NCI-H2030 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description disease: adenocarcinoma; non-small cell lung cancer (lung primary) (Cell Line Ontology, CLO_0008041)
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Genes

282 genes with high or low expression in NCI-H2030 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 3.60177
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa 3.2764
CKLF chemokine-like factor 2.72341
NR2E3 nuclear receptor subfamily 2, group E, member 3 2.71785
CPS1-IT1 CPS1 intronic transcript 1 2.69525
NIT1 nitrilase 1 2.6791
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) 2.61425
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 2.59982
FHOD1 formin homology 2 domain containing 1 2.59447
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A 2.57773
FGB fibrinogen beta chain 2.45446
CFLAR CASP8 and FADD-like apoptosis regulator 2.41346
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 2.38975
AP2B1 adaptor-related protein complex 2, beta 1 subunit 2.38724
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.3811
PPOX protoporphyrinogen oxidase 2.3357
PARD6A par-6 family cell polarity regulator alpha 2.31749
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa 2.29529
FGG fibrinogen gamma chain 2.27971
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.23967
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 2.23358
FGA fibrinogen alpha chain 2.22113
GYS2 glycogen synthase 2 (liver) 2.21121
SF3A3 splicing factor 3a, subunit 3, 60kDa 2.18448
BMP5 bone morphogenetic protein 5 2.18326
CXXC1 CXXC finger protein 1 2.16987
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) 2.16865
NOP10 NOP10 ribonucleoprotein 2.16601
GLA galactosidase, alpha 2.15148
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 2.1514
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 2.14012
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17 2.1394
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 2.12828
PDLIM5 PDZ and LIM domain 5 2.12781
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 2.11381
PDE1A phosphodiesterase 1A, calmodulin-dependent 2.08729
NR4A2 nuclear receptor subfamily 4, group A, member 2 2.00075
RAB5C RAB5C, member RAS oncogene family 1.97827
TRIM27 tripartite motif containing 27 1.9588
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 1.95835
RAB11A RAB11A, member RAS oncogene family 1.956
TUBG2 tubulin, gamma 2 1.92085
NMB neuromedin B 1.91947
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 1.91489
FOXC2 forkhead box C2 1.91438
LRP10 low density lipoprotein receptor-related protein 10 1.87251
FTO fat mass and obesity associated 1.85918
TAGLN2 transgelin 2 1.84698
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) 1.8421
PECR peroxisomal trans-2-enoyl-CoA reductase 1.83679
TRPC4 transient receptor potential cation channel, subfamily C, member 4 1.83346
IGFBP4 insulin-like growth factor binding protein 4 1.83309
DNAI1 dynein, axonemal, intermediate chain 1 1.82914
MLX MLX, MAX dimerization protein 1.82018
ADAT1 adenosine deaminase, tRNA-specific 1 1.80876
CRLF2 cytokine receptor-like factor 2 1.79944
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 1.79115
DOCK5 dedicator of cytokinesis 5 1.78531
PFDN2 prefoldin subunit 2 1.78376
GCHFR GTP cyclohydrolase I feedback regulator 1.77247
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 1.76603
CHEK2 checkpoint kinase 2 1.76282
COL4A4 collagen, type IV, alpha 4 1.74446
ERCC3 excision repair cross-complementation group 3 1.74178
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 1.72778
LGSN lengsin, lens protein with glutamine synthetase domain 1.71614
ASCC1 activating signal cointegrator 1 complex subunit 1 1.71287
FKBP10 FK506 binding protein 10, 65 kDa 1.71116
TK2 thymidine kinase 2, mitochondrial 1.71087
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 1.7097
TUBG1 tubulin, gamma 1 1.69513
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 1.68808
PIGF phosphatidylinositol glycan anchor biosynthesis, class F 1.6812
OGFRL1 opioid growth factor receptor-like 1 1.67645
FXYD7 FXYD domain containing ion transport regulator 7 1.67044
RYR3 ryanodine receptor 3 1.65708
ANGPTL4 angiopoietin-like 4 1.65585
COASY CoA synthase 1.65272
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 1.64895
USP36 ubiquitin specific peptidase 36 1.6489
PDE8A phosphodiesterase 8A 1.64856
BMP6 bone morphogenetic protein 6 1.64403
FBXO31 F-box protein 31 1.62855
MT1X metallothionein 1X 1.61886
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 1.61524
UFC1 ubiquitin-fold modifier conjugating enzyme 1 1.61445
CCHCR1 coiled-coil alpha-helical rod protein 1 1.60907
APOA2 apolipoprotein A-II 1.60731
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 1.60119
KYNU kynureninase 1.58642
FGD6 FYVE, RhoGEF and PH domain containing 6 1.58313
ITGA10 integrin, alpha 10 1.57755
TBC1D19 TBC1 domain family, member 19 1.57417
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 1.57169
PLLP plasmolipin 1.5673
KIAA0586 KIAA0586 1.56482
MT1H metallothionein 1H 1.56322
UBL4A ubiquitin-like 4A 1.55328
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 1.54388
RXFP3 relaxin/insulin-like family peptide receptor 3 1.53888
UPK1A uroplakin 1A 1.53835
PLS3 plastin 3 1.53746
GTPBP6 GTP binding protein 6 (putative) 1.53701
SHCBP1 SHC SH2-domain binding protein 1 1.53498
GRB14 growth factor receptor-bound protein 14 1.53319
CTPS2 CTP synthase 2 1.53158
GABARAPL2 GABA(A) receptor-associated protein-like 2 1.52323
TLDC1 TBC/LysM-associated domain containing 1 1.52113
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 1.52005
MT2A metallothionein 2A 1.51291
RPE ribulose-5-phosphate-3-epimerase 1.5078
DDAH2 dimethylarginine dimethylaminohydrolase 2 1.50751
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) 1.50665
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 1.5024
KLRC4 killer cell lectin-like receptor subfamily C, member 4 1.49498
SNUPN snurportin 1 1.49454
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 1.4925
CREM cAMP responsive element modulator 1.491
DOCK4 dedicator of cytokinesis 4 1.48276
HYAL3 hyaluronoglucosaminidase 3 1.48274
SNRPG small nuclear ribonucleoprotein polypeptide G 1.47901
CFDP1 craniofacial development protein 1 1.47048
MTX1 metaxin 1 1.46049
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 1.46006
RMDN3 regulator of microtubule dynamics 3 1.45485
ELANE elastase, neutrophil expressed 1.44943
CCL2 chemokine (C-C motif) ligand 2 1.44757
PTP4A1 protein tyrosine phosphatase type IVA, member 1 1.44649
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 1.44488
PPT2 palmitoyl-protein thioesterase 2 1.44446
CENPN centromere protein N 1.44332
NCSTN nicastrin 1.44067
TTC31 tetratricopeptide repeat domain 31 1.43779
KIAA0391 KIAA0391 1.43445
SERF2 small EDRK-rich factor 2 1.43371
BRD7 bromodomain containing 7 1.42992
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 1.42933
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 1.42886
HMGN4 high mobility group nucleosomal binding domain 4 1.42857
BBS4 Bardet-Biedl syndrome 4 1.42807
KIAA0319 KIAA0319 1.42671
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 1.42306
OSGIN1 oxidative stress induced growth inhibitor 1 1.42267
MPV17 MpV17 mitochondrial inner membrane protein 1.41857
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 1.41705

low expression

Symbol Name Standardized Value
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 -3.53725
RPL35 ribosomal protein L35 -3.53725
PEBP1 phosphatidylethanolamine binding protein 1 -3.52722
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1 -2.79331
ZNF510 zinc finger protein 510 -2.76414
NAAA N-acylethanolamine acid amidase -2.7438
TEX10 testis expressed 10 -2.70797
DPYS dihydropyrimidinase -2.58691
TXK TXK tyrosine kinase -2.5524
UBAC1 UBA domain containing 1 -2.52313
SIX5 SIX homeobox 5 -2.49321
ZNF134 zinc finger protein 134 -2.47106
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.44776
ZNF250 zinc finger protein 250 -2.39908
IARS isoleucyl-tRNA synthetase -2.38105
ACTL7A actin-like 7A -2.37183
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.33605
WWC3 WWC family member 3 -2.33347
RPUSD2 RNA pseudouridylate synthase domain containing 2 -2.29574
ZNF266 zinc finger protein 266 -2.24339
ZNF551 zinc finger protein 551 -2.19702
GDF11 growth differentiation factor 11 -2.17883
RAB28 RAB28, member RAS oncogene family -2.17424
IKZF1 IKAROS family zinc finger 1 (Ikaros) -2.16978
MGEA5 meningioma expressed antigen 5 (hyaluronidase) -2.16282
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -2.16254
ECH1 enoyl CoA hydratase 1, peroxisomal -2.15636
TASP1 taspase, threonine aspartase, 1 -2.13956
RPAIN RPA interacting protein -2.12646
HSDL2 hydroxysteroid dehydrogenase like 2 -2.10228
SLC30A9 solute carrier family 30 (zinc transporter), member 9 -2.09527
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -2.05396
CAMSAP1 calmodulin regulated spectrin-associated protein 1 -2.04294
FASTKD5 FAST kinase domains 5 -2.02633
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -2.01982
NPEPPS aminopeptidase puromycin sensitive -1.98118
TLK2 tousled-like kinase 2 -1.9597
CAMK4 calcium/calmodulin-dependent protein kinase IV -1.95862
CARTPT CART prepropeptide -1.95382
ALOX5 arachidonate 5-lipoxygenase -1.95298
U2AF1 U2 small nuclear RNA auxiliary factor 1 -1.9302
CDK8 cyclin-dependent kinase 8 -1.92697
MBNL2 muscleblind-like splicing regulator 2 -1.92484
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 -1.92422
TSKS testis-specific serine kinase substrate -1.92164
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa -1.90345
PMPCA peptidase (mitochondrial processing) alpha -1.89868
TBL1X transducin (beta)-like 1X-linked -1.89678
STAP2 signal transducing adaptor family member 2 -1.8942
EGR2 early growth response 2 -1.86945
TFB2M transcription factor B2, mitochondrial -1.85566
OSBPL9 oxysterol binding protein-like 9 -1.84626
DFNA5 deafness, autosomal dominant 5 -1.83331
DEFA6 defensin, alpha 6, Paneth cell-specific -1.82525
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -1.82477
FUBP3 far upstream element (FUSE) binding protein 3 -1.82277
GPALPP1 GPALPP motifs containing 1 -1.8181
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 -1.81276
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 -1.80796
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 -1.78515
KIAA0368 KIAA0368 -1.78107
ATP9B ATPase, class II, type 9B -1.7661
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit -1.76473
ACSL5 acyl-CoA synthetase long-chain family member 5 -1.76369
MAK male germ cell-associated kinase -1.75187
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -1.74116
TRIP6 thyroid hormone receptor interactor 6 -1.74063
LILRP2 leukocyte immunoglobulin-like receptor pseudogene 2 -1.73009
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein -1.72667
EGR3 early growth response 3 -1.71979
GREM1 gremlin 1, DAN family BMP antagonist -1.7191
IQCB1 IQ motif containing B1 -1.70893
ESR2 estrogen receptor 2 (ER beta) -1.6956
TBC1D15 TBC1 domain family, member 15 -1.68147
SNCG synuclein, gamma (breast cancer-specific protein 1) -1.67728
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -1.6687
SURF2 surfeit 2 -1.66528
MAEA macrophage erythroblast attacher -1.64625
LOC157562 uncharacterized LOC157562 -1.64221
MTRF1 mitochondrial translational release factor 1 -1.64177
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled -1.64031
PIGG phosphatidylinositol glycan anchor biosynthesis, class G -1.63346
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa -1.63326
NXT1 nuclear transport factor 2-like export factor 1 -1.62776
LECT1 leukocyte cell derived chemotaxin 1 -1.62079
RNF138 ring finger protein 138, E3 ubiquitin protein ligase -1.61855
GP1BA glycoprotein Ib (platelet), alpha polypeptide -1.6057
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 -1.60401
TRAPPC8 trafficking protein particle complex 8 -1.60357
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus -1.59413
MDK midkine (neurite growth-promoting factor 2) -1.58815
CTNNA2 catenin (cadherin-associated protein), alpha 2 -1.58626
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 -1.58415
ZFP30 ZFP30 zinc finger protein -1.58217
GAPVD1 GTPase activating protein and VPS9 domains 1 -1.58093
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 -1.58043
ADIPOR2 adiponectin receptor 2 -1.58022
NPAT nuclear protein, ataxia-telangiectasia locus -1.57478
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) -1.57165
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 -1.5703
ZNF133 zinc finger protein 133 -1.56936
SARDH sarcosine dehydrogenase -1.56544
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -1.55562
OPA1 optic atrophy 1 (autosomal dominant) -1.54826
RHCG Rh family, C glycoprotein -1.54763
RIOK3 RIO kinase 3 -1.54654
SNRPB2 small nuclear ribonucleoprotein polypeptide B -1.54501
SHMT1 serine hydroxymethyltransferase 1 (soluble) -1.54496
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 -1.54016
HIST1H3C histone cluster 1, H3c -1.53896
CCL7 chemokine (C-C motif) ligand 7 -1.53424
ETNK2 ethanolamine kinase 2 -1.52855
APOA1 apolipoprotein A-I -1.51429
TSPAN31 tetraspanin 31 -1.51046
SIGLEC15 sialic acid binding Ig-like lectin 15 -1.5102
SENP5 SUMO1/sentrin specific peptidase 5 -1.50424
ZNF639 zinc finger protein 639 -1.5033
SH3GLB2 SH3-domain GRB2-like endophilin B2 -1.50123
MMP25 matrix metallopeptidase 25 -1.49824
ZNF10 zinc finger protein 10 -1.49781
FCAR Fc fragment of IgA receptor -1.48491
CRNKL1 crooked neck pre-mRNA splicing factor 1 -1.47959
TPP2 tripeptidyl peptidase II -1.46987
ADGRV1 adhesion G protein-coupled receptor V1 -1.46801
ZNF189 zinc finger protein 189 -1.46787
APOD apolipoprotein D -1.45983
FBXL4 F-box and leucine-rich repeat protein 4 -1.45934
DHRS7B dehydrogenase/reductase (SDR family) member 7B -1.45231
MRPS31 mitochondrial ribosomal protein S31 -1.45097
HCAR3 hydroxycarboxylic acid receptor 3 -1.44741
FBXW2 F-box and WD repeat domain containing 2 -1.44732
REV1 REV1, polymerase (DNA directed) -1.4399
CDKL5 cyclin-dependent kinase-like 5 -1.43895
MRPL20 mitochondrial ribosomal protein L20 -1.43848
KRT84 keratin 84, type II -1.43656
PSAT1 phosphoserine aminotransferase 1 -1.43545
ZNF529 zinc finger protein 529 -1.43106