NCI-H2030 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: adenocarcinoma; non-small cell lung cancer (lung primary) (Cell Line Ontology, CLO_0008041)
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Genes

120 genes mutated in the NCI-H2030 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADCY6 adenylate cyclase 6
ADD3 adducin 3 (gamma)
AK3 adenylate kinase 3
ALYREF Aly/REF export factor
AMPD3 adenosine monophosphate deaminase 3
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
ARHGAP44 Rho GTPase activating protein 44
ASMTL acetylserotonin O-methyltransferase-like
BMP1 bone morphogenetic protein 1
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2
C16ORF86 chromosome 16 open reading frame 86
CCNL2 cyclin L2
CEP44 centrosomal protein 44kDa
CHD8 chromodomain helicase DNA binding protein 8
CLASP2 cytoplasmic linker associated protein 2
DCLK1 doublecortin-like kinase 1
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DMXL2 Dmx-like 2
DPF1 D4, zinc and double PHD fingers family 1
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EFHC1 EF-hand domain (C-terminal) containing 1
EFNA4 ephrin-A4
EHBP1 EH domain binding protein 1
EID3 EP300 interacting inhibitor of differentiation 3
ELOVL2 ELOVL fatty acid elongase 2
EPRS glutamyl-prolyl-tRNA synthetase
EXOC6B exocyst complex component 6B
EXT2 exostosin glycosyltransferase 2
FAM160B2 family with sequence similarity 160, member B2
FBXW9 F-box and WD repeat domain containing 9
FEM1C fem-1 homolog c (C. elegans)
FGA fibrinogen alpha chain
FLRT2 fibronectin leucine rich transmembrane protein 2
FRS3 fibroblast growth factor receptor substrate 3
FSTL5 follistatin-like 5
FZD3 frizzled class receptor 3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GFRA1 GDNF family receptor alpha 1
GMPS guanine monphosphate synthase
HACD1 3-hydroxyacyl-CoA dehydratase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ING3 inhibitor of growth family, member 3
INHBB inhibin, beta B
IRF5 interferon regulatory factor 5
KAT6A K(lysine) acetyltransferase 6A
KEAP1 kelch-like ECH-associated protein 1
KMT2C lysine (K)-specific methyltransferase 2C
KRAS Kirsten rat sarcoma viral oncogene homolog
LAMB2 laminin, beta 2 (laminin S)
LATS2 large tumor suppressor kinase 2
LMBR1L limb development membrane protein 1-like
LRRC42 leucine rich repeat containing 42
LTBP3 latent transforming growth factor beta binding protein 3
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MBD5 methyl-CpG binding domain protein 5
MT1A metallothionein 1A
MT3 metallothionein 3
MT4 metallothionein 4
MTHFSD methenyltetrahydrofolate synthetase domain containing
NPBWR1 neuropeptides B/W receptor 1
PCDH17 protocadherin 17
PCYOX1L prenylcysteine oxidase 1 like
PDZD8 PDZ domain containing 8
PIGO phosphatidylinositol glycan anchor biosynthesis, class O
PIGV phosphatidylinositol glycan anchor biosynthesis, class V
POLE polymerase (DNA directed), epsilon, catalytic subunit
PTGFRN prostaglandin F2 receptor inhibitor
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PUM2 pumilio RNA-binding family member 2
PWWP2B PWWP domain containing 2B
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RCC1 regulator of chromosome condensation 1
RNF208 ring finger protein 208
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SERINC3 serine incorporator 3
SETD2 SET domain containing 2
SIX5 SIX homeobox 5
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SNAPIN SNAP-associated protein
SP140L SP140 nuclear body protein-like
STARD8 StAR-related lipid transfer (START) domain containing 8
STK11 serine/threonine kinase 11
STX16 syntaxin 16
SULF2 sulfatase 2
SYNPO2 synaptopodin 2
SYT11 synaptotagmin XI
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TARBP1 TAR (HIV-1) RNA binding protein 1
TBX18 T-box 18
TCF20 transcription factor 20 (AR1)
TGFBR3 transforming growth factor, beta receptor III
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TLN2 talin 2
TNK1 tyrosine kinase, non-receptor, 1
TP53 tumor protein p53
TRIM3 tripartite motif containing 3
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TTC30A tetratricopeptide repeat domain 30A
TWIST1 twist family bHLH transcription factor 1
UBR1 ubiquitin protein ligase E3 component n-recognin 1
USP11 ubiquitin specific peptidase 11
USP36 ubiquitin specific peptidase 36
VCL vinculin
VWDE von Willebrand factor D and EGF domains
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XPO4 exportin 4
ZBTB12 zinc finger and BTB domain containing 12
ZC2HC1C zinc finger, C2HC-type containing 1C
ZFP64 ZFP64 zinc finger protein
ZNF214 zinc finger protein 214
ZNF219 zinc finger protein 219