NCI-H146 Gene Set

Dataset COSMIC Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description Small cell lung cancer cell line. (BRENDA Tissue and Enzyme Source Ontology, BTO_0003024)
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Genes

416 genes mutated in the NCI-H146 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACSL6 acyl-CoA synthetase long-chain family member 6
ACSS3 acyl-CoA synthetase short-chain family member 3
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ACVR2A activin A receptor, type IIA
ADAM32 ADAM metallopeptidase domain 32
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8
ADGRE3 adhesion G protein-coupled receptor E3
ADGRL3 adhesion G protein-coupled receptor L3
ADRA1A adrenoceptor alpha 1A
AFM afamin
AK9 adenylate kinase 9
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALPP alkaline phosphatase, placental
ANKRD24 ankyrin repeat domain 24
ANKRD31 ankyrin repeat domain 31
ANKRD55 ankyrin repeat domain 55
ANO4 anoctamin 4
ARHGAP26 Rho GTPase activating protein 26
ARL10 ADP-ribosylation factor-like 10
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
AUTS2 autism susceptibility candidate 2
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BAIAP2 BAI1-associated protein 2
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
C2 complement component 2
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CADM3 cell adhesion molecule 3
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CAMTA1 calmodulin binding transcription activator 1
CARD11 caspase recruitment domain family, member 11
CASC5 cancer susceptibility candidate 5
CASP14 caspase 14, apoptosis-related cysteine peptidase
CCDC136 coiled-coil domain containing 136
CCDC155 coiled-coil domain containing 155
CCDC27 coiled-coil domain containing 27
CCDC7 coiled-coil domain containing 7
CCNT1 cyclin T1
CD244 CD244 molecule, natural killer cell receptor 2B4
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like)
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CHSY3 chondroitin sulfate synthase 3
CIB3 calcium and integrin binding family member 3
CIT citron rho-interacting serine/threonine kinase
CLASP1 cytoplasmic linker associated protein 1
CLDN10 claudin 10
CLDN18 claudin 18
CLEC4F C-type lectin domain family 4, member F
CLOCK clock circadian regulator
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CMYA5 cardiomyopathy associated 5
CNGB3 cyclic nucleotide gated channel beta 3
CNST consortin, connexin sorting protein
CNTN5 contactin 5
CNTNAP5 contactin associated protein-like 5
COL11A1 collagen, type XI, alpha 1
COL17A1 collagen, type XVII, alpha 1
COL22A1 collagen, type XXII, alpha 1
COL6A3 collagen, type VI, alpha 3
COX6A1P2 cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2
CPNE3 copine III
CPNE4 copine IV
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa
CRABP1 cellular retinoic acid binding protein 1
CRELD2 cysteine-rich with EGF-like domains 2
CRTC2 CREB regulated transcription coactivator 2
CSMD3 CUB and Sushi multiple domains 3
CYFIP1 cytoplasmic FMR1 interacting protein 1
DAAM1 dishevelled associated activator of morphogenesis 1
DCC DCC netrin 1 receptor
DCDC5 doublecortin domain containing 5
DDX12P DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DENND2A DENN/MADD domain containing 2A
DGKZ diacylglycerol kinase, zeta
DNAH14 dynein, axonemal, heavy chain 14
DNAH5 dynein, axonemal, heavy chain 5
DNAH8 dynein, axonemal, heavy chain 8
DNAH9 dynein, axonemal, heavy chain 9
DOCK1 dedicator of cytokinesis 1
DOCK9 dedicator of cytokinesis 9
DPP10 dipeptidyl-peptidase 10 (non-functional)
DSC1 desmocollin 1
DSP desmoplakin
DZIP1 DAZ interacting zinc finger protein 1
EDN3 endothelin 3
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFHB EF-hand domain family, member B
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
ELAVL4 ELAV like neuron-specific RNA binding protein 4
ELSPBP1 epididymal sperm binding protein 1
EMCN endomucin
EMP3 epithelial membrane protein 3
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans)
ERCC8 excision repair cross-complementation group 8
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FAM109B family with sequence similarity 109, member B
FAM114A1 family with sequence similarity 114, member A1
FAM135B family with sequence similarity 135, member B
FAM177B family with sequence similarity 177, member B
FAM189B family with sequence similarity 189, member B
FAM90A20P putative protein FAM90A20
FAT2 FAT atypical cadherin 2
FBLN2 fibulin 2
FBN2 fibrillin 2
FCRL3 Fc receptor-like 3
FGB fibrinogen beta chain
FGFR4 fibroblast growth factor receptor 4
FLT1 fms-related tyrosine kinase 1
FMNL2 formin-like 2
FMO4 flavin containing monooxygenase 4
FNBP1 formin binding protein 1
FRG1 FSHD region gene 1
FTMT ferritin mitochondrial
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GARS glycyl-tRNA synthetase
GBP3 guanylate binding protein 3
GDPD1 glycerophosphodiester phosphodiesterase domain containing 1
GFRAL GDNF family receptor alpha like
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GIMAP8 GTPase, IMAP family member 8
GJA1 gap junction protein, alpha 1, 43kDa
GLB1L3 galactosidase, beta 1-like 3
GLMN glomulin, FKBP associated protein
GPR39 G protein-coupled receptor 39
GPR50 G protein-coupled receptor 50
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRK7 G protein-coupled receptor kinase 7
GRM5 glutamate receptor, metabotropic 5
GRPR gastrin-releasing peptide receptor
GSTZ1 glutathione S-transferase zeta 1
GUCY2C guanylate cyclase 2C
GYS2 glycogen synthase 2 (liver)
H3F3A H3 histone, family 3A
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMCN1 hemicentin 1
HPX hemopexin
HRNR hornerin
HS6ST2 heparan sulfate 6-O-sulfotransferase 2
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
IFNA14 interferon, alpha 14
IL17RE interleukin 17 receptor E
IL1RAPL1 interleukin 1 receptor accessory protein-like 1
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
ING4 inhibitor of growth family, member 4
IRF4 interferon regulatory factor 4
IRS1 insulin receptor substrate 1
IRX1 iroquois homeobox 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
ITK IL2-inducible T-cell kinase
IWS1 IWS1 homolog (S. cerevisiae)
KAT6A K(lysine) acetyltransferase 6A
KCNIP4 Kv channel interacting protein 4
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
KCNK10 potassium channel, two pore domain subfamily K, member 10
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
KIAA0232 KIAA0232
KIAA0754 KIAA0754
KIAA2026 KIAA2026
KIF1A kinesin family member 1A
KLHL42 kelch-like family member 42
KMT2D lysine (K)-specific methyltransferase 2D
KRT15 keratin 15, type I
KRTAP4-6 keratin associated protein 4-6
KRTAP5-4 keratin associated protein 5-4
LAMA3 laminin, alpha 3
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LCA5 Leber congenital amaurosis 5
LCT lactase
LEKR1 leucine, glutamate and lysine rich 1
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LONRF2 LON peptidase N-terminal domain and ring finger 2
LRGUK leucine-rich repeats and guanylate kinase domain containing
LRIF1 ligand dependent nuclear receptor interacting factor 1
LRP1B low density lipoprotein receptor-related protein 1B
LRPPRC leucine-rich pentatricopeptide repeat containing
LRRC8B leucine rich repeat containing 8 family, member B
LRRIQ4 leucine-rich repeats and IQ motif containing 4
LRRK1 leucine-rich repeat kinase 1
MAGEB6 melanoma antigen family B6
MAMDC4 MAM domain containing 4
MAPK7 mitogen-activated protein kinase 7
MAPT microtubule-associated protein tau
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MED1 mediator complex subunit 1
MICU3 mitochondrial calcium uptake family, member 3
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
MRPL37 mitochondrial ribosomal protein L37
MTERF1 mitochondrial transcription termination factor 1
MTSS1 metastasis suppressor 1
MUC12 mucin 12, cell surface associated
MUC16 mucin 16, cell surface associated
MUC17 mucin 17, cell surface associated
MUC21 mucin 21, cell surface associated
MUC4 mucin 4, cell surface associated
MX1 MX dynamin-like GTPase 1
MYBPC1 myosin binding protein C, slow type
MYH13 myosin, heavy chain 13, skeletal muscle
MYH15 myosin, heavy chain 15
MYLK2 myosin light chain kinase 2
MYO3A myosin IIIA
MYO5B myosin VB
MYOM2 myomesin 2
MYPN myopalladin
MYT1L myelin transcription factor 1-like
NALCN sodium leak channel, non selective
NAV2 neuron navigator 2
NCAPD3 non-SMC condensin II complex, subunit D3
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NELL1 NEL-like 1 (chicken)
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1
NID2 nidogen 2 (osteonidogen)
NOS1 nitric oxide synthase 1 (neuronal)
NPAS3 neuronal PAS domain protein 3
NPC1 Niemann-Pick disease, type C1
NPC1L1 NPC1-like 1
NPFFR2 neuropeptide FF receptor 2
NPPA natriuretic peptide A
NRXN1 neurexin 1
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2
NUP153 nucleoporin 153kDa
NUP85 nucleoporin 85kDa
NWD2 NACHT and WD repeat domain containing 2
NXF3 nuclear RNA export factor 3
OGDHL oxoglutarate dehydrogenase-like
OLIG3 oligodendrocyte transcription factor 3
OR10J1 olfactory receptor, family 10, subfamily J, member 1
OR10Q1 olfactory receptor, family 10, subfamily Q, member 1
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1
OR2J1 olfactory receptor, family 2, subfamily J, member 1 (gene/pseudogene)
OR4C6 olfactory receptor, family 4, subfamily C, member 6
OR4K15 olfactory receptor, family 4, subfamily K, member 15
OR51B4 olfactory receptor, family 51, subfamily B, member 4
OR52A1 olfactory receptor, family 52, subfamily A, member 1
OR5D18 olfactory receptor, family 5, subfamily D, member 18
OR6C75 olfactory receptor, family 6, subfamily C, member 75
OR6Y1 olfactory receptor, family 6, subfamily Y, member 1
OR8D2 olfactory receptor, family 8, subfamily D, member 2 (gene/pseudogene)
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1
OSMR oncostatin M receptor
OTOGL otogelin-like
PAH phenylalanine hydroxylase
PARD3 par-3 family cell polarity regulator
PARP2 poly (ADP-ribose) polymerase 2
PAX6 paired box 6
PCDH12 protocadherin 12
PCDH9 protocadherin 9
PCDHA8 protocadherin alpha 8
PCDHG@ protocadherin gamma cluster
PCDHGA2 protocadherin gamma subfamily A, 2
PCDHGB6 protocadherin gamma subfamily B, 6
PCNX pecanex homolog (Drosophila)
PIH1D2 PIH1 domain containing 2
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLA2G4E phospholipase A2, group IVE
PLCB4 phospholipase C, beta 4
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
PM20D1 peptidase M20 domain containing 1
PMFBP1 polyamine modulated factor 1 binding protein 1
POLK polymerase (DNA directed) kappa
POTEI POTE ankyrin domain family, member I
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRICKLE2 prickle homolog 2 (Drosophila)
PRKCI protein kinase C, iota
PROKR2 prokineticin receptor 2
PRPF4B pre-mRNA processing factor 4B
PRRC2A proline-rich coiled-coil 2A
PSG5 pregnancy specific beta-1-glycoprotein 5
PYROXD2 pyridine nucleotide-disulphide oxidoreductase domain 2
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RAET1L retinoic acid early transcript 1L
RANBP6 RAN binding protein 6
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RB1 retinoblastoma 1
RBM14 RNA binding motif protein 14
RBMXL3 RNA binding motif protein, X-linked-like 3
RECQL5 RecQ protein-like 5
REEP6 receptor accessory protein 6
REPIN1 replication initiator 1
RGAG1 retrotransposon gag domain containing 1
RHBDL3 rhomboid, veinlet-like 3 (Drosophila)
RIMBP2 RIMS binding protein 2
RNF121 ring finger protein 121
RNF122 ring finger protein 122
RNF141 ring finger protein 141
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RRBP1 ribosome binding protein 1
RSPH3 radial spoke 3 homolog (Chlamydomonas)
RTTN rotatin
SAAL1 serum amyloid A-like 1
SELPLG selectin P ligand
SERPINB12 serpin peptidase inhibitor, clade B (ovalbumin), member 12
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SF3B2 splicing factor 3b, subunit 2, 145kDa
SHISA9 shisa family member 9
SI sucrase-isomaltase (alpha-glucosidase)
SIDT1 SID1 transmembrane family, member 1
SIGLEC6 sialic acid binding Ig-like lectin 6
SIGLEC9 sialic acid binding Ig-like lectin 9
SIL1 SIL1 nucleotide exchange factor
SIRT1 sirtuin 1
SLAMF6 SLAM family member 6
SLC26A5 solute carrier family 26 (anion exchanger), member 5
SLC35F1 solute carrier family 35, member F1
SLC38A5 solute carrier family 38, member 5
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SLCO1B7 solute carrier organic anion transporter family, member 1B7 (non-functional)
SMC6 structural maintenance of chromosomes 6
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SORCS3 sortilin-related VPS10 domain containing receptor 3
SOX10 SRY (sex determining region Y)-box 10
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SPTBN2 spectrin, beta, non-erythrocytic 2
SPTBN5 spectrin, beta, non-erythrocytic 5
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
SREBF2 sterol regulatory element binding transcription factor 2
SSBP3 single stranded DNA binding protein 3
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STAB1 stabilin 1
STEAP3 STEAP family member 3, metalloreductase
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SYNE1 spectrin repeat containing, nuclear envelope 1
SYTL2 synaptotagmin-like 2
TAAR5 trace amine associated receptor 5
TACR3 tachykinin receptor 3
TBC1D24 TBC1 domain family, member 24
TLN1 talin 1
TLR2 toll-like receptor 2
TMC1 transmembrane channel-like 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNK2 tyrosine kinase, non-receptor, 2
TNXB tenascin XB
TP53 tumor protein p53
TRHDE thyrotropin-releasing hormone degrading enzyme
TRIM32 tripartite motif containing 32
TRIM33 tripartite motif containing 33
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TSHZ1 teashirt zinc finger homeobox 1
TSPAN19 tetraspanin 19
TSPEAR thrombospondin-type laminin G domain and EAR repeats
TSPYL6 TSPY-like 6
TTC21B tetratricopeptide repeat domain 21B
TUBB7P tubulin, beta 7, pseudogene
TUBGCP2 tubulin, gamma complex associated protein 2
TUSC3 tumor suppressor candidate 3
TYRP1 tyrosinase-related protein 1
U2SURP U2 snRNP-associated SURP domain containing
UCN3 urocortin 3
ULK1 unc-51 like autophagy activating kinase 1
UNC119 unc-119 homolog (C. elegans)
UNC13B unc-13 homolog B (C. elegans)
UNC13C unc-13 homolog C (C. elegans)
UNC50 unc-50 homolog (C. elegans)
USF1 upstream transcription factor 1
USH2A Usher syndrome 2A (autosomal recessive, mild)
USP44 ubiquitin specific peptidase 44
USP46 ubiquitin specific peptidase 46
USP49 ubiquitin specific peptidase 49
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
UXS1 UDP-glucuronate decarboxylase 1
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
VWA3B von Willebrand factor A domain containing 3B
VWF von Willebrand factor
WDR33 WD repeat domain 33
WDR49 WD repeat domain 49
WNK3 WNK lysine deficient protein kinase 3
YBX1 Y box binding protein 1
YME1L1 YME1-like 1 ATPase
ZBED9 zinc finger, BED-type containing 9
ZC2HC1C zinc finger, C2HC-type containing 1C
ZC3H15 zinc finger CCCH-type containing 15
ZFYVE26 zinc finger, FYVE domain containing 26
ZHX2 zinc fingers and homeoboxes 2
ZIC1 Zic family member 1
ZNF100 zinc finger protein 100
ZNF12 zinc finger protein 12
ZNF134 zinc finger protein 134
ZNF205 zinc finger protein 205
ZNF267 zinc finger protein 267
ZNF329 zinc finger protein 329
ZNF33A zinc finger protein 33A
ZNF354C zinc finger protein 354C
ZNF418 zinc finger protein 418
ZNF44 zinc finger protein 44
ZNF532 zinc finger protein 532
ZNF536 zinc finger protein 536
ZNF665 zinc finger protein 665
ZNF717 zinc finger protein 717
ZNF75D zinc finger protein 75D
ZNF768 zinc finger protein 768
ZNF805 zinc finger protein 805