NCI-H1651 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: adenocarcinoma; non-small cell lung cancer (Cell Line Ontology, CLO_0008008)
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Genes

381 genes mutated in the NCI-H1651 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ACAT1 acetyl-CoA acetyltransferase 1
ACOT9 acyl-CoA thioesterase 9
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADCY1 adenylate cyclase 1 (brain)
ADCY7 adenylate cyclase 7
ADGRD1 adhesion G protein-coupled receptor D1
ADGRL3 adhesion G protein-coupled receptor L3
ADRA2A adrenoceptor alpha 2A
AFF4 AF4/FMR2 family, member 4
AGO3 argonaute RISC catalytic component 3
AKAP1 A kinase (PRKA) anchor protein 1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALPI alkaline phosphatase, intestinal
ALPL alkaline phosphatase, liver/bone/kidney
AMOT angiomotin
ANGPTL4 angiopoietin-like 4
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
ANXA6 annexin A6
ARFGEF3 ARFGEF family member 3
ARHGAP21 Rho GTPase activating protein 21
ARHGAP24 Rho GTPase activating protein 24
ARHGAP25 Rho GTPase activating protein 25
ARHGAP39 Rho GTPase activating protein 39
ARPIN actin-related protein 2/3 complex inhibitor
ARSB arylsulfatase B
ARSE arylsulfatase E (chondrodysplasia punctata 1)
ASL argininosuccinate lyase
ATF6 activating transcription factor 6
ATMIN ATM interactor
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3
ATPAF1 ATP synthase mitochondrial F1 complex assembly factor 1
ATXN1L ataxin 1-like
ATXN7L3 ataxin 7-like 3
BBX bobby sox homolog (Drosophila)
BCAS2 breast carcinoma amplified sequence 2
BCORL1 BCL6 corepressor-like 1
BEND4 BEN domain containing 4
BIRC6 baculoviral IAP repeat containing 6
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
BRSK2 BR serine/threonine kinase 2
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C15ORF38-AP3S2 C15orf38-AP3S2 readthrough
C2CD3 C2 calcium-dependent domain containing 3
C3ORF52 chromosome 3 open reading frame 52
CAPRIN2 caprin family member 2
CASKIN2 CASK interacting protein 2
CATSPER1 cation channel, sperm associated 1
CCM2 cerebral cavernous malformation 2
CCNH cyclin H
CDAN1 codanin 1
CDCA4 cell division cycle associated 4
CDH8 cadherin 8, type 2
CDK13 cyclin-dependent kinase 13
CDK14 cyclin-dependent kinase 14
CDK9 cyclin-dependent kinase 9
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase)
CDYL chromodomain protein, Y-like
CENPJ centromere protein J
CENPL centromere protein L
CEP162 centrosomal protein 162kDa
CEP250 centrosomal protein 250kDa
CEP97 centrosomal protein 97kDa
CERS6 ceramide synthase 6
CGNL1 cingulin-like 1
CHD3 chromodomain helicase DNA binding protein 3
CHRND cholinergic receptor, nicotinic, delta (muscle)
CLCN5 chloride channel, voltage-sensitive 5
CLDN11 claudin 11
CLDN3 claudin 3
CMTM4 CKLF-like MARVEL transmembrane domain containing 4
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3
CNOT8 CCR4-NOT transcription complex, subunit 8
CNTN1 contactin 1
COBL cordon-bleu WH2 repeat protein
COL1A1 collagen, type I, alpha 1
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CREB5 cAMP responsive element binding protein 5
CREBBP CREB binding protein
CRYBG3 beta-gamma crystallin domain containing 3
CSAD cysteine sulfinic acid decarboxylase
CTNND2 catenin (cadherin-associated protein), delta 2
CTU1 cytosolic thiouridylase subunit 1
CUL1 cullin 1
CYBB cytochrome b-245, beta polypeptide
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DDHD1 DDHD domain containing 1
DDX26B DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
DENND5B DENN/MADD domain containing 5B
DHTKD1 dehydrogenase E1 and transketolase domain containing 1
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DMBX1 diencephalon/mesencephalon homeobox 1
DNMBP dynamin binding protein
DOCK7 dedicator of cytokinesis 7
DRD2 dopamine receptor D2
DRG1 developmentally regulated GTP binding protein 1
DSC2 desmocollin 2
DSTYK dual serine/threonine and tyrosine protein kinase
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EIF3M eukaryotic translation initiation factor 3, subunit M
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHA8 EPH receptor A8
EXOC6 exocyst complex component 6
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM131B family with sequence similarity 131, member B
FANCE Fanconi anemia, complementation group E
FBXO17 F-box protein 17
FBXO41 F-box protein 41
FEM1C fem-1 homolog c (C. elegans)
FLT4 fms-related tyrosine kinase 4
FMNL1 formin-like 1
FMNL2 formin-like 2
FRYL FRY-like
FUK fucokinase
FYCO1 FYVE and coiled-coil domain containing 1
GABPB2 GA binding protein transcription factor, beta subunit 2
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLI2 GLI family zinc finger 2
GNL1 guanine nucleotide binding protein-like 1
GOLGB1 golgin B1
GPC4 glypican 4
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GSR glutathione reductase
GXYLT1 glucoside xylosyltransferase 1
HAUS4 HAUS augmin-like complex, subunit 4
HEXB hexosaminidase B (beta polypeptide)
HIP1R huntingtin interacting protein 1 related
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXA10 homeobox A10
HOXA6 homeobox A6
HOXB2 homeobox B2
HSF1 heat shock transcription factor 1
HSPA13 heat shock protein 70kDa family, member 13
HSPB3 heat shock 27kDa protein 3
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ICK intestinal cell (MAK-like) kinase
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL17RB interleukin 17 receptor B
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
IRS1 insulin receptor substrate 1
IRX3 iroquois homeobox 3
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KDELC1 KDEL (Lys-Asp-Glu-Leu) containing 1
KDM6A lysine (K)-specific demethylase 6A
KIAA0753 KIAA0753
KIAA1109 KIAA1109
KIAA1217 KIAA1217
KIAA1456 KIAA1456
KIF5A kinesin family member 5A
KLHL11 kelch-like family member 11
KPNA1 karyopherin alpha 1 (importin alpha 5)
KRT3 keratin 3, type II
KRTCAP2 keratinocyte associated protein 2
LAMA2 laminin, alpha 2
LARP7 La ribonucleoprotein domain family, member 7
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
LRRC41 leucine rich repeat containing 41
LRRC57 leucine rich repeat containing 57
LTBP1 latent transforming growth factor beta binding protein 1
MADD MAP-kinase activating death domain
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3
MAP3K10 mitogen-activated protein kinase kinase kinase 10
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K7CL MAP3K7 C-terminal like
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MARS methionyl-tRNA synthetase
MCM4 minichromosome maintenance complex component 4
MCM9 minichromosome maintenance complex component 9
MDH2 malate dehydrogenase 2, NAD (mitochondrial)
MED29 mediator complex subunit 29
MEF2B myocyte enhancer factor 2B
MEF2BNB-MEF2B MEF2BNB-MEF2B readthrough
MEIS1 Meis homeobox 1
MFN2 mitofusin 2
MKI67 marker of proliferation Ki-67
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
MPHOSPH9 M-phase phosphoprotein 9
MRC2 mannose receptor, C type 2
MSH5 mutS homolog 5
MTFR2 mitochondrial fission regulator 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MXRA8 matrix-remodelling associated 8
MYH14 myosin, heavy chain 14, non-muscle
MYO1E myosin IE
MZF1 myeloid zinc finger 1
N4BP1 NEDD4 binding protein 1
N4BP2L2 NEDD4 binding protein 2-like 2
NCAPH non-SMC condensin I complex, subunit H
NCOA2 nuclear receptor coactivator 2
NDRG4 NDRG family member 4
NEK4 NIMA-related kinase 4
NFX1 nuclear transcription factor, X-box binding 1
NGLY1 N-glycanase 1
NID2 nidogen 2 (osteonidogen)
NIN ninein (GSK3B interacting protein)
NLK nemo-like kinase
NOP2 NOP2 nucleolar protein
NOSTRIN nitric oxide synthase trafficking
NOTCH1 notch 1
NPBWR1 neuropeptides B/W receptor 1
NPY neuropeptide Y
NR6A1 nuclear receptor subfamily 6, group A, member 1
NUP107 nucleoporin 107kDa
NUP210 nucleoporin 210kDa
NUP93 nucleoporin 93kDa
OPLAH 5-oxoprolinase (ATP-hydrolysing)
PANK4 pantothenate kinase 4
PAPD7 PAP associated domain containing 7
PARN poly(A)-specific ribonuclease
PCCB propionyl CoA carboxylase, beta polypeptide
PCDH8 protocadherin 8
PCGF3 polycomb group ring finger 3
PDCD2L programmed cell death 2-like
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDLIM3 PDZ and LIM domain 3
PDX1 pancreatic and duodenal homeobox 1
PDZD7 PDZ domain containing 7
PEG10 paternally expressed 10
PHLDB3 pleckstrin homology-like domain, family B, member 3
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PJA1 praja ring finger 1, E3 ubiquitin protein ligase
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCG1 phospholipase C, gamma 1
PLEC plectin
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
PLXND1 plexin D1
PMEL premelanosome protein
POLG polymerase (DNA directed), gamma
POLL polymerase (DNA directed), lambda
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PRICKLE4 prickle homolog 4 (Drosophila)
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PRR14L proline rich 14-like
PRRT4 proline-rich transmembrane protein 4
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
PTPRR protein tyrosine phosphatase, receptor type, R
PUF60 poly-U binding splicing factor 60KDa
PUM1 pumilio RNA-binding family member 1
PXDN peroxidasin
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RAP2B RAP2B, member of RAS oncogene family
RBBP6 retinoblastoma binding protein 6
RBM20 RNA binding motif protein 20
RBM27 RNA binding motif protein 27
RBM47 RNA binding motif protein 47
RBM5 RNA binding motif protein 5
RELL1 RELT-like 1
RGAG4 retrotransposon gag domain containing 4
RGS9 regulator of G-protein signaling 9
RHBDL1 rhomboid, veinlet-like 1 (Drosophila)
RNF166 ring finger protein 166
RSBN1L round spermatid basic protein 1-like
RSPH1 radial spoke head 1 homolog (Chlamydomonas)
RSU1 Ras suppressor protein 1
RUNX2 runt-related transcription factor 2
SART3 squamous cell carcinoma antigen recognized by T cells 3
SATB1 SATB homeobox 1
SAV1 salvador family WW domain containing protein 1
SCNN1D sodium channel, non voltage gated 1 delta subunit
SDK1 sidekick cell adhesion molecule 1
SEC23A Sec23 homolog A (S. cerevisiae)
SEC31B SEC31 homolog B (S. cerevisiae)
SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
SETD7 SET domain containing (lysine methyltransferase) 7
SF1 splicing factor 1
SFSWAP splicing factor, suppressor of white-apricot family
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3GLB2 SH3-domain GRB2-like endophilin B2
SIPA1L2 signal-induced proliferation-associated 1 like 2
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC26A11 solute carrier family 26 (anion exchanger), member 11
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1
SLC38A4 solute carrier family 38, member 4
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC44A3 solute carrier family 44, member 3
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SLIT2 slit homolog 2 (Drosophila)
SLITRK5 SLIT and NTRK-like family, member 5
SNX2 sorting nexin 2
SNX30 sorting nexin family member 30
SORBS1 sorbin and SH3 domain containing 1
SPAG5 sperm associated antigen 5
SPAST spastin
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
SRP68 signal recognition particle 68kDa
SSFA2 sperm specific antigen 2
STRIP2 striatin interacting protein 2
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SV2A synaptic vesicle glycoprotein 2A
SYNRG synergin, gamma
SYT12 synaptotagmin XII
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TAOK2 TAO kinase 2
TBC1D2 TBC1 domain family, member 2
TBC1D4 TBC1 domain family, member 4
TBKBP1 TBK1 binding protein 1
TBRG4 transforming growth factor beta regulator 4
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TGFBR3 transforming growth factor, beta receptor III
THOC2 THO complex 2
THRAP3 thyroid hormone receptor associated protein 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMCO4 transmembrane and coiled-coil domains 4
TMEM184A transmembrane protein 184A
TMEM44 transmembrane protein 44
TMF1 TATA element modulatory factor 1
TMUB1 transmembrane and ubiquitin-like domain containing 1
TOR1AIP1 torsin A interacting protein 1
TP53 tumor protein p53
TRAPPC12 trafficking protein particle complex 12
TRAPPC3 trafficking protein particle complex 3
TRERF1 transcriptional regulating factor 1
TRIM16 tripartite motif containing 16
TRIM23 tripartite motif containing 23
TRIO trio Rho guanine nucleotide exchange factor
TRIP4 thyroid hormone receptor interactor 4
TSC2 tuberous sclerosis 2
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
TTBK2 tau tubulin kinase 2
TTLL4 tubulin tyrosine ligase-like family member 4
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UBXN11 UBX domain protein 11
UNC13A unc-13 homolog A (C. elegans)
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
USP2 ubiquitin specific peptidase 2
USP9X ubiquitin specific peptidase 9, X-linked
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
UVRAG UV radiation resistance associated
VEGFC vascular endothelial growth factor C
VLDLR very low density lipoprotein receptor
WBP4 WW domain binding protein 4
WDFY3 WD repeat and FYVE domain containing 3
WDR33 WD repeat domain 33
WDR90 WD repeat domain 90
WNT5A wingless-type MMTV integration site family, member 5A
ZBTB8OS zinc finger and BTB domain containing 8 opposite strand
ZC3H13 zinc finger CCCH-type containing 13
ZC3H6 zinc finger CCCH-type containing 6
ZEB1 zinc finger E-box binding homeobox 1
ZFHX2 zinc finger homeobox 2
ZFHX3 zinc finger homeobox 3
ZFPM2 zinc finger protein, FOG family member 2
ZFYVE1 zinc finger, FYVE domain containing 1
ZFYVE19 zinc finger, FYVE domain containing 19
ZFYVE9 zinc finger, FYVE domain containing 9
ZGRF1 zinc finger, GRF-type containing 1
ZHX2 zinc fingers and homeoboxes 2
ZMAT1 zinc finger, matrin-type 1
ZMAT2 zinc finger, matrin-type 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZMYM3 zinc finger, MYM-type 3
ZMYND10 zinc finger, MYND-type containing 10
ZNF16 zinc finger protein 16
ZNF217 zinc finger protein 217
ZNF268 zinc finger protein 268
ZNF318 zinc finger protein 318
ZNF462 zinc finger protein 462
ZNF583 zinc finger protein 583
ZNF843 zinc finger protein 843
ZSWIM8 zinc finger, SWIM-type containing 8
ZW10 zw10 kinetochore protein