NCI-H2023 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: adenocarcinoma; non-small cell lung cancer (lung primary) (Cell Line Ontology, CLO_0008039)
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207 genes mutated in the NCI-H2023 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADCK3 aarF domain containing kinase 3
ADGRE5 adhesion G protein-coupled receptor E5
ADSSL1 adenylosuccinate synthase like 1
AHCYL2 adenosylhomocysteinase-like 2
AK9 adenylate kinase 9
AKR1C3 aldo-keto reductase family 1, member C3
AKR1C4 aldo-keto reductase family 1, member C4
AKT2 v-akt murine thymoma viral oncogene homolog 2
AMOTL1 angiomotin like 1
APP amyloid beta (A4) precursor protein
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARHGAP23 Rho GTPase activating protein 23
ARHGAP24 Rho GTPase activating protein 24
ARHGAP33 Rho GTPase activating protein 33
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATRN attractin
BAIAP2 BAI1-associated protein 2
BAIAP3 BAI1-associated protein 3
BIRC6 baculoviral IAP repeat containing 6
BRSK1 BR serine/threonine kinase 1
C2CD3 C2 calcium-dependent domain containing 3
C5ORF42 chromosome 5 open reading frame 42
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CBR1 carbonyl reductase 1
CCDC109B coiled-coil domain containing 109B
CCER2 coiled-coil glutamate-rich protein 2
CEP135 centrosomal protein 135kDa
CEP295 centrosomal protein 295kDa
CES5A carboxylesterase 5A
CFAP69 cilia and flagella associated protein 69
CFI complement factor I
CHD5 chromodomain helicase DNA binding protein 5
CILP2 cartilage intermediate layer protein 2
CNOT1 CCR4-NOT transcription complex, subunit 1
COL27A1 collagen, type XXVII, alpha 1
COL5A2 collagen, type V, alpha 2
CORO2A coronin, actin binding protein, 2A
CPNE8 copine VIII
CUTC cutC copper transporter
CXORF38 chromosome X open reading frame 38
DEDD2 death effector domain containing 2
DGAT1 diacylglycerol O-acyltransferase 1
DIAPH3 diaphanous-related formin 3
DOCK5 dedicator of cytokinesis 5
DPP3 dipeptidyl-peptidase 3
DTNA dystrobrevin, alpha
DYM dymeclin
EHBP1 EH domain binding protein 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EMID1 EMI domain containing 1
EYS eyes shut homolog (Drosophila)
FAM193A family with sequence similarity 193, member A
FAT1 FAT atypical cadherin 1
FAT3 FAT atypical cadherin 3
FBLN2 fibulin 2
FBN1 fibrillin 1
FECH ferrochelatase
FER fer (fps/fes related) tyrosine kinase
FGFR1OP FGFR1 oncogene partner
FOXG1 forkhead box G1
FZD1 frizzled class receptor 1
GAP43 growth associated protein 43
GATAD2A GATA zinc finger domain containing 2A
GCC1 GRIP and coiled-coil domain containing 1
GEMIN5 gem (nuclear organelle) associated protein 5
GJD3 gap junction protein, delta 3, 31.9kDa
GLE1 GLE1 RNA export mediator
GLI2 GLI family zinc finger 2
GLTPD2 glycolipid transfer protein domain containing 2
GPATCH8 G patch domain containing 8
GPBP1 GC-rich promoter binding protein 1
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HKDC1 hexokinase domain containing 1
HOXB13 homeobox B13
HOXC6 homeobox C6
HOXD13 homeobox D13
HSPH1 heat shock 105kDa/110kDa protein 1
HTT huntingtin
ICE1 interactor of little elongation complex ELL subunit 1
IFT80 intraflagellar transport 80
IKBIP IKBKB interacting protein
IRF2BPL interferon regulatory factor 2 binding protein-like
ISCU iron-sulfur cluster assembly enzyme
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB7 integrin, beta 7
KCTD3 potassium channel tetramerization domain containing 3
KEAP1 kelch-like ECH-associated protein 1
KIAA0020 KIAA0020
KIAA0556 KIAA0556
KIAA1109 KIAA1109
KIF4B kinesin family member 4B
KLHL29 kelch-like family member 29
KRT75 keratin 75, type II
KRT83 keratin 83, type II
LOC730183 uncharacterized LOC730183
LRRC56 leucine rich repeat containing 56
LRRC8C leucine rich repeat containing 8 family, member C
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae)
LYST lysosomal trafficking regulator
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MASTL microtubule associated serine/threonine kinase-like
MCC mutated in colorectal cancers
MERTK MER proto-oncogene, tyrosine kinase
METTL4 methyltransferase like 4
MINOS1-NBL1 MINOS1-NBL1 readthrough
MKI67 marker of proliferation Ki-67
MRPL32 mitochondrial ribosomal protein L32
MST1R macrophage stimulating 1 receptor
MTAP methylthioadenosine phosphorylase
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYO10 myosin X
NBEAL1 neurobeachin-like 1
NBL1 neuroblastoma 1, DAN family BMP antagonist
NCOA5 nuclear receptor coactivator 5
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NRDE2 NRDE-2, necessary for RNA interference, domain containing
NRG1 neuregulin 1
NUBP1 nucleotide binding protein 1
NUBP2 nucleotide binding protein 2
OLFM3 olfactomedin 3
OR51B4 olfactory receptor, family 51, subfamily B, member 4
PDCD11 programmed cell death 11
PDE3A phosphodiesterase 3A, cGMP-inhibited
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDZD2 PDZ domain containing 2
PER3 period circadian clock 3
PGAM5 phosphoglycerate mutase family member 5
PICALM phosphatidylinositol binding clathrin assembly protein
PIEZO2 piezo-type mechanosensitive ion channel component 2
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHH3 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
PLXNA1 plexin A1
POF1B premature ovarian failure, 1B
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
PPP1R21 protein phosphatase 1, regulatory subunit 21
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRAME preferentially expressed antigen in melanoma
PRDM15 PR domain containing 15
PRKCA protein kinase C, alpha
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPRS protein tyrosine phosphatase, receptor type, S
RABGAP1L RAB GTPase activating protein 1-like
RSF1 remodeling and spacing factor 1
SACS sacsin molecular chaperone
SCARA5 scavenger receptor class A, member 5
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SIX5 SIX homeobox 5
SLC41A3 solute carrier family 41, member 3
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SOS2 son of sevenless homolog 2 (Drosophila)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK31 serine/threonine kinase 31
STX1A syntaxin 1A (brain)
STX2 syntaxin 2
SULF1 sulfatase 1
SYNJ2 synaptojanin 2
TBKBP1 TBK1 binding protein 1
TBX3 T-box 3
TCF20 transcription factor 20 (AR1)
TGS1 trimethylguanosine synthase 1
THAP4 THAP domain containing 4
TLE4 transducin-like enhancer of split 4
TMEM245 transmembrane protein 245
TOP3B topoisomerase (DNA) III beta
TP53 tumor protein p53
TPR translocated promoter region, nuclear basket protein
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TRIM45 tripartite motif containing 45
TRIM56 tripartite motif containing 56
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TTC7B tetratricopeptide repeat domain 7B
UHRF1BP1L UHRF1 binding protein 1-like
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
USP19 ubiquitin specific peptidase 19
USP40 ubiquitin specific peptidase 40
USP42 ubiquitin specific peptidase 42
USP43 ubiquitin specific peptidase 43
UTRN utrophin
UXS1 UDP-glucuronate decarboxylase 1
VPS13B vacuolar protein sorting 13 homolog B (yeast)
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae)
VWDE von Willebrand factor D and EGF domains
WDFY3 WD repeat and FYVE domain containing 3
WDR11 WD repeat domain 11
WDR4 WD repeat domain 4
WDR59 WD repeat domain 59
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WNT11 wingless-type MMTV integration site family, member 11
YAP1 Yes-associated protein 1
ZADH2 zinc binding alcohol dehydrogenase domain containing 2
ZBTB20 zinc finger and BTB domain containing 20
ZBTB37 zinc finger and BTB domain containing 37
ZFPM2 zinc finger protein, FOG family member 2
ZNF507 zinc finger protein 507
ZNF512 zinc finger protein 512
ZNF527 zinc finger protein 527
ZNF585B zinc finger protein 585B
ZSCAN21 zinc finger and SCAN domain containing 21