NCI-H1048 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description disease: carcinoma; small cell lung cancer (lung primary) (Cell Line Ontology, CLO_0007979)
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Genes

353 genes with high or low expression in NCI-H1048 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 3.09397
POU2F3 POU class 2 homeobox 3 2.89999
CERS6 ceramide synthase 6 2.77164
COL2A1 collagen, type II, alpha 1 2.74748
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 2.71822
HIC1 hypermethylated in cancer 1 2.711
GPATCH4 G patch domain containing 4 2.70535
KLHL29 kelch-like family member 29 2.69705
H3F3A H3 histone, family 3A 2.68082
RFX3 regulatory factor X, 3 (influences HLA class II expression) 2.63135
ZNF232 zinc finger protein 232 2.60792
RPA4 replication protein A4, 30kDa 2.5838
TIPRL TOR signaling pathway regulator 2.58174
LMO3 LIM domain only 3 (rhombotin-like 2) 2.57674
PAX2 paired box 2 2.53597
TPR translocated promoter region, nuclear basket protein 2.4485
DMWD dystrophia myotonica, WD repeat containing 2.44152
ZNF692 zinc finger protein 692 2.44046
TROVE2 TROVE domain family, member 2 2.43617
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) 2.40527
IPO9 importin 9 2.40039
GPR161 G protein-coupled receptor 161 2.3984
CORT cortistatin 2.33543
KLHL22 kelch-like family member 22 2.33178
ADGRB2 adhesion G protein-coupled receptor B2 2.32423
NT5DC2 5'-nucleotidase domain containing 2 2.31906
SSRP1 structure specific recognition protein 1 2.27191
CDH22 cadherin 22, type 2 2.26966
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 2.24246
PBRM1 polybromo 1 2.23013
LRP1B low density lipoprotein receptor-related protein 1B 2.21993
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 2.17534
PCNXL2 pecanex-like 2 (Drosophila) 2.17176
AMH anti-Mullerian hormone 2.16645
ZNF638 zinc finger protein 638 2.14925
SLC22A17 solute carrier family 22, member 17 2.14786
CCKBR cholecystokinin B receptor 2.11665
U2AF1 U2 small nuclear RNA auxiliary factor 1 2.10682
CRYBB2 crystallin, beta B2 2.094
VAMP4 vesicle-associated membrane protein 4 2.09055
FANCG Fanconi anemia, complementation group G 2.08885
NHLRC2 NHL repeat containing 2 2.08709
PTPRT protein tyrosine phosphatase, receptor type, T 2.07087
ADORA1 adenosine A1 receptor 2.06524
SOX4 SRY (sex determining region Y)-box 4 2.03352
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C) 2.02618
IPCEF1 interaction protein for cytohesin exchange factors 1 2.01085
PAIP1 poly(A) binding protein interacting protein 1 2.00529
ZNF124 zinc finger protein 124 1.99811
CRLF1 cytokine receptor-like factor 1 1.99601
NBR2 neighbor of BRCA1 gene 2 (non-protein coding) 1.99584
ZNF672 zinc finger protein 672 1.99231
ETV7 ets variant 7 1.99101
DLX5 distal-less homeobox 5 1.98881
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 1.9866
DCHS1 dachsous cadherin-related 1 1.98062
NSG1 neuron specific gene family member 1 1.969
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 1.96873
ZNF324 zinc finger protein 324 1.9667
PMF1 polyamine-modulated factor 1 1.96343
SLC30A3 solute carrier family 30 (zinc transporter), member 3 1.93687
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 1.93425
GNAT3 guanine nucleotide binding protein, alpha transducing 3 1.93007
NLGN3 neuroligin 3 1.92833
FLJ22184 1.92183
EFS embryonal Fyn-associated substrate 1.91711
NISCH nischarin 1.91335
RBM4B RNA binding motif protein 4B 1.91201
ZNF419 zinc finger protein 419 1.90691
TMCC2 transmembrane and coiled-coil domain family 2 1.90677
GABARAP GABA(A) receptor-associated protein 1.89495
NBPF10 neuroblastoma breakpoint family, member 10 1.89472
FCN3 ficolin (collagen/fibrinogen domain containing) 3 1.8911
IFT22 intraflagellar transport 22 1.88458
SMG7 SMG7 nonsense mediated mRNA decay factor 1.87781
E2F3 E2F transcription factor 3 1.87313
TRPC3 transient receptor potential cation channel, subfamily C, member 3 1.87308
STAG1 stromal antigen 1 1.86992
IPP intracisternal A particle-promoted polypeptide 1.8653
OR2J3 olfactory receptor, family 2, subfamily J, member 3 1.85924
RNPEP arginyl aminopeptidase (aminopeptidase B) 1.8548
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 1.85152
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 1.85147
LMO4 LIM domain only 4 1.84739
FGF7 fibroblast growth factor 7 1.83311
RAB36 RAB36, member RAS oncogene family 1.82833
ADRA1B adrenoceptor alpha 1B 1.82639
YLPM1 YLP motif containing 1 1.82082
AVIL advillin 1.81957
SMR3B submaxillary gland androgen regulated protein 3B 1.81146
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C 1.80732
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 1.80598
PCGF2 polycomb group ring finger 2 1.80583
DNAI1 dynein, axonemal, intermediate chain 1 1.80317
FANCC Fanconi anemia, complementation group C 1.8025
KLF11 Kruppel-like factor 11 1.78331
ZNF544 zinc finger protein 544 1.78329
RAB11FIP2 RAB11 family interacting protein 2 (class I) 1.7812
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 1.76879
ZNF710 zinc finger protein 710 1.76689
PITX2 paired-like homeodomain 2 1.75943
INTS3 integrator complex subunit 3 1.74831
TMEM121 transmembrane protein 121 1.74396
NT5M 5',3'-nucleotidase, mitochondrial 1.73812
CEP350 centrosomal protein 350kDa 1.73169
MTMR7 myotubularin related protein 7 1.73023
RAD9A RAD9 homolog A (S. pombe) 1.72632
NKX2-5 NK2 homeobox 5 1.72041
TNNT2 troponin T type 2 (cardiac) 1.7204
HMX1 H6 family homeobox 1 1.71391
DUSP9 dual specificity phosphatase 9 1.70416
ECEL1 endothelin converting enzyme-like 1 1.702
TRIM58 tripartite motif containing 58 1.70199
LPGAT1 lysophosphatidylglycerol acyltransferase 1 1.69977
IL17RB interleukin 17 receptor B 1.69752
FCGBP Fc fragment of IgG binding protein 1.69658
KHK ketohexokinase (fructokinase) 1.6947
IP6K1 inositol hexakisphosphate kinase 1 1.69328
PELP1 proline, glutamate and leucine rich protein 1 1.67726
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) 1.66987
FNDC4 fibronectin type III domain containing 4 1.66935
RAVER2 ribonucleoprotein, PTB-binding 2 1.6655
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 1.66303
NENF neudesin neurotrophic factor 1.66229
PTOV1 prostate tumor overexpressed 1 1.65776
GLTSCR1 glioma tumor suppressor candidate region gene 1 1.65581
SRA1 steroid receptor RNA activator 1 1.65505
NRF1 nuclear respiratory factor 1 1.65281
ZNF669 zinc finger protein 669 1.6452
SETD5 SET domain containing 5 1.642
PATZ1 POZ (BTB) and AT hook containing zinc finger 1 1.63772
HOXC10 homeobox C10 1.6282
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 1.62723
GYPB glycophorin B (MNS blood group) 1.61666
KIAA1614 KIAA1614 1.61074
NFIB nuclear factor I/B 1.60982
MLXIPL MLX interacting protein-like 1.60739
BRD3 bromodomain containing 3 1.60723
ELF2 E74-like factor 2 (ets domain transcription factor) 1.60219
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.59789
EPRS glutamyl-prolyl-tRNA synthetase 1.59517
FZD9 frizzled class receptor 9 1.59265
SOSTDC1 sclerostin domain containing 1 1.59203
ADNP2 ADNP homeobox 2 1.58605
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 1.58467
LPL lipoprotein lipase 1.58239
FBXO42 F-box protein 42 1.56467
RPRD2 regulation of nuclear pre-mRNA domain containing 2 1.56282
WDHD1 WD repeat and HMG-box DNA binding protein 1 1.55882
EFR3B EFR3 homolog B (S. cerevisiae) 1.55681
MSTN myostatin 1.55679
FOXD2 forkhead box D2 1.55506
FXR2 fragile X mental retardation, autosomal homolog 2 1.5548
TBX1 T-box 1 1.55241
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 1.55226
OR7A17 olfactory receptor, family 7, subfamily A, member 17 1.55223
TTC13 tetratricopeptide repeat domain 13 1.55191
GOLGA2P5 golgin A2 pseudogene 5 1.55075
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 1.5476
RAD54L2 RAD54-like 2 (S. cerevisiae) 1.54451
GRM2 glutamate receptor, metabotropic 2 1.54217
TMEM106C transmembrane protein 106C 1.53867
KLHL25 kelch-like family member 25 1.53652
CIDEA cell death-inducing DFFA-like effector a 1.53485
DLG3 discs, large homolog 3 (Drosophila) 1.53328
TUBGCP4 tubulin, gamma complex associated protein 4 1.52848
PAX6 paired box 6 1.52564
TBC1D2B TBC1 domain family, member 2B 1.52466
CNTN5 contactin 5 1.52181
AHI1 Abelson helper integration site 1 1.51908
CACNB3 calcium channel, voltage-dependent, beta 3 subunit 1.51667
ZCCHC8 zinc finger, CCHC domain containing 8 1.51665
EFNA4 ephrin-A4 1.51648
LOC257152 uncharacterized LOC257152 1.51538
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 1.5094
GPR137 G protein-coupled receptor 137 1.50585
TBCD tubulin folding cofactor D 1.50574
TMSB15A thymosin beta 15a 1.5057
EMX2 empty spiracles homeobox 2 1.50524
MSH4 mutS homolog 4 1.50458
MTA2 metastasis associated 1 family, member 2 1.50047
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 1.4982
POU4F3 POU class 4 homeobox 3 1.49754
TTLL5 tubulin tyrosine ligase-like family member 5 1.49613
MNX1 motor neuron and pancreas homeobox 1 1.49457
SORBS3 sorbin and SH3 domain containing 3 1.49451
FAM90A1 family with sequence similarity 90, member A1 1.49442
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 1.49424
SETD1B SET domain containing 1B 1.4933
TMF1 TATA element modulatory factor 1 1.4901
PASK PAS domain containing serine/threonine kinase 1.49002
CCL1 chemokine (C-C motif) ligand 1 1.48897
TLE2 transducin-like enhancer of split 2 1.48548
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6 1.48479
ANKRD36B ankyrin repeat domain 36B 1.48219
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 1.47988
MARC2 mitochondrial amidoxime reducing component 2 1.47604
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 1.47281
CLUL1 clusterin-like 1 (retinal) 1.47059
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae) 1.46609
T T, brachyury homolog (mouse) 1.46354
TEX14 testis expressed 14 1.46159
RBM8A RNA binding motif protein 8A 1.46095
CCNE1 cyclin E1 1.45971
WDR6 WD repeat domain 6 1.45659
SEPHS1 selenophosphate synthetase 1 1.45546
GPC6 glypican 6 1.45501
ADGRL1 adhesion G protein-coupled receptor L1 1.4528
RBM6 RNA binding motif protein 6 1.4504
YBX2 Y box binding protein 2 1.45008
ZMIZ1 zinc finger, MIZ-type containing 1 1.44966
NRTN neurturin 1.44743
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma 1.44653
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 1.44301
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 1.44293
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 1.44052
LRP3 low density lipoprotein receptor-related protein 3 1.43772
BGLAP bone gamma-carboxyglutamate (gla) protein 1.43554
DEPDC5 DEP domain containing 5 1.43545
EFNB3 ephrin-B3 1.43099
CIRBP cold inducible RNA binding protein 1.42843
ISL1 ISL LIM homeobox 1 1.42456
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 1.42406
PCBP2 poly(rC) binding protein 2 1.42308
CLK2 CDC-like kinase 2 1.42263
GLP2R glucagon-like peptide 2 receptor 1.42213
APAF1 apoptotic peptidase activating factor 1 1.41999
KMT2A lysine (K)-specific methyltransferase 2A 1.41927
PPY2P pancreatic polypeptide 2, pseudogene 1.41892
CRYM crystallin, mu 1.41851

low expression

Symbol Name Standardized Value
RSRC1 arginine/serine-rich coiled-coil 1 -3.53723
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -3.48614
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 -3.29495
ZC3H7A zinc finger CCCH-type containing 7A -2.66526
SERINC3 serine incorporator 3 -2.63202
UBFD1 ubiquitin family domain containing 1 -2.51907
HMOX2 heme oxygenase 2 -2.38593
MYOZ3 myozenin 3 -2.33475
SELT selenoprotein T -2.32634
GABARAPL2 GABA(A) receptor-associated protein-like 2 -2.27601
TMCO1 transmembrane and coiled-coil domains 1 -2.2396
CENPN centromere protein N -2.21371
EMC8 ER membrane protein complex subunit 8 -2.21274
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -2.16884
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 -2.14617
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit -2.12491
MLH1 mutL homolog 1 -2.11098
NRP2 neuropilin 2 -2.1045
S100A11 S100 calcium binding protein A11 -2.08343
TUBA4B tubulin, alpha 4b -2.07506
CENPO centromere protein O -2.06812
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein -2.06036
IMPAD1 inositol monophosphatase domain containing 1 -2.05941
HIST1H2AG histone cluster 1, H2ag -2.05144
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 -2.05031
PTGER3 prostaglandin E receptor 3 (subtype EP3) -2.04092
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 -2.0317
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -2.02994
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 -2.01372
TRPC5 transient receptor potential cation channel, subfamily C, member 5 -1.99255
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -1.97666
ZNF140 zinc finger protein 140 -1.9395
CCDC91 coiled-coil domain containing 91 -1.93149
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase -1.92398
DERL1 derlin 1 -1.9173
TTC17 tetratricopeptide repeat domain 17 -1.90164
NMT1 N-myristoyltransferase 1 -1.89267
ESR2 estrogen receptor 2 (ER beta) -1.88836
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -1.88315
DLD dihydrolipoamide dehydrogenase -1.87463
TMEM8A transmembrane protein 8A -1.86548
MED31 mediator complex subunit 31 -1.8633
ZNF557 zinc finger protein 557 -1.83537
AKAP11 A kinase (PRKA) anchor protein 11 -1.82724
ICAM1 intercellular adhesion molecule 1 -1.82221
ZFP69B ZFP69 zinc finger protein B -1.81133
MRPS33 mitochondrial ribosomal protein S33 -1.77828
ZNF37BP zinc finger protein 37B, pseudogene -1.76988
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) -1.76603
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like -1.75395
SH3GLB1 SH3-domain GRB2-like endophilin B1 -1.74693
TXNDC9 thioredoxin domain containing 9 -1.74641
ITFG1 integrin alpha FG-GAP repeat containing 1 -1.74201
HIST1H2BE histone cluster 1, H2be -1.73544
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 -1.73493
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -1.71462
TM9SF3 transmembrane 9 superfamily member 3 -1.71322
ALS2CL ALS2 C-terminal like -1.70391
HIST1H2AC histone cluster 1, H2ac -1.70286
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 -1.7024
PPP4C protein phosphatase 4, catalytic subunit -1.68556
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -1.67653
ARL2BP ADP-ribosylation factor-like 2 binding protein -1.66668
STX4 syntaxin 4 -1.65536
ADAM10 ADAM metallopeptidase domain 10 -1.6358
MAP3K7 mitogen-activated protein kinase kinase kinase 7 -1.63448
TCTA T-cell leukemia translocation altered -1.63082
ZNF277 zinc finger protein 277 -1.62564
HLA-DOA major histocompatibility complex, class II, DO alpha -1.61856
ERCC4 excision repair cross-complementation group 4 -1.61479
WNT3 wingless-type MMTV integration site family, member 3 -1.61264
HEATR3 HEAT repeat containing 3 -1.60775
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa -1.60329
GLIPR1 GLI pathogenesis-related 1 -1.59907
PRR13 proline rich 13 -1.58988
TM9SF4 transmembrane 9 superfamily protein member 4 -1.5879
UXS1 UDP-glucuronate decarboxylase 1 -1.58258
MIA2 melanoma inhibitory activity 2 -1.58232
ZMYM6 zinc finger, MYM-type 6 -1.58024
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2 -1.57817
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -1.57752
CDR2 cerebellar degeneration-related protein 2, 62kDa -1.57712
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase -1.57424
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) -1.56907
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -1.56161
ZDHHC7 zinc finger, DHHC-type containing 7 -1.55841
NINJ1 ninjurin 1 -1.5583
MPI mannose phosphate isomerase -1.54813
PTGES prostaglandin E synthase -1.54715
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 -1.53743
RNF139 ring finger protein 139 -1.5321
ERN1 endoplasmic reticulum to nucleus signaling 1 -1.50768
IGLJ3 immunoglobulin lambda joining 3 -1.50302
STAT1 signal transducer and activator of transcription 1, 91kDa -1.49998
FRZB frizzled-related protein -1.49266
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 -1.49107
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -1.48988
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -1.48909
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -1.4885
PNRC1 proline-rich nuclear receptor coactivator 1 -1.47928
RPL36AL ribosomal protein L36a-like -1.46404
SWAP70 SWAP switching B-cell complex 70kDa subunit -1.46045
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -1.46027
VDAC1 voltage-dependent anion channel 1 -1.45999
PTRH2 peptidyl-tRNA hydrolase 2 -1.45914
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -1.4553
HLTF helicase-like transcription factor -1.44192
UBE2H ubiquitin-conjugating enzyme E2H -1.4419
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -1.44155
S100A4 S100 calcium binding protein A4 -1.43826
RNF170 ring finger protein 170 -1.43608
CASP1 caspase 1, apoptosis-related cysteine peptidase -1.43581
TFCP2 transcription factor CP2 -1.43231
FAM118A family with sequence similarity 118, member A -1.43199
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -1.43031
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -1.42495
SLFN12 schlafen family member 12 -1.42325
SEPHS2 selenophosphate synthetase 2 -1.42218
ERO1L ERO1-like (S. cerevisiae) -1.4212
MAP2K1 mitogen-activated protein kinase kinase 1 -1.42112
CTSC cathepsin C -1.421
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -1.41786
CCT8L2 chaperonin containing TCP1, subunit 8 (theta)-like 2 -1.41675