NCI-H1930 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: carcinoma; classic small cell lung cancer (lung primary) (Cell Line Ontology, CLO_0008031)
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Genes

355 genes mutated in the NCI-H1930 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ADAM22 ADAM metallopeptidase domain 22
ADAR adenosine deaminase, RNA-specific
ADNP2 ADNP homeobox 2
AFF3 AF4/FMR2 family, member 3
AGK acylglycerol kinase
AGPAT6 1-acylglycerol-3-phosphate O-acyltransferase 6
AGTPBP1 ATP/GTP binding protein 1
ALKBH3 alkB, alkylation repair homolog 3 (E. coli)
ALMS1 Alstrom syndrome protein 1
AMPD2 adenosine monophosphate deaminase 2
ANGEL1 angel homolog 1 (Drosophila)
ANK2 ankyrin 2, neuronal
ANKS3 ankyrin repeat and sterile alpha motif domain containing 3
ANXA2R annexin A2 receptor
AP3B2 adaptor-related protein complex 3, beta 2 subunit
APC2 adenomatosis polyposis coli 2
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARFIP2 ADP-ribosylation factor interacting protein 2
ARHGAP39 Rho GTPase activating protein 39
ARMC3 armadillo repeat containing 3
ARMCX4 armadillo repeat containing, X-linked 4
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASTN2 astrotactin 2
ASXL1 additional sex combs like transcriptional regulator 1
ASXL3 additional sex combs like transcriptional regulator 3
ATF2 activating transcription factor 2
ATF7IP activating transcription factor 7 interacting protein
ATG2A autophagy related 2A
ATG9B autophagy related 9B
ATP7B ATPase, Cu++ transporting, beta polypeptide
ATRNL1 attractin-like 1
BARD1 BRCA1 associated RING domain 1
BCAN brevican
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL2L1 BCL2-like 1
BMP6 bone morphogenetic protein 6
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C11ORF96 chromosome 11 open reading frame 96
C14ORF2 chromosome 14 open reading frame 2
C17ORF51 chromosome 17 open reading frame 51
CABLES1 Cdk5 and Abl enzyme substrate 1
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CAPN15 calpain 15
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CCDC85A coiled-coil domain containing 85A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPF centromere protein F, 350/400kDa
CEP135 centrosomal protein 135kDa
CGNL1 cingulin-like 1
CHL1 cell adhesion molecule L1-like
CHMP4B charged multivesicular body protein 4B
CIC capicua transcriptional repressor
CLASP1 cytoplasmic linker associated protein 1
CMTM3 CKLF-like MARVEL transmembrane domain containing 3
CNN3 calponin 3, acidic
COL22A1 collagen, type XXII, alpha 1
COL4A2 collagen, type IV, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COPA coatomer protein complex, subunit alpha
COPG1 coatomer protein complex, subunit gamma 1
CPNE3 copine III
CPNE5 copine V
CRLF1 cytokine receptor-like factor 1
CRYZ crystallin, zeta (quinone reductase)
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CTNND2 catenin (cadherin-associated protein), delta 2
CTSW cathepsin W
CUX1 cut-like homeobox 1
CYB5R3 cytochrome b5 reductase 3
DICER1 dicer 1, ribonuclease type III
DLEC1 deleted in lung and esophageal cancer 1
DLL3 delta-like 3 (Drosophila)
DNAI1 dynein, axonemal, intermediate chain 1
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
DOCK9 dedicator of cytokinesis 9
DST dystonin
DTX1 deltex 1, E3 ubiquitin ligase
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EDEM3 ER degradation enhancer, mannosidase alpha-like 3
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EFTUD2 elongation factor Tu GTP binding domain containing 2
EGLN1 egl-9 family hypoxia-inducible factor 1
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
EML6 echinoderm microtubule associated protein like 6
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENY2 enhancer of yellow 2 homolog (Drosophila)
ERC1 ELKS/RAB6-interacting/CAST family member 1
ERMP1 endoplasmic reticulum metallopeptidase 1
EXOC1 exocyst complex component 1
EXOC2 exocyst complex component 2
EXOC3 exocyst complex component 3
EXT2 exostosin glycosyltransferase 2
EYA2 EYA transcriptional coactivator and phosphatase 2
FADS3 fatty acid desaturase 3
FAM65B family with sequence similarity 65, member B
FANCM Fanconi anemia, complementation group M
FBL fibrillarin
FBN1 fibrillin 1
FBXL21 F-box and leucine-rich repeat protein 21 (gene/pseudogene)
FCHO1 FCH domain only 1
FGF13 fibroblast growth factor 13
FGF5 fibroblast growth factor 5
FMN2 formin 2
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GATA2 GATA binding protein 2
GFI1 growth factor independent 1 transcription repressor
GLMN glomulin, FKBP associated protein
GLT1D1 glycosyltransferase 1 domain containing 1
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GSAP gamma-secretase activating protein
GYS1 glycogen synthase 1 (muscle)
HAS1 hyaluronan synthase 1
HAUS5 HAUS augmin-like complex, subunit 5
HBS1L HBS1-like translational GTPase
HEATR4 HEAT repeat containing 4
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HOXB2 homeobox B2
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
ILDR2 immunoglobulin-like domain containing receptor 2
INTS1 integrator complex subunit 1
IRF5 interferon regulatory factor 5
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JMJD4 jumonji domain containing 4
KAT8 K(lysine) acetyltransferase 8
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNT2 potassium channel, sodium activated subfamily T, member 2
KCTD16 potassium channel tetramerization domain containing 16
KDM2A lysine (K)-specific demethylase 2A
KDM2B lysine (K)-specific demethylase 2B
KHSRP KH-type splicing regulatory protein
KIAA1324 KIAA1324
KIAA1551 KIAA1551
KIF1B kinesin family member 1B
KIF27 kinesin family member 27
KIF5A kinesin family member 5A
KIFC2 kinesin family member C2
KMT2D lysine (K)-specific methyltransferase 2D
LAMA1 laminin, alpha 1
LARS2 leucyl-tRNA synthetase 2, mitochondrial
LDB1 LIM domain binding 1
LIG4 ligase IV, DNA, ATP-dependent
LMTK2 lemur tyrosine kinase 2
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRP1 low density lipoprotein receptor-related protein 1
LRP5 low density lipoprotein receptor-related protein 5
LRP5L low density lipoprotein receptor-related protein 5-like
LRRC32 leucine rich repeat containing 32
LTBP1 latent transforming growth factor beta binding protein 1
LTBP2 latent transforming growth factor beta binding protein 2
MAGEA10 melanoma antigen family A10
MAGEL2 melanoma antigen family L2
MAP2K5 mitogen-activated protein kinase kinase 5
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAPK10 mitogen-activated protein kinase 10
MARK1 MAP/microtubule affinity-regulating kinase 1
MBOAT1 membrane bound O-acyltransferase domain containing 1
MCUR1 mitochondrial calcium uniporter regulator 1
MDH1 malate dehydrogenase 1, NAD (soluble)
MED13 mediator complex subunit 13
MED29 mediator complex subunit 29
MEF2A myocyte enhancer factor 2A
MEGF9 multiple EGF-like-domains 9
MEN1 multiple endocrine neoplasia I
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MIB2 mindbomb E3 ubiquitin protein ligase 2
MLH3 mutL homolog 3
MTG2 mitochondrial ribosome-associated GTPase 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC15 mucin 15, cell surface associated
MUC4 mucin 4, cell surface associated
MUT methylmalonyl CoA mutase
MUTYH mutY homolog
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYEF2 myelin expression factor 2
MYO10 myosin X
MZF1 myeloid zinc finger 1
N4BP2L2 NEDD4 binding protein 2-like 2
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative)
NCAPD3 non-SMC condensin II complex, subunit D3
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
NEB nebulin
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEK3 NIMA-related kinase 3
NEK7 NIMA-related kinase 7
NKD2 naked cuticle homolog 2 (Drosophila)
NOTUM notum pectinacetylesterase homolog (Drosophila)
NPTXR neuronal pentraxin receptor
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRK Nik related kinase
NRXN3 neurexin 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ODF2 outer dense fiber of sperm tails 2
OLFM3 olfactomedin 3
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7
PARD3B par-3 family cell polarity regulator beta
PCDH10 protocadherin 10
PCDHB13 protocadherin beta 13
PCDHGA4 protocadherin gamma subfamily A, 4
PCNXL2 pecanex-like 2 (Drosophila)
PDE11A phosphodiesterase 11A
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PEX11B peroxisomal biogenesis factor 11 beta
PFKL phosphofructokinase, liver
PGAP2 post-GPI attachment to proteins 2
PHGDH phosphoglycerate dehydrogenase
PHLDB2 pleckstrin homology-like domain, family B, member 2
PIEZO2 piezo-type mechanosensitive ion channel component 2
PITX3 paired-like homeodomain 3
PLCH1 phospholipase C, eta 1
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLB polymerase (DNA directed), beta
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRDM4 PR domain containing 4
PRSS41 protease, serine, 41
PTPRK protein tyrosine phosphatase, receptor type, K
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PWWP2A PWWP domain containing 2A
R3HCC1L R3H domain and coiled-coil containing 1-like
RAP2C RAP2C, member of RAS oncogene family
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RB1CC1 RB1-inducible coiled-coil 1
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like
REEP2 receptor accessory protein 2
RFX4 regulatory factor X, 4 (influences HLA class II expression)
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RIC8B RIC8 guanine nucleotide exchange factor B
RIMS2 regulating synaptic membrane exocytosis 2
RNF157 ring finger protein 157
RNF212 ring finger protein 212
RPAP1 RNA polymerase II associated protein 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RSL1D1 ribosomal L1 domain containing 1
RXRA retinoid X receptor, alpha
RYR2 ryanodine receptor 2 (cardiac)
SAP130 Sin3A-associated protein, 130kDa
SEC23B Sec23 homolog B (S. cerevisiae)
SEC63 SEC63 homolog (S. cerevisiae)
SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
SERINC3 serine incorporator 3
SGSM1 small G protein signaling modulator 1
SHCBP1 SHC SH2-domain binding protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC38A4 solute carrier family 38, member 4
SLC44A5 solute carrier family 44, member 5
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMO smoothened, frizzled class receptor
SMOX spermine oxidase
SNAP91 synaptosomal-associated protein, 91kDa
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SPATA17 spermatogenesis associated 17
SPATC1L spermatogenesis and centriole associated 1-like
SPEN spen family transcriptional repressor
SPG11 spastic paraplegia 11 (autosomal recessive)
SPTB spectrin, beta, erythrocytic
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
STAC3 SH3 and cysteine rich domain 3
STK11IP serine/threonine kinase 11 interacting protein
STX1B syntaxin 1B
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SV2C synaptic vesicle glycoprotein 2C
SYNE2 spectrin repeat containing, nuclear envelope 2
TADA2A transcriptional adaptor 2A
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
TC2N tandem C2 domains, nuclear
TCF12 transcription factor 12
TCTN2 tectonic family member 2
TFB2M transcription factor B2, mitochondrial
THBS3 thrombospondin 3
THRB thyroid hormone receptor, beta
TLN1 talin 1
TMEM132A transmembrane protein 132A
TMEM132C transmembrane protein 132C
TMEM161A transmembrane protein 161A
TMEM182 transmembrane protein 182
TMEM194B transmembrane protein 194B
TMEM38A transmembrane protein 38A
TMTC1 transmembrane and tetratricopeptide repeat containing 1
TONSL tonsoku-like, DNA repair protein
TP53 tumor protein p53
TP53RK TP53 regulating kinase
TPP2 tripeptidyl peptidase II
TRAPPC9 trafficking protein particle complex 9
TRIM25 tripartite motif containing 25
TRIO trio Rho guanine nucleotide exchange factor
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TSPAN8 tetraspanin 8
TTBK1 tau tubulin kinase 1
UBE3A ubiquitin protein ligase E3A
UBOX5 U-box domain containing 5
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
URGCP upregulator of cell proliferation
USP31 ubiquitin specific peptidase 31
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VSTM2A V-set and transmembrane domain containing 2A
WDR35 WD repeat domain 35
WDR48 WD repeat domain 48
WNK2 WNK lysine deficient protein kinase 2
XRN1 5'-3' exoribonuclease 1
YIPF3 Yip1 domain family, member 3
YY1 YY1 transcription factor
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBP1 Z-DNA binding protein 1
ZBTB17 zinc finger and BTB domain containing 17
ZBTB20 zinc finger and BTB domain containing 20
ZBTB33 zinc finger and BTB domain containing 33
ZDHHC17 zinc finger, DHHC-type containing 17
ZFHX3 zinc finger homeobox 3
ZFPL1 zinc finger protein-like 1
ZMAT3 zinc finger, matrin-type 3
ZNF106 zinc finger protein 106
ZNF112 zinc finger protein 112
ZNF229 zinc finger protein 229
ZNF234 zinc finger protein 234
ZNF292 zinc finger protein 292
ZNF318 zinc finger protein 318
ZNF324B zinc finger protein 324B
ZNF333 zinc finger protein 333
ZNF512B zinc finger protein 512B
ZNF536 zinc finger protein 536
ZNF566 zinc finger protein 566
ZNF606 zinc finger protein 606
ZNF638 zinc finger protein 638
ZNF649 zinc finger protein 649
ZNF688 zinc finger protein 688
ZNF711 zinc finger protein 711
ZRANB3 zinc finger, RAN-binding domain containing 3
ZSCAN1 zinc finger and SCAN domain containing 1