NCI-H2126 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
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245 genes mutated in the NCI-H2126 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABLIM3 actin binding LIM protein family, member 3
ACACA acetyl-CoA carboxylase alpha
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
AGFG1 ArfGAP with FG repeats 1
AKAP2 A kinase (PRKA) anchor protein 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOA aldolase A, fructose-bisphosphate
ALPPL2 alkaline phosphatase, placental-like 2
ANKRD54 ankyrin repeat domain 54
ANO6 anoctamin 6
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARID2 AT rich interactive domain 2 (ARID, RFX-like)
ASPHD1 aspartate beta-hydroxylase domain containing 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP11A ATPase, class VI, type 11A
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
ATR ATR serine/threonine kinase
ATRIP ATR interacting protein
ATXN7L1 ataxin 7-like 1
BMP6 bone morphogenetic protein 6
BNC1 basonuclin 1
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
C10ORF2 chromosome 10 open reading frame 2
C22ORF29 chromosome 22 open reading frame 29
C2CD2 C2 calcium-dependent domain containing 2
C2ORF54 chromosome 2 open reading frame 54
C7ORF31 chromosome 7 open reading frame 31
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CARD10 caspase recruitment domain family, member 10
CARD14 caspase recruitment domain family, member 14
CASC3 cancer susceptibility candidate 3
CCDC132 coiled-coil domain containing 132
CCDC150 coiled-coil domain containing 150
CCDC183 coiled-coil domain containing 183
CD53 CD53 molecule
CEP192 centrosomal protein 192kDa
CGNL1 cingulin-like 1
CIR1 corepressor interacting with RBPJ, 1
CIT citron rho-interacting serine/threonine kinase
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COMMD4 COMM domain containing 4
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)
CROCC ciliary rootlet coiled-coil, rootletin
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DCAF4L2 DDB1 and CUL4 associated factor 4-like 2
DCPS decapping enzyme, scavenger
DENND5B DENN/MADD domain containing 5B
DET1 de-etiolated homolog 1 (Arabidopsis)
DFNB31 deafness, autosomal recessive 31
DLG1 discs, large homolog 1 (Drosophila)
DMD dystrophin
DNAH11 dynein, axonemal, heavy chain 11
DOCK9 dedicator of cytokinesis 9
DPP8 dipeptidyl-peptidase 8
DUSP2 dual specificity phosphatase 2
DVL3 dishevelled segment polarity protein 3
EGR3 early growth response 3
EIF2A eukaryotic translation initiation factor 2A, 65kDa
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
EPHB6 EPH receptor B6
EPSTI1 epithelial stromal interaction 1 (breast)
ESYT2 extended synaptotagmin-like protein 2
EVC2 Ellis van Creveld syndrome 2
EVL Enah/Vasp-like
EZR ezrin
FAM111B family with sequence similarity 111, member B
FAM221A family with sequence similarity 221, member A
FAM83B family with sequence similarity 83, member B
FASN fatty acid synthase
FASTKD2 FAST kinase domains 2
FBXL12 F-box and leucine-rich repeat protein 12
FBXO17 F-box protein 17
FBXW8 F-box and WD repeat domain containing 8
FMNL3 formin-like 3
FOXP4 forkhead box P4
FYN FYN proto-oncogene, Src family tyrosine kinase
GATA2 GATA binding protein 2
GLI4 GLI family zinc finger 4
GMPPA GDP-mannose pyrophosphorylase A
GON4L gon-4-like (C. elegans)
GXYLT1 glucoside xylosyltransferase 1
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HES1 hes family bHLH transcription factor 1
HEXIM2 hexamethylene bis-acetamide inducible 2
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
ICE1 interactor of little elongation complex ELL subunit 1
IFT172 intraflagellar transport 172
INO80E INO80 complex subunit E
INPP1 inositol polyphosphate-1-phosphatase
INTS6 integrator complex subunit 6
IRF4 interferon regulatory factor 4
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JAK2 Janus kinase 2
KANK1 KN motif and ankyrin repeat domains 1
KANK4 KN motif and ankyrin repeat domains 4
KCNK1 potassium channel, two pore domain subfamily K, member 1
KEAP1 kelch-like ECH-associated protein 1
KIAA0040 KIAA0040
KIAA0556 KIAA0556
KIAA2018 KIAA2018
KIDINS220 kinase D-interacting substrate, 220kDa
KIF13B kinesin family member 13B
KIF16B kinesin family member 16B
KIF21A kinesin family member 21A
KLK10 kallikrein-related peptidase 10
KREMEN1 kringle containing transmembrane protein 1
KRIT1 KRIT1, ankyrin repeat containing
KRT73 keratin 73, type II
KRT75 keratin 75, type II
KRT79 keratin 79, type II
KRT84 keratin 84, type II
LACE1 lactation elevated 1
LAT linker for activation of T cells
LATS2 large tumor suppressor kinase 2
LCMT2 leucine carboxyl methyltransferase 2
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LNX2 ligand of numb-protein X 2
LRP1 low density lipoprotein receptor-related protein 1
LRP5 low density lipoprotein receptor-related protein 5
LYST lysosomal trafficking regulator
MAPK14 mitogen-activated protein kinase 14
MCM3AP minichromosome maintenance complex component 3 associated protein
MED13L mediator complex subunit 13-like
MEF2A myocyte enhancer factor 2A
MFSD8 major facilitator superfamily domain containing 8
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIER3 mesoderm induction early response 1, family member 3
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MTMR6 myotubularin related protein 6
MUC16 mucin 16, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYO1E myosin IE
NALCN sodium leak channel, non selective
NAP1L2 nucleosome assembly protein 1-like 2
NCAPD3 non-SMC condensin II complex, subunit D3
NHEJ1 nonhomologous end-joining factor 1
NID2 nidogen 2 (osteonidogen)
NKX1-2 NK1 homeobox 2
NOL11 nucleolar protein 11
NOL8 nucleolar protein 8
NT5C3B 5'-nucleotidase, cytosolic IIIB
NT5DC2 5'-nucleotidase domain containing 2
NUP54 nucleoporin 54kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OSBPL5 oxysterol binding protein-like 5
PALM2-AKAP2 PALM2-AKAP2 readthrough
PAM peptidylglycine alpha-amidating monooxygenase
PARP8 poly (ADP-ribose) polymerase family, member 8
PBX3 pre-B-cell leukemia homeobox 3
PCNXL3 pecanex-like 3 (Drosophila)
PER1 period circadian clock 1
PFKP phosphofructokinase, platelet
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PLBD2 phospholipase B domain containing 2
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLXNB2 plexin B2
PLXNB3 plexin B3
PODXL podocalyxin-like
PPIE peptidylprolyl isomerase E (cyclophilin E)
PQLC1 PQ loop repeat containing 1
PRDX2 peroxiredoxin 2
PRKD2 protein kinase D2
PTPN9 protein tyrosine phosphatase, non-receptor type 9
PTPRG protein tyrosine phosphatase, receptor type, G
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAP1GAP2 RAP1 GTPase activating protein 2
RAP2B RAP2B, member of RAS oncogene family
RASA2 RAS p21 protein activator 2
RASA3 RAS p21 protein activator 3
RASEF RAS and EF-hand domain containing
RAVER1 ribonucleoprotein, PTB-binding 1
RBM14-RBM4 RBM14-RBM4 readthrough
RBM15B RNA binding motif protein 15B
RBM28 RNA binding motif protein 28
RBM39 RNA binding motif protein 39
RBM4 RNA binding motif protein 4
RGS14 regulator of G-protein signaling 14
RIN3 Ras and Rab interactor 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
ROGDI rogdi homolog (Drosophila)
RUSC2 RUN and SH3 domain containing 2
RUVBL1 RuvB-like AAA ATPase 1
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SETX senataxin
SF3A1 splicing factor 3a, subunit 1, 120kDa
SH3PXD2A SH3 and PX domains 2A
SH3RF2 SH3 domain containing ring finger 2
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SKA3 spindle and kinetochore associated complex subunit 3
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMC2 structural maintenance of chromosomes 2
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SMTN smoothelin
SORBS1 sorbin and SH3 domain containing 1
SRSF7 serine/arginine-rich splicing factor 7
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
STK11 serine/threonine kinase 11
SYCP2 synaptonemal complex protein 2
TADA2B transcriptional adaptor 2B
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TBL3 transducin (beta)-like 3
TCHH trichohyalin
TMEM131 transmembrane protein 131
TMTC4 transmembrane and tetratricopeptide repeat containing 4
TNXB tenascin XB
TP53 tumor protein p53
TP53INP1 tumor protein p53 inducible nuclear protein 1
TPR translocated promoter region, nuclear basket protein
TRIM17 tripartite motif containing 17
TRIM37 tripartite motif containing 37
TSPAN12 tetraspanin 12
TTC31 tetratricopeptide repeat domain 31
TTN titin
TXLNG taxilin gamma
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UNC5B unc-5 homolog B (C. elegans)
USP31 ubiquitin specific peptidase 31
USP37 ubiquitin specific peptidase 37
VARS valyl-tRNA synthetase
WBSCR28 Williams-Beuren syndrome chromosome region 28
WDR74 WD repeat domain 74
WDR83 WD repeat domain 83
WNK1 WNK lysine deficient protein kinase 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB10 zinc finger and BTB domain containing 10
ZBTB37 zinc finger and BTB domain containing 37
ZC3H13 zinc finger CCCH-type containing 13
ZFP91 ZFP91 zinc finger protein
ZNF274 zinc finger protein 274
ZNF365 zinc finger protein 365
ZNF414 zinc finger protein 414
ZRANB2 zinc finger, RAN-binding domain containing 2
ZZZ3 zinc finger, ZZ-type containing 3