NCI-H2081 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: carcinoma; classic small cell lung cancer (lung primary) (Cell Line Ontology, CLO_0008046)
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Genes

139 genes mutated in the NCI-H2081 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
ADGRL3 adhesion G protein-coupled receptor L3
AHCTF1 AT hook containing transcription factor 1
ANKRD11 ankyrin repeat domain 11
ANO10 anoctamin 10
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ARID5B AT rich interactive domain 5B (MRF1-like)
ARMCX1 armadillo repeat containing, X-linked 1
BECN1 beclin 1, autophagy related
BIRC6 baculoviral IAP repeat containing 6
BMP2K BMP2 inducible kinase
C18ORF8 chromosome 18 open reading frame 8
C2CD4C C2 calcium-dependent domain containing 4C
C2ORF81 chromosome 2 open reading frame 81
CADM2 cell adhesion molecule 2
CAPN15 calpain 15
CASKIN1 CASK interacting protein 1
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
CBX4 chromobox homolog 4
CCDC109B coiled-coil domain containing 109B
CCDC132 coiled-coil domain containing 132
CCDC15 coiled-coil domain containing 15
CCDC169-SOHLH2 CCDC169-SOHLH2 readthrough
CCDC18 coiled-coil domain containing 18
CCDC9 coiled-coil domain containing 9
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CD276 CD276 molecule
CDC40 cell division cycle 40
CDC7 cell division cycle 7
CDH22 cadherin 22, type 2
CEP192 centrosomal protein 192kDa
CEP350 centrosomal protein 350kDa
CFAP126 cilia and flagella associated protein 126
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CLASP1 cytoplasmic linker associated protein 1
CLDN24 claudin 24
CLSTN2 calsyntenin 2
COL3A1 collagen, type III, alpha 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUL3 cullin 3
DNHD1 dynein heavy chain domain 1
DOCK6 dedicator of cytokinesis 6
DPYD dihydropyrimidine dehydrogenase
EGFR epidermal growth factor receptor
ESRRG estrogen-related receptor gamma
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EYS eyes shut homolog (Drosophila)
FAM129A family with sequence similarity 129, member A
FAM200B family with sequence similarity 200, member B
FAM98B family with sequence similarity 98, member B
FANCL Fanconi anemia, complementation group L
FBXO11 F-box protein 11
FGFR1OP FGFR1 oncogene partner
FIGN fidgetin
FLJ22184
FMN2 formin 2
FZD9 frizzled class receptor 9
GALNT4 polypeptide N-acetylgalactosaminyltransferase 4
GARS glycyl-tRNA synthetase
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GK5 glycerol kinase 5 (putative)
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GON4L gon-4-like (C. elegans)
GPX4 glutathione peroxidase 4
GRAMD1C GRAM domain containing 1C
HAUS6 HAUS augmin-like complex, subunit 6
HSPG2 heparan sulfate proteoglycan 2
ITPKC inositol-trisphosphate 3-kinase C
KDM2B lysine (K)-specific demethylase 2B
KIF21A kinesin family member 21A
KIF5B kinesin family member 5B
KMT2D lysine (K)-specific methyltransferase 2D
LAPTM4B lysosomal protein transmembrane 4 beta
LIPT2 lipoyl(octanoyl) transferase 2 (putative)
LSG1 large 60S subunit nuclear export GTPase 1
MAN2A2 mannosidase, alpha, class 2A, member 2
MAP1S microtubule-associated protein 1S
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MECR mitochondrial trans-2-enoyl-CoA reductase
MED19 mediator complex subunit 19
MICALL1 MICAL-like 1
MOB1B MOB kinase activator 1B
MYCBPAP MYCBP associated protein
NAGA N-acetylgalactosaminidase, alpha-
NAV3 neuron navigator 3
NCAM2 neural cell adhesion molecule 2
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NCL nucleolin
NIPBL Nipped-B homolog (Drosophila)
NOP58 NOP58 ribonucleoprotein
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PARP12 poly (ADP-ribose) polymerase family, member 12
PCDHGB1 protocadherin gamma subfamily B, 1
PCNXL2 pecanex-like 2 (Drosophila)
PDIA5 protein disulfide isomerase family A, member 5
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
PNISR PNN-interacting serine/arginine-rich protein
POC1B-GALNT4 POC1B-GALNT4 readthrough
PPAT phosphoribosyl pyrophosphate amidotransferase
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PTEN phosphatase and tensin homolog
PTPRU protein tyrosine phosphatase, receptor type, U
PUM2 pumilio RNA-binding family member 2
PWWP2A PWWP domain containing 2A
RARS2 arginyl-tRNA synthetase 2, mitochondrial
RB1 retinoblastoma 1
RFX1 regulatory factor X, 1 (influences HLA class II expression)
RFX3 regulatory factor X, 3 (influences HLA class II expression)
RFXANK regulatory factor X-associated ankyrin-containing protein
RNF111 ring finger protein 111
RNF167 ring finger protein 167
SCAPER S-phase cyclin A-associated protein in the ER
SCP2 sterol carrier protein 2
SEC31A SEC31 homolog A (S. cerevisiae)
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2
STIP1 stress-induced phosphoprotein 1
TECPR1 tectonin beta-propeller repeat containing 1
TEP1 telomerase-associated protein 1
TET1 tet methylcytosine dioxygenase 1
TEX22 testis expressed 22
TMEM176A transmembrane protein 176A
TMEM87A transmembrane protein 87A
TRIM11 tripartite motif containing 11
TRIM13 tripartite motif containing 13
TRIM21 tripartite motif containing 21
TRIP12 thyroid hormone receptor interactor 12
TTN titin
UHMK1 U2AF homology motif (UHM) kinase 1
ULK4 unc-51 like kinase 4
USP6NL USP6 N-terminal like
XAB2 XPA binding protein 2
YLPM1 YLP motif containing 1
ZBTB45 zinc finger and BTB domain containing 45
ZBTB7B zinc finger and BTB domain containing 7B
ZDHHC11 zinc finger, DHHC-type containing 11
ZKSCAN5 zinc finger with KRAB and SCAN domains 5
ZNF264 zinc finger protein 264
ZNF609 zinc finger protein 609
ZNF678 zinc finger protein 678
ZNF804A zinc finger protein 804A