NCI-H1975 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
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Genes

308 genes with high or low expression in NCI-H1975 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
KIAA0586 KIAA0586 3.10036
ZNF350 zinc finger protein 350 2.61682
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 2.55133
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) 2.50819
STX10 syntaxin 10 2.49107
BBS1 Bardet-Biedl syndrome 1 2.37148
ZNF556 zinc finger protein 556 2.33175
ZNF266 zinc finger protein 266 2.31588
MRPL11 mitochondrial ribosomal protein L11 2.25301
IL1RL1 interleukin 1 receptor-like 1 2.20518
ADK adenosine kinase 2.19936
ZNF20 zinc finger protein 20 2.16729
SPATA7 spermatogenesis associated 7 2.1351
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 2.135
ACOX2 acyl-CoA oxidase 2, branched chain 2.1288
DPP3 dipeptidyl-peptidase 3 2.1229
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) 2.11667
ZNF675 zinc finger protein 675 2.08925
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) 2.07053
NUP88 nucleoporin 88kDa 2.02333
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 1.99761
VTI1B vesicle transport through interaction with t-SNAREs 1B 1.95088
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 1.93224
ZMAT5 zinc finger, matrin-type 5 1.93195
CA7 carbonic anhydrase VII 1.91139
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 1.89651
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 1.88156
ATF1 activating transcription factor 1 1.8661
BLVRA biliverdin reductase A 1.8612
ABHD5 abhydrolase domain containing 5 1.85917
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) 1.84998
CEP70 centrosomal protein 70kDa 1.83529
RNASEH1 ribonuclease H1 1.83048
GLRX3 glutaredoxin 3 1.82323
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1.81096
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 1.80883
RABEP1 rabaptin, RAB GTPase binding effector protein 1 1.80524
CDC37 cell division cycle 37 1.80462
MED6 mediator complex subunit 6 1.80317
EFHC2 EF-hand domain (C-terminal) containing 2 1.79171
DLD dihydrolipoamide dehydrogenase 1.79127
NUPL2 nucleoporin like 2 1.78971
SFTPB surfactant protein B 1.78745
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 1.78723
ZNF155 zinc finger protein 155 1.78586
ZNF665 zinc finger protein 665 1.78022
UCK2 uridine-cytidine kinase 2 1.77137
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 1.76764
SLC39A9 solute carrier family 39, member 9 1.76397
COG2 component of oligomeric golgi complex 2 1.76382
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae) 1.74771
CLCF1 cardiotrophin-like cytokine factor 1 1.74539
EIF4A1 eukaryotic translation initiation factor 4A1 1.74484
TFB2M transcription factor B2, mitochondrial 1.73795
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 1.73426
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 1.72474
DAPK3 death-associated protein kinase 3 1.72081
LDHC lactate dehydrogenase C 1.71743
ZNF43 zinc finger protein 43 1.71274
STYXL1 serine/threonine/tyrosine interacting-like 1 1.70791
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 1.68405
ACP6 acid phosphatase 6, lysophosphatidic 1.67999
UPP1 uridine phosphorylase 1 1.67968
GGPS1 geranylgeranyl diphosphate synthase 1 1.66965
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense 1.66593
CRHR2 corticotropin releasing hormone receptor 2 1.65961
ANKEF1 ankyrin repeat and EF-hand domain containing 1 1.64898
ULBP1 UL16 binding protein 1 1.6449
ZNF562 zinc finger protein 562 1.64446
ZNF614 zinc finger protein 614 1.6436
ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) 1.64298
MRPL24 mitochondrial ribosomal protein L24 1.63692
THOC5 THO complex 5 1.63438
SYTL2 synaptotagmin-like 2 1.63215
AP4S1 adaptor-related protein complex 4, sigma 1 subunit 1.62697
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 1.62207
RAD51B RAD51 paralog B 1.61725
ZNF426 zinc finger protein 426 1.61218
CPD carboxypeptidase D 1.61182
PCDHA10 protocadherin alpha 10 1.60646
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 1.60338
ACTR10 actin-related protein 10 homolog (S. cerevisiae) 1.59991
SFMBT1 Scm-like with four mbt domains 1 1.59939
SIX5 SIX homeobox 5 1.58841
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 1.58813
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 1.58204
RNF115 ring finger protein 115 1.58015
UBL5 ubiquitin-like 5 1.57659
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) 1.57424
TDP1 tyrosyl-DNA phosphodiesterase 1 1.5742
ZDHHC24 zinc finger, DHHC-type containing 24 1.57075
CCNH cyclin H 1.5693
MLH1 mutL homolog 1 1.56679
SMPX small muscle protein, X-linked 1.56628
GFAP glial fibrillary acidic protein 1.56269
GCDH glutaryl-CoA dehydrogenase 1.56212
TCAP titin-cap 1.55899
SDHAF3 succinate dehydrogenase complex assembly factor 3 1.55704
DHRS2 dehydrogenase/reductase (SDR family) member 2 1.55638
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 1.55086
LEP leptin 1.53995
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 1.53957
CLCNKB chloride channel, voltage-sensitive Kb 1.53407
GMPR2 guanosine monophosphate reductase 2 1.53391
PLAC1 placenta-specific 1 1.53246
MNAT1 MNAT CDK-activating kinase assembly factor 1 1.52427
CCS copper chaperone for superoxide dismutase 1.5225
GUF1 GUF1 GTPase homolog (S. cerevisiae) 1.52121
ARF1P1 ADP-ribosylation factor 1 pseudogene 1 1.51706
SLCO2A1 solute carrier organic anion transporter family, member 2A1 1.51016
SDPR serum deprivation response 1.49927
TSPY1 testis specific protein, Y-linked 1 1.49527
UBA6 ubiquitin-like modifier activating enzyme 6 1.48443
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 1.48341
FH fumarate hydratase 1.47841
EDNRA endothelin receptor type A 1.4781
SHMT1 serine hydroxymethyltransferase 1 (soluble) 1.47593
FASTKD2 FAST kinase domains 2 1.47181
ZNF214 zinc finger protein 214 1.46519
PPAN peter pan homolog (Drosophila) 1.45395
HIST1H2BH histone cluster 1, H2bh 1.44673
KLRC3 killer cell lectin-like receptor subfamily C, member 3 1.44251
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 1.4383
CDK7 cyclin-dependent kinase 7 1.43626
UBA5 ubiquitin-like modifier activating enzyme 5 1.43425
ZNF93 zinc finger protein 93 1.43292
OSMR oncostatin M receptor 1.42937
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase 1.42592
ZC3H14 zinc finger CCCH-type containing 14 1.42591
SSBP1 single-stranded DNA binding protein 1, mitochondrial 1.4258
DPY19L1 dpy-19-like 1 (C. elegans) 1.4238
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 1.41947
DHRS7 dehydrogenase/reductase (SDR family) member 7 1.41883
ICT1 immature colon carcinoma transcript 1 1.41843
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 1.41678

low expression

Symbol Name Standardized Value
STK24 serine/threonine kinase 24 -3.53725
TM7SF3 transmembrane 7 superfamily member 3 -3.53725
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) -3.53696
TBX19 T-box 19 -2.97194
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 -2.85033
RPS16 ribosomal protein S16 -2.83044
ASAP1-IT1 ASAP1 intronic transcript 1 -2.76849
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -2.67107
RANBP10 RAN binding protein 10 -2.60078
EGLN2 egl-9 family hypoxia-inducible factor 2 -2.59805
RNASEH2B ribonuclease H2, subunit B -2.59175
FBXO42 F-box protein 42 -2.55582
LMO2 LIM domain only 2 (rhombotin-like 1) -2.54963
MARK4 MAP/microtubule affinity-regulating kinase 4 -2.46219
N4BP2L2 NEDD4 binding protein 2-like 2 -2.41698
IFT81 intraflagellar transport 81 -2.38556
HOXA9 homeobox A9 -2.38007
KLC2 kinesin light chain 2 -2.36548
MRPL44 mitochondrial ribosomal protein L44 -2.34439
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -2.33949
RPS19 ribosomal protein S19 -2.33773
ZDHHC18 zinc finger, DHHC-type containing 18 -2.29363
AGO2 argonaute RISC catalytic component 2 -2.28487
TLE4 transducin-like enhancer of split 4 -2.25925
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -2.24146
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast) -2.23649
CBX4 chromobox homolog 4 -2.23575
RBM10 RNA binding motif protein 10 -2.17719
RAD54L2 RAD54-like 2 (S. cerevisiae) -2.14681
COL9A2 collagen, type IX, alpha 2 -2.14662
SPEN spen family transcriptional repressor -2.13651
SIKE1 suppressor of IKBKE 1 -2.1154
NID1 nidogen 1 -2.10665
TTF1 transcription termination factor, RNA polymerase I -2.10071
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 -2.09578
PDS5B PDS5 cohesin associated factor B -2.05852
ANKZF1 ankyrin repeat and zinc finger domain containing 1 -2.03948
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.0262
F5 coagulation factor V (proaccelerin, labile factor) -2.01895
FLJ11292 -2.01156
CEP350 centrosomal protein 350kDa -1.98599
PLCB4 phospholipase C, beta 4 -1.98481
ECH1 enoyl CoA hydratase 1, peroxisomal -1.98344
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -1.98319
ADAMTSL3 ADAMTS-like 3 -1.96635
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -1.94419
PHF1 PHD finger protein 1 -1.93944
INADL InaD-like (Drosophila) -1.93478
SIPA1L3 signal-induced proliferation-associated 1 like 3 -1.89664
PAPOLG poly(A) polymerase gamma -1.87876
NOL10 nucleolar protein 10 -1.87868
GPR137B G protein-coupled receptor 137B -1.87672
ATXN7L1 ataxin 7-like 1 -1.86976
PHF20L1 PHD finger protein 20-like 1 -1.82813
HOXA2 homeobox A2 -1.81437
SSX3 synovial sarcoma, X breakpoint 3 -1.81278
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 -1.79751
POMP proteasome maturation protein -1.79001
LARS leucyl-tRNA synthetase -1.78962
RFX3 regulatory factor X, 3 (influences HLA class II expression) -1.78883
NUP214 nucleoporin 214kDa -1.78127
NCOR2 nuclear receptor corepressor 2 -1.77965
UBE4B ubiquitination factor E4B -1.76958
HOXB5 homeobox B5 -1.76569
ZC3H13 zinc finger CCCH-type containing 13 -1.76355
ZNF592 zinc finger protein 592 -1.76213
RNF111 ring finger protein 111 -1.75935
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -1.7586
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 -1.75813
POMT1 protein-O-mannosyltransferase 1 -1.75296
WBP2 WW domain binding protein 2 -1.74822
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8 -1.74699
SIRT2 sirtuin 2 -1.73894
SPAG6 sperm associated antigen 6 -1.73699
MTOR mechanistic target of rapamycin (serine/threonine kinase) -1.7363
ERCC1 excision repair cross-complementation group 1 -1.7268
HLF hepatic leukemia factor -1.72168
EHMT2 euchromatic histone-lysine N-methyltransferase 2 -1.715
SETD1B SET domain containing 1B -1.71468
ZNF574 zinc finger protein 574 -1.71331
SF3A3 splicing factor 3a, subunit 3, 60kDa -1.70517
S100PBP S100P binding protein -1.70132
RBM12B RNA binding motif protein 12B -1.6999
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -1.68801
PRRC2C proline-rich coiled-coil 2C -1.68681
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits -1.68342
TMEM19 transmembrane protein 19 -1.67571
SRSF6 serine/arginine-rich splicing factor 6 -1.67271
RAB4B RAB4B, member RAS oncogene family -1.66088
FAM168A family with sequence similarity 168, member A -1.65758
INTS6 integrator complex subunit 6 -1.65719
TDG thymine-DNA glycosylase -1.6481
SOCS7 suppressor of cytokine signaling 7 -1.63998
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding) -1.63438
ABHD2 abhydrolase domain containing 2 -1.63272
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) -1.62382
ARMC7 armadillo repeat containing 7 -1.62367
SCRIB scribbled planar cell polarity protein -1.62232
JAM3 junctional adhesion molecule 3 -1.62227
DLX4 distal-less homeobox 4 -1.62117
TIPRL TOR signaling pathway regulator -1.61116
KRAS Kirsten rat sarcoma viral oncogene homolog -1.60871
CSDE1 cold shock domain containing E1, RNA-binding -1.60829
CRELD1 cysteine-rich with EGF-like domains 1 -1.6059
CACYBP calcyclin binding protein -1.60291
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) -1.59948
CERK ceramide kinase -1.59535
HAS1 hyaluronan synthase 1 -1.59264
GPM6B glycoprotein M6B -1.58541
CSNK1D casein kinase 1, delta -1.58507
MED13L mediator complex subunit 13-like -1.58242
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 -1.57598
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -1.57144
PCDHA6 protocadherin alpha 6 -1.5677
MTMR8 myotubularin related protein 8 -1.56718
SNCA synuclein, alpha (non A4 component of amyloid precursor) -1.56323
HBE1 hemoglobin, epsilon 1 -1.56268
ANKRD46 ankyrin repeat domain 46 -1.55996
OSR2 odd-skipped related transciption factor 2 -1.55904
BSDC1 BSD domain containing 1 -1.55895
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 -1.55475
GCH1 GTP cyclohydrolase 1 -1.55121
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa -1.54924
PRRC2B proline-rich coiled-coil 2B -1.53964
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -1.53907
UTP14C UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) -1.537
TCF4 transcription factor 4 -1.53549
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -1.53052
COLGALT2 collagen beta(1-O)galactosyltransferase 2 -1.53005
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -1.52951
POLR1D polymerase (RNA) I polypeptide D, 16kDa -1.525
MTA1 metastasis associated 1 -1.52466
CIT citron rho-interacting serine/threonine kinase -1.5237
MFAP5 microfibrillar associated protein 5 -1.52336
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 -1.51866
JMJD6 jumonji domain containing 6 -1.5149
CANT1 calcium activated nucleotidase 1 -1.51293
ZFC3H1 zinc finger, C3H1-type containing -1.51171
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12) -1.51002
ANK2 ankyrin 2, neuronal -1.50564
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -1.50356
PRDM2 PR domain containing 2, with ZNF domain -1.50158
CASC3 cancer susceptibility candidate 3 -1.5004
STK3 serine/threonine kinase 3 -1.49725
ALK anaplastic lymphoma receptor tyrosine kinase -1.49459
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta -1.49272
SCAF8 SR-related CTD-associated factor 8 -1.48749
NCK2 NCK adaptor protein 2 -1.48597
CD1E CD1e molecule -1.47995
ATXN2 ataxin 2 -1.47686
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 -1.47365
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -1.46923
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 -1.46728
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -1.46324
HAO2 hydroxyacid oxidase 2 (long chain) -1.46163
FBL fibrillarin -1.45841
CEP131 centrosomal protein 131kDa -1.4575
RAD21 RAD21 homolog (S. pombe) -1.45382
RNFT2 ring finger protein, transmembrane 2 -1.45066
HBB hemoglobin, beta -1.44712
ESD esterase D -1.44549
CIC capicua transcriptional repressor -1.44489
CDC42 cell division cycle 42 -1.44486
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 -1.44242
MORF4L1 mortality factor 4 like 1 -1.44208
FGF23 fibroblast growth factor 23 -1.44138
BMP7 bone morphogenetic protein 7 -1.43686
SYMPK symplekin -1.43664
KPNA3 karyopherin alpha 3 (importin alpha 4) -1.43461
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) -1.43382
PNPLA2 patatin-like phospholipase domain containing 2 -1.43106
CHD4 chromodomain helicase DNA binding protein 4 -1.42255
MTF1 metal-regulatory transcription factor 1 -1.41933