N-acetyl-L-leucine-6462 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the N-acetyl-L-leucine-6462 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY10 adenylate cyclase 10 (soluble)
AIM2 absent in melanoma 2
ANXA2P3 annexin A2 pseudogene 3
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APOL2 apolipoprotein L, 2
ARL2BP ADP-ribosylation factor-like 2 binding protein
ASPH aspartate beta-hydroxylase
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BCO1 beta-carotene oxygenase 1
CA1 carbonic anhydrase I
CCDC134 coiled-coil domain containing 134
CD44 CD44 molecule (Indian blood group)
CD86 CD86 molecule
CD8A CD8a molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CFLAR CASP8 and FADD-like apoptosis regulator
CLCN7 chloride channel, voltage-sensitive 7
CLEC4E C-type lectin domain family 4, member E
CLEC7A C-type lectin domain family 7, member A
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
COL3A1 collagen, type III, alpha 1
CRHR2 corticotropin releasing hormone receptor 2
CSNK1G1 casein kinase 1, gamma 1
DFNB31 deafness, autosomal recessive 31
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERAP1 endoplasmic reticulum aminopeptidase 1
ERO1LB ERO1-like beta (S. cerevisiae)
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FOXP3 forkhead box P3
FSCN3 fascin actin-bundling protein 3, testicular
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GJB3 gap junction protein, beta 3, 31kDa
HBS1L HBS1-like translational GTPase
HIST1H3F histone cluster 1, H3f
IFNAR1 interferon (alpha, beta and omega) receptor 1
IHH indian hedgehog
IL18BP interleukin 18 binding protein
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIF21B kinesin family member 21B
KIF5A kinesin family member 5A
LEFTY1 left-right determination factor 1
LRP12 low density lipoprotein receptor-related protein 12
LRP2 low density lipoprotein receptor-related protein 2
LRRC23 leucine rich repeat containing 23
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LRRN2 leucine rich repeat neuronal 2
LTB4R leukotriene B4 receptor
MAPK10 mitogen-activated protein kinase 10
MCTP2 multiple C2 domains, transmembrane 2
MED14 mediator complex subunit 14
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MUC6 mucin 6, oligomeric mucus/gel-forming
NHLH2 nescient helix loop helix 2
NKX3-2 NK3 homeobox 2
NR1H4 nuclear receptor subfamily 1, group H, member 4
NT5M 5',3'-nucleotidase, mitochondrial
NUP188 nucleoporin 188kDa
OCM2 oncomodulin 2
PAX8 paired box 8
PCDH1 protocadherin 1
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PKLR pyruvate kinase, liver and RBC
PLTP phospholipid transfer protein
PLXNB3 plexin B3
POMT2 protein-O-mannosyltransferase 2
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
PVR poliovirus receptor
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RASAL2 RAS protein activator like 2
RGS11 regulator of G-protein signaling 11
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RUNX1 runt-related transcription factor 1
SAA3P serum amyloid A3 pseudogene
SAMD9 sterile alpha motif domain containing 9
SIRT5 sirtuin 5
SIX1 SIX homeobox 1
SLA Src-like-adaptor
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SPAG6 sperm associated antigen 6
TENM4 teneurin transmembrane protein 4
TMEM246 transmembrane protein 246
TRA2A transformer 2 alpha homolog (Drosophila)
TSC22D2 TSC22 domain family, member 2
USP46 ubiquitin specific peptidase 46
VSNL1 visinin-like 1
ZNF750 zinc finger protein 750
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ADAP2 ArfGAP with dual PH domains 2
ADTRP androgen-dependent TFPI-regulating protein
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APOD apolipoprotein D
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASPN asporin
BAG4 BCL2-associated athanogene 4
CA11 carbonic anhydrase XI
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CAPRIN2 caprin family member 2
CCDC85C coiled-coil domain containing 85C
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CD3D CD3d molecule, delta (CD3-TCR complex)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHRM3 cholinergic receptor, muscarinic 3
CLCN6 chloride channel, voltage-sensitive 6
CLDN17 claudin 17
CLSPN claspin
CXADR coxsackie virus and adenovirus receptor
CXXC4 CXXC finger protein 4
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DDIT3 DNA-damage-inducible transcript 3
DYSF dysferlin
EGFL7 EGF-like-domain, multiple 7
FBXO2 F-box protein 2
GBP2 guanylate binding protein 2, interferon-inducible
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H4D histone cluster 1, H4d
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXC5 homeobox C5
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGSF1 immunoglobulin superfamily, member 1
IL15RA interleukin 15 receptor, alpha
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
INCENP inner centromere protein antigens 135/155kDa
IRF1 interferon regulatory factor 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KDM8 lysine (K)-specific demethylase 8
KPNA4 karyopherin alpha 4 (importin alpha 3)
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOC100287590 uncharacterized LOC100287590
LRP5L low density lipoprotein receptor-related protein 5-like
LRRC8E leucine rich repeat containing 8 family, member E
LY6G5C lymphocyte antigen 6 complex, locus G5C
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MCC mutated in colorectal cancers
MCTP1 multiple C2 domains, transmembrane 1
MED31 mediator complex subunit 31
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MXD3 MAX dimerization protein 3
MYBBP1A MYB binding protein (P160) 1a
NECAP2 NECAP endocytosis associated 2
NELL2 NEL-like 2 (chicken)
NPTX1 neuronal pentraxin I
NR1H2 nuclear receptor subfamily 1, group H, member 2
NT5DC3 5'-nucleotidase domain containing 3
PADI2 peptidyl arginine deiminase, type II
PARP12 poly (ADP-ribose) polymerase family, member 12
PLD3 phospholipase D family, member 3
PRDM14 PR domain containing 14
PRSS22 protease, serine, 22
PTPRE protein tyrosine phosphatase, receptor type, E
PTPRU protein tyrosine phosphatase, receptor type, U
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF19B ring finger protein 19B
RNF31 ring finger protein 31
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SECTM1 secreted and transmembrane 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLMO1 slowmo homolog 1 (Drosophila)
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SSFA2 sperm specific antigen 2
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
STK16 serine/threonine kinase 16
STRA6 stimulated by retinoic acid 6
SYNC syncoilin, intermediate filament protein
SYNGR3 synaptogyrin 3
THBS3 thrombospondin 3
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TLR5 toll-like receptor 5
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TOM1 target of myb1 (chicken)
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TTC4 tetratricopeptide repeat domain 4
UBQLN4 ubiquilin 4
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR62 WD repeat domain 62
XYLT2 xylosyltransferase II
ZNF365 zinc finger protein 365
ZNF428 zinc finger protein 428
ZNF442 zinc finger protein 442
ZNF492 zinc finger protein 492
ZNF506 zinc finger protein 506
ZNF623 zinc finger protein 623