein 2)
CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
CLASRP CLK4-associating serine/arginine rich protein
CLMP CXADR-like membrane protein
CNTRL centriolin
COG1 component of oligomeric golgi complex 1
CPNE8 copine VIII
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa
CR1L complement component (3b/4b) receptor 1-like
CRAMP1L Crm, cramped-like (Drosophila)
CRIP2 cysteine-rich protein 2
CUL5 cullin 5
DAB2IP DAB2 interacting protein
DCAF5 DDB1 and CUL4 associated factor 5
DCAF6 DDB1 and CUL4 associated factor 6
DCTN2 dynactin 2 (p50)
DENND1B DENN/MADD domain containing 1B
DISP1 dispatched homolog 1 (Drosophila)
DLG1 discs, large homolog 1 (Drosophila)
DNAH14 dynein, axonemal, heavy chain 14
DNAH6 dynein, axonemal, heavy chain 6
DUSP2 dual specificity phosphatase 2
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DZIP3 DAZ interacting zinc finger protein 3
ELMOD1 ELMO/CED-12 domain containing 1
EPN1 epsin 1
EPN3 epsin 3
ERCC5 excision repair cross-complementation group 5
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM161A family with sequence similarity 161, member A
FAM193B family with sequence similarity 193, member B
FAM208A family with sequence similarity 208, member A
FAM221A family with sequence similarity 221, member A
FANCI Fanconi anemia, complementation group I
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FAXC failed axon connections homolog (Drosophila)
FBXO30 F-box protein 30
FGD6 FYVE, RhoGEF and PH domain containing 6
FLNC filamin C, gamma
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FZD5 frizzled class receptor 5
GCSAM germinal center-associated, signaling and motility
GGT6 gamma-glutamyltransferase 6
GNPTG N-acetylglucosamine-1-phosphate transferase, gamma subunit
GPATCH8 G patch domain containing 8
GPR107 G protein-coupled receptor 107
HACD2 3-hydroxyacyl-CoA dehydratase 2
HACL1 2-hydroxyacyl-CoA lyase 1
HELB helicase (DNA) B
HID1 HID1 domain containing
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HOXA1 homeobox A1
HOXA11 homeobox A11
ICE1 interactor of little elongation complex ELL subunit 1
ICE2 interactor of little elongation complex ELL subunit 2
IFT122 intraflagellar transport 122
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IRS2 insulin receptor substrate 2
JMJD7-PLA2G4B JMJD7-PLA2G4B readthrough
KAT6A K(lysine) acetyltransferase 6A
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8
KIAA0895L KIAA0895-like
KIAA1586 KIAA1586
KIAA2018 KIAA2018
KIF17 kinesin family member 17
KIN Kin17 DNA and RNA binding protein
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LARS2 leucyl-tRNA synthetase 2, mitochondrial
LETM1 leucine zipper-EF-hand containing transmembrane protein 1
LHX6 LIM homeobox 6
LRP1 low density lipoprotein receptor-related protein 1
MACROD1 MACRO domain containing 1
MAOA monoamine oxidase A
MAP4 microtubule-associated protein 4
MB21D2 Mab-21 domain containing 2
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MCM6 minichromosome maintenance complex component 6
METTL4 methyltransferase like 4
MGA MGA, MAX dimerization protein
MSH3 mutS homolog 3
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MYLK myosin light chain kinase
N4BP3 NEDD4 binding protein 3
NAGLU N-acetylglucosaminidase, alpha
NBEAL2 neurobeachin-like 2
NCDN neurochondrin
NCOA1 nuclear receptor coactivator 1
NLE1 notchless homolog 1 (Drosophila)
NR6A1 nuclear receptor subfamily 6, group A, member 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRD1 nardilysin (N-arginine dibasic convertase)
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
OSBPL11 oxysterol binding protein-like 11
OSTM1 osteopetrosis associated transmembrane protein 1
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PARP8 poly (ADP-ribose) polymerase family, member 8
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDHAC2 protocadherin alpha subfamily C, 2
PCDHB10 protocadherin beta 10
PDE2A phosphodiesterase 2A, cGMP-stimulated
PEX10 peroxisomal biogenesis factor 10
PGS1 phosphatidylglycerophosphate synthase 1
PHKG1 phosphorylase kinase, gamma 1 (muscle)
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLA2G4B phospholipase A2, group IVB (cytosolic)
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLD1 phospholipase D1, phosphatidylcholine-specific
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5
PLXND1 plexin D1
PPAN-P2RY11 PPAN-P2RY11 readthrough
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRDM13 PR domain containing 13
QRICH2 glutamine rich 2
RAD54L2 RAD54-like 2 (S. cerevisiae)
RBM48 RNA binding motif protein 48
RELN reelin
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RNF20 ring finger protein 20, E3 ubiquitin protein ligase
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SCAF11 SR-related CTD-associated factor 11
SDCCAG8 serologically defined colon cancer antigen 8
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SERINC1 serine incorporator 1
SETD2 SET domain containing 2
SETDB2 SET domain, bifurcated 2
SF3B1 splicing factor 3b, subunit 1, 155kDa
SLC12A8 solute carrier family 12, member 8
SLC38A10 solute carrier family 38, member 10
SLFN11 schlafen family member 11
SMAD4 SMAD family member 4
SNUPN snurportin 1
SPTBN2 spectrin, beta, non-erythrocytic 2
STARD10 StAR-related lipid transfer (START) domain containing 10
STK33 serine/threonine kinase 33
SUMF2 sulfatase modifying factor 2
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like
SYNM synemin, intermediate filament protein
TBC1D17 TBC1 domain family, member 17
TCTEX1D4 Tctex1 domain containing 4
TDRD7 tudor domain containing 7
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TEP1 telomerase-associated protein 1
TES testin LIM domain protein
THPO thrombopoietin
TLCD2 TLC domain containing 2
TNRC18 trinucleotide repeat containing 18
TNXB tenascin XB
TP53 tumor protein p53
TRAPPC6A trafficking protein particle complex 6A
TRIM56 tripartite motif containing 56
TTC21B tetratricopeptide repeat domain 21B
TTC28 tetratricopeptide repeat domain 28
TTC39B tetratricopeptide repeat domain 39B
TTLL5 tubulin tyrosine ligase-like family member 5
TXNDC11 thioredoxin domain containing 11
U2AF2 U2 small nuclear RNA auxiliary factor 2
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
UBQLN2 ubiquilin 2
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative)
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
USP24 ubiquitin specific peptidase 24
USP45 ubiquitin specific peptidase 45
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast)
VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae)
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae)
WRNIP1 Werner helicase interacting protein 1
XK X-linked Kx blood group
YY2 YY2 transcription factor
ZBTB41 zinc finger and BTB domain containing 41
ZEB1 zinc finger E-box binding homeobox 1
ZFHX3 zinc finger homeobox 3
ZFR zinc finger RNA binding protein
ZNF106 zinc finger protein 106
ZNF280A zinc finger protein 280A
ZNF292 zinc finger protein 292
ZNF419 zinc finger protein 419
ZNF57 zinc finger protein 57
ZNF609 zinc finger protein 609
ZNF639 zinc finger protein 639
ZNF714 zinc finger protein 714
ZNF784 zinc finger protein 784