NCI-H2009 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
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Genes

423 genes mutated in the NCI-H2009 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACTBL2 actin, beta-like 2
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6
ADD3 adducin 3 (gamma)
ADGRL2 adhesion G protein-coupled receptor L2
AFAP1 actin filament associated protein 1
AKAP13 A kinase (PRKA) anchor protein 13
ALDOA aldolase A, fructose-bisphosphate
ALMS1 Alstrom syndrome protein 1
ANGPTL2 angiopoietin-like 2
ANKHD1 ankyrin repeat and KH domain containing 1
ANKHD1-EIF4EBP3 ANKHD1-EIF4EBP3 readthrough
ANKLE2 ankyrin repeat and LEM domain containing 2
ANKRD9 ankyrin repeat domain 9
ANPEP alanyl (membrane) aminopeptidase
APAF1 apoptotic peptidase activating factor 1
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARHGAP19 Rho GTPase activating protein 19
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARMT1 acidic residue methyltransferase 1
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATF2 activating transcription factor 2
ATF7IP activating transcription factor 7 interacting protein
ATG2B autophagy related 2B
ATG3 autophagy related 3
ATP13A2 ATPase type 13A2
ATP13A3 ATPase type 13A3
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATXN7L2 ataxin 7-like 2
B2M beta-2-microglobulin
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
B9D2 B9 protein domain 2
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BEND3 BEN domain containing 3
BPTF bromodomain PHD finger transcription factor
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
BRI3BP BRI3 binding protein
BSG basigin (Ok blood group)
BTBD10 BTB (POZ) domain containing 10
BTG2 BTG family, member 2
BTN2A2 butyrophilin, subfamily 2, member A2
C14ORF169 chromosome 14 open reading frame 169
C15ORF52 chromosome 15 open reading frame 52
C16ORF93 chromosome 16 open reading frame 93
C17ORF53 chromosome 17 open reading frame 53
C3ORF58 chromosome 3 open reading frame 58
C8ORF31 chromosome 8 open reading frame 31
C9ORF3 chromosome 9 open reading frame 3
CANX calnexin
CASP4 caspase 4, apoptosis-related cysteine peptidase
CCDC57 coiled-coil domain containing 57
CCDC88B coiled-coil domain containing 88B
CCDC91 coiled-coil domain containing 91
CCND2 cyclin D2
CCNH cyclin H
CCR7 chemokine (C-C motif) receptor 7
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CD27 CD27 molecule
CD53 CD53 molecule
CD6 CD6 molecule
CDC26 cell division cycle 26
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CELF2 CUGBP, Elav-like family member 2
CEP170 centrosomal protein 170kDa
CEP72 centrosomal protein 72kDa
CGNL1 cingulin-like 1
CHD1 chromodomain helicase DNA binding protein 1
CHD6 chromodomain helicase DNA binding protein 6
CHD9 chromodomain helicase DNA binding protein 9
CIAO1 cytosolic iron-sulfur assembly component 1
CILP2 cartilage intermediate layer protein 2
CIT citron rho-interacting serine/threonine kinase
CNTN1 contactin 1
COL27A1 collagen, type XXVII, alpha 1
COL5A2 collagen, type V, alpha 2
CORO1A coronin, actin binding protein, 1A
CSK c-src tyrosine kinase
CTTNBP2 cortactin binding protein 2
DENND4B DENN/MADD domain containing 4B
DHTKD1 dehydrogenase E1 and transketolase domain containing 1
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila)
DIXDC1 DIX domain containing 1
DLG5 discs, large homolog 5 (Drosophila)
DMXL1 Dmx-like 1
DOCK2 dedicator of cytokinesis 2
DOCK3 dedicator of cytokinesis 3
DOCK6 dedicator of cytokinesis 6
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGR2 early growth response 2
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ELMO1 engulfment and cell motility 1
ENGASE endo-beta-N-acetylglucosaminidase
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
ERAP1 endoplasmic reticulum aminopeptidase 1
ERBB2IP erbb2 interacting protein
ERF Ets2 repressor factor
ERMP1 endoplasmic reticulum metallopeptidase 1
FAM126B family with sequence similarity 126, member B
FAM129A family with sequence similarity 129, member A
FAM160A1 family with sequence similarity 160, member A1
FAM161A family with sequence similarity 161, member A
FAM171A1 family with sequence similarity 171, member A1
FAM172A family with sequence similarity 172, member A
FAM193A family with sequence similarity 193, member A
FBXO33 F-box protein 33
FBXO34 F-box protein 34
FDXR ferredoxin reductase
FHOD1 formin homology 2 domain containing 1
FIGN fidgetin
FLNC filamin C, gamma
FMNL3 formin-like 3
FNIP2 folliculin interacting protein 2
FOCAD focadhesin
FXR2 fragile X mental retardation, autosomal homolog 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18
GDAP1 ganglioside induced differentiation associated protein 1
GIGYF2 GRB10 interacting GYF protein 2
GLG1 golgi glycoprotein 1
GMFG glia maturation factor, gamma
GOLGA5 golgin A5
GPR63 G protein-coupled receptor 63
GPR65 G protein-coupled receptor 65
GPRIN1 G protein regulated inducer of neurite outgrowth 1
GRAMD1B GRAM domain containing 1B
GSKIP GSK3B interacting protein
GSPT1 G1 to S phase transition 1
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
HAGH hydroxyacylglutathione hydrolase
HCLS1 hematopoietic cell-specific Lyn substrate 1
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HSPA14 heat shock 70kDa protein 14
HSPA1L heat shock 70kDa protein 1-like
HTT huntingtin
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase
IFT140 intraflagellar transport 140
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1
IGHMBP2 immunoglobulin mu binding protein 2
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL11 interleukin 11
IL16 interleukin 16
IL21R interleukin 21 receptor
IPO11 importin 11
IRAK1 interleukin-1 receptor-associated kinase 1
IRF4 interferon regulatory factor 4
IRF6 interferon regulatory factor 6
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB7 integrin, beta 7
ITK IL2-inducible T-cell kinase
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAK2 Janus kinase 2
KAT6B K(lysine) acetyltransferase 6B
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1
KDM3B lysine (K)-specific demethylase 3B
KDM6B lysine (K)-specific demethylase 6B
KIAA0408 KIAA0408
KIAA0430 KIAA0430
KIAA0754 KIAA0754
KIAA1468 KIAA1468
KIF18A kinesin family member 18A
KIF4B kinesin family member 4B
KIZ kizuna centrosomal protein
KLF10 Kruppel-like factor 10
KLHL11 kelch-like family member 11
KMT2B lysine (K)-specific methyltransferase 2B
KMT2D lysine (K)-specific methyltransferase 2D
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT75 keratin 75, type II
KRT80 keratin 80, type II
LAMA3 laminin, alpha 3
LAPTM5 lysosomal protein transmembrane 5
LEF1 lymphoid enhancer-binding factor 1
LEMD2 LEM domain containing 2
LIMK1 LIM domain kinase 1
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBP1 latent transforming growth factor beta binding protein 1
LYAR Ly1 antibody reactive
MALT1 MALT1 paracaspase
MAN2B1 mannosidase, alpha, class 2B, member 1
MANEA mannosidase, endo-alpha
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MAP7D1 MAP7 domain containing 1
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MBD4 methyl-CpG binding domain protein 4
MKL1 megakaryoblastic leukemia (translocation) 1
MLEC malectin
MOB3A MOB kinase activator 3A
MPST mercaptopyruvate sulfurtransferase
MROH1 maestro heat-like repeat family member 1
MRPL18 mitochondrial ribosomal protein L18
MRPL34 mitochondrial ribosomal protein L34
MRPL44 mitochondrial ribosomal protein L44
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MUC16 mucin 16, cell surface associated
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYH11 myosin, heavy chain 11, smooth muscle
MYH9 myosin, heavy chain 9, non-muscle
MYO19 myosin XIX
MYOF myoferlin
N4BP2L2 NEDD4 binding protein 2-like 2
NCOA2 nuclear receptor coactivator 2
NDE1 nudE neurodevelopment protein 1
NEO1 neogenin 1
NES nestin
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFXL1 nuclear transcription factor, X-box binding-like 1
NHLRC2 NHL repeat containing 2
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTHL1 nth endonuclease III-like 1 (E. coli)
NUP160 nucleoporin 160kDa
NUP93 nucleoporin 93kDa
OPA1 optic atrophy 1 (autosomal dominant)
OPTN optineurin
ORAI1 ORAI calcium release-activated calcium modulator 1
OSTF1 osteoclast stimulating factor 1
OXLD1 oxidoreductase-like domain containing 1
P3H2 prolyl 3-hydroxylase 2
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARG poly (ADP-ribose) glycohydrolase
PARP10 poly (ADP-ribose) polymerase family, member 10
PBX4 pre-B-cell leukemia homeobox 4
PCDH7 protocadherin 7
PCDHA1 protocadherin alpha 1
PCDHA10 protocadherin alpha 10
PCDHA11 protocadherin alpha 11
PCDHA12 protocadherin alpha 12
PCDHA13 protocadherin alpha 13
PCDHA2 protocadherin alpha 2
PCDHA3 protocadherin alpha 3
PCDHA4 protocadherin alpha 4
PCDHA5 protocadherin alpha 5
PCDHA6 protocadherin alpha 6
PCDHA7 protocadherin alpha 7
PCDHA8 protocadherin alpha 8
PCDHA9 protocadherin alpha 9
PCDHAC1 protocadherin alpha subfamily C, 1
PCDHAC2 protocadherin alpha subfamily C, 2
PCLO piccolo presynaptic cytomatrix protein
PDE4DIP phosphodiesterase 4D interacting protein
PDGFB platelet-derived growth factor beta polypeptide
PDIA3 protein disulfide isomerase family A, member 3
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PER2 period circadian clock 2
PGM2L1 phosphoglucomutase 2-like 1
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PHTF1 putative homeodomain transcription factor 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PIP5KL1 phosphatidylinositol-4-phosphate 5-kinase-like 1
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCG1 phospholipase C, gamma 1
PLEC plectin
PPARA peroxisome proliferator-activated receptor alpha
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PRPF19 pre-mRNA processing factor 19
PSD pleckstrin and Sec7 domain containing
PTBP2 polypyrimidine tract binding protein 2
PTDSS1 phosphatidylserine synthase 1
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRF protein tyrosine phosphatase, receptor type, F
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RAD51D RAD51 paralog D
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RBL1 retinoblastoma-like 1
RBM10 RNA binding motif protein 10
RBM23 RNA binding motif protein 23
RBM38 RNA binding motif protein 38
RCAN1 regulator of calcineurin 1
RCOR1 REST corepressor 1
REST RE1-silencing transcription factor
RHBDD1 rhomboid domain containing 1
RHOBTB3 Rho-related BTB domain containing 3
RHPN1 rhophilin, Rho GTPase binding protein 1
RIC8A RIC8 guanine nucleotide exchange factor A
RIMS3 regulating synaptic membrane exocytosis 3
RIPK2 receptor-interacting serine-threonine kinase 2
RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
RNF40 ring finger protein 40, E3 ubiquitin protein ligase
RPAP2 RNA polymerase II associated protein 2
RPRD2 regulation of nuclear pre-mRNA domain containing 2
RSRC1 arginine/serine-rich coiled-coil 1
RSRC2 arginine/serine-rich coiled-coil 2
S1PR1 sphingosine-1-phosphate receptor 1
SASH3 SAM and SH3 domain containing 3
SATB1 SATB homeobox 1
SATB2 SATB homeobox 2
SCAF1 SR-related CTD-associated factor 1
SCAMP5 secretory carrier membrane protein 5
SCPEP1 serine carboxypeptidase 1
SCYL2 SCY1-like 2 (S. cerevisiae)
SDCCAG8 serologically defined colon cancer antigen 8
SEC31A SEC31 homolog A (S. cerevisiae)
SELK selenoprotein K
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFXN4 sideroflexin 4
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase
SKAP1 src kinase associated phosphoprotein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC35E4 solute carrier family 35, member E4
SLC44A3 solute carrier family 44, member 3
SLC46A1 solute carrier family 46 (folate transporter), member 1
SLC7A6OS solute carrier family 7, member 6 opposite strand
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SNX27 sorting nexin family member 27
SOX9 SRY (sex determining region Y)-box 9
SP100 SP100 nuclear antigen
SP110 SP110 nuclear body protein
SPAG1 sperm associated antigen 1
SPATA2L spermatogenesis associated 2-like
SPPL2B signal peptide peptidase like 2B
STAU1 staufen double-stranded RNA binding protein 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK39 serine threonine kinase 39
STRIP2 striatin interacting protein 2
STX1A syntaxin 1A (brain)
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
SYBU syntabulin (syntaxin-interacting)
SYT16 synaptotagmin XVI
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D10C TBC1 domain family, member 10C
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCTN3 tectonic family member 3
TGM2 transglutaminase 2
TGOLN2 trans-golgi network protein 2
THEMIS thymocyte selection associated
THOC7 THO complex 7
THOP1 thimet oligopeptidase 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TIPRL TOR signaling pathway regulator
TLE3 transducin-like enhancer of split 3
TLR6 toll-like receptor 6
TMCO3 transmembrane and coiled-coil domains 3
TMEM8A transmembrane protein 8A
TMOD2 tropomodulin 2 (neuronal)
TNK2 tyrosine kinase, non-receptor, 2
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TOP2B topoisomerase (DNA) II beta 180kDa
TP53 tumor protein p53
TP53INP1 tumor protein p53 inducible nuclear protein 1
TPP1 tripeptidyl peptidase I
TPX2 TPX2, microtubule-associated
TRAPPC10 trafficking protein particle complex 10
TRIM26 tripartite motif containing 26
TRIM33 tripartite motif containing 33
TRPS1 trichorhinophalangeal syndrome I
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
TTC27 tetratricopeptide repeat domain 27
TTC39B tetratricopeptide repeat domain 39B
TYK2 tyrosine kinase 2
UBE3A ubiquitin protein ligase E3A
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP34 ubiquitin specific peptidase 34
USP38 ubiquitin specific peptidase 38
USP54 ubiquitin specific peptidase 54
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
WAS Wiskott-Aldrich syndrome
WDFY3 WD repeat and FYVE domain containing 3
WDR44 WD repeat domain 44
WDR90 WD repeat domain 90
WIZ widely interspaced zinc finger motifs
XYLB xylulokinase homolog (H. influenzae)
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZCCHC11 zinc finger, CCHC domain containing 11
ZFHX4 zinc finger homeobox 4
ZFP62 ZFP62 zinc finger protein
ZFYVE9 zinc finger, FYVE domain containing 9
ZGRF1 zinc finger, GRF-type containing 1
ZKSCAN8 zinc finger with KRAB and SCAN domains 8
ZNF12 zinc finger protein 12
ZNF121 zinc finger protein 121
ZNF142 zinc finger protein 142
ZNF205 zinc finger protein 205
ZNF283 zinc finger protein 283
ZNF292 zinc finger protein 292
ZNF511 zinc finger protein 511
ZNF512 zinc finger protein 512
ZNF585A zinc finger protein 585A
ZNF594 zinc finger protein 594
ZNF610 zinc finger protein 610
ZNF616 zinc finger protein 616
ZNF628 zinc finger protein 628
ZNF711 zinc finger protein 711
ZNF773 zinc finger protein 773
ZNF776 zinc finger protein 776
ZNF790 zinc finger protein 790
ZNF880 zinc finger protein 880
ZSCAN18 zinc finger and SCAN domain containing 18
ZZZ3 zinc finger, ZZ-type containing 3