NCI-H2030 Gene Set

Dataset COSMIC Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: adenocarcinoma; non-small cell lung cancer (lung primary) (Cell Line Ontology, CLO_0008041)
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439 genes mutated in the NCI-H2030 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

Symbol Name
AARS2 alanyl-tRNA synthetase 2, mitochondrial
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ABHD1 abhydrolase domain containing 1
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACAD11 acyl-CoA dehydrogenase family, member 11
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACAN aggrecan
ACIN1 apoptotic chromatin condensation inducer 1
ACTA1 actin, alpha 1, skeletal muscle
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADCY6 adenylate cyclase 6
ADCY8 adenylate cyclase 8 (brain)
ADD2 adducin 2 (beta)
ADD3 adducin 3 (gamma)
ADGRA2 adhesion G protein-coupled receptor A2
ADGRB3 adhesion G protein-coupled receptor B3
ADGRL1 adhesion G protein-coupled receptor L1
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1
AHNAK2 AHNAK nucleoprotein 2
AMN amnion associated transmembrane protein
AMPD3 adenosine monophosphate deaminase 3
ANK2 ankyrin 2, neuronal
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
APOB apolipoprotein B
ARHGAP44 Rho GTPase activating protein 44
ARPP21 cAMP-regulated phosphoprotein, 21kDa
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATP9A ATPase, class II, type 9A
BBS12 Bardet-Biedl syndrome 12
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BCO1 beta-carotene oxygenase 1
BMP1 bone morphogenetic protein 1
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BMS1 BMS1 ribosome biogenesis factor
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CARD11 caspase recruitment domain family, member 11
CCDC141 coiled-coil domain containing 141
CCDC69 coiled-coil domain containing 69
CCDC74A coiled-coil domain containing 74A
CCNL2 cyclin L2
CCNT2 cyclin T2
CD33 CD33 molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH16 cadherin 16, KSP-cadherin
CDH18 cadherin 18, type 2
CDH20 cadherin 20, type 2
CDHR5 cadherin-related family member 5
CDYL2 chromodomain protein, Y-like 2
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CEP44 centrosomal protein 44kDa
CFAP74 cilia and flagella associated protein 74
CHD5 chromodomain helicase DNA binding protein 5
CHGB chromogranin B
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHTOP chromatin target of PRMT1
CKAP2L cytoskeleton associated protein 2-like
CLASP2 cytoplasmic linker associated protein 2
CLEC4G C-type lectin domain family 4, member G
CLNK cytokine-dependent hematopoietic cell linker
CNTN2 contactin 2 (axonal)
CNTNAP2 contactin associated protein-like 2
CNTNAP4 contactin associated protein-like 4
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL11A1 collagen, type XI, alpha 1
COL11A2 collagen, type XI, alpha 2
COL22A1 collagen, type XXII, alpha 1
COL2A1 collagen, type II, alpha 1
COL6A1 collagen, type VI, alpha 1
COQ10A coenzyme Q10 homolog A (S. cerevisiae)
CSMD2 CUB and Sushi multiple domains 2
CSMD3 CUB and Sushi multiple domains 3
CTSW cathepsin W
CTTNBP2 cortactin binding protein 2
CUBN cubilin (intrinsic factor-cobalamin receptor)
CYB5D2 cytochrome b5 domain containing 2
DBF4B DBF4 zinc finger B
DCLK1 doublecortin-like kinase 1
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DLG2 discs, large homolog 2 (Drosophila)
DMXL2 Dmx-like 2
DNAH10 dynein, axonemal, heavy chain 10
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DPCR1 diffuse panbronchiolitis critical region 1
DPF1 D4, zinc and double PHD fingers family 1
DST dystonin
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
DZIP1L DAZ interacting zinc finger protein 1-like
ECH1 enoyl CoA hydratase 1, peroxisomal
EFHC1 EF-hand domain (C-terminal) containing 1
EHBP1 EH domain binding protein 1
EID3 EP300 interacting inhibitor of differentiation 3
ELOVL2 ELOVL fatty acid elongase 2
EPHB2 EPH receptor B2
EPPK1 epiplakin 1
EPRS glutamyl-prolyl-tRNA synthetase
ERC2 ELKS/RAB6-interacting/CAST family member 2
ERMP1 endoplasmic reticulum metallopeptidase 1
EXOC6B exocyst complex component 6B
EXT2 exostosin glycosyltransferase 2
FABP9 fatty acid binding protein 9, testis
FAM160B2 family with sequence similarity 160, member B2
FAM183A family with sequence similarity 183, member A
FAM3A family with sequence similarity 3, member A
FAN1 FANCD2/FANCI-associated nuclease 1
FAP fibroblast activation protein, alpha
FAT2 FAT atypical cadherin 2
FAT3 FAT atypical cadherin 3
FBN1 fibrillin 1
FBXL13 F-box and leucine-rich repeat protein 13
FBXL18 F-box and leucine-rich repeat protein 18
FBXW9 F-box and WD repeat domain containing 9
FCRLB Fc receptor-like B
FECH ferrochelatase
FEM1C fem-1 homolog c (C. elegans)
FGA fibrinogen alpha chain
FGF8 fibroblast growth factor 8 (androgen-induced)
FKBP3 FK506 binding protein 3, 25kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
FRG2B FSHD region gene 2 family, member B
FRS3 fibroblast growth factor receptor substrate 3
FSIP1 fibrous sheath interacting protein 1
FSTL5 follistatin-like 5
FZD3 frizzled class receptor 3
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GAS2L2 growth arrest-specific 2 like 2
GDF6 growth differentiation factor 6
GFRA1 GDNF family receptor alpha 1
GLP2R glucagon-like peptide 2 receptor
GMPS guanine monphosphate synthase
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
GP2 glycoprotein 2 (zymogen granule membrane)
GPAM glycerol-3-phosphate acyltransferase, mitochondrial
GPR52 G protein-coupled receptor 52
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GREB1 growth regulation by estrogen in breast cancer 1
GRIA4 glutamate receptor, ionotropic, AMPA 4
GSX2 GS homeobox 2
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HEPACAM2 HEPACAM family member 2
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
HIST1H3J histone cluster 1, H3j
HLA-C major histocompatibility complex, class I, C
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1
HOXA10 homeobox A10
HR hair growth associated
HRNR hornerin
HSDL2 hydroxysteroid dehydrogenase like 2
IFITM10 interferon induced transmembrane protein 10
IFT57 intraflagellar transport 57
IGDCC3 immunoglobulin superfamily, DCC subclass, member 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGSF10 immunoglobulin superfamily, member 10
IL18R1 interleukin 18 receptor 1
IL1F10 interleukin 1 family, member 10 (theta)
IL20RA interleukin 20 receptor, alpha
IL36B interleukin 36, beta
IMP4 IMP4, U3 small nucleolar ribonucleoprotein
ING3 inhibitor of growth family, member 3
IRF5 interferon regulatory factor 5
ITGA8 integrin, alpha 8
ITGAD integrin, alpha D
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
IZUMO3 IZUMO family member 3
JAKMIP1 janus kinase and microtubule interacting protein 1
KAT6A K(lysine) acetyltransferase 6A
KAT6B K(lysine) acetyltransferase 6B
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KDM4E lysine (K)-specific demethylase 4E
KDR kinase insert domain receptor
KEAP1 kelch-like ECH-associated protein 1
KIAA1107 KIAA1107
KIAA1217 KIAA1217
KIAA1324 KIAA1324
KIF18A kinesin family member 18A
KIF21B kinesin family member 21B
KIF26B kinesin family member 26B
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KMT2C lysine (K)-specific methyltransferase 2C
KRAS Kirsten rat sarcoma viral oncogene homolog
KY kyphoscoliosis peptidase
L3MBTL3 l(3)mbt-like 3 (Drosophila)
LAMB2 laminin, beta 2 (laminin S)
LATS2 large tumor suppressor kinase 2
LCN15 lipocalin 15
LCT lactase
LDB2 LIM domain binding 2
LEPR leptin receptor
LHCGR luteinizing hormone/choriogonadotropin receptor
LIFR leukemia inhibitory factor receptor alpha
LMBR1L limb development membrane protein 1-like
LRIT2 leucine-rich repeat, immunoglobulin-like and transmembrane domains 2
LRP1B low density lipoprotein receptor-related protein 1B
LRRC42 leucine rich repeat containing 42
LRRTM4 leucine rich repeat transmembrane neuronal 4
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAGEB4 melanoma antigen family B4
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K10 mitogen-activated protein kinase kinase kinase 10
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MARK1 MAP/microtubule affinity-regulating kinase 1
MATN4 matrilin 4
MCCD1 mitochondrial coiled-coil domain 1
MCF2 MCF.2 cell line derived transforming sequence
MCM3AP minichromosome maintenance complex component 3 associated protein
MED24 mediator complex subunit 24
MEFV Mediterranean fever
MICALCL MICAL C-terminal like
MKRN3 makorin ring finger protein 3
MMP8 matrix metallopeptidase 8
MSC musculin
MTHFSD methenyltetrahydrofolate synthetase domain containing
MUC4 mucin 4, cell surface associated
MUC6 mucin 6, oligomeric mucus/gel-forming
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYO15A myosin XVA
MYO18B myosin XVIIIB
MYO1A myosin IA
MYO5B myosin VB
MYO7B myosin VIIB
NALCN sodium leak channel, non selective
NAPSB napsin B aspartic peptidase, pseudogene
NBEA neurobeachin
NCKAP5 NCK-associated protein 5
NEURL1 neuralized E3 ubiquitin protein ligase 1
NEUROD2 neuronal differentiation 2
NF1 neurofibromin 1
NID2 nidogen 2 (osteonidogen)
NLGN1 neuroligin 1
NLRP3 NLR family, pyrin domain containing 3
NME7 NME/NM23 family member 7
NOBOX NOBOX oogenesis homeobox
NOTCH1 notch 1
NRSN1 neurensin 1
NRXN3 neurexin 3
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OGDHL oxoglutarate dehydrogenase-like
OGFR opioid growth factor receptor
OR12D3 olfactory receptor, family 12, subfamily D, member 3
OR13G1 olfactory receptor, family 13, subfamily G, member 1
OR14A2 olfactory receptor, family 14, subfamily A, member 2
OR14C36 olfactory receptor, family 14, subfamily C, member 36
OR14K1 olfactory receptor, family 14, subfamily K, member 1
OR1C1 olfactory receptor, family 1, subfamily C, member 1
OR2T8 olfactory receptor, family 2, subfamily T, member 8
OR4D5 olfactory receptor, family 4, subfamily D, member 5
OR4K1 olfactory receptor, family 4, subfamily K, member 1
OR4N5 olfactory receptor, family 4, subfamily N, member 5
OR52E2 olfactory receptor, family 52, subfamily E, member 2
OR5K4 olfactory receptor, family 5, subfamily K, member 4
OR5M9 olfactory receptor, family 5, subfamily M, member 9
OR6X1 olfactory receptor, family 6, subfamily X, member 1
OR9K2 olfactory receptor, family 9, subfamily K, member 2
OVCH2 ovochymase 2 (gene/pseudogene)
OXA1L oxidase (cytochrome c) assembly 1-like
PARK2 parkin RBR E3 ubiquitin protein ligase
PARPBP PARP1 binding protein
PATE1 prostate and testis expressed 1
PAX2 paired box 2
PCDH17 protocadherin 17
PCDH7 protocadherin 7
PCDHA3 protocadherin alpha 3
PCDHA4 protocadherin alpha 4
PCDHB16 protocadherin beta 16
PCDHB7 protocadherin beta 7
PCM1 pericentriolar material 1
PCNT pericentrin
PCYOX1L prenylcysteine oxidase 1 like
PDHB pyruvate dehydrogenase (lipoamide) beta
PEG3 paternally expressed 3
PES1 pescadillo ribosomal biogenesis factor 1
PGK1 phosphoglycerate kinase 1
PHACTR3 phosphatase and actin regulator 3
PHKB phosphorylase kinase, beta
PIGO phosphatidylinositol glycan anchor biosynthesis, class O
PKD1L2 polycystic kidney disease 1-like 2 (gene/pseudogene)
PKD1L3 polycystic kidney disease 1-like 3
PLD5 phospholipase D family, member 5
PLEKHA5 pleckstrin homology domain containing, family A member 5
PNRC2 proline-rich nuclear receptor coactivator 2
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLR3B polymerase (RNA) III (DNA directed) polypeptide B
POM121L2 POM121 transmembrane nucleoporin-like 2
POM121L3P POM121 transmembrane nucleoporin-like 3, pseudogene
POU2F1 POU class 2 homeobox 1
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PQLC2 PQ loop repeat containing 2
PRLR prolactin receptor
PRODH proline dehydrogenase (oxidase) 1
PRODH2 proline dehydrogenase (oxidase) 2
PROM2 prominin 2
PSG2 pregnancy specific beta-1-glycoprotein 2
PSKH2 protein serine kinase H2
PSMB11 proteasome (prosome, macropain) subunit, beta type, 11
PTGFRN prostaglandin F2 receptor inhibitor
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPRB protein tyrosine phosphatase, receptor type, B
PTPRN protein tyrosine phosphatase, receptor type, N
PTPRU protein tyrosine phosphatase, receptor type, U
PUM2 pumilio RNA-binding family member 2
PURB purine-rich element binding protein B
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic)
RAD54L RAD54-like (S. cerevisiae)
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RBAK RB-associated KRAB zinc finger
RCAN2 regulator of calcineurin 2
RCC1 regulator of chromosome condensation 1
REM1 RAS (RAD and GEM)-like GTP-binding 1
RHAG Rh-associated glycoprotein
RIMBP2 RIMS binding protein 2
RNF208 ring finger protein 208
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
RPL13A ribosomal protein L13a
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RRAD Ras-related associated with diabetes
RRBP1 ribosome binding protein 1
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RYR2 ryanodine receptor 2 (cardiac)
RYR3 ryanodine receptor 3
SCIN scinderin
SCUBE1 signal peptide, CUB domain, EGF-like 1
SECISBP2L SECIS binding protein 2-like
SERINC3 serine incorporator 3
SETD2 SET domain containing 2
SH2D3C SH2 domain containing 3C
SHC4 SHC (Src homology 2 domain containing) family, member 4
SI sucrase-isomaltase (alpha-glucosidase)
SIGLEC10 sialic acid binding Ig-like lectin 10
SIGLEC12 sialic acid binding Ig-like lectin 12 (gene/pseudogene)
SIM1 single-minded family bHLH transcription factor 1
SIRPD signal-regulatory protein delta
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC25A40 solute carrier family 25, member 40
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SLIT2 slit homolog 2 (Drosophila)
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNAPIN SNAP-associated protein
SNTG1 syntrophin, gamma 1
SNX29 sorting nexin 29
SORCS1 sortilin-related VPS10 domain containing receptor 1
SP140L SP140 nuclear body protein-like
SPAG16 sperm associated antigen 16
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SPATA31D1 SPATA31 subfamily D, member 1
SPATA31D4 SPATA31 subfamily D, member 4
SPATA7 spermatogenesis associated 7
STARD8 StAR-related lipid transfer (START) domain containing 8
STK11 serine/threonine kinase 11
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
STX16 syntaxin 16
SULF2 sulfatase 2
SYNE1 spectrin repeat containing, nuclear envelope 1
SYNPO2 synaptopodin 2
SYT11 synaptotagmin XI
SYT6 synaptotagmin VI
SYTL2 synaptotagmin-like 2
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TARBP1 TAR (HIV-1) RNA binding protein 1
TBCD tubulin folding cofactor D
TBX18 T-box 18
TCF20 transcription factor 20 (AR1)
TDP1 tyrosyl-DNA phosphodiesterase 1
TET2 tet methylcytosine dioxygenase 2
TEX15 testis expressed 15
THBS2 thrombospondin 2
THNSL2 threonine synthase-like 2 (S. cerevisiae)
THSD7A thrombospondin, type I, domain containing 7A
THUMPD2 THUMP domain containing 2
TLN2 talin 2
TMEM184A transmembrane protein 184A
TMEM63A transmembrane protein 63A
TNK1 tyrosine kinase, non-receptor, 1
TOX2 TOX high mobility group box family member 2
TP53 tumor protein p53
TREML2 triggering receptor expressed on myeloid cells-like 2
TRIM3 tripartite motif containing 3
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TSHZ3 teashirt zinc finger homeobox 3
TTC30A tetratricopeptide repeat domain 30A
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UNC79 unc-79 homolog (C. elegans)
USH2A Usher syndrome 2A (autosomal recessive, mild)
USP11 ubiquitin specific peptidase 11
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
USP36 ubiquitin specific peptidase 36
VCL vinculin
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
VWDE von Willebrand factor D and EGF domains
WDR78 WD repeat domain 78
WNT6 wingless-type MMTV integration site family, member 6
WRN Werner syndrome, RecQ helicase-like
WWC2 WW and C2 domain containing 2
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XIRP2 xin actin binding repeat containing 2
YTHDC2 YTH domain containing 2
ZBBX zinc finger, B-box domain containing
ZBTB12 zinc finger and BTB domain containing 12
ZC2HC1C zinc finger, C2HC-type containing 1C
ZC3H6 zinc finger CCCH-type containing 6
ZCCHC24 zinc finger, CCHC domain containing 24
ZFHX4 zinc finger homeobox 4
ZFP64 ZFP64 zinc finger protein
ZIM2 zinc finger, imprinted 2
ZNF135 zinc finger protein 135
ZNF208 zinc finger protein 208
ZNF214 zinc finger protein 214
ZNF462 zinc finger protein 462
ZNF492 zinc finger protein 492
ZNF677 zinc finger protein 677
ZNF75D zinc finger protein 75D
ZNF789 zinc finger protein 789
ZNF831 zinc finger protein 831
ZNF835 zinc finger protein 835
ZNF84 zinc finger protein 84
ZRANB3 zinc finger, RAN-binding domain containing 3