NCI-H2106 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: large cell neuro- endocrine carcinoma (lung primary) (Cell Line Ontology, CLO_0008050)
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Genes

386 genes mutated in the NCI-H2106 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACAD10 acyl-CoA dehydrogenase family, member 10
ADAM32 ADAM metallopeptidase domain 32
ADGRB3 adhesion G protein-coupled receptor B3
ADGRL1 adhesion G protein-coupled receptor L1
ADGRL3 adhesion G protein-coupled receptor L3
AFMID arylformamidase
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AGMO alkylglycerol monooxygenase
AKAP8 A kinase (PRKA) anchor protein 8
ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase
ALMS1 Alstrom syndrome protein 1
AMER1 APC membrane recruitment protein 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKRD46 ankyrin repeat domain 46
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
APLP1 amyloid beta (A4) precursor-like protein 1
AQR aquarius intron-binding spliceosomal factor
ARF3 ADP-ribosylation factor 3
ARHGAP23 Rho GTPase activating protein 23
ARHGAP29 Rho GTPase activating protein 29
ARHGAP5 Rho GTPase activating protein 5
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARID1A AT rich interactive domain 1A (SWI-like)
ARID1B AT rich interactive domain 1B (SWI1-like)
ARMC9 armadillo repeat containing 9
ARMCX3 armadillo repeat containing, X-linked 3
ARRB2 arrestin, beta 2
ASCC2 activating signal cointegrator 1 complex subunit 2
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATG2A autophagy related 2A
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
AUTS2 autism susceptibility candidate 2
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BAZ1A bromodomain adjacent to zinc finger domain, 1A
C19ORF47 chromosome 19 open reading frame 47
C19ORF70 chromosome 19 open reading frame 70
C5ORF56 chromosome 5 open reading frame 56
C9ORF89 chromosome 9 open reading frame 89
CAB39L calcium binding protein 39-like
CABIN1 calcineurin binding protein 1
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CADM2 cell adhesion molecule 2
CADM4 cell adhesion molecule 4
CADPS2 Ca++-dependent secretion activator 2
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAPN2 calpain 2, (m/II) large subunit
CAPZB capping protein (actin filament) muscle Z-line, beta
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CC2D1B coiled-coil and C2 domain containing 1B
CC2D2A coiled-coil and C2 domain containing 2A
CCDC174 coiled-coil domain containing 174
CCKBR cholecystokinin B receptor
CCPG1 cell cycle progression 1
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CDC45 cell division cycle 45
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
CDH24 cadherin 24, type 2
CDK8 cyclin-dependent kinase 8
CECR2 cat eye syndrome chromosome region, candidate 2
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CEP295 centrosomal protein 295kDa
CHD1 chromodomain helicase DNA binding protein 1
CHD7 chromodomain helicase DNA binding protein 7
CHUK conserved helix-loop-helix ubiquitous kinase
CIAO1 cytosolic iron-sulfur assembly component 1
CLDN12 claudin 12
CLGN calmegin
CLHC1 clathrin heavy chain linker domain containing 1
CLUAP1 clusterin associated protein 1
CNOT10 CCR4-NOT transcription complex, subunit 10
CNTNAP5 contactin associated protein-like 5
COL1A1 collagen, type I, alpha 1
CREBBP CREB binding protein
CRHR1 corticotropin releasing hormone receptor 1
CTBP1 C-terminal binding protein 1
CTIF CBP80/20-dependent translation initiation factor
CTNNA2 catenin (cadherin-associated protein), alpha 2
CTNND2 catenin (cadherin-associated protein), delta 2
CUL1 cullin 1
CUL7 cullin 7
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
DAAM1 dishevelled associated activator of morphogenesis 1
DAPK3 death-associated protein kinase 3
DCAF11 DDB1 and CUL4 associated factor 11
DDR1 discoidin domain receptor tyrosine kinase 1
DGCR8 DGCR8 microprocessor complex subunit
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DICER1 dicer 1, ribonuclease type III
DIDO1 death inducer-obliterator 1
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila)
DMD dystrophin
DMXL1 Dmx-like 1
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DNHD1 dynein heavy chain domain 1
DOCK10 dedicator of cytokinesis 10
DOCK7 dedicator of cytokinesis 7
DOPEY1 dopey family member 1
DPP6 dipeptidyl-peptidase 6
DPP7 dipeptidyl-peptidase 7
DPP8 dipeptidyl-peptidase 8
DRGX dorsal root ganglia homeobox
DSP desmoplakin
DUSP23 dual specificity phosphatase 23
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
DYSF dysferlin
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4
ELAC1 elaC ribonuclease Z 1
ELL elongation factor RNA polymerase II
EME1 essential meiotic structure-specific endonuclease 1
ERF Ets2 repressor factor
EXD2 exonuclease 3'-5' domain containing 2
FAM111B family with sequence similarity 111, member B
FAM120B family with sequence similarity 120B
FAM179B family with sequence similarity 179, member B
FAM208B family with sequence similarity 208, member B
FARSB phenylalanyl-tRNA synthetase, beta subunit
FBXW9 F-box and WD repeat domain containing 9
FIGNL1 fidgetin-like 1
FMNL2 formin-like 2
FNDC3A fibronectin type III domain containing 3A
FOXP1 forkhead box P1
FRAS1 Fraser extracellular matrix complex subunit 1
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GAS2L3 growth arrest-specific 2 like 3
GEMIN5 gem (nuclear organelle) associated protein 5
GNL2 guanine nucleotide binding protein-like 2 (nucleolar)
GPR1 G protein-coupled receptor 1
GPR158 G protein-coupled receptor 158
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPRIN1 G protein regulated inducer of neurite outgrowth 1
GRK5 G protein-coupled receptor kinase 5
GSTT1 glutathione S-transferase theta 1
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GTSE1 G-2 and S-phase expressed 1
HAGH hydroxyacylglutathione hydrolase
HAUS5 HAUS augmin-like complex, subunit 5
HBP1 HMG-box transcription factor 1
HELQ helicase, POLQ-like
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HMOX2 heme oxygenase 2
HOXC10 homeobox C10
HSPG2 heparan sulfate proteoglycan 2
HUNK hormonally up-regulated Neu-associated kinase
INTS3 integrator complex subunit 3
INTS7 integrator complex subunit 7
IPO11 importin 11
IRF1 interferon regulatory factor 1
JAG1 jagged 1
JAKMIP1 janus kinase and microtubule interacting protein 1
JRK Jrk homolog (mouse)
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1
KDM2B lysine (K)-specific demethylase 2B
KDM3B lysine (K)-specific demethylase 3B
KDM4C lysine (K)-specific demethylase 4C
KHK ketohexokinase (fructokinase)
KIAA0586 KIAA0586
KIF13B kinesin family member 13B
KIF14 kinesin family member 14
KIF19 kinesin family member 19
KIF3B kinesin family member 3B
KMT2A lysine (K)-specific methyltransferase 2A
KNTC1 kinetochore associated 1
KRIT1 KRIT1, ankyrin repeat containing
LARP6 La ribonucleoprotein domain family, member 6
LHX2 LIM homeobox 2
LIMD1 LIM domains containing 1
LOH12CR1 loss of heterozygosity, 12, chromosomal region 1
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRP6 low density lipoprotein receptor-related protein 6
LRRC26 leucine rich repeat containing 26
LRRC8A leucine rich repeat containing 8 family, member A
LRRN3 leucine rich repeat neuronal 3
LUC7L LUC7-like (S. cerevisiae)
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3
MAN2B1 mannosidase, alpha, class 2B, member 1
MANEAL mannosidase, endo-alpha-like
MAP1S microtubule-associated protein 1S
MAP2 microtubule-associated protein 2
MAP7D1 MAP7 domain containing 1
MAPK11 mitogen-activated protein kinase 11
MCM3 minichromosome maintenance complex component 3
MCM9 minichromosome maintenance complex component 9
MED13 mediator complex subunit 13
METTL16 methyltransferase like 16
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
MKL1 megakaryoblastic leukemia (translocation) 1
MOB3B MOB kinase activator 3B
MON2 MON2 homolog (S. cerevisiae)
MPST mercaptopyruvate sulfurtransferase
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MRPL37 mitochondrial ribosomal protein L37
MUTYH mutY homolog
MYO9A myosin IXA
MYT1 myelin transcription factor 1
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NAGA N-acetylgalactosaminidase, alpha-
NAMPT nicotinamide phosphoribosyltransferase
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma
NBEAL1 neurobeachin-like 1
NCKAP5L NCK-associated protein 5-like
NCOA3 nuclear receptor coactivator 3
NCOR2 nuclear receptor corepressor 2
NEK9 NIMA-related kinase 9
NELFE negative elongation factor complex member E
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NGEF neuronal guanine nucleotide exchange factor
NISCH nischarin
NKAIN2 Na+/K+ transporting ATPase interacting 2
NOL4 nucleolar protein 4
NQO2 NAD(P)H dehydrogenase, quinone 2
NRXN1 neurexin 1
NUMBL numb homolog (Drosophila)-like
OCIAD2 OCIA domain containing 2
OCRL oculocerebrorenal syndrome of Lowe
OSBP2 oxysterol binding protein 2
PALB2 partner and localizer of BRCA2
PC pyruvate carboxylase
PCBP3 poly(rC) binding protein 3
PCDHA2 protocadherin alpha 2
PHF2 PHD finger protein 2
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PIAS3 protein inhibitor of activated STAT, 3
PIGG phosphatidylinositol glycan anchor biosynthesis, class G
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLA2G4F phospholipase A2, group IVF
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POGZ pogo transposable element with ZNF domain
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLL polymerase (DNA directed), lambda
POMT1 protein-O-mannosyltransferase 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP6R1 protein phosphatase 6, regulatory subunit 1
PRDX1 peroxiredoxin 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTCHD2 patched domain containing 2
QRFPR pyroglutamylated RFamide peptide receptor
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RAP1A RAP1A, member of RAS oncogene family
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RBM26 RNA binding motif protein 26
RC3H2 ring finger and CCCH-type domains 2
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
REXO1 REX1, RNA exonuclease 1 homolog (S. cerevisiae)
REXO2 RNA exonuclease 2
RGS3 regulator of G-protein signaling 3
RIBC2 RIB43A domain with coiled-coils 2
RIF1 replication timing regulatory factor 1
RIMS2 regulating synaptic membrane exocytosis 2
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNMT RNA (guanine-7-) methyltransferase
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPL18 ribosomal protein L18
RPUSD1 RNA pseudouridylate synthase domain containing 1
RWDD2B RWD domain containing 2B
SAV1 salvador family WW domain containing protein 1
SCN3A sodium channel, voltage gated, type III alpha subunit
SDR42E1 short chain dehydrogenase/reductase family 42E, member 1
SEC16A SEC16 homolog A (S. cerevisiae)
SEC31A SEC31 homolog A (S. cerevisiae)
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
SENP7 SUMO1/sentrin specific peptidase 7
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SETD1A SET domain containing 1A
SETD2 SET domain containing 2
SETD3 SET domain containing 3
SEZ6 seizure related 6 homolog (mouse)
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SLC22A15 solute carrier family 22, member 15
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5
SLC30A7 solute carrier family 30 (zinc transporter), member 7
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC35D3 solute carrier family 35, member D3
SLC4A11 solute carrier family 4, sodium borate transporter, member 11
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNAP25 synaptosomal-associated protein, 25kDa
SNX19 sorting nexin 19
SOGA1 suppressor of glucose, autophagy associated 1
SPAG5 sperm associated antigen 5
SPIN4 spindlin family, member 4
SPINT1 serine peptidase inhibitor, Kunitz type 1
SRCAP Snf2-related CREBBP activator protein
SRCIN1 SRC kinase signaling inhibitor 1
SRRM4 serine/arginine repetitive matrix 4
ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
STON2 stonin 2
SUCLG1 succinate-CoA ligase, alpha subunit
SYMPK symplekin
SYNE2 spectrin repeat containing, nuclear envelope 2
SYNM synemin, intermediate filament protein
SYT2 synaptotagmin II
SYT5 synaptotagmin V
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TACC3 transforming, acidic coiled-coil containing protein 3
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
TAOK3 TAO kinase 3
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCP10L t-complex 10-like
TDP1 tyrosyl-DNA phosphodiesterase 1
TENM3 teneurin transmembrane protein 3
TEX15 testis expressed 15
TFR2 transferrin receptor 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLN1 talin 1
TMEM106C transmembrane protein 106C
TMEM108 transmembrane protein 108
TMEM151A transmembrane protein 151A
TMEM214 transmembrane protein 214
TMEM222 transmembrane protein 222
TMEM8A transmembrane protein 8A
TNRC6B trinucleotide repeat containing 6B
TNS3 tensin 3
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase
TRIO trio Rho guanine nucleotide exchange factor
TRIP11 thyroid hormone receptor interactor 11
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae)
TSC22D1 TSC22 domain family, member 1
TSFM Ts translation elongation factor, mitochondrial
TTC28 tetratricopeptide repeat domain 28
TTC7A tetratricopeptide repeat domain 7A
TTI1 TELO2 interacting protein 1
TTLL1 tubulin tyrosine ligase-like family member 1
TTLL5 tubulin tyrosine ligase-like family member 5
TWF2 twinfilin actin binding protein 2
UBQLN4 ubiquilin 4
UFL1 UFM1-specific ligase 1
UHRF1BP1 UHRF1 binding protein 1
UNC13B unc-13 homolog B (C. elegans)
UNC80 unc-80 homolog (C. elegans)
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
USF2 upstream transcription factor 2, c-fos interacting
USP20 ubiquitin specific peptidase 20
VARS valyl-tRNA synthetase
VLDLR very low density lipoprotein receptor
VPS13B vacuolar protein sorting 13 homolog B (yeast)
VWA5B2 von Willebrand factor A domain containing 5B2
WDR7 WD repeat domain 7
WNK2 WNK lysine deficient protein kinase 2
WNT6 wingless-type MMTV integration site family, member 6
WTAP Wilms tumor 1 associated protein
ZBED4 zinc finger, BED-type containing 4
ZC3H13 zinc finger CCCH-type containing 13
ZC3H14 zinc finger CCCH-type containing 14
ZC3H4 zinc finger CCCH-type containing 4
ZFP36L2 ZFP36 ring finger protein-like 2
ZFP64 ZFP64 zinc finger protein
ZFYVE1 zinc finger, FYVE domain containing 1
ZHX3 zinc fingers and homeoboxes 3
ZNF101 zinc finger protein 101
ZNF213 zinc finger protein 213
ZNF217 zinc finger protein 217
ZNF264 zinc finger protein 264
ZNF286B zinc finger protein 286B
ZNF33A zinc finger protein 33A
ZNF343 zinc finger protein 343
ZNF415 zinc finger protein 415
ZNF444 zinc finger protein 444
ZNF467 zinc finger protein 467
ZNF501 zinc finger protein 501
ZNF583 zinc finger protein 583
ZNF616 zinc finger protein 616
ZNF629 zinc finger protein 629
ZNF74 zinc finger protein 74
ZNF804A zinc finger protein 804A
ZNF839 zinc finger protein 839
ZNHIT6 zinc finger, HIT-type containing 6