NCI-H1793 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: adenocarcinoma; non-small cell lung cancer (Cell Line Ontology, CLO_0008020)
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Genes

336 genes mutated in the NCI-H1793 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
AARS alanyl-tRNA synthetase
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACIN1 apoptotic chromatin condensation inducer 1
ACTN1 actinin, alpha 1
ACVR1 activin A receptor, type I
ADD1 adducin 1 (alpha)
ADNP activity-dependent neuroprotector homeobox
AFAP1L1 actin filament associated protein 1-like 1
AFF1 AF4/FMR2 family, member 1
AFF4 AF4/FMR2 family, member 4
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AHNAK2 AHNAK nucleoprotein 2
ANKMY1 ankyrin repeat and MYND domain containing 1
ANKRD17 ankyrin repeat domain 17
AP3D1 adaptor-related protein complex 3, delta 1 subunit
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
APC adenomatous polyposis coli
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARMCX6 armadillo repeat containing, X-linked 6
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF6 activating transcription factor 6
ATG14 autophagy related 14
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP9A ATPase, class II, type 9A
BABAM1 BRISC and BRCA1 A complex member 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BCL3 B-cell CLL/lymphoma 3
BICD2 bicaudal D homolog 2 (Drosophila)
BIRC6 baculoviral IAP repeat containing 6
BNC2 basonuclin 2
BOD1L1 biorientation of chromosomes in cell division 1-like 1
BRCA1 breast cancer 1, early onset
BTG1 B-cell translocation gene 1, anti-proliferative
C11ORF63 chromosome 11 open reading frame 63
C12ORF57 chromosome 12 open reading frame 57
C14ORF169 chromosome 14 open reading frame 169
C22ORF29 chromosome 22 open reading frame 29
C3ORF33 chromosome 3 open reading frame 33
C6ORF136 chromosome 6 open reading frame 136
C7ORF60 chromosome 7 open reading frame 60
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CAPN2 calpain 2, (m/II) large subunit
CCAR1 cell division cycle and apoptosis regulator 1
CCDC107 coiled-coil domain containing 107
CCDC80 coiled-coil domain containing 80
CCDC85C coiled-coil domain containing 85C
CD79A CD79a molecule, immunoglobulin-associated alpha
CDK13 cyclin-dependent kinase 13
CDK8 cyclin-dependent kinase 8
CDKN2A cyclin-dependent kinase inhibitor 2A
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CEP192 centrosomal protein 192kDa
CHD7 chromodomain helicase DNA binding protein 7
CHMP2B charged multivesicular body protein 2B
CLK2 CDC-like kinase 2
CLN3 ceroid-lipofuscinosis, neuronal 3
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
CNST consortin, connexin sorting protein
COPA coatomer protein complex, subunit alpha
CRCP CGRP receptor component
CRYBG3 beta-gamma crystallin domain containing 3
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CUL1 cullin 1
CUL2 cullin 2
CUL3 cullin 3
DCLK2 doublecortin-like kinase 2
DCLRE1A DNA cross-link repair 1A
DCUN1D5 DCN1, defective in cullin neddylation 1, domain containing 5
DDHD1 DDHD domain containing 1
DENND4A DENN/MADD domain containing 4A
DENND5B DENN/MADD domain containing 5B
DGKH diacylglycerol kinase, eta
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DIAPH3 diaphanous-related formin 3
DLG5 discs, large homolog 5 (Drosophila)
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
DPYD dihydropyrimidine dehydrogenase
DSG2 desmoglein 2
DSN1 DSN1, MIS12 kinetochore complex component
DSP desmoplakin
DUSP7 dual specificity phosphatase 7
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
DYSF dysferlin
EGFR epidermal growth factor receptor
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ELF1 E74-like factor 1 (ets domain transcription factor)
ELF2 E74-like factor 2 (ets domain transcription factor)
EMC3 ER membrane protein complex subunit 3
ENTHD2 ENTH domain containing 2
EPHX4 epoxide hydrolase 4
EPN1 epsin 1
EXO1 exonuclease 1
FAM110B family with sequence similarity 110, member B
FAM134A family with sequence similarity 134, member A
FAM155B family with sequence similarity 155, member B
FAM160A1 family with sequence similarity 160, member A1
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FASN fatty acid synthase
FASTKD2 FAST kinase domains 2
FBLN2 fibulin 2
FBN1 fibrillin 1
FBXO7 F-box protein 7
FIG4 FIG4 phosphoinositide 5-phosphatase
FKTN fukutin
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18
GARS glycyl-tRNA synthetase
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GDI1 GDP dissociation inhibitor 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLIS3 GLIS family zinc finger 3
GNL1 guanine nucleotide binding protein-like 1
GOLGB1 golgin B1
GPAA1 glycosylphosphatidylinositol anchor attachment 1
GPR3 G protein-coupled receptor 3
GSE1 Gse1 coiled-coil protein
HCCS holocytochrome c synthase
HDAC9 histone deacetylase 9
HDDC2 HD domain containing 2
HEXIM2 hexamethylene bis-acetamide inducible 2
HIAT1 hippocampus abundant transcript 1
HIP1 huntingtin interacting protein 1
HIRA histone cell cycle regulator
HOXA4 homeobox A4
HOXC6 homeobox C6
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HSPG2 heparan sulfate proteoglycan 2
IFNGR1 interferon gamma receptor 1
IQCC IQ motif containing C
IQGAP3 IQ motif containing GTPase activating protein 3
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JAK1 Janus kinase 1
KAT2B K(lysine) acetyltransferase 2B
KIAA0195 KIAA0195
KIAA1211 KIAA1211
KIF2A kinesin heavy chain member 2A
KLC1 kinesin light chain 1
LAMB1 laminin, beta 1
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LDHB lactate dehydrogenase B
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
LGMN legumain
LIMK1 LIM domain kinase 1
LMAN2L lectin, mannose-binding 2-like
LPIN1 lipin 1
LRP12 low density lipoprotein receptor-related protein 12
LRP6 low density lipoprotein receptor-related protein 6
LRRC40 leucine rich repeat containing 40
LRRC47 leucine rich repeat containing 47
LZTS2 leucine zipper, putative tumor suppressor 2
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MED21 mediator complex subunit 21
MEX3B mex-3 RNA binding family member B
MFSD11 major facilitator superfamily domain containing 11
MIA3 melanoma inhibitory activity family, member 3
MINPP1 multiple inositol-polyphosphate phosphatase 1
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MMP2 matrix metallopeptidase 2
MRPL23 mitochondrial ribosomal protein L23
MTMR9 myotubularin related protein 9
MYEF2 myelin expression factor 2
MYSM1 Myb-like, SWIRM and MPN domains 1
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NACAD NAC alpha domain containing
NBN nibrin
NCOA5 nuclear receptor coactivator 5
NCOR1 nuclear receptor corepressor 1
NDNL2 necdin-like 2
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
NEK11 NIMA-related kinase 11
NISCH nischarin
NOA1 nitric oxide associated 1
NOTCH2 notch 2
NOTCH3 notch 3
NPC1 Niemann-Pick disease, type C1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR5A2 nuclear receptor subfamily 5, group A, member 2
NRCAM neuronal cell adhesion molecule
NRD1 nardilysin (N-arginine dibasic convertase)
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
OTUD7B OTU deubiquitinase 7B
OXA1L oxidase (cytochrome c) assembly 1-like
PAM peptidylglycine alpha-amidating monooxygenase
PAN3 PAN3 poly(A) specific ribonuclease subunit
PARD3B par-3 family cell polarity regulator beta
PARP8 poly (ADP-ribose) polymerase family, member 8
PBRM1 polybromo 1
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCBP3 poly(rC) binding protein 3
PCDH1 protocadherin 1
PCDH7 protocadherin 7
PCDHB2 protocadherin beta 2
PDCD2L programmed cell death 2-like
PDGFC platelet derived growth factor C
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1
PELP1 proline, glutamate and leucine rich protein 1
PEX6 peroxisomal biogenesis factor 6
PGBD2 piggyBac transposable element derived 2
PHIP pleckstrin homology domain interacting protein
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PI4KB phosphatidylinositol 4-kinase, catalytic, beta
PIBF1 progesterone immunomodulatory binding factor 1
PIGO phosphatidylinositol glycan anchor biosynthesis, class O
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEC plectin
PLS1 plastin 1
PODXL2 podocalyxin-like 2
POFUT2 protein O-fucosyltransferase 2
POT1 protection of telomeres 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP6R1 protein phosphatase 6, regulatory subunit 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PRPF8 pre-mRNA processing factor 8
PRRC2C proline-rich coiled-coil 2C
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTRF polymerase I and transcript release factor
QSER1 glutamine and serine rich 1
RAB33A RAB33A, member RAS oncogene family
RBM15 RNA binding motif protein 15
RBM20 RNA binding motif protein 20
RECQL4 RecQ protein-like 4
RHOBTB3 Rho-related BTB domain containing 3
RIC8A RIC8 guanine nucleotide exchange factor A
RIC8B RIC8 guanine nucleotide exchange factor B
RICTOR RPTOR independent companion of MTOR, complex 2
RIMS4 regulating synaptic membrane exocytosis 4
RNFT2 ring finger protein, transmembrane 2
RP9 retinitis pigmentosa 9 (autosomal dominant)
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RSRC1 arginine/serine-rich coiled-coil 1
S1PR1 sphingosine-1-phosphate receptor 1
SACS sacsin molecular chaperone
SAMD9 sterile alpha motif domain containing 9
SAR1A secretion associated, Ras related GTPase 1A
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SF1 splicing factor 1
SF3B3 splicing factor 3b, subunit 3, 130kDa
SH3KBP1 SH3-domain kinase binding protein 1
SIPA1L3 signal-induced proliferation-associated 1 like 3
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like
SPICE1 spindle and centriole associated protein 1
SPPL2A signal peptide peptidase like 2A
STAC SH3 and cysteine rich domain
STAG1 stromal antigen 1
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STAMBP STAM binding protein
STK10 serine/threonine kinase 10
STON2 stonin 2
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBC1D14 TBC1 domain family, member 14
TBC1D19 TBC1 domain family, member 19
TECPR2 tectonin beta-propeller repeat containing 2
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TM9SF2 transmembrane 9 superfamily member 2
TMBIM4 transmembrane BAX inhibitor motif containing 4
TMEM132B transmembrane protein 132B
TMEM185B transmembrane protein 185B
TMEM2 transmembrane protein 2
TMEM55B transmembrane protein 55B
TMPO thymopoietin
TMUB1 transmembrane and ubiquitin-like domain containing 1
TNNT1 troponin T type 1 (skeletal, slow)
TP53 tumor protein p53
TPP2 tripeptidyl peptidase II
TRIM5 tripartite motif containing 5
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRRAP transformation/transcription domain-associated protein
TST thiosulfate sulfurtransferase (rhodanese)
TTC27 tetratricopeptide repeat domain 27
TTLL4 tubulin tyrosine ligase-like family member 4
TUBGCP6 tubulin, gamma complex associated protein 6
UBE2Z ubiquitin-conjugating enzyme E2Z
ULK2 unc-51 like autophagy activating kinase 2
USP15 ubiquitin specific peptidase 15
USP21 ubiquitin specific peptidase 21
USP28 ubiquitin specific peptidase 28
USP34 ubiquitin specific peptidase 34
VANGL2 VANGL planar cell polarity protein 2
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VWA5A von Willebrand factor A domain containing 5A
WBP1L WW domain binding protein 1-like
WDHD1 WD repeat and HMG-box DNA binding protein 1
WDR13 WD repeat domain 13
WDR59 WD repeat domain 59
WDR78 WD repeat domain 78
WFS1 Wolfram syndrome 1 (wolframin)
WNK1 WNK lysine deficient protein kinase 1
XKR5 XK, Kell blood group complex subunit-related family, member 5
ZBTB21 zinc finger and BTB domain containing 21
ZBTB25 zinc finger and BTB domain containing 25
ZC3H13 zinc finger CCCH-type containing 13
ZFYVE1 zinc finger, FYVE domain containing 1
ZFYVE26 zinc finger, FYVE domain containing 26
ZFYVE28 zinc finger, FYVE domain containing 28
ZMAT3 zinc finger, matrin-type 3
ZNF101 zinc finger protein 101
ZNF134 zinc finger protein 134
ZNF142 zinc finger protein 142
ZNF416 zinc finger protein 416
ZNF585B zinc finger protein 585B
ZNF614 zinc finger protein 614
ZNF652 zinc finger protein 652
ZNF668 zinc finger protein 668
ZNF7 zinc finger protein 7
ZNF784 zinc finger protein 784
ZNF853 zinc finger protein 853
ZNFX1 zinc finger, NFX1-type containing 1
ZSWIM4 zinc finger, SWIM-type containing 4
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1