NCI-H2085 Gene Set

Dataset COSMIC Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: adenocarcinoma; non-small cell lung cancer (Cell Line Ontology, CLO_0008047)
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Genes

438 genes mutated in the NCI-H2085 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABHD17A abhydrolase domain containing 17A
ABI3BP ABI family, member 3 (NESH) binding protein
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACOT12 acyl-CoA thioesterase 12
ACOX1 acyl-CoA oxidase 1, palmitoyl
ACTN2 actinin, alpha 2
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADAMTSL4 ADAMTS-like 4
ADCY2 adenylate cyclase 2 (brain)
ADGRL3 adhesion G protein-coupled receptor L3
AFF1 AF4/FMR2 family, member 1
AFF3 AF4/FMR2 family, member 3
AK9 adenylate kinase 9
AKAP11 A kinase (PRKA) anchor protein 11
AKAP9 A kinase (PRKA) anchor protein 9
ALG3 ALG3, alpha-1,3- mannosyltransferase
ANK1 ankyrin 1, erythrocytic
ANKRD12 ankyrin repeat domain 12
ANKRD33 ankyrin repeat domain 33
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
APOB apolipoprotein B
ARL8A ADP-ribosylation factor-like 8A
ARMCX2 armadillo repeat containing, X-linked 2
ASB12 ankyrin repeat and SOCS box containing 12
ASTN2 astrotactin 2
ATG13 autophagy related 13
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
ATP8B4 ATPase, class I, type 8B, member 4
BACE2 beta-site APP-cleaving enzyme 2
BAIAP2 BAI1-associated protein 2
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BCL6B B-cell CLL/lymphoma 6, member B
BEND4 BEN domain containing 4
BIRC7 baculoviral IAP repeat containing 7
C2CD3 C2 calcium-dependent domain containing 3
C9 complement component 9
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CALCR calcitonin receptor
CAPNS1 calpain, small subunit 1
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC129 coiled-coil domain containing 129
CCDC160 coiled-coil domain containing 160
CCDC37 coiled-coil domain containing 37
CCDC42B coiled-coil domain containing 42B
CCL2 chemokine (C-C motif) ligand 2
CCNB3 cyclin B3
CD248 CD248 molecule, endosialin
CD38 CD38 molecule
CDC16 cell division cycle 16
CDC25A cell division cycle 25A
CDH7 cadherin 7, type 2
CDSN corneodesmosin
CFAP43 cilia and flagella associated protein 43
CFAP70 cilia and flagella associated protein 70
CIT citron rho-interacting serine/threonine kinase
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKAP2L cytoskeleton associated protein 2-like
CLEC1A C-type lectin domain family 1, member A
CLIC6 chloride intracellular channel 6
CLIP3 CAP-GLY domain containing linker protein 3
CLPTM1 cleft lip and palate associated transmembrane protein 1
CLUH clustered mitochondria (cluA/CLU1) homolog
CLYBL citrate lyase beta like
CNTNAP4 contactin associated protein-like 4
COG5 component of oligomeric golgi complex 5
COL11A1 collagen, type XI, alpha 1
COL13A1 collagen, type XIII, alpha 1
COL5A2 collagen, type V, alpha 2
COPG1 coatomer protein complex, subunit gamma 1
COPS7A COP9 signalosome subunit 7A
CORO2B coronin, actin binding protein, 2B
CPEB2 cytoplasmic polyadenylation element binding protein 2
CPZ carboxypeptidase Z
CREB3L2 cAMP responsive element binding protein 3-like 2
CREB5 cAMP responsive element binding protein 5
CSF1R colony stimulating factor 1 receptor
CSMD1 CUB and Sushi multiple domains 1
CSPG4 chondroitin sulfate proteoglycan 4
CUL4A cullin 4A
DCLK1 doublecortin-like kinase 1
DCST1 DC-STAMP domain containing 1
DCST2 DC-STAMP domain containing 2
DET1 de-etiolated homolog 1 (Arabidopsis)
DIS3L2 DIS3 like 3'-5' exoribonuclease 2
DMAP1 DNA methyltransferase 1 associated protein 1
DNAAF2 dynein, axonemal, assembly factor 2
DOK3 docking protein 3
DOPEY2 dopey family member 2
DRD5 dopamine receptor D5
DSCAM Down syndrome cell adhesion molecule
DTNA dystrobrevin, alpha
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
EAF1 ELL associated factor 1
ECE2 endothelin converting enzyme 2
EFCAB5 EF-hand calcium binding domain 5
EID2 EP300 interacting inhibitor of differentiation 2
EID2B EP300 interacting inhibitor of differentiation 2B
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELMO1 engulfment and cell motility 1
ELMOD1 ELMO/CED-12 domain containing 1
EPS15 epidermal growth factor receptor pathway substrate 15
ERCC3 excision repair cross-complementation group 3
EXD2 exonuclease 3'-5' domain containing 2
EZR ezrin
FAM104B family with sequence similarity 104, member B
FAM135B family with sequence similarity 135, member B
FAM13C family with sequence similarity 13, member C
FAM160A2 family with sequence similarity 160, member A2
FAM168B family with sequence similarity 168, member B
FAM170A family with sequence similarity 170, member A
FAM171B family with sequence similarity 171, member B
FAM177B family with sequence similarity 177, member B
FAM208A family with sequence similarity 208, member A
FAM213B family with sequence similarity 213, member B
FAM46D family with sequence similarity 46, member D
FAM65B family with sequence similarity 65, member B
FAM73A family with sequence similarity 73, member A
FASTK Fas-activated serine/threonine kinase
FAT3 FAT atypical cadherin 3
FBLN2 fibulin 2
FBN1 fibrillin 1
FBXW12 F-box and WD repeat domain containing 12
FCGBP Fc fragment of IgG binding protein
FCRL3 Fc receptor-like 3
FCRLA Fc receptor-like A
FERD3L Fer3-like bHLH transcription factor
FGD6 FYVE, RhoGEF and PH domain containing 6
FIG4 FIG4 phosphoinositide 5-phosphatase
FLRT1 fibronectin leucine rich transmembrane protein 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FLT1 fms-related tyrosine kinase 1
FMR1 fragile X mental retardation 1
FOLH1B folate hydrolase 1B
FOXB1 forkhead box B1
FOXI2 forkhead box I2
FSCN3 fascin actin-bundling protein 3, testicular
FUBP1 far upstream element (FUSE) binding protein 1
FXR2 fragile X mental retardation, autosomal homolog 2
FZD10 frizzled class receptor 10
G0S2 G0/G1 switch 2
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6
GAS2L3 growth arrest-specific 2 like 3
GCM1 glial cells missing homolog 1 (Drosophila)
GCSH glycine cleavage system protein H (aminomethyl carrier)
GIGYF2 GRB10 interacting GYF protein 2
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GK2 glycerol kinase 2
GLB1L3 galactosidase, beta 1-like 3
GLI3 GLI family zinc finger 3
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPN1 GPN-loop GTPase 1
GPNMB glycoprotein (transmembrane) nmb
GPR148 G protein-coupled receptor 148
GPR152 G protein-coupled receptor 152
GRHL2 grainyhead-like 2 (Drosophila)
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIK2 glutamate receptor, ionotropic, kainate 2
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GSTA1 glutathione S-transferase alpha 1
GSTM5 glutathione S-transferase mu 5
GUCA2A guanylate cyclase activator 2A (guanylin)
HDC histidine decarboxylase
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HEPHL1 hephaestin-like 1
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
HIST1H2AC histone cluster 1, H2ac
HPD 4-hydroxyphenylpyruvate dioxygenase
HPS3 Hermansky-Pudlak syndrome 3
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HYDIN HYDIN, axonemal central pair apparatus protein
IGSF10 immunoglobulin superfamily, member 10
IL17RC interleukin 17 receptor C
IL1RAPL1 interleukin 1 receptor accessory protein-like 1
IRF3 interferon regulatory factor 3
ITGA8 integrin, alpha 8
ITPKB inositol-trisphosphate 3-kinase B
ITSN1 intersectin 1 (SH3 domain protein)
JADE2 jade family PHD finger 2
JUP junction plakoglobin
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8
KCNK15 potassium channel, two pore domain subfamily K, member 15
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0319L KIAA0319-like
KIF1A kinesin family member 1A
KIF20B kinesin family member 20B
KIF7 kinesin family member 7
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KLRG2 killer cell lectin-like receptor subfamily G, member 2
KRTAP25-1 keratin associated protein 25-1
LAMA2 laminin, alpha 2
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LIPC lipase, hepatic
LMO7 LIM domain 7
LPPR4 lipid phosphate phosphatase-related protein type 4
LPPR5 lipid phosphate phosphatase-related protein type 5
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRFN5 leucine rich repeat and fibronectin type III domain containing 5
LRP1 low density lipoprotein receptor-related protein 1
LRP1B low density lipoprotein receptor-related protein 1B
LRRC14B leucine rich repeat containing 14B
LRRC3B leucine rich repeat containing 3B
LRRTM1 leucine rich repeat transmembrane neuronal 1
LRRTM3 leucine rich repeat transmembrane neuronal 3
LYN LYN proto-oncogene, Src family tyrosine kinase
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAML1 mastermind-like 1 (Drosophila)
MATK megakaryocyte-associated tyrosine kinase
MATN3 matrilin 3
MCM8 minichromosome maintenance complex component 8
MED12L mediator complex subunit 12-like
MED14 mediator complex subunit 14
MERTK MER proto-oncogene, tyrosine kinase
MFSD9 major facilitator superfamily domain containing 9
MIOX myo-inositol oxygenase
MLXIP MLX interacting protein
MME membrane metallo-endopeptidase
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MPHOSPH9 M-phase phosphoprotein 9
MRPS18C mitochondrial ribosomal protein S18C
MTMR8 myotubularin related protein 8
MUC12 mucin 12, cell surface associated
MUC16 mucin 16, cell surface associated
MUC3A mucin 3A, cell surface associated
MUC3B mucin 3B, cell surface associated
MUC4 mucin 4, cell surface associated
MVD mevalonate (diphospho) decarboxylase
MYH1 myosin, heavy chain 1, skeletal muscle, adult
MYH7 myosin, heavy chain 7, cardiac muscle, beta
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYLK2 myosin light chain kinase 2
MYO15A myosin XVA
MYO16 myosin XVI
MYO19 myosin XIX
MYO3A myosin IIIA
MYT1 myelin transcription factor 1
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NBEA neurobeachin
NBEAL2 neurobeachin-like 2
NCAN neurocan
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
NEB nebulin
NEK10 NIMA-related kinase 10
NEMF nuclear export mediator factor
NF1 neurofibromin 1
NISCH nischarin
NLRP12 NLR family, pyrin domain containing 12
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR5A2 nuclear receptor subfamily 5, group A, member 2
NUP98 nucleoporin 98kDa
NUSAP1 nucleolar and spindle associated protein 1
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OFCC1 orofacial cleft 1 candidate 1
OR10G7 olfactory receptor, family 10, subfamily G, member 7
OR10J5 olfactory receptor, family 10, subfamily J, member 5
OR2A7 olfactory receptor, family 2, subfamily A, member 7
OR2T3 olfactory receptor, family 2, subfamily T, member 3
OR2W1 olfactory receptor, family 2, subfamily W, member 1
OR4C5 olfactory receptor, family 4, subfamily C, member 5 (gene/pseudogene)
OR4K17 olfactory receptor, family 4, subfamily K, member 17
OR52L1 olfactory receptor, family 52, subfamily L, member 1
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)
OR5A1 olfactory receptor, family 5, subfamily A, member 1
OR5I1 olfactory receptor, family 5, subfamily I, member 1
OR6N1 olfactory receptor, family 6, subfamily N, member 1
OSTN osteocrin
P2RY10 purinergic receptor P2Y, G-protein coupled, 10
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP2 poly (ADP-ribose) polymerase 2
PARS2 prolyl-tRNA synthetase 2, mitochondrial (putative)
PASK PAS domain containing serine/threonine kinase
PCDHB13 protocadherin beta 13
PCDHB3 protocadherin beta 3
PCDHGA8 protocadherin gamma subfamily A, 8
PCDHGB7 protocadherin gamma subfamily B, 7
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCLO piccolo presynaptic cytomatrix protein
PCNT pericentrin
PDE3A phosphodiesterase 3A, cGMP-inhibited
PDE4DIP phosphodiesterase 4D interacting protein
PECR peroxisomal trans-2-enoyl-CoA reductase
PEG3 paternally expressed 3
PGF placental growth factor
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEC plectin
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLG plasminogen
PLS1 plastin 1
PNPLA8 patatin-like phospholipase domain containing 8
POPDC2 popeye domain containing 2
POTEG POTE ankyrin domain family, member G
PPL periplakin
PRAMEF10 PRAME family member 10
PRDM9 PR domain containing 9
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRMT6 protein arginine methyltransferase 6
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROM2 prominin 2
PRR14 proline rich 14
PRTG protogenin
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
PTCD2 pentatricopeptide repeat domain 2
PTGFRN prostaglandin F2 receptor inhibitor
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PXYLP1 2-phosphoxylose phosphatase 1
QRICH1 glutamine-rich 1
QRICH2 glutamine rich 2
RADIL Ras association and DIL domains
RANGAP1 Ran GTPase activating protein 1
RAP1B RAP1B, member of RAS oncogene family
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1
RBM19 RNA binding motif protein 19
RBM34 RNA binding motif protein 34
RCC2 regulator of chromosome condensation 2
REG1A regenerating islet-derived 1 alpha
RFX8 RFX family member 8, lacking RFX DNA binding domain
RGN regucalcin
RGPD4 RANBP2-like and GRIP domain containing 4
RHPN2 rhophilin, Rho GTPase binding protein 2
RIPK2 receptor-interacting serine-threonine kinase 2
RIPK3 receptor-interacting serine-threonine kinase 3
RPA1 replication protein A1, 70kDa
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SCN11A sodium channel, voltage gated, type XI alpha subunit
SCN4A sodium channel, voltage gated, type IV alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDPR serum deprivation response
SERPINB12 serpin peptidase inhibitor, clade B (ovalbumin), member 12
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SI sucrase-isomaltase (alpha-glucosidase)
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SIGLEC16 sialic acid binding Ig-like lectin 16 (gene/pseudogene)
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16
SLC22A9 solute carrier family 22 (organic anion transporter), member 9
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC38A2 solute carrier family 38, member 2
SLIT1 slit homolog 1 (Drosophila)
SLITRK2 SLIT and NTRK-like family, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMC5 structural maintenance of chromosomes 5
SNRNP48 small nuclear ribonucleoprotein 48kDa (U11/U12)
SNX8 sorting nexin 8
SORBS1 sorbin and SH3 domain containing 1
SPEG SPEG complex locus
SPERT spermatid associated
SPHKAP SPHK1 interactor, AKAP domain containing
SPTA1 spectrin, alpha, erythrocytic 1
SPTB spectrin, beta, erythrocytic
SRCAP Snf2-related CREBBP activator protein
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein)
STAB1 stabilin 1
STAMBPL1 STAM binding protein-like 1
STRA6 stimulated by retinoic acid 6
STXBP5L syntaxin binding protein 5-like
SV2A synaptic vesicle glycoprotein 2A
SYCP2L synaptonemal complex protein 2-like
TAAR6 trace amine associated receptor 6
TAC1 tachykinin, precursor 1
TACC2 transforming, acidic coiled-coil containing protein 2
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TARDBP TAR DNA binding protein
TAS2R31 taste receptor, type 2, member 31
TBCE tubulin folding cofactor E
TBX3 T-box 3
TCAF2 TRPM8 channel-associated factor 2
TENM2 teneurin transmembrane protein 2
TEP1 telomerase-associated protein 1
TFCP2L1 transcription factor CP2-like 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
THAP2 THAP domain containing, apoptosis associated protein 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TMTC1 transmembrane and tetratricopeptide repeat containing 1
TNFRSF19 tumor necrosis factor receptor superfamily, member 19
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53 tumor protein p53
TPR translocated promoter region, nuclear basket protein
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TRIB2 tribbles pseudokinase 2
TRIM16 tripartite motif containing 16
TRIM56 tripartite motif containing 56
TRIM64B tripartite motif containing 64B
TSSK4 testis-specific serine kinase 4
TTLL4 tubulin tyrosine ligase-like family member 4
TTN titin
TUFM Tu translation elongation factor, mitochondrial
UFL1 UFM1-specific ligase 1
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1
USP6 ubiquitin specific peptidase 6
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
VWA3B von Willebrand factor A domain containing 3B
WDR47 WD repeat domain 47
WRN Werner syndrome, RecQ helicase-like
WRNIP1 Werner helicase interacting protein 1
XIRP1 xin actin binding repeat containing 1
ZBTB41 zinc finger and BTB domain containing 41
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZDBF2 zinc finger, DBF-type containing 2
ZIM2 zinc finger, imprinted 2
ZNF229 zinc finger protein 229
ZNF248 zinc finger protein 248
ZNF253 zinc finger protein 253
ZNF354C zinc finger protein 354C
ZNF382 zinc finger protein 382
ZNF440 zinc finger protein 440
ZNF534 zinc finger protein 534
ZNF536 zinc finger protein 536
ZNF564 zinc finger protein 564
ZNF567 zinc finger protein 567
ZNF570 zinc finger protein 570
ZNF665 zinc finger protein 665
ZNF724P zinc finger protein 724, pseudogene
ZNF770 zinc finger protein 770
ZNF841 zinc finger protein 841
ZNF90 zinc finger protein 90
ZNF92 zinc finger protein 92
ZPLD1 zona pellucida-like domain containing 1