NCI-H1435 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description Non-small cell lung cancer cell line. (BRENDA Tissue and Enzyme Source Ontology, BTO_0003004)
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311 genes mutated in the NCI-H1435 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACY3 aminoacylase 3
ADAM19 ADAM metallopeptidase domain 19
ADCY6 adenylate cyclase 6
ADGRE2 adhesion G protein-coupled receptor E2
ADNP2 ADNP homeobox 2
AFF1 AF4/FMR2 family, member 1
AGO3 argonaute RISC catalytic component 3
AKAP13 A kinase (PRKA) anchor protein 13
AKNA AT-hook transcription factor
ALDH9A1 aldehyde dehydrogenase 9 family, member A1
ALKBH7 alkB, alkylation repair homolog 7 (E. coli)
ALS2CL ALS2 C-terminal like
ANAPC2 anaphase promoting complex subunit 2
ANKRD37 ankyrin repeat domain 37
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APC adenomatous polyposis coli
ARHGAP39 Rho GTPase activating protein 39
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ARV1 ARV1 homolog (S. cerevisiae)
ASNSD1 asparagine synthetase domain containing 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASTN2 astrotactin 2
ASUN asunder spermatogenesis regulator
ATM ATM serine/threonine kinase
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
ATXN7L2 ataxin 7-like 2
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BBS2 Bardet-Biedl syndrome 2
BCLAF1 BCL2-associated transcription factor 1
BDKRB2 bradykinin receptor B2
BIRC6 baculoviral IAP repeat containing 6
BIVM basic, immunoglobulin-like variable motif containing
BIVM-ERCC5 BIVM-ERCC5 readthrough
BMP5 bone morphogenetic protein 5
BTBD11 BTB (POZ) domain containing 11
BTN2A2 butyrophilin, subfamily 2, member A2
C11ORF24 chromosome 11 open reading frame 24
C14ORF28 chromosome 14 open reading frame 28
C2CD5 C2 calcium-dependent domain containing 5
C3 complement component 3
C3ORF18 chromosome 3 open reading frame 18
C5ORF42 chromosome 5 open reading frame 42
C9ORF3 chromosome 9 open reading frame 3
CABLES1 Cdk5 and Abl enzyme substrate 1
CATSPERG catsper channel auxiliary subunit gamma
CCDC14 coiled-coil domain containing 14
CCDC186 coiled-coil domain containing 186
CCDC66 coiled-coil domain containing 66
CCND1 cyclin D1
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDC14B cell division cycle 14B
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEP162 centrosomal protein 162kDa
CEP164 centrosomal protein 164kDa
CEP83 centrosomal protein 83kDa
CFLAR CASP8 and FADD-like apoptosis regulator
CHD9 chromodomain helicase DNA binding protein 9
CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6
CLCN2 chloride channel, voltage-sensitive 2
CLCN4 chloride channel, voltage-sensitive 4
CLCN5 chloride channel, voltage-sensitive 5
CNPY3 canopy FGF signaling regulator 3
COBL cordon-bleu WH2 repeat protein
COBLL1 cordon-bleu WH2 repeat protein-like 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRACR2B calcium release activated channel regulator 2B
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSMD1 CUB and Sushi multiple domains 1
CSPP1 centrosome and spindle pole associated protein 1
CTNND1 catenin (cadherin-associated protein), delta 1
CXORF58 chromosome X open reading frame 58
DCAF13 DDB1 and CUL4 associated factor 13
DIDO1 death inducer-obliterator 1
DLG4 discs, large homolog 4 (Drosophila)
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNMBP dynamin binding protein
DOCK11 dedicator of cytokinesis 11
DOCK5 dedicator of cytokinesis 5
DPYD dihydropyrimidine dehydrogenase
DTX3 deltex 3, E3 ubiquitin ligase
DUSP1 dual specificity phosphatase 1
EFTUD1 elongation factor Tu GTP binding domain containing 1
EPHB3 EPH receptor B3
EPHX4 epoxide hydrolase 4
EXPH5 exophilin 5
FAM84A family with sequence similarity 84, member A
FANCA Fanconi anemia, complementation group A
FAT1 FAT atypical cadherin 1
FDX1 ferredoxin 1
FGD2 FYVE, RhoGEF and PH domain containing 2
FICD FIC domain containing
FNIP2 folliculin interacting protein 2
GAA glucosidase, alpha; acid
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GBE1 glucan (1,4-alpha-), branching enzyme 1
GJA9 gap junction protein, alpha 9, 59kDa
GLDC glycine dehydrogenase (decarboxylating)
GNS glucosamine (N-acetyl)-6-sulfatase
GSE1 Gse1 coiled-coil protein
H3F3C H3 histone, family 3C
HAX1 HCLS1 associated protein X-1
HEMGN hemogen
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HOMEZ homeobox and leucine zipper encoding
HOXB4 homeobox B4
HOXC12 homeobox C12
HPN hepsin
HRCT1 histidine rich carboxyl terminus 1
HSBP1 heat shock factor binding protein 1
HSPA1L heat shock 70kDa protein 1-like
HYPK huntingtin interacting protein K
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IDS iduronate 2-sulfatase
IER5L immediate early response 5-like
IFNGR1 interferon gamma receptor 1
IFT172 intraflagellar transport 172
INCENP inner centromere protein antigens 135/155kDa
INTS6 integrator complex subunit 6
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
KALRN kalirin, RhoGEF kinase
KAT6B K(lysine) acetyltransferase 6B
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KEAP1 kelch-like ECH-associated protein 1
KIAA0319 KIAA0319
KIAA0753 KIAA0753
KIAA1211 KIAA1211
KIAA1429 KIAA1429
KIAA2013 KIAA2013
KIF4B kinesin family member 4B
KLHL17 kelch-like family member 17
KMT2B lysine (K)-specific methyltransferase 2B
KMT2C lysine (K)-specific methyltransferase 2C
L3HYPDH L-3-hydroxyproline dehydratase (trans-)
LACE1 lactation elevated 1
LARP4 La ribonucleoprotein domain family, member 4
LRRC61 leucine rich repeat containing 61
LRRC66 leucine rich repeat containing 66
LYSMD4 LysM, putative peptidoglycan-binding, domain containing 4
MALT1 MALT1 paracaspase
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
MCM2 minichromosome maintenance complex component 2
MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
MIA3 melanoma inhibitory activity family, member 3
MINPP1 multiple inositol-polyphosphate phosphatase 1
MSL1 male-specific lethal 1 homolog (Drosophila)
MTMR10 myotubularin related protein 10
MVB12B multivesicular body subunit 12B
MYH14 myosin, heavy chain 14, non-muscle
MYLIP myosin regulatory light chain interacting protein
MYO1C myosin IC
N4BP2 NEDD4 binding protein 2
NALCN sodium leak channel, non selective
NAT6 N-acetyltransferase 6 (GCN5-related)
NBAS neuroblastoma amplified sequence
NCAPH non-SMC condensin I complex, subunit H
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NOL4L nucleolar protein 4-like
NPDC1 neural proliferation, differentiation and control, 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRSN2 neurensin 2
NSUN6 NOP2/Sun domain family, member 6
NUP160 nucleoporin 160kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OGDHL oxoglutarate dehydrogenase-like
PANK1 pantothenate kinase 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PARL presenilin associated, rhomboid-like
PARP9 poly (ADP-ribose) polymerase family, member 9
PCTP phosphatidylcholine transfer protein
PDLIM5 PDZ and LIM domain 5
PDZD8 PDZ domain containing 8
PELP1 proline, glutamate and leucine rich protein 1
PEX2 peroxisomal biogenesis factor 2
PGD phosphogluconate dehydrogenase
PHC2 polyhomeotic homolog 2 (Drosophila)
PHLDB3 pleckstrin homology-like domain, family B, member 3
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PLEKHH1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
PLRG1 pleiotropic regulator 1
PPCS phosphopantothenoylcysteine synthetase
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPP1R16A protein phosphatase 1, regulatory subunit 16A
PPP1R35 protein phosphatase 1, regulatory subunit 35
PPP1R7 protein phosphatase 1, regulatory subunit 7
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PROM2 prominin 2
PROSER3 proline and serine rich 3
PTPRS protein tyrosine phosphatase, receptor type, S
PYGO2 pygopus family PHD finger 2
RAB10 RAB10, member RAS oncogene family
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RAD54L RAD54-like (S. cerevisiae)
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
RBBP6 retinoblastoma binding protein 6
RBM10 RNA binding motif protein 10
RBM41 RNA binding motif protein 41
RC3H1 ring finger and CCCH-type domains 1
RCAN1 regulator of calcineurin 1
RNF141 ring finger protein 141
RPS20 ribosomal protein S20
RTN2 reticulon 2
RUNX2 runt-related transcription factor 2
SACS sacsin molecular chaperone
SAMD4A sterile alpha motif domain containing 4A
SCFD1 sec1 family domain containing 1
SDCCAG8 serologically defined colon cancer antigen 8
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SFSWAP splicing factor, suppressor of white-apricot family
SH2B1 SH2B adaptor protein 1
SH3D19 SH3 domain containing 19
SIN3A SIN3 transcription regulator family member A
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC46A3 solute carrier family 46, member 3
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SLX4 SLX4 structure-specific endonuclease subunit
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMOX spermine oxidase
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SPTBN1 spectrin, beta, non-erythrocytic 1
SRCIN1 SRC kinase signaling inhibitor 1
SRRM2 serine/arginine repetitive matrix 2
ST5 suppression of tumorigenicity 5
STAB1 stabilin 1
STK10 serine/threonine kinase 10
STK11 serine/threonine kinase 11
STK38L serine/threonine kinase 38 like
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SYNE2 spectrin repeat containing, nuclear envelope 2
SYNGR1 synaptogyrin 1
SYTL4 synaptotagmin-like 4
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TAOK3 TAO kinase 3
TARSL2 threonyl-tRNA synthetase-like 2
TBC1D15 TBC1 domain family, member 15
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCEA3 transcription elongation factor A (SII), 3
TCF20 transcription factor 20 (AR1)
TEAD2 TEA domain family member 2
TENM4 teneurin transmembrane protein 4
TGM2 transglutaminase 2
TGS1 trimethylguanosine synthase 1
THAP9 THAP domain containing 9
TIAM1 T-cell lymphoma invasion and metastasis 1
TIGD7 tigger transposable element derived 7
TJP3 tight junction protein 3
TM9SF4 transmembrane 9 superfamily protein member 4
TMEM185B transmembrane protein 185B
TMEM214 transmembrane protein 214
TMEM64 transmembrane protein 64
TMEM67 transmembrane protein 67
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TP53 tumor protein p53
TRAPPC10 trafficking protein particle complex 10
TRIM44 tripartite motif containing 44
TTBK2 tau tubulin kinase 2
TTC39C tetratricopeptide repeat domain 39C
TTLL7 tubulin tyrosine ligase-like family member 7
TTPA tocopherol (alpha) transfer protein
TULP4 tubby like protein 4
UBAP2L ubiquitin associated protein 2-like
UBASH3B ubiquitin associated and SH3 domain containing B
UBE4B ubiquitination factor E4B
UBTD2 ubiquitin domain containing 2
UHRF1BP1L UHRF1 binding protein 1-like
UNC13B unc-13 homolog B (C. elegans)
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
USP34 ubiquitin specific peptidase 34
USP47 ubiquitin specific peptidase 47
VANGL2 VANGL planar cell polarity protein 2
VEGFA vascular endothelial growth factor A
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WAPAL wings apart-like homolog (Drosophila)
WBP4 WW domain binding protein 4
WDFY3 WD repeat and FYVE domain containing 3
WNT11 wingless-type MMTV integration site family, member 11
WWC2 WW and C2 domain containing 2
ZBTB43 zinc finger and BTB domain containing 43
ZDHHC9 zinc finger, DHHC-type containing 9
ZFHX3 zinc finger homeobox 3
ZFP14 ZFP14 zinc finger protein
ZFYVE26 zinc finger, FYVE domain containing 26
ZNF106 zinc finger protein 106
ZNF17 zinc finger protein 17
ZNF280B zinc finger protein 280B
ZNF283 zinc finger protein 283
ZNF34 zinc finger protein 34
ZNF384 zinc finger protein 384
ZNF717 zinc finger protein 717
ZNF776 zinc finger protein 776
ZNF850 zinc finger protein 850
ZNFX1 zinc finger, NFX1-type containing 1
ZYG11B zyg-11 family member B, cell cycle regulator