NCI-H2066 Gene Set

Dataset COSMIC Cell Line Gene CNV Profiles
Category genomics
Type cell line
Description disease: small cell lung cancer; adenocar- cinoma; squamous cell carcinoma (Cell Line Ontology, CLO_0008044)
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Genes

215 genes with high or low copy number in NCI-H2066 relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.

high copy number

Symbol Name Standardized Value
MMRN1 multimerin 1 4.51153
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 3.12177
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 3.12177
MIR320C1 microRNA 320c-1 3.12177
MIB1 mindbomb E3 ubiquitin protein ligase 1 3.12177
ABHD3 abhydrolase domain containing 3 3.12177
MIR133A1 microRNA 133a-1 3.12177
MIR1-2 microRNA 1-2 3.12177
GREB1L growth regulation by estrogen in breast cancer-like 2.93899
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 2.76305
FSCB fibrous sheath CABYR binding protein 2.59653
MKX mohawk homeobox 2.49065
MIR5586 microRNA 5586 2.49065
LYZL1 lysozyme-like 1 2.49065
ARMC4 armadillo repeat containing 4 2.49065
WAC-AS1 WAC antisense RNA 1 (head to head) 2.49065
LINC00837 long intergenic non-protein coding RNA 837 2.49065
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 2.49065
BAMBI BMP and activin membrane-bound inhibitor 2.49065
WAC WW domain containing adaptor with coiled-coil 2.49065
PTCHD3P1 patched domain containing 3 pseudogene 1 2.49065
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 2.41451
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 2.39327
CD44 CD44 molecule (Indian blood group) 2.39327
SCFD1 sec1 family domain containing 1 2.36889
LOC100506071 uncharacterized LOC100506071 2.36889
COCH cochlin 2.36889
FOXG1 forkhead box G1 2.35236
PRKD1 protein kinase D1 2.35236
MIA2 melanoma inhibitory activity 2 2.35236
MIR624 microRNA 624 2.35236
PNN pinin, desmosome associated protein 2.35236
GEMIN2 gem (nuclear organelle) associated protein 2 2.35236
EGLN3 egl-9 family hypoxia-inducible factor 3 2.35236
LINC01551 long intergenic non-protein coding RNA 1551 2.35236
SEC23A Sec23 homolog A (S. cerevisiae) 2.35236
TRAPPC6B trafficking protein particle complex 6B 2.35236
AP4S1 adaptor-related protein complex 4, sigma 1 subunit 2.35236
CFL2 cofilin 2 (muscle) 2.35236
STRN3 striatin, calmodulin binding protein 3 2.3178
BAZ1A bromodomain adjacent to zinc finger domain, 1A 2.3178
SPTSSA serine palmitoyltransferase, small subunit A 2.3178
LINC00639 long intergenic non-protein coding RNA 639 2.3178
MIR548AI microRNA 548ai 2.3178
EAPP E2F-associated phosphoprotein 2.3178
IGBP1P1 immunoglobulin (CD79A) binding protein 1 pseudogene 1 2.3178
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 2.3178
SNX6 sorting nexin 6 2.3178
SRP54 signal recognition particle 54kDa 2.3178
FAM177A1 family with sequence similarity 177, member A1 2.3178
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 2.30944
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma 2.30944
KIAA0391 KIAA0391 2.30944
SSTR1 somatostatin receptor 1 2.30944
CLEC14A C-type lectin domain family 14, member A 2.30944
DTD2 D-tyrosyl-tRNA deacylase 2 (putative) 2.283
FOXA1 forkhead box A1 2.283
MIR4503 microRNA 4503 2.283
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.283
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 2.283
HEATR5A HEAT repeat containing 5A 2.283
AKAP6 A kinase (PRKA) anchor protein 6 2.283
TSPAN13 tetraspanin 13 2.26395
PTCSC3 papillary thyroid carcinoma susceptibility candidate 3 (non-protein coding) 2.26395
NUBPL nucleotide binding protein-like 2.26395
AGR3 anterior gradient 3 2.26395
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 2.26395
LINC00609 long intergenic non-protein coding RNA 609 2.26395
TTC6 tetratricopeptide repeat domain 6 2.26395
BRMS1L breast cancer metastasis-suppressor 1-like 2.26395
INSM2 insulinoma-associated 2 2.26395
AGR2 anterior gradient 2 2.26395
ARHGAP5-AS1 ARHGAP5 antisense RNA 1 (head to head) 2.26395
ARHGAP5 Rho GTPase activating protein 5 2.26395
PAX9 paired box 9 2.25904
SLC25A21-AS1 SLC25A21 antisense RNA 1 2.25904
NKX2-1 NK2 homeobox 1 2.25904
NKX2-8 NK2 homeobox 8 2.25904
LRRC72 leucine rich repeat containing 72 2.25904
ANKMY2 ankyrin repeat and MYND domain containing 2 2.25904
SOSTDC1 sclerostin domain containing 1 2.25904
MIPOL1 mirror-image polydactyly 1 2.25904
MBIP MAP3K12 binding inhibitory protein 1 2.24845
SFTA3 surfactant associated 3 2.24845
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 2.2355
DPPA3 developmental pluripotency associated 3 2.22917
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B 2.22123
LRRC14B leucine rich repeat containing 14B 2.22123
EXOC3-AS1 EXOC3 antisense RNA 1 2.21727
LOC100506688 uncharacterized LOC100506688 2.21727
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 2.21727
CCDC127 coiled-coil domain containing 127 2.21727
NKD2 naked cuticle homolog 2 (Drosophila) 2.21727
PDCD6 programmed cell death 6 2.21727
CLPTM1L CLPTM1-like 2.21727
AHRR aryl-hydrocarbon receptor repressor 2.21727
MIR4457 microRNA 4457 2.21727
MIR4635 microRNA 4635 2.21727
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 2.21727
MIR4277 microRNA 4277 2.21258
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.21258
MRPL36 mitochondrial ribosomal protein L36 2.21258
MIR4456 microRNA 4456 2.21258
LOC100996325 uncharacterized LOC100996325 2.21258
TPPP tubulin polymerization promoting protein 2.21258
TRIP13 thyroid hormone receptor interactor 13 2.21258
CEP72 centrosomal protein 72kDa 2.21258
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 2.21258
EXOC3 exocyst complex component 3 2.21258
PP7080 uncharacterized LOC25845 2.21258
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 2.21258
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.21096
TERT telomerase reverse transcriptase 2.21096
LPCAT1 lysophosphatidylcholine acyltransferase 1 2.21096
LOC728613 programmed cell death 6 pseudogene 2.21096
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 2.21096
SDHAP3 succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 3 2.21096
ZDHHC11 zinc finger, DHHC-type containing 11 2.20309
LOC285696 uncharacterized LOC285696 2.20053
BASP1 brain abundant, membrane attached signal protein 1 2.19863
MYO10 myosin X 2.19301
AMACR alpha-methylacyl-CoA racemase 2.19301
C1QTNF3 C1q and tumor necrosis factor related protein 3 2.19301
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 2.19301
LOC401177 uncharacterized LOC401177 2.19301
SLC45A2 solute carrier family 45, member 2 2.19301
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 2.18778
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 2.18778
NUP155 nucleoporin 155kDa 2.18778
RICTOR RPTOR independent companion of MTOR, complex 2 2.18778
WDR70 WD repeat domain 70 2.18778
SPEF2 sperm flagellar 2 2.18778
EGFLAM EGF-like, fibronectin type III and laminin G domains 2.18778
EGFLAM-AS4 EGFLAM antisense RNA 4 2.18778
IL7R interleukin 7 receptor 2.18778
EGFLAM-AS2 EGFLAM antisense RNA 2 2.18778
MIR3650 microRNA 3650 2.18778
C5ORF42 chromosome 5 open reading frame 42 2.18778
FYB FYN binding protein 2.18778
GDNF-AS1 GDNF antisense RNA 1 (head to head) 2.18778
C6 complement component 6 2.18778
C9 complement component 9 2.18778
LIFR leukemia inhibitory factor receptor alpha 2.18778
GDNF glial cell derived neurotrophic factor 2.18778
LOC646719 2.18124
CAPSL calcyphosine-like 2.18124
LOC100132356 uncharacterized LOC100132356 2.18124
LOC100506639 uncharacterized LOC100506639 2.18124
ANXA2R annexin A2 receptor 2.18124
GHR growth hormone receptor 2.18124
NIPBL Nipped-B homolog (Drosophila) 2.18124
FBXO4 F-box protein 4 2.18124
LOC648987 uncharacterized LOC648987 2.18124
OXCT1 3-oxoacid CoA transferase 1 2.18124
ZNF131 zinc finger protein 131 2.18124
C5ORF51 chromosome 5 open reading frame 51 2.18124
LOC153684 uncharacterized LOC153684 2.18124
OSMR oncostatin M receptor 2.18124
SEPP1 selenoprotein P, plasma, 1 2.17694
C5ORF28 chromosome 5 open reading frame 28 2.17694
PAIP1 poly(A) binding protein interacting protein 1 2.17694
CCDC152 coiled-coil domain containing 152 2.17694
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 2.17694
UGT3A1 UDP glycosyltransferase 3 family, polypeptide A1 2.17694
LMBRD2 LMBR1 domain containing 2 2.17694
MRPS30 mitochondrial ribosomal protein S30 2.17694
RANBP3L RAN binding protein 3-like 2.17694
C5ORF34 chromosome 5 open reading frame 34 2.17694
MIR580 microRNA 580 2.17694
UGT3A2 UDP glycosyltransferase 3 family, polypeptide A2 2.17694
TTC23L tetratricopeptide repeat domain 23-like 2.16947
RAI14 retinoic acid induced 14 2.16947
BRIX1 BRX1, biogenesis of ribosomes 2.16947
FGF10 fibroblast growth factor 10 2.16947
AGXT2 alanine--glyoxylate aminotransferase 2 2.16947
RAD1 RAD1 checkpoint DNA exonuclease 2.16947
PRLR prolactin receptor 2.16947
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 2.16947
NNT nicotinamide nucleotide transhydrogenase 2.16816
SNORA31 small nucleolar RNA, H/ACA box 31 2.16564
CCSER1 coiled-coil serine-rich protein 1 2.15848
CABLES1 Cdk5 and Abl enzyme substrate 1 2.14311
TMEM241 transmembrane protein 241 2.14311
RIOK3 RIO kinase 3 2.14311
IMPACT impact RWD domain protein 2.14116
MIR320C2 microRNA 320c-2 2.14116
LAMA3 laminin, alpha 3 2.14116
NPC1 Niemann-Pick disease, type C1 2.14116
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated 2.14116
HRH4 histamine receptor H4 2.14116
C18ORF8 chromosome 18 open reading frame 8 2.14116
OSBPL1A oxysterol binding protein-like 1A 2.14116
ANKRD29 ankyrin repeat domain 29 2.14116
TTC39C tetratricopeptide repeat domain 39C 2.14116
CYYR1 cysteine/tyrosine-rich 1 2.12225
CTAGE1 cutaneous T-cell lymphoma-associated antigen 1 2.12225
GATA6 GATA binding protein 6 2.10992
RBBP8 retinoblastoma binding protein 8 2.10992
MIR4741 microRNA 4741 2.10992
SVIL supervillin 2.09529
CTAGE5 CTAGE family, member 5 2.07822
FBXO33 F-box protein 33 2.07822
LOC100288846 uncharacterized LOC100288846 2.07776
NPAS3 neuronal PAS domain protein 3 2.0731
BZW2 basic leucine zipper and W2 domains 2 2.06473
BRD9 bromodomain containing 9 2.05559
CDH18 cadherin 18, type 2 2.0489

low copy number

Symbol Name Standardized Value
PIP prolactin-induced protein -3.36169
TAS2R39 taste receptor, type 2, member 39 -3.36169
FLT1 fms-related tyrosine kinase 1 -3.32901
PAN3 PAN3 poly(A) specific ribonuclease subunit -3.32901
ESD esterase D -3.24687
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -3.24687
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled -3.11641
CES1P1 carboxylesterase 1 pseudogene 1 -2.74485