NCI-H1869 Gene Set

Dataset COSMIC Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: squamous cell carcinoma (lung primary) (Cell Line Ontology, CLO_0008024)
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369 genes mutated in the NCI-H1869 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13
ABHD1 abhydrolase domain containing 1
ACTC1 actin, alpha, cardiac muscle 1
ADAM21 ADAM metallopeptidase domain 21
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14
ADGRB3 adhesion G protein-coupled receptor B3
ADGRV1 adhesion G protein-coupled receptor V1
ADSSL1 adenylosuccinate synthase like 1
AGMO alkylglycerol monooxygenase
AHCTF1 AT hook containing transcription factor 1
AHNAK2 AHNAK nucleoprotein 2
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALLC allantoicase
ALPK2 alpha-kinase 2
ALPP alkaline phosphatase, placental
AMHR2 anti-Mullerian hormone receptor, type II
ANKRD50 ankyrin repeat domain 50
ANXA5 annexin A5
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
APOL5 apolipoprotein L, 5
ARFGEF3 ARFGEF family member 3
ARHGAP22 Rho GTPase activating protein 22
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARID1A AT rich interactive domain 1A (SWI-like)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2B ATPase family, AAA domain containing 2B
BAIAP2L1 BAI1-associated protein 2-like 1
BMP5 bone morphogenetic protein 5
BRD9 bromodomain containing 9
BTN2A1 butyrophilin, subfamily 2, member A1
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CAPN2 calpain 2, (m/II) large subunit
CD163L1 CD163 molecule-like 1
CD226 CD226 molecule
CDH18 cadherin 18, type 2
CDSN corneodesmosin
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CINP cyclin-dependent kinase 2 interacting protein
CIR1 corepressor interacting with RBPJ, 1
CLCA1 chloride channel accessory 1
CLCC1 chloride channel CLIC-like 1
CLDN22 claudin 22
CLTC clathrin, heavy chain (Hc)
CMYA5 cardiomyopathy associated 5
CNGB3 cyclic nucleotide gated channel beta 3
CNTNAP2 contactin associated protein-like 2
COL15A1 collagen, type XV, alpha 1
COL5A1 collagen, type V, alpha 1
COL7A1 collagen, type VII, alpha 1
COX5B cytochrome c oxidase subunit Vb
CPA6 carboxypeptidase A6
CPM carboxypeptidase M
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRIP1 cysteine-rich protein 1 (intestinal)
CSMD1 CUB and Sushi multiple domains 1
CSMD2 CUB and Sushi multiple domains 2
CSMD3 CUB and Sushi multiple domains 3
CTNNA3 catenin (cadherin-associated protein), alpha 3
CTSK cathepsin K
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCAF8 DDB1 and CUL4 associated factor 8
DDHD2 DDHD domain containing 2
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX12P DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene
DGKB diacylglycerol kinase, beta 90kDa
DLC1 DLC1 Rho GTPase activating protein
DNAH1 dynein, axonemal, heavy chain 1
DNAH17 dynein, axonemal, heavy chain 17
DNAH3 dynein, axonemal, heavy chain 3
DNAH5 dynein, axonemal, heavy chain 5
DNAH9 dynein, axonemal, heavy chain 9
DOCK2 dedicator of cytokinesis 2
DPEP1 dipeptidase 1 (renal)
DPP10 dipeptidyl-peptidase 10 (non-functional)
DSP desmoplakin
DST dystonin
DUSP27 dual specificity phosphatase 27 (putative)
EPDR1 ependymin related 1
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB4 erb-b2 receptor tyrosine kinase 4
ERCC5 excision repair cross-complementation group 5
ERO1LB ERO1-like beta (S. cerevisiae)
ESRP1 epithelial splicing regulatory protein 1
EVI5L ecotropic viral integration site 5-like
EXO1 exonuclease 1
F11 coagulation factor XI
FAM107B family with sequence similarity 107, member B
FAM117A family with sequence similarity 117, member A
FAM134B family with sequence similarity 134, member B
FAM169A family with sequence similarity 169, member A
FAM219A family with sequence similarity 219, member A
FAM76B family with sequence similarity 76, member B
FAM83H family with sequence similarity 83, member H
FAM91A1 family with sequence similarity 91, member A1
FCMR Fc fragment of IgM receptor
FER1L6 fer-1-like family member 6
FOXA3 forkhead box A3
FOXO1 forkhead box O1
FOXRED1 FAD-dependent oxidoreductase domain containing 1
FRG2 FSHD region gene 2
FRMD5 FERM domain containing 5
FRMPD2 FERM and PDZ domain containing 2
FSHR follicle stimulating hormone receptor
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13
GATA4 GATA binding protein 4
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2
GLRA3 glycine receptor, alpha 3
GLYCTK glycerate kinase
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRM2 glutamate receptor, metabotropic 2
GUCA1A guanylate cyclase activator 1A (retina)
H2AFX H2A histone family, member X
HAUS3 HAUS augmin-like complex, subunit 3
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1
HEPACAM hepatic and glial cell adhesion molecule
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
HIST1H2BC histone cluster 1, H2bc
ICE1 interactor of little elongation complex ELL subunit 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFT172 intraflagellar transport 172
IL16 interleukin 16
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL31 interleukin 31
IMPG1 interphotoreceptor matrix proteoglycan 1
INSM2 insulinoma-associated 2
INTS2 integrator complex subunit 2
ITGB4 integrin, beta 4
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KAT6A K(lysine) acetyltransferase 6A
KCNA10 potassium channel, voltage gated shaker related subfamily A, member 10
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KDM4C lysine (K)-specific demethylase 4C
KDM7A lysine (K)-specific demethylase 7A
KERA keratocan
KIAA0226L KIAA0226-like
KIAA0825 KIAA0825
KIAA1875 KIAA1875
KIF13B kinesin family member 13B
KIF1A kinesin family member 1A
KLB klotho beta
KLHDC8A kelch domain containing 8A
KLHL22 kelch-like family member 22
KMT2C lysine (K)-specific methyltransferase 2C
KRT71 keratin 71, type II
KRTAP10-3 keratin associated protein 10-3
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
LMBRD2 LMBR1 domain containing 2
LMO4 LIM domain only 4
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRFN1 leucine rich repeat and fibronectin type III domain containing 1
LRP1 low density lipoprotein receptor-related protein 1
LY75 lymphocyte antigen 75
MAGEA11 melanoma antigen family A11
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MAPK10 mitogen-activated protein kinase 10
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MBD3 methyl-CpG binding domain protein 3
MBD5 methyl-CpG binding domain protein 5
MBTD1 mbt domain containing 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MET MET proto-oncogene, receptor tyrosine kinase
MFAP3 microfibrillar-associated protein 3
MFSD11 major facilitator superfamily domain containing 11
MFSD12 major facilitator superfamily domain containing 12
MKI67 marker of proliferation Ki-67
MKX mohawk homeobox
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MMP13 matrix metallopeptidase 13
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MRGPRG MAS-related GPR, member G
MRPS18B mitochondrial ribosomal protein S18B
MSH4 mutS homolog 4
MTA3 metastasis associated 1 family, member 3
MTMR12 myotubularin related protein 12
MUC16 mucin 16, cell surface associated
MUC3A mucin 3A, cell surface associated
MUC3B mucin 3B, cell surface associated
MUC4 mucin 4, cell surface associated
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic
MYLK myosin light chain kinase
MYO18B myosin XVIIIB
MYT1L myelin transcription factor 1-like
NALCN sodium leak channel, non selective
NAV2 neuron navigator 2
NCKAP5 NCK-associated protein 5
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NID1 nidogen 1
NINJ2 ninjurin 2
NLRP3 NLR family, pyrin domain containing 3
NOL8 nucleolar protein 8
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NPR3 natriuretic peptide receptor 3
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NUP93 nucleoporin 93kDa
NWD2 NACHT and WD repeat domain containing 2
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OC90 otoconin 90
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OLFML2B olfactomedin-like 2B
OPCML opioid binding protein/cell adhesion molecule-like
OR13C5 olfactory receptor, family 13, subfamily C, member 5
OR2B2 olfactory receptor, family 2, subfamily B, member 2
OR2T34 olfactory receptor, family 2, subfamily T, member 34
OR52K1 olfactory receptor, family 52, subfamily K, member 1
OR6F1 olfactory receptor, family 6, subfamily F, member 1
OR6N2 olfactory receptor, family 6, subfamily N, member 2
OR8H3 olfactory receptor, family 8, subfamily H, member 3
OR8U1 olfactory receptor, family 8, subfamily U, member 1
OTUD6B OTU domain containing 6B
OTULIN OTU deubiquitinase with linear linkage specificity
P3H3 prolyl 3-hydroxylase 3
PARD3 par-3 family cell polarity regulator
PARP8 poly (ADP-ribose) polymerase family, member 8
PCDHA2 protocadherin alpha 2
PCDHB4 protocadherin beta 4
PCLO piccolo presynaptic cytomatrix protein
PEX16 peroxisomal biogenesis factor 16
PFAS phosphoribosylformylglycinamidine synthase
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PLA2R1 phospholipase A2 receptor 1, 180kDa
POLE polymerase (DNA directed), epsilon, catalytic subunit
PPAPDC1A phosphatidic acid phosphatase type 2 domain containing 1A
PPT1 palmitoyl-protein thioesterase 1
PRB4 proline-rich protein BstNI subfamily 4
PRICKLE1 prickle homolog 1 (Drosophila)
PRND prion protein 2 (dublet)
PROCA1 protein interacting with cyclin A1
PRRC2B proline-rich coiled-coil 2B
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRC protein tyrosine phosphatase, receptor type, C
R3HDM1 R3H domain containing 1
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RASAL3 RAS protein activator like 3
RBM39 RNA binding motif protein 39
REV1 REV1, polymerase (DNA directed)
RGS12 regulator of G-protein signaling 12
RHOXF1 Rhox homeobox family, member 1
RIBC1 RIB43A domain with coiled-coils 1
RICTOR RPTOR independent companion of MTOR, complex 2
RNF139 ring finger protein 139
RYR1 ryanodine receptor 1 (skeletal)
RYR2 ryanodine receptor 2 (cardiac)
S100A11 S100 calcium binding protein A11
SAAL1 serum amyloid A-like 1
SBF2 SET binding factor 2
SCAF8 SR-related CTD-associated factor 8
SCN1A sodium channel, voltage gated, type I alpha subunit
SEC13 SEC13 homolog (S. cerevisiae)
SEC14L3 SEC14-like 3 (S. cerevisiae)
SEMG2 semenogelin II
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
SERTAD4 SERTA domain containing 4
SFTPD surfactant protein D
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLAIN2 SLAIN motif family, member 2
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC35E3 solute carrier family 35, member E3
SLC38A10 solute carrier family 38, member 10
SLC45A4 solute carrier family 45, member 4
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
SLC6A16 solute carrier family 6, member 16
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3
SLC9C1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
SLIT3 slit homolog 3 (Drosophila)
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SNTG2 syntrophin, gamma 2
SNX18 sorting nexin 18
SPARCL1 SPARC-like 1 (hevin)
SPATA1 spermatogenesis associated 1
SPEF2 sperm flagellar 2
SPG11 spastic paraplegia 11 (autosomal recessive)
SPNS2 spinster homolog 2 (Drosophila)
SPRR2G small proline-rich protein 2G
SPRYD3 SPRY domain containing 3
SPTA1 spectrin, alpha, erythrocytic 1
SRPR signal recognition particle receptor (docking protein)
SSFA2 sperm specific antigen 2
STAB1 stabilin 1
STAB2 stabilin 2
STARD6 StAR-related lipid transfer (START) domain containing 6
STAT5B signal transducer and activator of transcription 5B
STEAP4 STEAP family member 4
SULT4A1 sulfotransferase family 4A, member 1
SUOX sulfite oxidase
SYT1 synaptotagmin I
TATDN1 TatD DNase domain containing 1
TBCCD1 TBCC domain containing 1
TBCK TBC1 domain containing kinase
TBRG4 transforming growth factor beta regulator 4
TBX20 T-box 20
TCF4 transcription factor 4
TCP11L1 t-complex 11, testis-specific-like 1
TDP1 tyrosyl-DNA phosphodiesterase 1
TFCP2L1 transcription factor CP2-like 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THOC2 THO complex 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TKFC triokinase/FMN cyclase
TLR4 toll-like receptor 4
TMC2 transmembrane channel-like 2
TMED6 transmembrane emp24 protein transport domain containing 6
TMEM106C transmembrane protein 106C
TMEM163 transmembrane protein 163
TMEM209 transmembrane protein 209
TMEM39B transmembrane protein 39B
TMEM57 transmembrane protein 57
TMPRSS11F transmembrane protease, serine 11F
TOE1 target of EGR1, member 1 (nuclear)
TOP2B topoisomerase (DNA) II beta 180kDa
TP53 tumor protein p53
TRAF3 TNF receptor-associated factor 3
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TRAPPC10 trafficking protein particle complex 10
TREX1 three prime repair exonuclease 1
TTN titin
TXN2 thioredoxin 2
UBC ubiquitin C
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4
ULK4 unc-51 like kinase 4
UNC5C unc-5 homolog C (C. elegans)
UNC80 unc-80 homolog (C. elegans)
UPB1 ureidopropionase, beta
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
VASN vasorin
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
WBP5 WW domain binding protein 5
WDFY3 WD repeat and FYVE domain containing 3
WDR24 WD repeat domain 24
WDR49 WD repeat domain 49
WDR66 WD repeat domain 66
WFS1 Wolfram syndrome 1 (wolframin)
WNK3 WNK lysine deficient protein kinase 3
XIRP2 xin actin binding repeat containing 2
YTHDC1 YTH domain containing 1
YTHDC2 YTH domain containing 2
ZFP57 ZFP57 zinc finger protein
ZFR2 zinc finger RNA binding protein 2
ZFYVE28 zinc finger, FYVE domain containing 28
ZHX3 zinc fingers and homeoboxes 3
ZNF10 zinc finger protein 10
ZNF2 zinc finger protein 2
ZNF236 zinc finger protein 236
ZNF525 zinc finger protein 525
ZNF713 zinc finger protein 713
ZNF721 zinc finger protein 721
ZNF76 zinc finger protein 76
ZNF804A zinc finger protein 804A
ZNF804B zinc finger protein 804B
ZSCAN31 zinc finger and SCAN domain containing 31