NCI-H1048 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: carcinoma; small cell lung cancer (lung primary) (Cell Line Ontology, CLO_0007979)
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Genes

229 genes mutated in the NCI-H1048 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ABHD14B abhydrolase domain containing 14B
ABHD4 abhydrolase domain containing 4
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
ACAT2 acetyl-CoA acetyltransferase 2
ACO1 aconitase 1, soluble
ADD2 adducin 2 (beta)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKAP9 A kinase (PRKA) anchor protein 9
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ANKS6 ankyrin repeat and sterile alpha motif domain containing 6
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
ARCN1 archain 1
ARSA arylsulfatase A
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASXL1 additional sex combs like transcriptional regulator 1
ASXL2 additional sex combs like transcriptional regulator 2
ATG5 autophagy related 5
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BCORL1 BCL6 corepressor-like 1
BRD3 bromodomain containing 3
BRD9 bromodomain containing 9
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C15ORF39 chromosome 15 open reading frame 39
C2CD4A C2 calcium-dependent domain containing 4A
CAAP1 caspase activity and apoptosis inhibitor 1
CASC3 cancer susceptibility candidate 3
CBR4 carbonyl reductase 4
CCDC82 coiled-coil domain containing 82
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
CEP170B centrosomal protein 170B
CEP250 centrosomal protein 250kDa
CEP70 centrosomal protein 70kDa
CEP72 centrosomal protein 72kDa
CHD3 chromodomain helicase DNA binding protein 3
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
COPS6 COP9 signalosome subunit 6
CORO1A coronin, actin binding protein, 1A
CTCF CCCTC-binding factor (zinc finger protein)
CTGF connective tissue growth factor
CUL4A cullin 4A
CYB5R4 cytochrome b5 reductase 4
DAP3 death associated protein 3
DCLRE1B DNA cross-link repair 1B
DCP2 decapping mRNA 2
DET1 de-etiolated homolog 1 (Arabidopsis)
DGCR2 DiGeorge syndrome critical region gene 2
DLG5 discs, large homolog 5 (Drosophila)
DOLK dolichol kinase
DRAM2 DNA-damage regulated autophagy modulator 2
EFTUD1 elongation factor Tu GTP binding domain containing 1
EMC10 ER membrane protein complex subunit 10
EMC9 ER membrane protein complex subunit 9
EPB41 erythrocyte membrane protein band 4.1
EPC1 enhancer of polycomb homolog 1 (Drosophila)
EPS8L1 EPS8-like 1
ETNK1 ethanolamine kinase 1
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM171A2 family with sequence similarity 171, member A2
FASN fatty acid synthase
FAT3 FAT atypical cadherin 3
FAT4 FAT atypical cadherin 4
FBN2 fibrillin 2
FBRSL1 fibrosin-like 1
FBXO38 F-box protein 38
FCHO1 FCH domain only 1
FCN3 ficolin (collagen/fibrinogen domain containing) 3
FERMT1 fermitin family member 1
FLNC filamin C, gamma
FMNL3 formin-like 3
FN3K fructosamine 3 kinase
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FRMD6 FERM domain containing 6
FUNDC2 FUN14 domain containing 2
FUT10 fucosyltransferase 10 (alpha (1,3) fucosyltransferase)
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GALNS galactosamine (N-acetyl)-6-sulfatase
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GBGT1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
GGT7 gamma-glutamyltransferase 7
GLB1 galactosidase, beta 1
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GOLGA4 golgin A4
GORAB golgin, RAB6-interacting
HCFC1 host cell factor C1
HDGF hepatoma-derived growth factor
HEATR5A HEAT repeat containing 5A
HES6 hes family bHLH transcription factor 6
HSPG2 heparan sulfate proteoglycan 2
IFT140 intraflagellar transport 140
INO80 INO80 complex subunit
INTS1 integrator complex subunit 1
INTS12 integrator complex subunit 12
INTS6 integrator complex subunit 6
ITFG1 integrin alpha FG-GAP repeat containing 1
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein
ITPRIPL1 inositol 1,4,5-trisphosphate receptor interacting protein-like 1
KBTBD7 kelch repeat and BTB (POZ) domain containing 7
KCNK2 potassium channel, two pore domain subfamily K, member 2
KCTD13 potassium channel tetramerization domain containing 13
KDM2B lysine (K)-specific demethylase 2B
KIAA1210 KIAA1210
KIAA1211 KIAA1211
KIAA1429 KIAA1429
KIDINS220 kinase D-interacting substrate, 220kDa
KLC2 kinesin light chain 2
KTN1 kinectin 1 (kinesin receptor)
LAMA5 laminin, alpha 5
LAMP3 lysosomal-associated membrane protein 3
LIG4 ligase IV, DNA, ATP-dependent
LPPR3 lipid phosphate phosphatase-related protein type 3
LRRC8D leucine rich repeat containing 8 family, member D
LTA4H leukotriene A4 hydrolase
MAF1 MAF1 homolog (S. cerevisiae)
MAGED1 melanoma antigen family D1
MAPK4 mitogen-activated protein kinase 4
MAPKBP1 mitogen-activated protein kinase binding protein 1
MCM5 minichromosome maintenance complex component 5
MED12 mediator complex subunit 12
MOGS mannosyl-oligosaccharide glucosidase
MSH6 mutS homolog 6
MTG2 mitochondrial ribosome-associated GTPase 2
MUC20 mucin 20, cell surface associated
MYH14 myosin, heavy chain 14, non-muscle
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit
NAT10 N-acetyltransferase 10 (GCN5-related)
NAV2 neuron navigator 2
NCAPD3 non-SMC condensin II complex, subunit D3
NCKAP1 NCK-associated protein 1
NCKIPSD NCK interacting protein with SH3 domain
NCOA5 nuclear receptor coactivator 5
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NELFA negative elongation factor complex member A
NES nestin
NPAS1 neuronal PAS domain protein 1
NQO2 NAD(P)H dehydrogenase, quinone 2
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
PAPD5 PAP associated domain containing 5
PCNT pericentrin
PELP1 proline, glutamate and leucine rich protein 1
PEX26 peroxisomal biogenesis factor 26
PGBD5 piggyBac transposable element derived 5
PHF8 PHD finger protein 8
PIAS2 protein inhibitor of activated STAT, 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PNPLA6 patatin-like phospholipase domain containing 6
POFUT1 protein O-fucosyltransferase 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRKCQ protein kinase C, theta
PROX1 prospero homeobox 1
PRPF4 pre-mRNA processing factor 4
PTGER4 prostaglandin E receptor 4 (subtype EP4)
REEP4 receptor accessory protein 4
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
REV1 REV1, polymerase (DNA directed)
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RPP40 ribonuclease P/MRP 40kDa subunit
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RRP1 ribosomal RNA processing 1
RTN3 reticulon 3
RUFY1 RUN and FYVE domain containing 1
RWDD3 RWD domain containing 3
SACS sacsin molecular chaperone
SDC1 syndecan 1
SEC16A SEC16 homolog A (S. cerevisiae)
SEC24D SEC24 family member D
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFT2D1 SFT2 domain containing 1
SGK223 homolog of rat pragma of Rnd2
SGSM3 small G protein signaling modulator 3
SH2B1 SH2B adaptor protein 1
SIMC1 SUMO-interacting motifs containing 1
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC35E4 solute carrier family 35, member E4
SLC38A9 solute carrier family 38, member 9
SLC46A1 solute carrier family 46 (folate transporter), member 1
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMG6 SMG6 nonsense mediated mRNA decay factor
SMYD4 SET and MYND domain containing 4
SRCAP Snf2-related CREBBP activator protein
SRSF1 serine/arginine-rich splicing factor 1
SRXN1 sulfiredoxin 1
STK32B serine/threonine kinase 32B
STON1 stonin 1
STON1-GTF2A1L STON1-GTF2A1L readthrough
SV2B synaptic vesicle glycoprotein 2B
SYMPK symplekin
TEX264 testis expressed 264
TFIP11 tuftelin interacting protein 11
TJP1 tight junction protein 1
TMEM168 transmembrane protein 168
TMEM261 transmembrane protein 261
TMEM41B transmembrane protein 41B
TMEM43 transmembrane protein 43
TNC tenascin C
TP53 tumor protein p53
TPR translocated promoter region, nuclear basket protein
TRAPPC5 trafficking protein particle complex 5
TRRAP transformation/transcription domain-associated protein
TTC17 tetratricopeptide repeat domain 17
UNK unkempt family zinc finger
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
VPS26A vacuolar protein sorting 26 homolog A (S. pombe)
WASF3 WAS protein family, member 3
WRN Werner syndrome, RecQ helicase-like
WWC1 WW and C2 domain containing 1
XYLB xylulokinase homolog (H. influenzae)
ZBED4 zinc finger, BED-type containing 4
ZER1 zyg-11 related, cell cycle regulator
ZFHX3 zinc finger homeobox 3
ZFP64 ZFP64 zinc finger protein
ZFYVE16 zinc finger, FYVE domain containing 16
ZMYM2 zinc finger, MYM-type 2
ZNF197 zinc finger protein 197
ZNF268 zinc finger protein 268
ZNF438 zinc finger protein 438
ZNF689 zinc finger protein 689
ZNF707 zinc finger protein 707
ZNF814 zinc finger protein 814