NCI-H1666 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: adenocarcinoma; bronchoalveolar carcinoma (lung primary) (Cell Line Ontology, CLO_0008009)
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Genes

98 genes mutated in the NCI-H1666 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ADCK1 aarF domain containing kinase 1
ADGRL2 adhesion G protein-coupled receptor L2
ADTRP androgen-dependent TFPI-regulating protein
AIM1L absent in melanoma 1-like
AKR1D1 aldo-keto reductase family 1, member D1
APAF1 apoptotic peptidase activating factor 1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ATM ATM serine/threonine kinase
ATMIN ATM interactor
BBC3 BCL2 binding component 3
BBS10 Bardet-Biedl syndrome 10
BLZF1 basic leucine zipper nuclear factor 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
C12ORF80 chromosome 12 open reading frame 80
C17ORF58 chromosome 17 open reading frame 58
C2CD3 C2 calcium-dependent domain containing 3
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CALD1 caldesmon 1
CCDC88A coiled-coil domain containing 88A
CDC45 cell division cycle 45
CDK6 cyclin-dependent kinase 6
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CILP2 cartilage intermediate layer protein 2
CLUH clustered mitochondria (cluA/CLU1) homolog
COL7A1 collagen, type VII, alpha 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
DENND6A DENN/MADD domain containing 6A
DNAH11 dynein, axonemal, heavy chain 11
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DST dystonin
ESRP2 epithelial splicing regulatory protein 2
FAHD1 fumarylacetoacetate hydrolase domain containing 1
FBXO33 F-box protein 33
FBXW11 F-box and WD repeat domain containing 11
FUBP1 far upstream element (FUSE) binding protein 1
GNPAT glyceronephosphate O-acyltransferase
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HK2 hexokinase 2
HYAL2 hyaluronoglucosaminidase 2
IFT140 intraflagellar transport 140
KDM3A lysine (K)-specific demethylase 3A
KHSRP KH-type splicing regulatory protein
KIF1C kinesin family member 1C
KNTC1 kinetochore associated 1
KRT71 keratin 71, type II
KRT75 keratin 75, type II
KRT83 keratin 83, type II
LRP1 low density lipoprotein receptor-related protein 1
MAPT microtubule-associated protein tau
MARK4 MAP/microtubule affinity-regulating kinase 4
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MRPL44 mitochondrial ribosomal protein L44
MXD1 MAX dimerization protein 1
MYH9 myosin, heavy chain 9, non-muscle
NBR1 neighbor of BRCA1 gene 1
NCLN nicalin
NOTCH3 notch 3
OSTM1 osteopetrosis associated transmembrane protein 1
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PCM1 pericentriolar material 1
PHLDB2 pleckstrin homology-like domain, family B, member 2
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRX periaxin
RANBP3 RAN binding protein 3
RNF213 ring finger protein 213
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPP40 ribonuclease P/MRP 40kDa subunit
RPUSD2 RNA pseudouridylate synthase domain containing 2
SBSN suprabasin
SF3B3 splicing factor 3b, subunit 3, 130kDa
SGOL2 shugoshin-like 2 (S. pombe)
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
SLC41A1 solute carrier family 41 (magnesium transporter), member 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SPRED1 sprouty-related, EVH1 domain containing 1
SRCAP Snf2-related CREBBP activator protein
SYNC syncoilin, intermediate filament protein
SYNJ2 synaptojanin 2
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TBC1D10B TBC1 domain family, member 10B
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TMC6 transmembrane channel-like 6
TTC30B tetratricopeptide repeat domain 30B
TUBG2 tubulin, gamma 2
UBE4A ubiquitination factor E4A
USP24 ubiquitin specific peptidase 24
USP42 ubiquitin specific peptidase 42
ZBTB21 zinc finger and BTB domain containing 21
ZFAND5 zinc finger, AN1-type domain 5
ZNF280C zinc finger protein 280C
ZNF404 zinc finger protein 404
ZNF865 zinc finger protein 865
ZSCAN9 zinc finger and SCAN domain containing 9