NCI-H1666 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description disease: adenocarcinoma; bronchoalveolar carcinoma (lung primary) (Cell Line Ontology, CLO_0008009)
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Genes

338 genes with high or low expression in NCI-H1666 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 3.09873
RDH16 retinol dehydrogenase 16 (all-trans) 2.60897
XDH xanthine dehydrogenase 2.41254
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 2.40702
THBD thrombomodulin 2.40582
IL1A interleukin 1, alpha 2.4056
RHCG Rh family, C glycoprotein 2.32135
PIGF phosphatidylinositol glycan anchor biosynthesis, class F 2.31551
PHF10 PHD finger protein 10 2.28123
DEFB1 defensin, beta 1 2.26146
LXN latexin 2.2067
NPAS2 neuronal PAS domain protein 2 2.20232
PELO pelota homolog (Drosophila) 2.18825
TREM1 triggering receptor expressed on myeloid cells 1 2.15758
MPZL2 myelin protein zero-like 2 2.13034
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.1297
CLCA2 chloride channel accessory 2 2.09402
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.07732
CD14 CD14 molecule 2.07688
PTGES prostaglandin E synthase 2.03517
CCL20 chemokine (C-C motif) ligand 20 2.01453
CSE1L CSE1 chromosome segregation 1-like (yeast) 1.99354
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 1.96381
HBEGF heparin-binding EGF-like growth factor 1.94347
PCTP phosphatidylcholine transfer protein 1.93337
ART3 ADP-ribosyltransferase 3 1.91054
KRT81 keratin 81, type II 1.89711
NOP16 NOP16 nucleolar protein 1.88934
IL1B interleukin 1, beta 1.87247
ZNF337 zinc finger protein 337 1.83641
SNX5 sorting nexin 5 1.83611
S100A9 S100 calcium binding protein A9 1.82218
FABP4 fatty acid binding protein 4, adipocyte 1.82097
SHB Src homology 2 domain containing adaptor protein B 1.80622
FXYD5 FXYD domain containing ion transport regulator 5 1.80457
ADCY3 adenylate cyclase 3 1.79449
MAP2K1 mitogen-activated protein kinase kinase 1 1.76804
SMOX spermine oxidase 1.76038
RUFY1 RUN and FYVE domain containing 1 1.75569
MRPS12 mitochondrial ribosomal protein S12 1.75249
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 1.74061
CXCL11 chemokine (C-X-C motif) ligand 11 1.72845
RAB31 RAB31, member RAS oncogene family 1.72791
HDAC3 histone deacetylase 3 1.72513
HAL histidine ammonia-lyase 1.71825
ZMYM1 zinc finger, MYM-type 1 1.71264
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 1.70926
ZNF133 zinc finger protein 133 1.68684
CAPN2 calpain 2, (m/II) large subunit 1.68552
GPR157 G protein-coupled receptor 157 1.67488
HES2 hes family bHLH transcription factor 2 1.67394
CCT4 chaperonin containing TCP1, subunit 4 (delta) 1.66807
CREG1 cellular repressor of E1A-stimulated genes 1 1.65621
SEC23B Sec23 homolog B (S. cerevisiae) 1.64265
EIF3K eukaryotic translation initiation factor 3, subunit K 1.64132
FAM49B family with sequence similarity 49, member B 1.62752
MAPK9 mitogen-activated protein kinase 9 1.61928
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 1.61901
ARL14 ADP-ribosylation factor-like 14 1.60682
SRPX2 sushi-repeat containing protein, X-linked 2 1.60028
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa 1.59873
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa 1.58917
BLVRA biliverdin reductase A 1.5876
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 1.57611
RHOBTB2 Rho-related BTB domain containing 2 1.56611
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 1.56556
ADAMTSL4 ADAMTS-like 4 1.5629
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 1.55557
ADAM19 ADAM metallopeptidase domain 19 1.55182
IER5 immediate early response 5 1.54984
PDCD2 programmed cell death 2 1.53768
TASP1 taspase, threonine aspartase, 1 1.53315
NT5E 5'-nucleotidase, ecto (CD73) 1.52878
CCL1 chemokine (C-C motif) ligand 1 1.51572
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 1.51455
ASCC3 activating signal cointegrator 1 complex subunit 3 1.51252
S100A7 S100 calcium binding protein A7 1.49929
PFKP phosphofructokinase, platelet 1.49588
PFDN4 prefoldin subunit 4 1.49328
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 1.49216
TCERG1 transcription elongation regulator 1 1.48976
NRIP1 nuclear receptor interacting protein 1 1.48798
LIPA lipase A, lysosomal acid, cholesterol esterase 1.4856
IVL involucrin 1.48196
ADORA2B adenosine A2b receptor 1.46852
LIPG lipase, endothelial 1.46805
SH2D3A SH2 domain containing 3A 1.4617
PGBD5 piggyBac transposable element derived 5 1.45626
LTA4H leukotriene A4 hydrolase 1.4554
AQP3 aquaporin 3 (Gill blood group) 1.45315
ZNF750 zinc finger protein 750 1.4471
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 1.44175
SLC25A51 solute carrier family 25, member 51 1.43686
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae) 1.43549
HEBP2 heme binding protein 2 1.43356
F12 coagulation factor XII (Hageman factor) 1.42979

low expression

Symbol Name Standardized Value
MON1B MON1 secretory trafficking family member B -3.53721
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) -3.05485
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.75533
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 -2.70568
PKDREJ polycystin (PKD) family receptor for egg jelly -2.69073
ZNF20 zinc finger protein 20 -2.60116
CARD8 caspase recruitment domain family, member 8 -2.58232
ZNF44 zinc finger protein 44 -2.48087
DET1 de-etiolated homolog 1 (Arabidopsis) -2.47912
GOLGA3 golgin A3 -2.46275
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 -2.4392
ADGRA2 adhesion G protein-coupled receptor A2 -2.4289
LATS1 large tumor suppressor kinase 1 -2.42006
CDH17 cadherin 17, LI cadherin (liver-intestine) -2.41962
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 -2.39084
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 -2.37857
PAX2 paired box 2 -2.37035
TRPM8 transient receptor potential cation channel, subfamily M, member 8 -2.34616
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 -2.28217
ZNF32 zinc finger protein 32 -2.27711
CRHBP corticotropin releasing hormone binding protein -2.27151
HKDC1 hexokinase domain containing 1 -2.26953
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -2.26438
TMOD1 tropomodulin 1 -2.25231
TACC1 transforming, acidic coiled-coil containing protein 1 -2.24076
LAT linker for activation of T cells -2.20787
ZNF443 zinc finger protein 443 -2.20264
HDAC6 histone deacetylase 6 -2.19307
SELL selectin L -2.19125
HOXC11 homeobox C11 -2.18772
IPCEF1 interaction protein for cytohesin exchange factors 1 -2.18423
PPP5C protein phosphatase 5, catalytic subunit -2.17747
FBN2 fibrillin 2 -2.14203
LY6G5C lymphocyte antigen 6 complex, locus G5C -2.11785
ADAM23 ADAM metallopeptidase domain 23 -2.10659
MVK mevalonate kinase -2.09957
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -2.09674
KRTAP4-7 keratin associated protein 4-7 -2.09649
OMP olfactory marker protein -2.0908
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 -2.08985
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 -2.07643
GPR15 G protein-coupled receptor 15 -2.06651
NARFL nuclear prelamin A recognition factor-like -2.04553
SYNE1 spectrin repeat containing, nuclear envelope 1 -2.02828
DIABLO diablo, IAP-binding mitochondrial protein -2.02793
SFRP4 secreted frizzled-related protein 4 -2.02758
RNF32 ring finger protein 32 -2.01769
SNX15 sorting nexin 15 -2.00035
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma -1.98142
RPGR retinitis pigmentosa GTPase regulator -1.96135
DEFA6 defensin, alpha 6, Paneth cell-specific -1.95673
ZNF266 zinc finger protein 266 -1.94977
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 -1.94613
TNRC6B trinucleotide repeat containing 6B -1.94342
RP2 retinitis pigmentosa 2 (X-linked recessive) -1.94333
CD209 CD209 molecule -1.9423
KIR2DS3 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3 -1.93694
MSL3 male-specific lethal 3 homolog (Drosophila) -1.92233
PPARA peroxisome proliferator-activated receptor alpha -1.91487
OR2H1 olfactory receptor, family 2, subfamily H, member 1 -1.91465
CRLF2 cytokine receptor-like factor 2 -1.91418
FCGBP Fc fragment of IgG binding protein -1.91283
CDK19 cyclin-dependent kinase 19 -1.91112
MASP2 mannan-binding lectin serine peptidase 2 -1.90392
TMEM176A transmembrane protein 176A -1.89981
CCDC82 coiled-coil domain containing 82 -1.89263
GAB1 GRB2-associated binding protein 1 -1.89195
SLC45A2 solute carrier family 45, member 2 -1.89174
MX2 MX dynamin-like GTPase 2 -1.88926
ANO2 anoctamin 2, calcium activated chloride channel -1.88269
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) -1.87821
GPR4 G protein-coupled receptor 4 -1.87804
SBSPON somatomedin B and thrombospondin, type 1 domain containing -1.87007
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 -1.86519
GIMAP6 GTPase, IMAP family member 6 -1.8645
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase -1.86374
NCOR1 nuclear receptor corepressor 1 -1.85245
PCDHB12 protocadherin beta 12 -1.84778
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 -1.84619
ERP29 endoplasmic reticulum protein 29 -1.83972
C1QTNF3 C1q and tumor necrosis factor related protein 3 -1.83004
CHRD chordin -1.82565
ATF3 activating transcription factor 3 -1.82211
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -1.81497
TBC1D15 TBC1 domain family, member 15 -1.80189
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -1.80171
CALB1 calbindin 1, 28kDa -1.80038
GZMK granzyme K (granzyme 3; tryptase II) -1.79983
ADRA2A adrenoceptor alpha 2A -1.79964
SULT4A1 sulfotransferase family 4A, member 1 -1.79599
HIST2H2AA3 histone cluster 2, H2aa3 -1.79597
ADAMDEC1 ADAM-like, decysin 1 -1.79322
MYH6 myosin, heavy chain 6, cardiac muscle, alpha -1.78804
EDNRB endothelin receptor type B -1.78533
LUM lumican -1.78351
LPAR4 lysophosphatidic acid receptor 4 -1.77453
CD93 CD93 molecule -1.77172
DRP2 dystrophin related protein 2 -1.76678
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -1.76208
MLYCD malonyl-CoA decarboxylase -1.75466
DGKE diacylglycerol kinase, epsilon 64kDa -1.75463
MYH15 myosin, heavy chain 15 -1.74537
BCOR BCL6 corepressor -1.74422
C5 complement component 5 -1.74294
LRRC20 leucine rich repeat containing 20 -1.73864
DPF3 D4, zinc and double PHD fingers, family 3 -1.73655
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 -1.73162
LPAL2 lipoprotein, Lp(a)-like 2, pseudogene -1.7266
NRSN2 neurensin 2 -1.71098
SP2 Sp2 transcription factor -1.70732
PDE5A phosphodiesterase 5A, cGMP-specific -1.70711
EPHB1 EPH receptor B1 -1.70587
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein -1.70455
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 -1.70326
TFDP3 transcription factor Dp family, member 3 -1.69488
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 -1.68854
CARD9 caspase recruitment domain family, member 9 -1.6862
KIDINS220 kinase D-interacting substrate, 220kDa -1.68434
PCDHB11 protocadherin beta 11 -1.68325
IFNA4 interferon, alpha 4 -1.6758
PKD2L2 polycystic kidney disease 2-like 2 -1.67406
STRN striatin, calmodulin binding protein -1.67341
SCGB2A1 secretoglobin, family 2A, member 1 -1.67088
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 -1.66749
EPOR erythropoietin receptor -1.66624
AMHR2 anti-Mullerian hormone receptor, type II -1.66427
FSTL4 follistatin-like 4 -1.66287
FOXN3 forkhead box N3 -1.66177
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -1.65716
PRG4 proteoglycan 4 -1.65398
RGL1 ral guanine nucleotide dissociation stimulator-like 1 -1.65236
DTX3 deltex 3, E3 ubiquitin ligase -1.64136
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 -1.63998
DDIT3 DNA-damage-inducible transcript 3 -1.63388
SREBF2 sterol regulatory element binding transcription factor 2 -1.63054
TRIM9 tripartite motif containing 9 -1.6281
EVC Ellis van Creveld protein -1.62562
ZNF136 zinc finger protein 136 -1.62356
SYT13 synaptotagmin XIII -1.62058
KLHL24 kelch-like family member 24 -1.61914
DNAI2 dynein, axonemal, intermediate chain 2 -1.61472
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 -1.61167
LRP1B low density lipoprotein receptor-related protein 1B -1.60931
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -1.60852
ATG13 autophagy related 13 -1.60581
CRISP2 cysteine-rich secretory protein 2 -1.60555
CKB creatine kinase, brain -1.60479
USP11 ubiquitin specific peptidase 11 -1.60447
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 -1.60118
KCTD14 potassium channel tetramerization domain containing 14 -1.59897
HIST1H3G histone cluster 1, H3g -1.59736
TLX1 T-cell leukemia homeobox 1 -1.59587
ROR2 receptor tyrosine kinase-like orphan receptor 2 -1.59116
CLEC11A C-type lectin domain family 11, member A -1.59057
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -1.59053
TDO2 tryptophan 2,3-dioxygenase -1.58456
TEX13B testis expressed 13B -1.58079
CDHR1 cadherin-related family member 1 -1.57785
TMEM35 transmembrane protein 35 -1.57783
FEZF2 FEZ family zinc finger 2 -1.57415
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G -1.5707
AP3D1 adaptor-related protein complex 3, delta 1 subunit -1.56939
PAEP progestagen-associated endometrial protein -1.56449
TSPYL2 TSPY-like 2 -1.56056
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1 -1.55756
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 -1.5552
MSLN mesothelin -1.55295
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -1.55257
GRM2 glutamate receptor, metabotropic 2 -1.54954
EAF2 ELL associated factor 2 -1.548
PPY2P pancreatic polypeptide 2, pseudogene -1.54792
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) -1.5474
CBX6 chromobox homolog 6 -1.54636
LOR loricrin -1.54628
MAPRE2 microtubule-associated protein, RP/EB family, member 2 -1.53964
CLDN1 claudin 1 -1.53945
FOXE1 forkhead box E1 -1.53515
PROSC proline synthetase co-transcribed homolog (bacterial) -1.53158
TMSB15A thymosin beta 15a -1.53046
DPPA4 developmental pluripotency associated 4 -1.52927
GK glycerol kinase -1.52798
MLEC malectin -1.5221
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -1.51989
GPKOW G patch domain and KOW motifs -1.51952
PHKG1 phosphorylase kinase, gamma 1 (muscle) -1.51925
IRF2BP1 interferon regulatory factor 2 binding protein 1 -1.51794
KAT5 K(lysine) acetyltransferase 5 -1.51706
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) -1.51631
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -1.51197
CLUL1 clusterin-like 1 (retinal) -1.51145
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide -1.50785
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) -1.50768
AVP arginine vasopressin -1.50421
CPB2 carboxypeptidase B2 (plasma) -1.5041
CHRM5 cholinergic receptor, muscarinic 5 -1.49956
MTMR3 myotubularin related protein 3 -1.49892
HBD hemoglobin, delta -1.49736
ATXN2 ataxin 2 -1.49472
LCK LCK proto-oncogene, Src family tyrosine kinase -1.49381
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -1.49306
BBS4 Bardet-Biedl syndrome 4 -1.4913
G6PC glucose-6-phosphatase, catalytic subunit -1.49053
USP22 ubiquitin specific peptidase 22 -1.49033
ZNF14 zinc finger protein 14 -1.48567
PRG3 proteoglycan 3 -1.48518
DZIP1 DAZ interacting zinc finger protein 1 -1.48129
ZNF835 zinc finger protein 835 -1.47597
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -1.47463
B3GAT3 beta-1,3-glucuronyltransferase 3 -1.4736
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q -1.47287
MMP13 matrix metallopeptidase 13 -1.47122
ZNF157 zinc finger protein 157 -1.46792
CLCN6 chloride channel, voltage-sensitive 6 -1.46496
GMPPA GDP-mannose pyrophosphorylase A -1.46272
KLHL21 kelch-like family member 21 -1.46205
FLCN folliculin -1.4602
TAC3 tachykinin 3 -1.45895
KDM5D lysine (K)-specific demethylase 5D -1.45759
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit -1.45627
ID2B inhibitor of DNA binding 2B, dominant negative helix-loop-helix protein (pseudogene) -1.45478
FGF8 fibroblast growth factor 8 (androgen-induced) -1.45232
WWOX WW domain containing oxidoreductase -1.45122
CFP complement factor properdin -1.4497
CNGB3 cyclic nucleotide gated channel beta 3 -1.44931
F11 coagulation factor XI -1.44677
CSN1S1 casein alpha s1 -1.44108
RIC3 RIC3 acetylcholine receptor chaperone -1.43721
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 -1.43626
PLXNC1 plexin C1 -1.43618
MYOZ2 myozenin 2 -1.43457
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) -1.4319
KLHL9 kelch-like family member 9 -1.43073
TPSD1 tryptase delta 1 -1.42986
NOX1 NADPH oxidase 1 -1.42648
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase -1.42573
ACADL acyl-CoA dehydrogenase, long chain -1.4251
TUBA3C tubulin, alpha 3c -1.42424
KLK11 kallikrein-related peptidase 11 -1.42404
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -1.42268
TBC1D2B TBC1 domain family, member 2B -1.4215
CPEB1 cytoplasmic polyadenylation element binding protein 1 -1.42105
TECTA tectorin alpha -1.4206