NCI-H146 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description Small cell lung cancer cell line. (BRENDA Tissue and Enzyme Source Ontology, BTO_0003024)
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Genes

106 genes mutated in the NCI-H146 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
ACSL6 acyl-CoA synthetase long-chain family member 6
ADGRL3 adhesion G protein-coupled receptor L3
AHDC1 AT hook, DNA binding motif, containing 1
AK9 adenylate kinase 9
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C11ORF68 chromosome 11 open reading frame 68
CADM2 cell adhesion molecule 2
CASC5 cancer susceptibility candidate 5
CASKIN1 CASK interacting protein 1
CASZ1 castor zinc finger 1
CCDC88B coiled-coil domain containing 88B
CCNT1 cyclin T1
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like)
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CHD8 chromodomain helicase DNA binding protein 8
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLDN10 claudin 10
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CNTN5 contactin 5
COL22A1 collagen, type XXII, alpha 1
CPNE3 copine III
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa
CRABP1 cellular retinoic acid binding protein 1
CRTC2 CREB regulated transcription coactivator 2
CSMD3 CUB and Sushi multiple domains 3
CYFIP1 cytoplasmic FMR1 interacting protein 1
DGKZ diacylglycerol kinase, zeta
DOCK1 dedicator of cytokinesis 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ERICH3 glutamate-rich 3
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FGFR4 fibroblast growth factor receptor 4
FNBP1 formin binding protein 1
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GLB1L3 galactosidase, beta 1-like 3
GLMN glomulin, FKBP associated protein
GSTZ1 glutathione S-transferase zeta 1
HDAC10 histone deacetylase 10
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
IER5 immediate early response 5
IRS4 insulin receptor substrate 4
IWS1 IWS1 homolog (S. cerevisiae)
KAT6A K(lysine) acetyltransferase 6A
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNK10 potassium channel, two pore domain subfamily K, member 10
KIAA1551 KIAA1551
KIAA2026 KIAA2026
KMT2B lysine (K)-specific methyltransferase 2B
KMT2D lysine (K)-specific methyltransferase 2D
LAMA3 laminin, alpha 3
LRRIQ4 leucine-rich repeats and IQ motif containing 4
MAMDC4 MAM domain containing 4
MAPK7 mitogen-activated protein kinase 7
MAPT microtubule-associated protein tau
MICU3 mitochondrial calcium uptake family, member 3
MTERF1 mitochondrial transcription termination factor 1
MYO3A myosin IIIA
MYT1L myelin transcription factor 1-like
NALCN sodium leak channel, non selective
NCAPD3 non-SMC condensin II complex, subunit D3
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
NRXN1 neurexin 1
OTOGL otogelin-like
PAH phenylalanine hydroxylase
PIH1D2 PIH1 domain containing 2
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
PNPLA7 patatin-like phospholipase domain containing 7
POLK polymerase (DNA directed) kappa
PRICKLE2 prickle homolog 2 (Drosophila)
PRPF4B pre-mRNA processing factor 4B
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RANBP6 RAN binding protein 6
RB1 retinoblastoma 1
RBM14 RNA binding motif protein 14
REPIN1 replication initiator 1
RIMBP2 RIMS binding protein 2
RNF122 ring finger protein 122
RNF141 ring finger protein 141
RTTN rotatin
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SF3B2 splicing factor 3b, subunit 2, 145kDa
SIL1 SIL1 nucleotide exchange factor
SIRT1 sirtuin 1
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
SREBF2 sterol regulatory element binding transcription factor 2
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
SYNM synemin, intermediate filament protein
TBC1D24 TBC1 domain family, member 24
TRIM24 tripartite motif containing 24
TSHZ1 teashirt zinc finger homeobox 1
TTC21B tetratricopeptide repeat domain 21B
TUSC3 tumor suppressor candidate 3
UNC119 unc-119 homolog (C. elegans)
UNC50 unc-50 homolog (C. elegans)
UNC80 unc-80 homolog (C. elegans)
USP44 ubiquitin specific peptidase 44
USP46 ubiquitin specific peptidase 46
USP49 ubiquitin specific peptidase 49
WDR33 WD repeat domain 33
ZFYVE26 zinc finger, FYVE domain containing 26
ZNF134 zinc finger protein 134
ZNF205 zinc finger protein 205
ZNF267 zinc finger protein 267
ZNF717 zinc finger protein 717
ZNF768 zinc finger protein 768