NCI-H1838 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: adenocarcinoma; non-small cell lung cancer (Cell Line Ontology, CLO_0008023)
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Genes

172 genes mutated in the NCI-H1838 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABLIM1 actin binding LIM protein 1
ACSS3 acyl-CoA synthetase short-chain family member 3
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADAM15 ADAM metallopeptidase domain 15
ADGRE5 adhesion G protein-coupled receptor E5
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ANKLE2 ankyrin repeat and LEM domain containing 2
ANKRD17 ankyrin repeat domain 17
AP3B1 adaptor-related protein complex 3, beta 1 subunit
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37
ARID5A AT rich interactive domain 5A (MRF1-like)
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP10A ATPase, class V, type 10A
ATRN attractin
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2
BOP1 block of proliferation 1
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
C1ORF112 chromosome 1 open reading frame 112
CACTIN cactin, spliceosome C complex subunit
CAPRIN2 caprin family member 2
CASD1 CAS1 domain containing 1
CCDC66 coiled-coil domain containing 66
CD320 CD320 molecule
CDC5L cell division cycle 5-like
CDK12 cyclin-dependent kinase 12
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CEP295 centrosomal protein 295kDa
CERS4 ceramide synthase 4
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CLDN12 claudin 12
COG5 component of oligomeric golgi complex 5
COL4A5 collagen, type IV, alpha 5
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CROCC ciliary rootlet coiled-coil, rootletin
CYBRD1 cytochrome b reductase 1
DBF4 DBF4 zinc finger
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DICER1 dicer 1, ribonuclease type III
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOCK5 dedicator of cytokinesis 5
DPH7 diphthamide biosynthesis 7
DSP desmoplakin
DST dystonin
DTX2 deltex 2, E3 ubiquitin ligase
DUSP10 dual specificity phosphatase 10
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans)
EXOC6 exocyst complex component 6
FAM110A family with sequence similarity 110, member A
FAM46B family with sequence similarity 46, member B
FAM53A family with sequence similarity 53, member A
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial
FAS Fas cell surface death receptor
FLNC filamin C, gamma
FRYL FRY-like
FXYD5 FXYD domain containing ion transport regulator 5
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GID8 GID complex subunit 8
GJC1 gap junction protein, gamma 1, 45kDa
GLTSCR2 glioma tumor suppressor candidate region gene 2
GMEB2 glucocorticoid modulatory element binding protein 2
GMPPB GDP-mannose pyrophosphorylase B
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GPC4 glypican 4
GPSM1 G-protein signaling modulator 1
GRK5 G protein-coupled receptor kinase 5
GRSF1 G-rich RNA sequence binding factor 1
GSE1 Gse1 coiled-coil protein
HEATR1 HEAT repeat containing 1
HES1 hes family bHLH transcription factor 1
HRH1 histamine receptor H1
ICE1 interactor of little elongation complex ELL subunit 1
IDH3B isocitrate dehydrogenase 3 (NAD+) beta
IL11 interleukin 11
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
IRX5 iroquois homeobox 5
ITFG3 integrin alpha FG-GAP repeat containing 3
KCTD2 potassium channel tetramerization domain containing 2
KDM5B lysine (K)-specific demethylase 5B
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLHDC7A kelch domain containing 7A
KMT2D lysine (K)-specific methyltransferase 2D
KTI12 KTI12 homolog, chromatin associated (S. cerevisiae)
LIX1L Lix1 homolog (chicken) like
LRRC8D leucine rich repeat containing 8 family, member D
LYAR Ly1 antibody reactive
MACF1 microtubule-actin crosslinking factor 1
MATN3 matrilin 3
MCM10 minichromosome maintenance complex component 10
MCM5 minichromosome maintenance complex component 5
MDN1 MDN1, midasin homolog (yeast)
MED12 mediator complex subunit 12
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
MICU3 mitochondrial calcium uptake family, member 3
MITF microphthalmia-associated transcription factor
MPDZ multiple PDZ domain protein
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MYEOV2 myeloma overexpressed 2
NMT2 N-myristoyltransferase 2
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRROS negative regulator of reactive oxygen species
NUP214 nucleoporin 214kDa
NUPL2 nucleoporin like 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PASK PAS domain containing serine/threonine kinase
PCF11 PCF11 cleavage and polyadenylation factor subunit
PCNXL2 pecanex-like 2 (Drosophila)
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PKM pyruvate kinase, muscle
PNPT1 polyribonucleotide nucleotidyltransferase 1
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAD50 RAD50 homolog (S. cerevisiae)
RBL2 retinoblastoma-like 2
RBM27 RNA binding motif protein 27
RBMS3 RNA binding motif, single stranded interacting protein 3
RPUSD2 RNA pseudouridylate synthase domain containing 2
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RTN2 reticulon 2
SAP18 Sin3A-associated protein, 18kDa
SBNO2 strawberry notch homolog 2 (Drosophila)
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SEC16A SEC16 homolog A (S. cerevisiae)
SEC23IP SEC23 interacting protein
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SEPT5 septin 5
SFN stratifin
SHANK2 SH3 and multiple ankyrin repeat domains 2
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SIKE1 suppressor of IKBKE 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SMAD6 SMAD family member 6
SMC2 structural maintenance of chromosomes 2
SMTN smoothelin
SSC4D scavenger receptor cysteine rich family, 4 domains
SSH2 slingshot protein phosphatase 2
STRN striatin, calmodulin binding protein
SUFU suppressor of fused homolog (Drosophila)
SZT2 seizure threshold 2 homolog (mouse)
TACC2 transforming, acidic coiled-coil containing protein 2
TET3 tet methylcytosine dioxygenase 3
TGFBR1 transforming growth factor, beta receptor 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TMED8 transmembrane emp24 protein transport domain containing 8
TNKS1BP1 tankyrase 1 binding protein 1, 182kDa
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TP53 tumor protein p53
TPR translocated promoter region, nuclear basket protein
TPRN taperin
TRIO trio Rho guanine nucleotide exchange factor
TRPS1 trichorhinophalangeal syndrome I
TTLL12 tubulin tyrosine ligase-like family member 12
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UNC119 unc-119 homolog (C. elegans)
USP53 ubiquitin specific peptidase 53
WTH3DI RAB6C-like
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF136 zinc finger protein 136
ZNF292 zinc finger protein 292
ZNF417 zinc finger protein 417
ZNF512 zinc finger protein 512
ZNF768 zinc finger protein 768