NCI-H1944 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: adenocarcinoma; non-small cell lung cancer (lung primary) (Cell Line Ontology, CLO_0008032)
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Genes

159 genes mutated in the NCI-H1944 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
AASDH aminoadipate-semialdehyde dehydrogenase
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADSL adenylosuccinate lyase
AGRN agrin
AHDC1 AT hook, DNA binding motif, containing 1
AHNAK AHNAK nucleoprotein
AKAP2 A kinase (PRKA) anchor protein 2
AKR1C3 aldo-keto reductase family 1, member C3
ALKBH6 alkB, alkylation repair homolog 6 (E. coli)
ANKMY1 ankyrin repeat and MYND domain containing 1
APOB apolipoprotein B
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARHGAP35 Rho GTPase activating protein 35
ATMIN ATM interactor
ATR ATR serine/threonine kinase
BFAR bifunctional apoptosis regulator
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CAPN15 calpain 15
CARD6 caspase recruitment domain family, member 6
CDC16 cell division cycle 16
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CEP152 centrosomal protein 152kDa
CEP192 centrosomal protein 192kDa
CEP250 centrosomal protein 250kDa
CMBL carboxymethylenebutenolidase homolog (Pseudomonas)
CNTRL centriolin
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
CWC22 CWC22 spliceosome-associated protein
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
DAPK1 death-associated protein kinase 1
DNAAF2 dynein, axonemal, assembly factor 2
DOCK9 dedicator of cytokinesis 9
DROSHA drosha, ribonuclease type III
EDA2R ectodysplasin A2 receptor
EFCAB11 EF-hand calcium binding domain 11
EFTUD2 elongation factor Tu GTP binding domain containing 2
EHBP1L1 EH domain binding protein 1-like 1
EMID1 EMI domain containing 1
EP400 E1A binding protein p400
EPHA5 EPH receptor A5
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAF1 Fas (TNFRSF6) associated factor 1
FAM160A2 family with sequence similarity 160, member A2
FAM83B family with sequence similarity 83, member B
FASN fatty acid synthase
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FECH ferrochelatase
FOLR3 folate receptor 3 (gamma)
FRS3 fibroblast growth factor receptor substrate 3
GOLGA5 golgin A5
GRB14 growth factor receptor-bound protein 14
GTF3A general transcription factor IIIA
HACD1 3-hydroxyacyl-CoA dehydratase 1
HDAC2 histone deacetylase 2
HMGXB4 HMG box domain containing 4
HMHA1 histocompatibility (minor) HA-1
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
INF2 inverted formin, FH2 and WH2 domain containing
INTS2 integrator complex subunit 2
IQGAP3 IQ motif containing GTPase activating protein 3
KBTBD6 kelch repeat and BTB (POZ) domain containing 6
KEAP1 kelch-like ECH-associated protein 1
KRAS Kirsten rat sarcoma viral oncogene homolog
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LYPLA1 lysophospholipase I
MACF1 microtubule-actin crosslinking factor 1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MCM8 minichromosome maintenance complex component 8
METTL2B methyltransferase like 2B
MFN1 mitofusin 1
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MPDZ multiple PDZ domain protein
MROH1 maestro heat-like repeat family member 1
MYRF myelin regulatory factor
NBN nibrin
NCOA1 nuclear receptor coactivator 1
NELFCD negative elongation factor complex member C/D
NIN ninein (GSK3B interacting protein)
NLRC5 NLR family, CARD domain containing 5
NPEPL1 aminopeptidase-like 1
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
PALM2-AKAP2 PALM2-AKAP2 readthrough
PCDHGB5 protocadherin gamma subfamily B, 5
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PIF1 PIF1 5'-to-3' DNA helicase
PIGK phosphatidylinositol glycan anchor biosynthesis, class K
PLD3 phospholipase D family, member 3
PMM1 phosphomannomutase 1
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PREP prolyl endopeptidase
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRPF3 pre-mRNA processing factor 3
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PTCH1 patched 1
RAP1GAP RAP1 GTPase activating protein
RARB retinoic acid receptor, beta
RBM10 RNA binding motif protein 10
RBM20 RNA binding motif protein 20
RNF213 ring finger protein 213
RNF219 ring finger protein 219
RNF24 ring finger protein 24
SAMD4A sterile alpha motif domain containing 4A
SBF1 SET binding factor 1
SCAF11 SR-related CTD-associated factor 11
SCP2 sterol carrier protein 2
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SMCR8 Smith-Magenis syndrome chromosome region, candidate 8
SMYD5 SMYD family member 5
SPAG5 sperm associated antigen 5
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
STK11 serine/threonine kinase 11
STK38L serine/threonine kinase 38 like
STS steroid sulfatase (microsomal), isozyme S
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SUZ12 SUZ12 polycomb repressive complex 2 subunit
SZRD1 SUZ RNA binding domain containing 1
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
TBCD tubulin folding cofactor D
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRA2B transformer 2 beta homolog (Drosophila)
TREML4 triggering receptor expressed on myeloid cells-like 4
TRIM34 tripartite motif containing 34
TRIM6-TRIM34 TRIM6-TRIM34 readthrough
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4
UGT1A5 UDP glucuronosyltransferase 1 family, polypeptide A5
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
ULK1 unc-51 like autophagy activating kinase 1
VLDLR very low density lipoprotein receptor
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WDR43 WD repeat domain 43
WDR59 WD repeat domain 59
WDR81 WD repeat domain 81
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
WNK2 WNK lysine deficient protein kinase 2
WWOX WW domain containing oxidoreductase
XRRA1 X-ray radiation resistance associated 1
ZNF205 zinc finger protein 205
ZNF229 zinc finger protein 229
ZNF329 zinc finger protein 329
ZNF451 zinc finger protein 451
ZNF467 zinc finger protein 467
ZNF485 zinc finger protein 485
ZNF496 zinc finger protein 496