NCI-H1623 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: adenocarcinoma; non-small cell lung cancer (lung primary) (Cell Line Ontology, CLO_0008005)
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Genes

253 genes mutated in the NCI-H1623 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
AAR2 AAR2 splicing factor homolog (S. cerevisiae)
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACADL acyl-CoA dehydrogenase, long chain
ACOT13 acyl-CoA thioesterase 13
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17
ADAR adenosine deaminase, RNA-specific
ADCK3 aarF domain containing kinase 3
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALPPL2 alkaline phosphatase, placental-like 2
AMOTL1 angiomotin like 1
ANAPC11 anaphase promoting complex subunit 11
ANKRD16 ankyrin repeat domain 16
ANKRD44 ankyrin repeat domain 44
ANXA3 annexin A3
AOC3 amine oxidase, copper containing 3
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARHGAP10 Rho GTPase activating protein 10
ARID2 AT rich interactive domain 2 (ARID, RFX-like)
ARL17A ADP-ribosylation factor-like 17A
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASMTL acetylserotonin O-methyltransferase-like
ASPG asparaginase
ASPH aspartate beta-hydroxylase
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF7IP activating transcription factor 7 interacting protein
ATG2B autophagy related 2B
ATN1 atrophin 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCAS2 breast carcinoma amplified sequence 2
BCAS3 breast carcinoma amplified sequence 3
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BOD1L2 biorientation of chromosomes in cell division 1-like 2
BTN2A2 butyrophilin, subfamily 2, member A2
C11ORF54 chromosome 11 open reading frame 54
C1RL complement component 1, r subcomponent-like
C2CD3 C2 calcium-dependent domain containing 3
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CALB2 calbindin 2
CALCOCO2 calcium binding and coiled-coil domain 2
CALU calumenin
CCDC102A coiled-coil domain containing 102A
CCDC136 coiled-coil domain containing 136
CDH23 cadherin-related 23
CECR5 cat eye syndrome chromosome region, candidate 5
CERKL ceramide kinase-like
CGNL1 cingulin-like 1
CLPTM1 cleft lip and palate associated transmembrane protein 1
CNBP CCHC-type zinc finger, nucleic acid binding protein
COG5 component of oligomeric golgi complex 5
COL7A1 collagen, type VII, alpha 1
CROT carnitine O-octanoyltransferase
CRY2 cryptochrome circadian clock 2
CRYBG3 beta-gamma crystallin domain containing 3
CTU1 cytosolic thiouridylase subunit 1
CUL9 cullin 9
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
DCTN1 dynactin 1
DENND3 DENN/MADD domain containing 3
DHRS4L2 dehydrogenase/reductase (SDR family) member 4 like 2
DIEXF digestive organ expansion factor homolog (zebrafish)
DLG1 discs, large homolog 1 (Drosophila)
DNER delta/notch-like EGF repeat containing
DNHD1 dynein heavy chain domain 1
DUOX2 dual oxidase 2
DUOXA2 dual oxidase maturation factor 2
DVL3 dishevelled segment polarity protein 3
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
ECT2 epithelial cell transforming 2
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ENO2 enolase 2 (gamma, neuronal)
ENOPH1 enolase-phosphatase 1
ENOX1 ecto-NOX disulfide-thiol exchanger 1
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
ERF Ets2 repressor factor
EVC2 Ellis van Creveld syndrome 2
EXPH5 exophilin 5
FANCD2 Fanconi anemia, complementation group D2
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FOXC2 forkhead box C2
FOXJ2 forkhead box J2
FUBP1 far upstream element (FUSE) binding protein 1
GBAS glioblastoma amplified sequence
GLTSCR1 glioma tumor suppressor candidate region gene 1
GPATCH1 G patch domain containing 1
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2
GTSE1 G-2 and S-phase expressed 1
HADH hydroxyacyl-CoA dehydrogenase
HDAC7 histone deacetylase 7
HDGFRP2 hepatoma-derived growth factor-related protein 2
HOXC11 homeobox C11
HOXD9 homeobox D9
IFT140 intraflagellar transport 140
IFT81 intraflagellar transport 81
IGFBPL1 insulin-like growth factor binding protein-like 1
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
INTS1 integrator complex subunit 1
ITGA8 integrin, alpha 8
JMJD1C jumonji domain containing 1C
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KEAP1 kelch-like ECH-associated protein 1
KIAA1109 KIAA1109
KIAA1841 KIAA1841
KIF21A kinesin family member 21A
KRBA1 KRAB-A domain containing 1
KRT75 keratin 75, type II
L1CAM L1 cell adhesion molecule
LCA5 Leber congenital amaurosis 5
LTBP1 latent transforming growth factor beta binding protein 1
LZTR1 leucine-zipper-like transcription regulator 1
MAGEB2 melanoma antigen family B2
MAK16 MAK16 homolog (S. cerevisiae)
MAN1B1 mannosidase, alpha, class 1B, member 1
MAP2 microtubule-associated protein 2
MAP7D3 MAP7 domain containing 3
MBD6 methyl-CpG binding domain protein 6
MED12L mediator complex subunit 12-like
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MMP28 matrix metallopeptidase 28
MRPL1 mitochondrial ribosomal protein L1
MRPL11 mitochondrial ribosomal protein L11
MTA3 metastasis associated 1 family, member 3
MUC16 mucin 16, cell surface associated
MUT methylmalonyl CoA mutase
MYEOV myeloma overexpressed
MYH14 myosin, heavy chain 14, non-muscle
MYO19 myosin XIX
MYO5C myosin VC
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NGF nerve growth factor (beta polypeptide)
NOP2 NOP2 nucleolar protein
NPEPPS aminopeptidase puromycin sensitive
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUMA1 nuclear mitotic apparatus protein 1
NUP210L nucleoporin 210kDa-like
ODF2 outer dense fiber of sperm tails 2
OLFML2A olfactomedin-like 2A
OTOF otoferlin
OXLD1 oxidoreductase-like domain containing 1
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2
P3H2 prolyl 3-hydroxylase 2
PARP1 poly (ADP-ribose) polymerase 1
PARP12 poly (ADP-ribose) polymerase family, member 12
PCCB propionyl CoA carboxylase, beta polypeptide
PCDHB16 protocadherin beta 16
PCGF5 polycomb group ring finger 5
PCNX pecanex homolog (Drosophila)
PHLDB1 pleckstrin homology-like domain, family B, member 1
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PICALM phosphatidylinositol binding clathrin assembly protein
PICK1 protein interacting with PRKCA 1
PKM pyruvate kinase, muscle
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCE1 phospholipase C, epsilon 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
PRCP prolylcarboxypeptidase (angiotensinase C)
PRPF8 pre-mRNA processing factor 8
PRR12 proline rich 12
PRRC2C proline-rich coiled-coil 2C
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PTER phosphotriesterase related
PTK7 protein tyrosine kinase 7 (inactive)
PVRIG poliovirus receptor related immunoglobulin domain containing
RABEPK Rab9 effector protein with kelch motifs
RALY RALY heterogeneous nuclear ribonucleoprotein
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RB1CC1 RB1-inducible coiled-coil 1
RIC8B RIC8 guanine nucleotide exchange factor B
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RNF169 ring finger protein 169
RNF213 ring finger protein 213
ROR1 receptor tyrosine kinase-like orphan receptor 1
RSRC2 arginine/serine-rich coiled-coil 2
RTEL1 regulator of telomere elongation helicase 1
SCML2 sex comb on midleg-like 2 (Drosophila)
SETBP1 SET binding protein 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SGK223 homolog of rat pragma of Rnd2
SIM2 single-minded family bHLH transcription factor 2
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC35F2 solute carrier family 35, member F2
SLC38A7 solute carrier family 38, member 7
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLU7 SLU7 splicing factor homolog (S. cerevisiae)
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SNUPN snurportin 1
SOCS6 suppressor of cytokine signaling 6
SOGA1 suppressor of glucose, autophagy associated 1
SORBS1 sorbin and SH3 domain containing 1
SOS2 son of sevenless homolog 2 (Drosophila)
SOST sclerostin
SPDL1 spindle apparatus coiled-coil protein 1
SPRY4 sprouty homolog 4 (Drosophila)
SSH1 slingshot protein phosphatase 1
ST7L suppression of tumorigenicity 7 like
STK11 serine/threonine kinase 11
STXBP5L syntaxin binding protein 5-like
TBC1D2 TBC1 domain family, member 2
TBCD tubulin folding cofactor D
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TEX2 testis expressed 2
TFCP2 transcription factor CP2
TFRC transferrin receptor
TGM5 transglutaminase 5
TGS1 trimethylguanosine synthase 1
THSD7A thrombospondin, type I, domain containing 7A
TLN2 talin 2
TMED1 transmembrane emp24 protein transport domain containing 1
TMEM136 transmembrane protein 136
TMEM260 transmembrane protein 260
TMEM55A transmembrane protein 55A
TNPO3 transportin 3
TNRC18 trinucleotide repeat containing 18
TNRC6A trinucleotide repeat containing 6A
TOB1 transducer of ERBB2, 1
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast)
TP53 tumor protein p53
TREML4 triggering receptor expressed on myeloid cells-like 4
TRIM39 tripartite motif containing 39
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TRPC4 transient receptor potential cation channel, subfamily C, member 4
TRRAP transformation/transcription domain-associated protein
TTC21B tetratricopeptide repeat domain 21B
TUBB1 tubulin, beta 1 class VI
TUBD1 tubulin, delta 1
TUBGCP2 tubulin, gamma complex associated protein 2
UBE2E3 ubiquitin-conjugating enzyme E2E 3
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
VEGFB vascular endothelial growth factor B
WRAP73 WD repeat containing, antisense to TP73
WWOX WW domain containing oxidoreductase
ZC3H7A zinc finger CCCH-type containing 7A
ZFP69B ZFP69 zinc finger protein B
ZIC1 Zic family member 1
ZNF12 zinc finger protein 12
ZNF180 zinc finger protein 180
ZNF518B zinc finger protein 518B
ZNF592 zinc finger protein 592
ZNF668 zinc finger protein 668
ZNF677 zinc finger protein 677
ZNF711 zinc finger protein 711
ZNF720 zinc finger protein 720
ZW10 zw10 kinetochore protein