NCI-H1568 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: adenocarcinoma; non-small cell lung cancer (lung primary) (Cell Line Ontology, CLO_0008001)
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Genes

251 genes mutated in the NCI-H1568 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABLIM3 actin binding LIM protein family, member 3
ACAD10 acyl-CoA dehydrogenase family, member 10
ACIN1 apoptotic chromatin condensation inducer 1
ADD1 adducin 1 (alpha)
ADGRA3 adhesion G protein-coupled receptor A3
ALMS1 Alstrom syndrome protein 1
ALPPL2 alkaline phosphatase, placental-like 2
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ARHGAP17 Rho GTPase activating protein 17
ARSG arylsulfatase G
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ATF2 activating transcription factor 2
ATF6 activating transcription factor 6
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATM ATM serine/threonine kinase
ATP10D ATPase, class V, type 10D
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
ATP7B ATPase, Cu++ transporting, beta polypeptide
AVPI1 arginine vasopressin-induced 1
BRAT1 BRCA1-associated ATM activator 1
BRIX1 BRX1, biogenesis of ribosomes
BRSK1 BR serine/threonine kinase 1
BUD13 BUD13 homolog (S. cerevisiae)
C1ORF56 chromosome 1 open reading frame 56
C7ORF26 chromosome 7 open reading frame 26
C7ORF43 chromosome 7 open reading frame 43
CASP8AP2 caspase 8 associated protein 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC88C coiled-coil domain containing 88C
CD46 CD46 molecule, complement regulatory protein
CDK13 cyclin-dependent kinase 13
CEP72 centrosomal protein 72kDa
CERK ceramide kinase
CHD1 chromodomain helicase DNA binding protein 1
CIB2 calcium and integrin binding family member 2
CLSPN claspin
CLUH clustered mitochondria (cluA/CLU1) homolog
CMSS1 cms1 ribosomal small subunit homolog (yeast)
COBL cordon-bleu WH2 repeat protein
COL4A5 collagen, type IV, alpha 5
COQ10B coenzyme Q10 homolog B (S. cerevisiae)
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
CSF1R colony stimulating factor 1 receptor
DCLK2 doublecortin-like kinase 2
DCLRE1A DNA cross-link repair 1A
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
E2F8 E2F transcription factor 8
EDIL3 EGF-like repeats and discoidin I-like domains 3
EGLN2 egl-9 family hypoxia-inducible factor 2
EGR1 early growth response 1
EMC2 ER membrane protein complex subunit 2
EPHB4 EPH receptor B4
ERMP1 endoplasmic reticulum metallopeptidase 1
FAM120A family with sequence similarity 120A
FASTKD2 FAST kinase domains 2
FBXL6 F-box and leucine-rich repeat protein 6
FBXO21 F-box protein 21
FKBP5 FK506 binding protein 5
FLNB filamin B, beta
FLOT1 flotillin 1
FNIP1 folliculin interacting protein 1
FUK fucokinase
GAK cyclin G associated kinase
GAR1 GAR1 ribonucleoprotein
GATAD1 GATA zinc finger domain containing 1
GCC2 GRIP and coiled-coil domain containing 2
GGT7 gamma-glutamyltransferase 7
GLCE glucuronic acid epimerase
GLG1 golgi glycoprotein 1
GLI3 GLI family zinc finger 3
GLOD4 glyoxalase domain containing 4
GOLGA4 golgin A4
GOLPH3L golgi phosphoprotein 3-like
GPSM1 G-protein signaling modulator 1
GSAP gamma-secretase activating protein
HCFC1 host cell factor C1
HEATR5B HEAT repeat containing 5B
HJURP Holliday junction recognition protein
HMG20A high mobility group 20A
HOXC6 homeobox C6
IGF2R insulin-like growth factor 2 receptor
IL27RA interleukin 27 receptor, alpha
IRS2 insulin receptor substrate 2
JRK Jrk homolog (mouse)
KARS lysyl-tRNA synthetase
KAT8 K(lysine) acetyltransferase 8
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KDM1B lysine (K)-specific demethylase 1B
KDM4C lysine (K)-specific demethylase 4C
KIAA1217 KIAA1217
KIAA1429 KIAA1429
KIAA2018 KIAA2018
KIF3B kinesin family member 3B
KMT2D lysine (K)-specific methyltransferase 2D
LAMA3 laminin, alpha 3
LAMB2 laminin, beta 2 (laminin S)
LAMB3 laminin, beta 3
LAPTM4B lysosomal protein transmembrane 4 beta
LARS leucyl-tRNA synthetase
LIMCH1 LIM and calponin homology domains 1
LINGO2 leucine rich repeat and Ig domain containing 2
LMBRD1 LMBR1 domain containing 1
LMF1 lipase maturation factor 1
LMO4 LIM domain only 4
LOC81691 exonuclease NEF-sp
LRP1 low density lipoprotein receptor-related protein 1
LRP4 low density lipoprotein receptor-related protein 4
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LRRCC1 leucine rich repeat and coiled-coil centrosomal protein 1
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAST4 microtubule associated serine/threonine kinase family member 4
MATK megakaryocyte-associated tyrosine kinase
MBNL1 muscleblind-like splicing regulator 1
MCOLN2 mucolipin 2
MED13L mediator complex subunit 13-like
MEF2D myocyte enhancer factor 2D
MFAP3L microfibrillar-associated protein 3-like
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MPHOSPH8 M-phase phosphoprotein 8
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRC2 mannose receptor, C type 2
MRPL11 mitochondrial ribosomal protein L11
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYO10 myosin X
NANP N-acetylneuraminic acid phosphatase
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NLGN2 neuroligin 2
NOTCH3 notch 3
NPAS2 neuronal PAS domain protein 2
NRK Nik related kinase
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUDT17 nudix (nucleoside diphosphate linked moiety X)-type motif 17
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3
NXF1 nuclear RNA export factor 1
OTUD1 OTU deubiquitinase 1
P3H3 prolyl 3-hydroxylase 3
PARD3 par-3 family cell polarity regulator
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCF11 PCF11 cleavage and polyadenylation factor subunit
PCGF6 polycomb group ring finger 6
PDGFC platelet derived growth factor C
PEAK1 pseudopodium-enriched atypical kinase 1
PGS1 phosphatidylglycerophosphate synthase 1
PHF3 PHD finger protein 3
PHLDB1 pleckstrin homology-like domain, family B, member 1
PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase
PLS1 plastin 1
PLXNA1 plexin A1
POLQ polymerase (DNA directed), theta
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCZ protein kinase C, zeta
PRTG protogenin
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PTGFRN prostaglandin F2 receptor inhibitor
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RAD21 RAD21 homolog (S. pombe)
RAD51AP1 RAD51 associated protein 1
RBL1 retinoblastoma-like 1
RBM14 RNA binding motif protein 14
RBM27 RNA binding motif protein 27
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RNF139 ring finger protein 139
RNF149 ring finger protein 149
RPS10-NUDT3 RPS10-NUDT3 readthrough
RTTN rotatin
S1PR3 sphingosine-1-phosphate receptor 3
SACS sacsin molecular chaperone
SEC24B SEC24 family member B
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SHCBP1 SHC SH2-domain binding protein 1
SHISA9 shisa family member 9
SIN3B SIN3 transcription regulator family member B
SIRT2 sirtuin 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC12A9 solute carrier family 12, member 9
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SNX15 sorting nexin 15
SPA17 sperm autoantigenic protein 17
ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
STK19 serine/threonine kinase 19
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SVIL supervillin
SYNPO2 synaptopodin 2
SYVN1 synovial apoptosis inhibitor 1, synoviolin
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TFIP11 tuftelin interacting protein 11
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia)
TGFBR1 transforming growth factor, beta receptor 1
TGM1 transglutaminase 1
THOC2 THO complex 2
TICRR TOPBP1-interacting checkpoint and replication regulator
TLN2 talin 2
TM2D2 TM2 domain containing 2
TMEM127 transmembrane protein 127
TMEM68 transmembrane protein 68
TMEM9 transmembrane protein 9
TMEM91 transmembrane protein 91
TMTC4 transmembrane and tetratricopeptide repeat containing 4
TNS1 tensin 1
TP53 tumor protein p53
TRAPPC5 trafficking protein particle complex 5
TRIO trio Rho guanine nucleotide exchange factor
TTC23 tetratricopeptide repeat domain 23
TUBGCP3 tubulin, gamma complex associated protein 3
TXNDC16 thioredoxin domain containing 16
UNC13B unc-13 homolog B (C. elegans)
USP33 ubiquitin specific peptidase 33
USP34 ubiquitin specific peptidase 34
UXS1 UDP-glucuronate decarboxylase 1
VWA5A von Willebrand factor A domain containing 5A
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZBTB41 zinc finger and BTB domain containing 41
ZFC3H1 zinc finger, C3H1-type containing
ZFHX3 zinc finger homeobox 3
ZFP30 ZFP30 zinc finger protein
ZFYVE27 zinc finger, FYVE domain containing 27
ZGRF1 zinc finger, GRF-type containing 1
ZMAT3 zinc finger, matrin-type 3
ZNF232 zinc finger protein 232
ZNF350 zinc finger protein 350
ZNF354A zinc finger protein 354A
ZNF358 zinc finger protein 358
ZNF398 zinc finger protein 398
ZNF460 zinc finger protein 460
ZNF484 zinc finger protein 484
ZNF622 zinc finger protein 622
ZNF638 zinc finger protein 638
ZNF778 zinc finger protein 778
ZNF787 zinc finger protein 787
ZNF791 zinc finger protein 791
ZNF8 zinc finger protein 8
ZNF821 zinc finger protein 821
ZNF827 zinc finger protein 827
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase