NCI-H196 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description Small cell lung cancer cell line. (BRENDA Tissue and Enzyme Source Ontology, BTO_0003027)
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Genes

181 genes mutated in the NCI-H196 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
AACS acetoacetyl-CoA synthetase
AARS alanyl-tRNA synthetase
ADAMTSL1 ADAMTS-like 1
ADGRB2 adhesion G protein-coupled receptor B2
AGPS alkylglycerone phosphate synthase
AHRR aryl-hydrocarbon receptor repressor
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
ANAPC5 anaphase promoting complex subunit 5
AP3D1 adaptor-related protein complex 3, delta 1 subunit
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
ARID1A AT rich interactive domain 1A (SWI-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough
C1QL4 complement component 1, q subcomponent-like 4
C8ORF58 chromosome 8 open reading frame 58
CCDC15 coiled-coil domain containing 15
CCDC6 coiled-coil domain containing 6
CCNL1 cyclin L1
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CDK13 cyclin-dependent kinase 13
CDON cell adhesion associated, oncogene regulated
CEP290 centrosomal protein 290kDa
CEP72 centrosomal protein 72kDa
CEP97 centrosomal protein 97kDa
CFB complement factor B
CHD8 chromodomain helicase DNA binding protein 8
CLASP1 cytoplasmic linker associated protein 1
COL11A1 collagen, type XI, alpha 1
COL12A1 collagen, type XII, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CORO2A coronin, actin binding protein, 2A
CPQ carboxypeptidase Q
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSDE1 cold shock domain containing E1, RNA-binding
CSNK1G1 casein kinase 1, gamma 1
CTC1 CTS telomere maintenance complex component 1
CTTN cortactin
CYBRD1 cytochrome b reductase 1
DCAF10 DDB1 and CUL4 associated factor 10
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DMXL1 Dmx-like 1
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DTX3L deltex 3 like, E3 ubiquitin ligase
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
E2F4 E2F transcription factor 4, p107/p130-binding
E2F7 E2F transcription factor 7
EMILIN1 elastin microfibril interfacer 1
EP400 E1A binding protein p400
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EXOC6 exocyst complex component 6
FAM98B family with sequence similarity 98, member B
FBXW2 F-box and WD repeat domain containing 2
GLIS1 GLIS family zinc finger 1
GPI glucose-6-phosphate isomerase
GPRASP2 G protein-coupled receptor associated sorting protein 2
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HES6 hes family bHLH transcription factor 6
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HTT huntingtin
ITFG3 integrin alpha FG-GAP repeat containing 3
ITPKB inositol-trisphosphate 3-kinase B
JPH2 junctophilin 2
JUP junction plakoglobin
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5
KCNT2 potassium channel, sodium activated subfamily T, member 2
KIAA2018 KIAA2018
KMT2D lysine (K)-specific methyltransferase 2D
KRT80 keratin 80, type II
LARP1B La ribonucleoprotein domain family, member 1B
LDAH lipid droplet associated hydrolase
LIME1 Lck interacting transmembrane adaptor 1
LOXL2 lysyl oxidase-like 2
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
LUM lumican
MDN1 MDN1, midasin homolog (yeast)
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MKI67 marker of proliferation Ki-67
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MON1B MON1 secretory trafficking family member B
MTO1 mitochondrial tRNA translation optimization 1
MUM1 melanoma associated antigen (mutated) 1
MYO7B myosin VIIB
NACAD NAC alpha domain containing
NECAB3 N-terminal EF-hand calcium binding protein 3
NOTCH3 notch 3
NPAS3 neuronal PAS domain protein 3
NPHP4 nephronophthisis 4
NPR1 natriuretic peptide receptor 1
NUP98 nucleoporin 98kDa
OTUD3 OTU deubiquitinase 3
PAPD5 PAP associated domain containing 5
PAPD7 PAP associated domain containing 7
PCDHB13 protocadherin beta 13
PDCD6IP programmed cell death 6 interacting protein
PFN2 profilin 2
PGBD2 piggyBac transposable element derived 2
PIGM phosphatidylinositol glycan anchor biosynthesis, class M
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLAA phospholipase A2-activating protein
PLXNA1 plexin A1
PLXNC1 plexin C1
POGZ pogo transposable element with ZNF domain
POLG polymerase (DNA directed), gamma
POLL polymerase (DNA directed), lambda
POMGNT2 protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)
PPARG peroxisome proliferator-activated receptor gamma
PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PRKCD protein kinase C, delta
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1
PTCD3 pentatricopeptide repeat domain 3
PURB purine-rich element binding protein B
R3HCC1L R3H domain and coiled-coil containing 1-like
RABGAP1L RAB GTPase activating protein 1-like
RAI1 retinoic acid induced 1
RB1 retinoblastoma 1
RNF219 ring finger protein 219
RSRC1 arginine/serine-rich coiled-coil 1
SAYSD1 SAYSVFN motif domain containing 1
SEC24D SEC24 family member D
SEC63 SEC63 homolog (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SETD1B SET domain containing 1B
SETDB1 SET domain, bifurcated 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SIX1 SIX homeobox 1
SKI SKI proto-oncogene
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT5A signal transducer and activator of transcription 5A
STMND1 stathmin domain containing 1
STON2 stonin 2
SUMF2 sulfatase modifying factor 2
SYTL3 synaptotagmin-like 3
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
TAOK1 TAO kinase 1
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TDO2 tryptophan 2,3-dioxygenase
TGFBR3 transforming growth factor, beta receptor III
TMEM87B transmembrane protein 87B
TNKS1BP1 tankyrase 1 binding protein 1, 182kDa
TONSL tonsoku-like, DNA repair protein
TP53 tumor protein p53
TRAF2 TNF receptor-associated factor 2
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase
TRIM56 tripartite motif containing 56
TRMT10B tRNA methyltransferase 10 homolog B (S. cerevisiae)
TTC3 tetratricopeptide repeat domain 3
TYMP thymidine phosphorylase
UBIAD1 UbiA prenyltransferase domain containing 1
UBXN1 UBX domain protein 1
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
USP34 ubiquitin specific peptidase 34
VWA9 von Willebrand factor A domain containing 9
WDR37 WD repeat domain 37
WDR74 WD repeat domain 74
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
WRN Werner syndrome, RecQ helicase-like
XAB2 XPA binding protein 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB39 zinc finger and BTB domain containing 39
ZEB1 zinc finger E-box binding homeobox 1
ZFHX4 zinc finger homeobox 4
ZFYVE26 zinc finger, FYVE domain containing 26
ZHX1 zinc fingers and homeoboxes 1
ZMYM2 zinc finger, MYM-type 2
ZNF184 zinc finger protein 184
ZNF318 zinc finger protein 318
ZNF345 zinc finger protein 345
ZNF365 zinc finger protein 365
ZNF438 zinc finger protein 438
ZNF721 zinc finger protein 721
ZNF773 zinc finger protein 773
ZNF827 zinc finger protein 827