NCI-H1581 Gene Set

Dataset COSMIC Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: large cell adenocarcinoma; non-small cell lung cancer (Cell Line Ontology, CLO_0008003)
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373 genes mutated in the NCI-H1581 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

Symbol Name
AAMP angio-associated, migratory cell protein
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACBD5 acyl-CoA binding domain containing 5
ACMSD aminocarboxymuconate semialdehyde decarboxylase
ACOT7 acyl-CoA thioesterase 7
ACOX1 acyl-CoA oxidase 1, palmitoyl
ACTL6A actin-like 6A
ACTRT2 actin-related protein T2
ADAM29 ADAM metallopeptidase domain 29
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
ADGRB3 adhesion G protein-coupled receptor B3
ADGRL3 adhesion G protein-coupled receptor L3
AFAP1L2 actin filament associated protein 1-like 2
AGGF1 angiogenic factor with G patch and FHA domains 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGXT2 alanine--glyoxylate aminotransferase 2
AIM1L absent in melanoma 1-like
ALKBH7 alkB, alkylation repair homolog 7 (E. coli)
AMOTL2 angiomotin like 2
AMPH amphiphysin
ANK2 ankyrin 2, neuronal
ANKK1 ankyrin repeat and kinase domain containing 1
ANKLE2 ankyrin repeat and LEM domain containing 2
ANKMY1 ankyrin repeat and MYND domain containing 1
ANKRD13B ankyrin repeat domain 13B
ANKRD20A20P ankyrin repeat domain 20 family, member A20, pseudogene
ANKRD35 ankyrin repeat domain 35
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APC adenomatous polyposis coli
APLP2 amyloid beta (A4) precursor-like protein 2
APMAP adipocyte plasma membrane associated protein
APOO apolipoprotein O
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARHGAP20 Rho GTPase activating protein 20
ARHGAP44 Rho GTPase activating protein 44
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARID1A AT rich interactive domain 1A (SWI-like)
ARID2 AT rich interactive domain 2 (ARID, RFX-like)
ARPP21 cAMP-regulated phosphoprotein, 21kDa
ARSB arylsulfatase B
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASIC2 acid sensing (proton gated) ion channel 2
ATG2B autophagy related 2B
ATG7 autophagy related 7
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
ATXN2L ataxin 2-like
BAIAP3 BAI1-associated protein 3
BEND3 BEN domain containing 3
BOD1L1 biorientation of chromosomes in cell division 1-like 1
BPIFC BPI fold containing family C
BRD1 bromodomain containing 1
C2CD3 C2 calcium-dependent domain containing 3
CA3 carbonic anhydrase III
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CALD1 caldesmon 1
CAPN13 calpain 13
CCDC146 coiled-coil domain containing 146
CCDC22 coiled-coil domain containing 22
CCDC82 coiled-coil domain containing 82
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CDH20 cadherin 20, type 2
CDK17 cyclin-dependent kinase 17
CDNF cerebral dopamine neurotrophic factor
CEP128 centrosomal protein 128kDa
CFAP44 cilia and flagella associated protein 44
CFAP52 cilia and flagella associated protein 52
CFH complement factor H
CHMP1A charged multivesicular body protein 1A
CLEC16A C-type lectin domain family 16, member A
CLK2 CDC-like kinase 2
CNGA2 cyclic nucleotide gated channel alpha 2
CNTN6 contactin 6
CNTNAP5 contactin associated protein-like 5
COBLL1 cordon-bleu WH2 repeat protein-like 1
COIL coilin
COL18A1 collagen, type XVIII, alpha 1
COL20A1 collagen, type XX, alpha 1
COL4A4 collagen, type IV, alpha 4
COL9A1 collagen, type IX, alpha 1
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CPXM2 carboxypeptidase X (M14 family), member 2
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CSH2 chorionic somatomammotropin hormone 2
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1
DCDC2 doublecortin domain containing 2
DCHS2 dachsous cadherin-related 2
DCSTAMP dendrocyte expressed seven transmembrane protein
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1
DEPDC5 DEP domain containing 5
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DMXL1 Dmx-like 1
DNAAF1 dynein, axonemal, assembly factor 1
DNAH7 dynein, axonemal, heavy chain 7
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DSC2 desmocollin 2
DYSF dysferlin
EML2 echinoderm microtubule associated protein like 2
EP400 E1A binding protein p400
EPAS1 endothelial PAS domain protein 1
ERCC6 excision repair cross-complementation group 6
ERICH6 glutamate-rich 6
ERLIN2 ER lipid raft associated 2
ETV1 ets variant 1
EXOC1 exocyst complex component 1
F5 coagulation factor V (proaccelerin, labile factor)
FAM124B family with sequence similarity 124B
FAM46A family with sequence similarity 46, member A
FAM71F2 family with sequence similarity 71, member F2
FANCB Fanconi anemia, complementation group B
FANCM Fanconi anemia, complementation group M
FAT3 FAT atypical cadherin 3
FAT4 FAT atypical cadherin 4
FBN2 fibrillin 2
FBXO11 F-box protein 11
FKBP6 FK506 binding protein 6, 36kDa
FLG2 filaggrin family member 2
FLRT1 fibronectin leucine rich transmembrane protein 1
FN1 fibronectin 1
FNDC1 fibronectin type III domain containing 1
GAA glucosidase, alpha; acid
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GBA glucosidase, beta, acid
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GJA1 gap junction protein, alpha 1, 43kDa
GLOD4 glyoxalase domain containing 4
GLT8D2 glycosyltransferase 8 domain containing 2
GMIP GEM interacting protein
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HELZ2 helicase with zinc finger 2, transcriptional coactivator
HEPHL1 hephaestin-like 1
HIST1H3I histone cluster 1, H3i
HK2 hexokinase 2
HMGXB4 HMG box domain containing 4
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
IFIH1 interferon induced with helicase C domain 1
IGF2 insulin-like growth factor 2
IGSF10 immunoglobulin superfamily, member 10
IL17F interleukin 17F
IL23R interleukin 23 receptor
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGA11 integrin, alpha 11
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
IZUMO3 IZUMO family member 3
JADE1 jade family PHD finger 1
JAG1 jagged 1
KANSL2 KAT8 regulatory NSL complex subunit 2
KDM4E lysine (K)-specific demethylase 4E
KIAA1324L KIAA1324-like
KIAA2026 KIAA2026
KIDINS220 kinase D-interacting substrate, 220kDa
KIF12 kinesin family member 12
KIF1A kinesin family member 1A
KIF6 kinesin family member 6
KNG1 kininogen 1
KPNA4 karyopherin alpha 4 (importin alpha 3)
KRTAP10-10 keratin associated protein 10-10
LAMA1 laminin, alpha 1
LAPTM5 lysosomal protein transmembrane 5
LATS2 large tumor suppressor kinase 2
LITAF lipopolysaccharide-induced TNF factor
LOC541473 FK506 binding protein 6, 36kDa pseudogene
LOXHD1 lipoxygenase homology domains 1
LPPR5 lipid phosphate phosphatase-related protein type 5
LRP2 low density lipoprotein receptor-related protein 2
LRRC31 leucine rich repeat containing 31
LRRC55 leucine rich repeat containing 55
LRRK2 leucine-rich repeat kinase 2
LYRM1 LYR motif containing 1
MAMDC4 MAM domain containing 4
MAP2 microtubule-associated protein 2
MAPK8 mitogen-activated protein kinase 8
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MED13 mediator complex subunit 13
MED13L mediator complex subunit 13-like
MED16 mediator complex subunit 16
MED21 mediator complex subunit 21
METTL3 methyltransferase like 3
MFN2 mitofusin 2
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MLF1 myeloid leukemia factor 1
MMRN1 multimerin 1
MOXD1 monooxygenase, DBH-like 1
MPDZ multiple PDZ domain protein
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MRPL16 mitochondrial ribosomal protein L16
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MTPAP mitochondrial poly(A) polymerase
MUC4 mucin 4, cell surface associated
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYH15 myosin, heavy chain 15
MYH7B myosin, heavy chain 7B, cardiac muscle, beta
MYT1L myelin transcription factor 1-like
NACA nascent polypeptide-associated complex alpha subunit
NAT10 N-acetyltransferase 10 (GCN5-related)
NCOA1 nuclear receptor coactivator 1
NCOA6 nuclear receptor coactivator 6
NOD1 nucleotide-binding oligomerization domain containing 1
NOS1 nitric oxide synthase 1 (neuronal)
NR3C2 nuclear receptor subfamily 3, group C, member 2
NRBP1 nuclear receptor binding protein 1
NRG3 neuregulin 3
NTNG1 netrin G1
NTSR2 neurotensin receptor 2
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
NXPH1 neurexophilin 1
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
ODF2L outer dense fiber of sperm tails 2-like
OGDHL oxoglutarate dehydrogenase-like
OR2T1 olfactory receptor, family 2, subfamily T, member 1
OR4A16 olfactory receptor, family 4, subfamily A, member 16
OR4C6 olfactory receptor, family 4, subfamily C, member 6
OR4N4 olfactory receptor, family 4, subfamily N, member 4
OR52B6 olfactory receptor, family 52, subfamily B, member 6
OR5R1 olfactory receptor, family 5, subfamily R, member 1 (gene/pseudogene)
OR5T3 olfactory receptor, family 5, subfamily T, member 3
OR5W2 olfactory receptor, family 5, subfamily W, member 2
OTOG otogelin
PARP12 poly (ADP-ribose) polymerase family, member 12
PCDH11Y protocadherin 11 Y-linked
PCDHGA10 protocadherin gamma subfamily A, 10
PCDHGA6 protocadherin gamma subfamily A, 6
PCDHGA7 protocadherin gamma subfamily A, 7
PCLO piccolo presynaptic cytomatrix protein
PCNXL3 pecanex-like 3 (Drosophila)
PDE4DIP phosphodiesterase 4D interacting protein
PDLIM3 PDZ and LIM domain 3
PER1 period circadian clock 1
PER2 period circadian clock 2
PGAP3 post-GPI attachment to proteins 3
PICK1 protein interacting with PRKCA 1
PIGV phosphatidylinositol glycan anchor biosynthesis, class V
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
PIRT phosphoinositide-interacting regulator of transient receptor potential channels
PIWIL1 piwi-like RNA-mediated gene silencing 1
PKD2L1 polycystic kidney disease 2-like 1
PKD2L2 polycystic kidney disease 2-like 2
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHN1 pleckstrin homology domain containing, family N member 1
PNLIP pancreatic lipase
POC1B POC1 centriolar protein B
POLI polymerase (DNA directed) iota
POLQ polymerase (DNA directed), theta
POLRMT polymerase (RNA) mitochondrial (DNA directed)
POTED POTE ankyrin domain family, member D
PPP6R2 protein phosphatase 6, regulatory subunit 2
PRAMEF2 PRAME family member 2
PRDM6 PR domain containing 6
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRPF6 pre-mRNA processing factor 6
PRRC2B proline-rich coiled-coil 2B
PTDSS2 phosphatidylserine synthase 2
PTK2 protein tyrosine kinase 2
PTPRH protein tyrosine phosphatase, receptor type, H
PVRIG poliovirus receptor related immunoglobulin domain containing
PXDNL peroxidasin-like
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAD51AP2 RAD51 associated protein 2
RAI2 retinoic acid induced 2
RASGEF1A RasGEF domain family, member 1A
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
REG1A regenerating islet-derived 1 alpha
RELN reelin
RIF1 replication timing regulatory factor 1
RNF10 ring finger protein 10
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPE ribulose-5-phosphate-3-epimerase
RREB1 ras responsive element binding protein 1
RTN1 reticulon 1
RWDD4 RWD domain containing 4
RYR2 ryanodine receptor 2 (cardiac)
SARDH sarcosine dehydrogenase
SCAF1 SR-related CTD-associated factor 1
SCAPER S-phase cyclin A-associated protein in the ER
SCN2A sodium channel, voltage gated, type II alpha subunit
SDK1 sidekick cell adhesion molecule 1
SEC24B SEC24 family member B
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
SEPT5 septin 5
SETD3 SET domain containing 3
SHB Src homology 2 domain containing adaptor protein B
SIGLEC11 sialic acid binding Ig-like lectin 11
SIVA1 SIVA1, apoptosis-inducing factor
SLC35B3 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SNRPN small nuclear ribonucleoprotein polypeptide N
SOCS5 suppressor of cytokine signaling 5
SPATA6 spermatogenesis associated 6
SPTA1 spectrin, alpha, erythrocytic 1
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STAB2 stabilin 2
STARD8 StAR-related lipid transfer (START) domain containing 8
STOX2 storkhead box 2
SUN5 Sad1 and UNC84 domain containing 5
SYT10 synaptotagmin X
SYT11 synaptotagmin XI
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TANGO6 transport and golgi organization 6 homolog (Drosophila)
TBC1D15 TBC1 domain family, member 15
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBCD tubulin folding cofactor D
TBX22 T-box 22
TCERG1L transcription elongation regulator 1-like
TCHHL1 trichohyalin-like 1
THSD4 thrombospondin, type I, domain containing 4
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TIPIN TIMELESS interacting protein
TM4SF5 transmembrane 4 L six family member 5
TMC3 transmembrane channel-like 3
TMEM131 transmembrane protein 131
TMPRSS11B transmembrane protease, serine 11B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNNI1 troponin I type 1 (skeletal, slow)
TP53 tumor protein p53
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TRIM11 tripartite motif containing 11
TRIM41 tripartite motif containing 41
TRIM42 tripartite motif containing 42
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TRPS1 trichorhinophalangeal syndrome I
TSNAXIP1 translin-associated factor X interacting protein 1
TTC21B tetratricopeptide repeat domain 21B
TTC6 tetratricopeptide repeat domain 6
TTN titin
UBAP2 ubiquitin associated protein 2
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UFSP1 UFM1-specific peptidase 1 (non-functional)
USH2A Usher syndrome 2A (autosomal recessive, mild)
USP10 ubiquitin specific peptidase 10
USP31 ubiquitin specific peptidase 31
USP32 ubiquitin specific peptidase 32
USP41 ubiquitin specific peptidase 41
USP47 ubiquitin specific peptidase 47
VAT1 vesicle amine transport 1
VBP1 von Hippel-Lindau binding protein 1
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae)
WDR41 WD repeat domain 41
WDR7 WD repeat domain 7
WNT2B wingless-type MMTV integration site family, member 2B
XKR4 XK, Kell blood group complex subunit-related family, member 4
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF217 zinc finger protein 217
ZNF229 zinc finger protein 229
ZNF33A zinc finger protein 33A
ZNF496 zinc finger protein 496
ZNF497 zinc finger protein 497
ZNF532 zinc finger protein 532
ZNF671 zinc finger protein 671
ZP3 zona pellucida glycoprotein 3 (sperm receptor)