NCI-H1975 Gene Set

Dataset COSMIC Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Similar Terms
Downloads & Tools


416 genes mutated in the NCI-H1975 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4
ABLIM3 actin binding LIM protein family, member 3
ACBD4 acyl-CoA binding domain containing 4
ACLY ATP citrate lyase
ACTRT1 actin-related protein T1
ADAM20 ADAM metallopeptidase domain 20
ADAM21 ADAM metallopeptidase domain 21
ADAM29 ADAM metallopeptidase domain 29
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17
ADGRA1 adhesion G protein-coupled receptor A1
ADGRE3 adhesion G protein-coupled receptor E3
ADGRF3 adhesion G protein-coupled receptor F3
ADGRF5 adhesion G protein-coupled receptor F5
AGBL5 ATP/GTP binding protein-like 5
AGO1 argonaute RISC catalytic component 1
AKAP11 A kinase (PRKA) anchor protein 11
ALOX15B arachidonate 15-lipoxygenase, type B
ALPK2 alpha-kinase 2
ANK2 ankyrin 2, neuronal
ANKS3 ankyrin repeat and sterile alpha motif domain containing 3
ANKS6 ankyrin repeat and sterile alpha motif domain containing 6
ANXA10 annexin A10
APC adenomatous polyposis coli
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARFGEF3 ARFGEF family member 3
ARHGAP19 Rho GTPase activating protein 19
ARHGAP28 Rho GTPase activating protein 28
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ARL2 ADP-ribosylation factor-like 2
AS3MT arsenite methyltransferase
ASIC4 acid sensing (proton gated) ion channel family member 4
ATF7IP activating transcription factor 7 interacting protein
ATG2A autophagy related 2A
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3
BAIAP3 BAI1-associated protein 3
BIRC6 baculoviral IAP repeat containing 6
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BRWD1 bromodomain and WD repeat domain containing 1
BTD biotinidase
BTNL8 butyrophilin-like 8
C1QC complement component 1, q subcomponent, C chain
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CADPS2 Ca++-dependent secretion activator 2
CAPN6 calpain 6
CASC3 cancer susceptibility candidate 3
CASQ2 calsequestrin 2 (cardiac muscle)
CASR calcium-sensing receptor
CCDC121 coiled-coil domain containing 121
CCDC129 coiled-coil domain containing 129
CCDC50 coiled-coil domain containing 50
CCDC80 coiled-coil domain containing 80
CD82 CD82 molecule
CDHR2 cadherin-related family member 2
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CEP350 centrosomal protein 350kDa
CHAMP1 chromosome alignment maintaining phosphoprotein 1
CHD5 chromodomain helicase DNA binding protein 5
CHIA chitinase, acidic
CLDN16 claudin 16
CLSTN2 calsyntenin 2
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CNTN5 contactin 5
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL7A1 collagen, type VII, alpha 1
CORIN corin, serine peptidase
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor
CPNE4 copine IV
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CR1L complement component (3b/4b) receptor 1-like
CRYBA4 crystallin, beta A4
CSF1R colony stimulating factor 1 receptor
CSPG4 chondroitin sulfate proteoglycan 4
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNND2 catenin (cadherin-associated protein), delta 2
CTTN cortactin
CTU2 cytosolic thiouridylase subunit 2 homolog (S. pombe)
CUL9 cullin 9
CXCL9 chemokine (C-X-C motif) ligand 9
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2
DACH2 dachshund family transcription factor 2
DBF4B DBF4 zinc finger B
DCLK3 doublecortin-like kinase 3
DCPS decapping enzyme, scavenger
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEFB123 defensin, beta 123
DICER1 dicer 1, ribonuclease type III
DLX3 distal-less homeobox 3
DNAH17 dynein, axonemal, heavy chain 17
DNAH3 dynein, axonemal, heavy chain 3
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
DNM3 dynamin 3
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
DPY19L1 dpy-19-like 1 (C. elegans)
DTNBP1 dystrobrevin binding protein 1
DUOX2 dual oxidase 2
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
EGFR epidermal growth factor receptor
EIF3G eukaryotic translation initiation factor 3, subunit G
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPCAM epithelial cell adhesion molecule
EPHA1 EPH receptor A1
ERV3-1 endogenous retrovirus group 3, member 1
EVC Ellis van Creveld protein
EYA1 EYA transcriptional coactivator and phosphatase 1
FAM109A family with sequence similarity 109, member A
FAM120B family with sequence similarity 120B
FAM161B family with sequence similarity 161, member B
FAM179B family with sequence similarity 179, member B
FAT2 FAT atypical cadherin 2
FAT3 FAT atypical cadherin 3
FBN2 fibrillin 2
FBRS fibrosin
FER1L5 fer-1-like family member 5
FGD6 FYVE, RhoGEF and PH domain containing 6
FGF5 fibroblast growth factor 5
FHL2 four and a half LIM domains 2
FLG filaggrin
FMN1 formin 1
FMN2 formin 2
FMO2 flavin containing monooxygenase 2 (non-functional)
FMOD fibromodulin
FNDC1 fibronectin type III domain containing 1
FOLR3 folate receptor 3 (gamma)
FOXD4 forkhead box D4
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GAPVD1 GTPase activating protein and VPS9 domains 1
GBA glucosidase, beta, acid
GBP6 guanylate binding protein family, member 6
GCKR glucokinase (hexokinase 4) regulator
GCLC glutamate-cysteine ligase, catalytic subunit
GIF gastric intrinsic factor (vitamin B synthesis)
GLI1 GLI family zinc finger 1
GLMN glomulin, FKBP associated protein
GOLGA3 golgin A3
GOLGA6L2 golgin A6 family-like 2
GOLIM4 golgi integral membrane protein 4
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GPATCH1 G patch domain containing 1
GPBAR1 G protein-coupled bile acid receptor 1
GPC6 glypican 6
GPR148 G protein-coupled receptor 148
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSTM3 glutathione S-transferase mu 3 (brain)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUK1 guanylate kinase 1
HDC histidine decarboxylase
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HHLA1 HERV-H LTR-associating 1
HIRA histone cell cycle regulator
HIST2H3D histone cluster 2, H3d
HKR1 HKR1, GLI-Kruppel zinc finger family member
HLA-C major histocompatibility complex, class I, C
HNMT histamine N-methyltransferase
HOXA7 homeobox A7
HOXB9 homeobox B9
HRH3 histamine receptor H3
HRNR hornerin
HYDIN HYDIN, axonemal central pair apparatus protein
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGSF1 immunoglobulin superfamily, member 1
IL1RL1 interleukin 1 receptor-like 1
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
IPO13 importin 13
ITLN1 intelectin 1 (galactofuranose binding)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JARID2 jumonji, AT rich interactive domain 2
KAT6B K(lysine) acetyltransferase 6B
KIAA0754 KIAA0754
KIAA0825 KIAA0825
KIAA1211 KIAA1211
KIAA1462 KIAA1462
KIF12 kinesin family member 12
KIF20A kinesin family member 20A
KIF20B kinesin family member 20B
KRT25 keratin 25, type I
KRT6B keratin 6B, type II
KRT6C keratin 6C, type II
KRT80 keratin 80, type II
KRTAP5-4 keratin associated protein 5-4
LAMC3 laminin, gamma 3
LCT lactase
LENG9 leukocyte receptor cluster (LRC) member 9
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
LONP2 lon peptidase 2, peroxisomal
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
LRIT1 leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
LRP1B low density lipoprotein receptor-related protein 1B
LRRC24 leucine rich repeat containing 24
LRRC46 leucine rich repeat containing 46
MACF1 microtubule-actin crosslinking factor 1
MAGEA9B melanoma antigen family A9B
MAGEC1 melanoma antigen family C1
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MARK1 MAP/microtubule affinity-regulating kinase 1
MBD5 methyl-CpG binding domain protein 5
MBD6 methyl-CpG binding domain protein 6
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2
MEGF6 multiple EGF-like-domains 6
MFSD4 major facilitator superfamily domain containing 4
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MMP10 matrix metallopeptidase 10
MPDZ multiple PDZ domain protein
MRPS5 mitochondrial ribosomal protein S5
MUC16 mucin 16, cell surface associated
MUC19 mucin 19, oligomeric
MUC21 mucin 21, cell surface associated
MUC4 mucin 4, cell surface associated
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYLK2 myosin light chain kinase 2
MYO3B myosin IIIB
MYO7A myosin VIIA
MYO7B myosin VIIB
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NACA nascent polypeptide-associated complex alpha subunit
NBR1 neighbor of BRCA1 gene 1
NEDD1 neural precursor cell expressed, developmentally down-regulated 1
NEK1 NIMA-related kinase 1
NELL2 NEL-like 2 (chicken)
NLRP5 NLR family, pyrin domain containing 5
NLRP7 NLR family, pyrin domain containing 7
NLRP8 NLR family, pyrin domain containing 8
NMNAT1 nicotinamide nucleotide adenylyltransferase 1
NOBOX NOBOX oogenesis homeobox
NPC1 Niemann-Pick disease, type C1
NSD1 nuclear receptor binding SET domain protein 1
NTPCR nucleoside-triphosphatase, cancer-related
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NYNRIN NYN domain and retroviral integrase containing
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
OBP2A odorant binding protein 2A
OLFM1 olfactomedin 1
OLFML1 olfactomedin-like 1
OR10J1 olfactory receptor, family 10, subfamily J, member 1
OR10Q1 olfactory receptor, family 10, subfamily Q, member 1
OR13G1 olfactory receptor, family 13, subfamily G, member 1
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4
OR2L3 olfactory receptor, family 2, subfamily L, member 3
OR2T33 olfactory receptor, family 2, subfamily T, member 33
OR2T8 olfactory receptor, family 2, subfamily T, member 8
OR4C11 olfactory receptor, family 4, subfamily C, member 11
OR51L1 olfactory receptor, family 51, subfamily L, member 1
OR5D13 olfactory receptor, family 5, subfamily D, member 13 (gene/pseudogene)
OR5D18 olfactory receptor, family 5, subfamily D, member 18
OR5D3P olfactory receptor, family 5, subfamily D, member 3 pseudogene
OSBP oxysterol binding protein
PABPC1L poly(A) binding protein, cytoplasmic 1-like
PAQR6 progestin and adipoQ receptor family member VI
PARK2 parkin RBR E3 ubiquitin protein ligase
PCBP4 poly(rC) binding protein 4
PCDH15 protocadherin-related 15
PCDHA2 protocadherin alpha 2
PCDHA5 protocadherin alpha 5
PCDHB6 protocadherin beta 6
PCDHGA11 protocadherin gamma subfamily A, 11
PCNX pecanex homolog (Drosophila)
PCYT1B phosphate cytidylyltransferase 1, choline, beta
PDC phosducin
PDE5A phosphodiesterase 5A, cGMP-specific
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PDILT protein disulfide isomerase-like, testis expressed
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1
PER2 period circadian clock 2
PF4V1 platelet factor 4 variant 1
PFN4 profilin family, member 4
PGK2 phosphoglycerate kinase 2
PIBF1 progesterone immunomodulatory binding factor 1
PIGV phosphatidylinositol glycan anchor biosynthesis, class V
PIGX phosphatidylinositol glycan anchor biosynthesis, class X
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIKFYVE phosphoinositide kinase, FYVE finger containing
PLA2G4E phospholipase A2, group IVE
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHS1 pleckstrin homology domain containing, family S member 1
POLK polymerase (DNA directed) kappa
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POU6F1 POU class 6 homeobox 1
POU6F2 POU class 6 homeobox 2
PPAT phosphoribosyl pyrophosphate amidotransferase
PPL periplakin
PRDM6 PR domain containing 6
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PROX2 prospero homeobox 2
PRPF4 pre-mRNA processing factor 4
PRRC2C proline-rich coiled-coil 2C
PRUNE2 prune homolog 2 (Drosophila)
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PTPRE protein tyrosine phosphatase, receptor type, E
PXDN peroxidasin
PYHIN1 pyrin and HIN domain family, member 1
QSOX2 quiescin Q6 sulfhydryl oxidase 2
RANGAP1 Ran GTPase activating protein 1
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
RBM10 RNA binding motif protein 10
RBP3 retinol binding protein 3, interstitial
REM2 RAS (RAD and GEM)-like GTP binding 2
RHOT2 ras homolog family member T2
RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
RNASE13 ribonuclease, RNase A family, 13 (non-active)
RPS4X ribosomal protein S4, X-linked
RPUSD3 RNA pseudouridylate synthase domain containing 3
RUNX3 runt-related transcription factor 3
SACS sacsin molecular chaperone
SAMD4A sterile alpha motif domain containing 4A
SBF1 SET binding factor 1
SCAI suppressor of cancer cell invasion
SCN3A sodium channel, voltage gated, type III alpha subunit
SCN7A sodium channel, voltage gated, type VII alpha subunit
SEC24D SEC24 family member D
SERINC3 serine incorporator 3
SERINC4 serine incorporator 4
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SIKE1 suppressor of IKBKE 1
SKA3 spindle and kinetochore associated complex subunit 3
SLC14A2 solute carrier family 14 (urea transporter), member 2
SLC17A3 solute carrier family 17 (organic anion transporter), member 3
SLC22A15 solute carrier family 22, member 15
SLC26A8 solute carrier family 26 (anion exchanger), member 8
SLC30A9 solute carrier family 30 (zinc transporter), member 9
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC39A12 solute carrier family 39 (zinc transporter), member 12
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLITRK3 SLIT and NTRK-like family, member 3
SLK STE20-like kinase
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMYD1 SET and MYND domain containing 1
SORCS1 sortilin-related VPS10 domain containing receptor 1
SORCS3 sortilin-related VPS10 domain containing receptor 3
SPDL1 spindle apparatus coiled-coil protein 1
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SSX7 synovial sarcoma, X breakpoint 7
STAT2 signal transducer and activator of transcription 2, 113kDa
STEAP3 STEAP family member 3, metalloreductase
STK4 serine/threonine kinase 4
SYT9 synaptotagmin IX
TACR1 tachykinin receptor 1
TANGO6 transport and golgi organization 6 homolog (Drosophila)
TBX22 T-box 22
TCAF1 TRPM8 channel-associated factor 1
TCP11L2 t-complex 11, testis-specific-like 2
TECTB tectorin beta
TEX13A testis expressed 13A
TG thyroglobulin
TGM7 transglutaminase 7
THAP9 THAP domain containing 9
THSD4 thrombospondin, type I, domain containing 4
TLN2 talin 2
TMX3 thioredoxin-related transmembrane protein 3
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNNT1 troponin T type 1 (skeletal, slow)
TNS3 tensin 3
TOP2B topoisomerase (DNA) II beta 180kDa
TOP3A topoisomerase (DNA) III alpha
TP53 tumor protein p53
TPSG1 tryptase gamma 1
TPX2 TPX2, microtubule-associated
TRIM17 tripartite motif containing 17
TRIM64C tripartite motif containing 64C
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TSC2 tuberous sclerosis 2
TTC21A tetratricopeptide repeat domain 21A
TTN titin
UBASH3A ubiquitin associated and SH3 domain containing A
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UCN3 urocortin 3
UGT3A1 UDP glycosyltransferase 3 family, polypeptide A1
UNC80 unc-80 homolog (C. elegans)
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USP34 ubiquitin specific peptidase 34
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
WBSCR17 Williams-Beuren syndrome chromosome region 17
WDFY4 WDFY family member 4
WDR17 WD repeat domain 17
WDR87 WD repeat domain 87
WISP2 WNT1 inducible signaling pathway protein 2
WSCD2 WSC domain containing 2
WWC3 WWC family member 3
XAB2 XPA binding protein 2
XYLT1 xylosyltransferase I
YTHDC2 YTH domain containing 2
ZBED9 zinc finger, BED-type containing 9
ZBTB48 zinc finger and BTB domain containing 48
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC6 zinc finger, CCHC domain containing 6
ZCWPW2 zinc finger, CW type with PWWP domain 2
ZMYM1 zinc finger, MYM-type 1
ZNF33B zinc finger protein 33B
ZNF729 zinc finger protein 729
ZNF737 zinc finger protein 737
ZNF98 zinc finger protein 98
ZNF99 zinc finger protein 99