NCI-H128 Gene Set

Dataset COSMIC Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description Small cell lung cancer cell line. (BRENDA Tissue and Enzyme Source Ontology, BTO_0003025)
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Genes

372 genes mutated in the NCI-H128 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

Symbol Name
AADAC arylacetamide deacetylase
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12
ABHD16B abhydrolase domain containing 16B
ACACB acetyl-CoA carboxylase beta
ACTBL2 actin, beta-like 2
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ADCY10 adenylate cyclase 10 (soluble)
ADGB androglobin
ADGRL3 adhesion G protein-coupled receptor L3
ADRA2A adrenoceptor alpha 2A
AFF1 AF4/FMR2 family, member 1
AGBL1 ATP/GTP binding protein-like 1
AHNAK2 AHNAK nucleoprotein 2
AMBP alpha-1-microglobulin/bikunin precursor
ANKRD13A ankyrin repeat domain 13A
ANP32C acidic (leucine-rich) nuclear phosphoprotein 32 family, member C
AOAH acyloxyacyl hydrolase (neutrophil)
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
APOD apolipoprotein D
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARID1A AT rich interactive domain 1A (SWI-like)
ARID4A AT rich interactive domain 4A (RBP1-like)
ASTN2 astrotactin 2
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
ATR ATR serine/threonine kinase
AUTS2 autism susceptibility candidate 2
BCHE butyrylcholinesterase
BUB3 BUB3 mitotic checkpoint protein
C3AR1 complement component 3a receptor 1
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAPNS2 calpain, small subunit 2
CASP5 caspase 5, apoptosis-related cysteine peptidase
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
CC2D1A coiled-coil and C2 domain containing 1A
CCAR2 cell cycle and apoptosis regulator 2
CCDC18 coiled-coil domain containing 18
CCDC27 coiled-coil domain containing 27
CCDC88B coiled-coil domain containing 88B
CCNT1 cyclin T1
CD101 CD101 molecule
CDC27 cell division cycle 27
CDCA8 cell division cycle associated 8
CDHR1 cadherin-related family member 1
CDK13 cyclin-dependent kinase 13
CECR2 cat eye syndrome chromosome region, candidate 2
CEP250 centrosomal protein 250kDa
CEP350 centrosomal protein 350kDa
CHAT choline O-acetyltransferase
CHD1L chromodomain helicase DNA binding protein 1-like
CHD9 chromodomain helicase DNA binding protein 9
CHPF2 chondroitin polymerizing factor 2
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CHTOP chromatin target of PRMT1
CLCA2 chloride channel accessory 2
CLCN1 chloride channel, voltage-sensitive 1
CLCN2 chloride channel, voltage-sensitive 2
CLDN22 claudin 22
CLK3 CDC-like kinase 3
CNBD1 cyclic nucleotide binding domain containing 1
CNGB3 cyclic nucleotide gated channel beta 3
CNTNAP2 contactin associated protein-like 2
COL18A1 collagen, type XVIII, alpha 1
COL21A1 collagen, type XXI, alpha 1
COL27A1 collagen, type XXVII, alpha 1
COL6A2 collagen, type VI, alpha 2
COLEC12 collectin sub-family member 12
CORIN corin, serine peptidase
COX4I1 cytochrome c oxidase subunit IV isoform 1
CROT carnitine O-octanoyltransferase
CSMD3 CUB and Sushi multiple domains 3
CST9L cystatin 9-like
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CTNNA2 catenin (cadherin-associated protein), alpha 2
CUBN cubilin (intrinsic factor-cobalamin receptor)
CUL4B cullin 4B
CYTH4 cytohesin 4
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DBN1 drebrin 1
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DIEXF digestive organ expansion factor homolog (zebrafish)
DLG2 discs, large homolog 2 (Drosophila)
DNAAF5 dynein, axonemal, assembly factor 5
DNAH5 dynein, axonemal, heavy chain 5
DNAH9 dynein, axonemal, heavy chain 9
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DNPEP aspartyl aminopeptidase
DOCK11 dedicator of cytokinesis 11
DOCK2 dedicator of cytokinesis 2
DOCK7 dedicator of cytokinesis 7
DOPEY2 dopey family member 2
DOT1L DOT1-like histone H3K79 methyltransferase
DPP6 dipeptidyl-peptidase 6
DROSHA drosha, ribonuclease type III
DSCAM Down syndrome cell adhesion molecule
DSE dermatan sulfate epimerase
DUOXA1 dual oxidase maturation factor 1
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EDNRB endothelin receptor type B
EHD4 EH-domain containing 4
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EIF6 eukaryotic translation initiation factor 6
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8
EOMES eomesodermin
EP400 E1A binding protein p400
EP400NL EP400 N-terminal like
EPHA6 EPH receptor A6
EPHA8 EPH receptor A8
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EYA4 EYA transcriptional coactivator and phosphatase 4
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM118B family with sequence similarity 118, member B
FAM129A family with sequence similarity 129, member A
FAM160A2 family with sequence similarity 160, member A2
FAM205A family with sequence similarity 205, member A
FAM83D family with sequence similarity 83, member D
FAT4 FAT atypical cadherin 4
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCRL1 Fc receptor-like 1
FCRL2 Fc receptor-like 2
FLT1 fms-related tyrosine kinase 1
FOXR2 forkhead box R2
FREM1 FRAS1 related extracellular matrix 1
FRG1 FSHD region gene 1
FRMPD3 FERM and PDZ domain containing 3
FUBP1 far upstream element (FUSE) binding protein 1
FYB FYN binding protein
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6
GAPVD1 GTPase activating protein and VPS9 domains 1
GBP5 guanylate binding protein 5
GCNT6 glucosaminyl (N-acetyl) transferase 6
GH1 growth hormone 1
GIMAP8 GTPase, IMAP family member 8
GIP gastric inhibitory polypeptide
GMNC geminin coiled-coil domain containing
GMPS guanine monphosphate synthase
GOLGA1 golgin A1
GPATCH3 G patch domain containing 3
GREB1L growth regulation by estrogen in breast cancer-like
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRK4 G protein-coupled receptor kinase 4
H2BFWT H2B histone family, member W, testis-specific
HDGF hepatoma-derived growth factor
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H1B histone cluster 1, H1b
HIST1H3C histone cluster 1, H3c
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HMCN1 hemicentin 1
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1
HPR haptoglobin-related protein
HRNR hornerin
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic
HTR3D 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic
HUS1B HUS1 checkpoint homolog b (S. pombe)
HYDIN HYDIN, axonemal central pair apparatus protein
IFI16 interferon, gamma-inducible protein 16
IL1RAPL1 interleukin 1 receptor accessory protein-like 1
INF2 inverted formin, FH2 and WH2 domain containing
ITGB4 integrin, beta 4
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2
KDM4B lysine (K)-specific demethylase 4B
KDM6A lysine (K)-specific demethylase 6A
KIAA1549 KIAA1549
KIAA1875 KIAA1875
KIF4B kinesin family member 4B
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
KLC4 kinesin light chain 4
KMT2A lysine (K)-specific methyltransferase 2A
KMT2C lysine (K)-specific methyltransferase 2C
KRT6C keratin 6C, type II
KRTAP5-4 keratin associated protein 5-4
KTN1 kinectin 1 (kinesin receptor)
LCE2A late cornified envelope 2A
LCT lactase
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LHCGR luteinizing hormone/choriogonadotropin receptor
LHX8 LIM homeobox 8
LIX1L Lix1 homolog (chicken) like
LRP1 low density lipoprotein receptor-related protein 1
LRP4 low density lipoprotein receptor-related protein 4
LYST lysosomal trafficking regulator
MAP9 microtubule-associated protein 9
MBD5 methyl-CpG binding domain protein 5
MBTPS1 membrane-bound transcription factor peptidase, site 1
MED23 mediator complex subunit 23
MEGF8 multiple EGF-like-domains 8
MFSD2B major facilitator superfamily domain containing 2B
MKKS McKusick-Kaufman syndrome
MRGPRX2 MAS-related GPR, member X2
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MSH4 mutS homolog 4
MTUS2 microtubule associated tumor suppressor candidate 2
MUC12 mucin 12, cell surface associated
MUC19 mucin 19, oligomeric
MUC4 mucin 4, cell surface associated
MUTYH mutY homolog
MYBPC3 myosin binding protein C, cardiac
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYL7 myosin, light chain 7, regulatory
MYO18B myosin XVIIIB
MYOM1 myomesin 1
MYOM3 myomesin 3
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2
NAV3 neuron navigator 3
NBAS neuroblastoma amplified sequence
NCKAP1L NCK-associated protein 1-like
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1
NKG7 natural killer cell granule protein 7
NLRP1 NLR family, pyrin domain containing 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NOV nephroblastoma overexpressed
NPC1 Niemann-Pick disease, type C1
NRSN1 neurensin 1
NT5M 5',3'-nucleotidase, mitochondrial
NTM neurotrimin
NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1
NTNG2 netrin G2
NUP153 nucleoporin 153kDa
OASL 2'-5'-oligoadenylate synthetase-like
OR11G2 olfactory receptor, family 11, subfamily G, member 2
OR11L1 olfactory receptor, family 11, subfamily L, member 1
OR2G6 olfactory receptor, family 2, subfamily G, member 6
OR2M2 olfactory receptor, family 2, subfamily M, member 2
OR2T34 olfactory receptor, family 2, subfamily T, member 34
OR52J3 olfactory receptor, family 52, subfamily J, member 3
OR7E24 olfactory receptor, family 7, subfamily E, member 24
OSCAR osteoclast associated, immunoglobulin-like receptor
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PARP6 poly (ADP-ribose) polymerase family, member 6
PCDH15 protocadherin-related 15
PCDHB3 protocadherin beta 3
PCDHB8 protocadherin beta 8
PCDHGA9 protocadherin gamma subfamily A, 9
PCLO piccolo presynaptic cytomatrix protein
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PDZK1IP1 PDZK1 interacting protein 1
PDZRN4 PDZ domain containing ring finger 4
PES1 pescadillo ribosomal biogenesis factor 1
PGLYRP3 peptidoglycan recognition protein 3
PHF3 PHD finger protein 3
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PIWIL2 piwi-like RNA-mediated gene silencing 2
PKD1L3 polycystic kidney disease 1-like 3
PLA1A phospholipase A1 member A
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHO1 pleckstrin homology domain containing, family O member 1
PNO1 partner of NOB1 homolog (S. cerevisiae)
POTEH POTE ankyrin domain family, member H
PPOX protoporphyrinogen oxidase
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRPF19 pre-mRNA processing factor 19
PRR14L proline rich 14-like
PRUNE2 prune homolog 2 (Drosophila)
PTCH2 patched 2
PTPRM protein tyrosine phosphatase, receptor type, M
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RABIF RAB interacting factor
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RASAL1 RAS protein activator like 1 (GAP1 like)
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RB1 retinoblastoma 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS22 regulator of G-protein signaling 22
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPS12 ribosomal protein S12
SCGN secretagogin, EF-hand calcium binding protein
SCN3A sodium channel, voltage gated, type III alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SEPT8 septin 8
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SESN3 sestrin 3
SH3BP4 SH3-domain binding protein 4
SHKBP1 SH3KBP1 binding protein 1
SIDT1 SID1 transmembrane family, member 1
SIGLEC10 sialic acid binding Ig-like lectin 10
SIGLEC12 sialic acid binding Ig-like lectin 12 (gene/pseudogene)
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLIT3 slit homolog 3 (Drosophila)
SOX30 SRY (sex determining region Y)-box 30
SPATA18 spermatogenesis associated 18
SPATA31D1 SPATA31 subfamily D, member 1
SPATA31D4 SPATA31 subfamily D, member 4
SPEN spen family transcriptional repressor
SPTBN4 spectrin, beta, non-erythrocytic 4
SRGN serglycin
SRSF1 serine/arginine-rich splicing factor 1
STX16 syntaxin 16
SVIL supervillin
SYNE1 spectrin repeat containing, nuclear envelope 1
SYNPO2 synaptopodin 2
SYT6 synaptotagmin VI
TADA1 transcriptional adaptor 1
TAOK3 TAO kinase 3
TAS2R1 taste receptor, type 2, member 1
TAS2R13 taste receptor, type 2, member 13
TBX20 T-box 20
TCF20 transcription factor 20 (AR1)
TCHHL1 trichohyalin-like 1
TET3 tet methylcytosine dioxygenase 3
TFAP2E transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
TJP3 tight junction protein 3
TLL2 tolloid-like 2
TM9SF3 transmembrane 9 superfamily member 3
TMTC2 transmembrane and tetratricopeptide repeat containing 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNN tenascin N
TNXB tenascin XB
TOX thymocyte selection-associated high mobility group box
TOX2 TOX high mobility group box family member 2
TP53 tumor protein p53
TP73 tumor protein p73
TPTE transmembrane phosphatase with tensin homology
TRAPPC2L trafficking protein particle complex 2-like
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae)
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSC22D2 TSC22 domain family, member 2
TSSK2 testis-specific serine kinase 2
TTN titin
TULP2 tubby like protein 2
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VWA5A von Willebrand factor A domain containing 5A
WAPAL wings apart-like homolog (Drosophila)
WBSCR17 Williams-Beuren syndrome chromosome region 17
WDFY1 WD repeat and FYVE domain containing 1
WDR41 WD repeat domain 41
WDR78 WD repeat domain 78
WDR87 WD repeat domain 87
XRN1 5'-3' exoribonuclease 1
YY1AP1 YY1 associated protein 1
ZBTB12 zinc finger and BTB domain containing 12
ZC3H11A zinc finger CCCH-type containing 11A
ZDBF2 zinc finger, DBF-type containing 2
ZFHX4 zinc finger homeobox 4
ZNF131 zinc finger protein 131
ZNF142 zinc finger protein 142
ZNF236 zinc finger protein 236
ZNF252P zinc finger protein 252, pseudogene
ZNF253 zinc finger protein 253
ZNF33A zinc finger protein 33A
ZNF385D zinc finger protein 385D
ZNF415 zinc finger protein 415
ZNF506 zinc finger protein 506
ZNF536 zinc finger protein 536
ZNF705G zinc finger protein 705G
ZNF831 zinc finger protein 831
ZNF90 zinc finger protein 90