NCI-H2073 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: adenocarcinoma; non-small cell lung cancer (Cell Line Ontology, CLO_0008045)
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Genes

153 genes mutated in the NCI-H2073 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
AADAC arylacetamide deacetylase
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4
ACIN1 apoptotic chromatin condensation inducer 1
ACTN4 actinin, alpha 4
AGRN agrin
ANKRD12 ankyrin repeat domain 12
ANKRD13A ankyrin repeat domain 13A
ANKRD13B ankyrin repeat domain 13B
ANKRD26 ankyrin repeat domain 26
APLP2 amyloid beta (A4) precursor-like protein 2
AQR aquarius intron-binding spliceosomal factor
ARID5B AT rich interactive domain 5B (MRF1-like)
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATE1 arginyltransferase 1
B9D2 B9 protein domain 2
BBS10 Bardet-Biedl syndrome 10
BCL2L12 BCL2-like 12 (proline rich)
BIRC3 baculoviral IAP repeat containing 3
C10ORF76 chromosome 10 open reading frame 76
CAMKV CaM kinase-like vesicle-associated
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CAPRIN1 cell cycle associated protein 1
COL1A1 collagen, type I, alpha 1
COPS6 COP9 signalosome subunit 6
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRYL1 crystallin, lambda 1
CTH cystathionine gamma-lyase
CTNNBL1 catenin, beta like 1
DAGLA diacylglycerol lipase, alpha
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
DEPDC1B DEP domain containing 1B
DEPDC7 DEP domain containing 7
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DPF1 D4, zinc and double PHD fingers family 1
DPY19L4 dpy-19-like 4 (C. elegans)
DYSF dysferlin
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ENGASE endo-beta-N-acetylglucosaminidase
EPHB2 EPH receptor B2
ETV1 ets variant 1
FAM214B family with sequence similarity 214, member B
FAT1 FAT atypical cadherin 1
FIBCD1 fibrinogen C domain containing 1
FKBP5 FK506 binding protein 5
FLNC filamin C, gamma
GAK cyclin G associated kinase
GFOD1 glucose-fructose oxidoreductase domain containing 1
GGNBP2 gametogenetin binding protein 2
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GPC6 glypican 6
GZF1 GDNF-inducible zinc finger protein 1
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
HMG20B high mobility group 20B
HTRA2 HtrA serine peptidase 2
HYOU1 hypoxia up-regulated 1
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1
INPPL1 inositol polyphosphate phosphatase-like 1
IQGAP3 IQ motif containing GTPase activating protein 3
IRS2 insulin receptor substrate 2
ITPKB inositol-trisphosphate 3-kinase B
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KIF21B kinesin family member 21B
KIF3B kinesin family member 3B
LRP5 low density lipoprotein receptor-related protein 5
MACF1 microtubule-actin crosslinking factor 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MARK4 MAP/microtubule affinity-regulating kinase 4
MDC1 mediator of DNA-damage checkpoint 1
MUC16 mucin 16, cell surface associated
MYH15 myosin, heavy chain 15
MYO9A myosin IXA
NCOA2 nuclear receptor coactivator 2
NCOR2 nuclear receptor corepressor 2
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
NEURL2 neuralized E3 ubiquitin protein ligase 2
NINL ninein-like
NIT1 nitrilase 1
NOTCH2 notch 2
NPBWR1 neuropeptides B/W receptor 1
NRDE2 NRDE-2, necessary for RNA interference, domain containing
NUP88 nucleoporin 88kDa
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OLFML2A olfactomedin-like 2A
OPLAH 5-oxoprolinase (ATP-hydrolysing)
ORAI3 ORAI calcium release-activated calcium modulator 3
PAAF1 proteasomal ATPase-associated factor 1
PARP1 poly (ADP-ribose) polymerase 1
PCDHB13 protocadherin beta 13
PCF11 PCF11 cleavage and polyadenylation factor subunit
PCGF1 polycomb group ring finger 1
PCLO piccolo presynaptic cytomatrix protein
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2
PGS1 phosphatidylglycerophosphate synthase 1
PIAS4 protein inhibitor of activated STAT, 4
PNISR PNN-interacting serine/arginine-rich protein
PRSS41 protease, serine, 41
PRX periaxin
PSME4 proteasome (prosome, macropain) activator subunit 4
PTCH1 patched 1
PTK2B protein tyrosine kinase 2 beta
PYGL phosphorylase, glycogen, liver
QRICH1 glutamine-rich 1
RBBP8 retinoblastoma binding protein 8
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RSAD2 radical S-adenosyl methionine domain containing 2
SDS serine dehydratase
SETD2 SET domain containing 2
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SMAP1 small ArfGAP 1
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12)
STAG1 stromal antigen 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STIM2 stromal interaction molecule 2
STK11 serine/threonine kinase 11
STK36 serine/threonine kinase 36
SYNJ2 synaptojanin 2
TBC1D30 TBC1 domain family, member 30
TBRG4 transforming growth factor beta regulator 4
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TEAD2 TEA domain family member 2
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TLN2 talin 2
TMEM131 transmembrane protein 131
TMEM56 transmembrane protein 56
TMEM56-RWDD3 TMEM56-RWDD3 readthrough
TNFRSF18 tumor necrosis factor receptor superfamily, member 18
TNS1 tensin 1
TP53 tumor protein p53
TRPS1 trichorhinophalangeal syndrome I
UQCC3 ubiquinol-cytochrome c reductase complex assembly factor 3
USH1C Usher syndrome 1C (autosomal recessive, severe)
VANGL1 VANGL planar cell polarity protein 1
VANGL2 VANGL planar cell polarity protein 2
WDR46 WD repeat domain 46
YME1L1 YME1-like 1 ATPase
ZBTB14 zinc finger and BTB domain containing 14
ZBTB40 zinc finger and BTB domain containing 40
ZNF263 zinc finger protein 263
ZNF292 zinc finger protein 292
ZNF33B zinc finger protein 33B
ZNF579 zinc finger protein 579
ZNF607 zinc finger protein 607
ZNF670 zinc finger protein 670
ZNF74 zinc finger protein 74
ZNF746 zinc finger protein 746
ZNF771 zinc finger protein 771
ZNF783 zinc finger family member 783
ZNF786 zinc finger protein 786